homoharringtonine has been researched along with Cicatrix* in 2 studies
2 other study(ies) available for homoharringtonine and Cicatrix
| Article | Year |
|---|---|
An experimental study on homoharringtonine liposome and glaucoma filtration surgery.
To observe the inhibitory action of homoharringtonine liposome during the healing process of wounds in the filtering sites.. Posterior sclerectomies were performed in 14 rabbits. Postoperatively one eye of each rabbit received subconjunctival injections of HH liposome and fellow eye received saline injection in a randomized masked fashion.. Fourteen days after operation the IOP of experimental eyes reduced significantly (P < 0.01) as compared with the controlled eyes, and the number of remaining filtering blebs increased noticeably (P < 0.05). Pathohistological examination revealed that the number of fibroblasts per square micron in the filtering sites and the thickness of the scars in the center of the filtering sites of the experimental eyes were less than those of the controlled eyes. No serious ocular toxic and side effects were found.. This experiment suggest that homoharringtonine liposome can markedly inhibit the scar formation of filtering sites after glaucoma filtering surgery, promote the formation of filtering blebs, and provide an experimental evidence for its clinical use in future. Topics: Animals; Cicatrix; Filtering Surgery; Glaucoma; Harringtonines; Homoharringtonine; Liposomes; Postoperative Period; Rabbits | 1999 |
[Low dosage of homoharringtonine for prevention of cicatrization after glaucoma filtering surgery].
To prevent the cicatrization of filtering blebs after glaucoma filtering surgery, subconjunctival injections of low dosage homoharringtonine were administered to 22 glaucomatous eyes (20 patients) postoperatively. The percentage of functional filtering blebs was 90.9% and the mean postoperative IOP was 2.04 +/- 0.68 kPa (1 kPa = 7.5 mmHg). In comparison with the control group, the differences were very significant (P < or = 0.01). The results suggest that the toxicity of low dosage of homoharringtonine be very low, it inhibit fibroblast proliferation and play important roles in the formation of the functional filtering blebs and elevation of the success rate of filtration operation. Topics: Adult; Aged; Antimetabolites; Cicatrix; Female; Filtering Surgery; Follow-Up Studies; Glaucoma, Angle-Closure; Harringtonines; Homoharringtonine; Humans; Male; Middle Aged | 1995 |