homogentisic acid has been researched along with Ochronosis in 92 studies
Homogentisic Acid: Dihydroxyphenylacetic acid with hydroxyls at the 2 and 5 positions of the phenyl ring.
homogentisic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents at the 2- and 5-positions.
Ochronosis: The yellowish discoloration of connective tissue due to deposition of HOMOGENTISIC ACID (a brown-black pigment). This is due to defects in the metabolism of PHENYLALANINE and TYROSINE. Ochronosis occurs in ALKAPTONURIA, but has also been associated with exposure to certain chemicals (e.g., PHENOL, trinitrophenol, BENZENE DERIVATIVES).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alkaptonuria (AKU) is an ultra-rare genetic disease caused by a deficient activity of the enzyme homogentisate 1,2-dioxygenase (HGD) leading to the accumulation of homogentisic acid (HGA) on connective tissues." | 8.12 | Homogentisic acid induces autophagy alterations leading to chondroptosis in human chondrocytes: Implications in Alkaptonuria. ( Bernardini, G; Braconi, D; Cicaloni, V; Galderisi, S; Giustarini, D; Lupetti, P; Milella, MS; Millucci, L; Prischi, F; Rossi, M; Rossi, R; Salvini, L; Santucci, A; Spiga, O; Tinti, C; Tinti, L, 2022) |
| " Morbidity of AKU is secondary to high circulating homogentisic acid (HGA) and ochronosis." | 7.96 | Homogentisic acid is not only eliminated by glomerular filtration and tubular secretion but also produced in the kidney in alkaptonuria. ( Arnoux, JB; Braconi, D; Bygott, H; Davison, AS; Fitzgerald, R; Gallagher, JA; Genovese, F; Glasova, H; Hughes, AT; Hughes, JH; Imrich, R; Jarvis, JC; Khedr, M; Laan, D; Le Quan Sang, KH; Luangrath, E; Mankowitz, L; Milan, AM; Norman, BP; Olsson, B; Psarelli, EE; Ranganath, LR; Rhodes, NP; Rudebeck, M; Santucci, A; Shweihdi, E; Sireau, N; Stančík, R; van Kan, C; Zatkova, A, 2020) |
| "Alkaptonuria (AKU) is a disease caused by a deficient homogentisate 1,2-dioxygenase activity leading to systemic accumulation of homogentisic acid (HGA), that forms a melanin-like polymer that progressively deposits onto connective tissues causing a pigmentation called "ochronosis" and tissue degeneration." | 7.91 | Homogentisic acid induces morphological and mechanical aberration of ochronotic cartilage in alkaptonuria. ( Bernardini, G; Braconi, D; Consumi, M; Galderisi, S; Giorgetti, G; Leone, G; Lupetti, P; Magnani, A; Marzocchi, B; Millucci, L; Santucci, A; Spiga, O; Viti, C, 2019) |
| "Nitisinone decreases homogentisic acid (HGA), but has not been shown to modify progression of Alkaptonuria (AKU)." | 7.88 | Nitisinone arrests ochronosis and decreases rate of progression of Alkaptonuria: Evaluation of the effect of nitisinone in the United Kingdom National Alkaptonuria Centre. ( Barton, GJ; Briggs, M; Cox, TF; Daroszewska, A; Davison, AS; Devine, JM; Dillon, JP; Fisher, M; Gallagher, JA; Griffin, R; Harrold, J; Hughes, AT; Hughes, G; Jarvis, JC; Jones, A; Judd, S; Khedr, M; Loftus, N; McCormick, M; Milan, AM; Psarelli, EE; Ranganath, LR; Sireau, N; Taylor, S; Usher, JL; Vinjamuri, S; West, E, 2018) |
| " Such a deficiency leads to the accumulation of homogentisic acid (HGA) and its oxidized/polymerized products in connective tissues, where melanin-like pigments accumulate (ochronosis)." | 7.77 | Redox-proteomics of the effects of homogentisic acid in an in vitro human serum model of alkaptonuric ochronosis. ( Bernardini, G; Bianchini, C; Braconi, D; Laschi, M; Millucci, L; Santucci, A; Spreafico, A, 2011) |
| "Ochronosis is the process in alkaptonuria (AKU) that causes all the debilitating morbidity." | 6.61 | Ochronotic pigmentation is caused by homogentisic acid and is the key event in alkaptonuria leading to the destructive consequences of the disease-A review. ( Gallagher, JA; Norman, BP; Ranganath, LR, 2019) |
| "Ochronosis and alkaptonuria are manifestations of the same condition-a rare autosomal recessive disorder resulting from a constitutional lack of homogentisate 1,2-dioxygenase (HGD) with the consequent accumulation of homogentisic acid (HGA)." | 5.12 | A Mimic of Ankylosing Spondylitis, Ochronosis: Case Report and Review of the Literature. ( Bracken, SJ; Chu, P; Cuellar, MC; Tarrant, TK, 2021) |
| "Alkaptonuria (AKU) is a very rare autosomal recessive disorder of tyrosine metabolism in the liver due to deficiency of homogentisate 1,2 dioxygenase (HGD) activity, resulting in the accumulation of homogentisic acid (HGA)." | 4.89 | Alkaptonuria: a very rare metabolic disorder. ( Aquaron, R, 2013) |
| "Alkaptonuria is a rare autosomal recessive metabolic disease that leads to the deposition of homogentisic acid." | 4.84 | Alkaptonuria presenting with ochronotic spondyloarthropathy. ( Al-Mahfoudh, R; Buxton, N; Clark, S, 2008) |
| " A diagnosis of ochronosis was made by the observation of bluish-brown pigmentation in the nose and ears, dark urine colors following alkalization, and high levels of homogentisic acid in the urine." | 4.84 | Ochronosis in differential diagnosis of patients with chronic backache: a review of the literature. ( Capkin, E; Karkucak, M; Serdaroğlu, M; Tosun, M; Yayli, S, 2007) |
| "Ochronosis is a rare disease caused by an inherited lack of homogentisic acid oxidase." | 4.79 | The clinical manifestations of ochronosis: a review. ( De Clerck, LS; Francx, LM; Stevens, WJ; Van Offel, JF, 1995) |
| " 203500) is a rare, slow-progressing, irreversible, multisystemic disease resulting from a deficiency of the homogentisate 1,2-dioxygenase enzyme, which leads to the accumulation of homogentisic acid (HGA) and subsequent deposition as pigment in connective tissues called ochronosis." | 4.31 | Nutritional interventions for patients with alkaptonuria: A minireview. ( Havranova, A; Imrich, R; Lukacova, O; Penesova, A; Radikova, Z; Ranganath, L; Sedlakova, J; Vlcek, M; Zanova, E; Zatkova, A, 2023) |
| "Alkaptonuria (AKU) is a rare genetic autosomal recessive disorder characterized by elevated serum levels of homogentisic acid (HGA)." | 4.31 | Identification of Potential Inhibitors for the Treatment of Alkaptonuria Using an Integrated In Silico Computational Strategy. ( Dera, AA; Hussain, N; Khan, I; Ogaly, HA; Rana, N; Zaib, S, 2023) |
| "Alkaptonuria (AKU) is an ultra-rare genetic disease caused by a deficient activity of the enzyme homogentisate 1,2-dioxygenase (HGD) leading to the accumulation of homogentisic acid (HGA) on connective tissues." | 4.12 | Homogentisic acid induces autophagy alterations leading to chondroptosis in human chondrocytes: Implications in Alkaptonuria. ( Bernardini, G; Braconi, D; Cicaloni, V; Galderisi, S; Giustarini, D; Lupetti, P; Milella, MS; Millucci, L; Prischi, F; Rossi, M; Rossi, R; Salvini, L; Santucci, A; Spiga, O; Tinti, C; Tinti, L, 2022) |
| "Alkaptonuria is characterized by the accumulation of homogentisic acid (HGA), part of which is excreted in the urine but the excess HGA forms a dark brown ochronotic pigment that deposits in the connective tissue (ochronosis), eventually leading to early-onset severe arthropathy." | 4.12 | Alkaptonuria in Russia. ( Kuzin, A; Samarkina, E; Soltysova, A; Zatkova, A, 2022) |
| "Alkaptonuria (AKU), a rare genetic disorder, is characterized by the accumulation of homogentisic acid (HGA) in organs due to a deficiency in functional levels of the enzyme homogentisate 1,2-dioxygenase (HGD), required for the breakdown of HGA, because of mutations in the HGD gene." | 4.02 | A molecular spectroscopy approach for the investigation of early phase ochronotic pigment development in Alkaptonuria. ( Atrei, A; Baratto, MC; Bernini, A; Manetti, F; Petricci, E; Santucci, A, 2021) |
| "Alkaptonuria (AKU) is an ultra-rare disease caused by the deficient activity of homogentisate 1,2-dioxygenase enzyme, leading the accumulation of homogentisic acid (HGA) in connective tissues implicating the formation of a black pigmentation called "ochronosis." | 4.02 | Homogentisic acid induces cytoskeleton and extracellular matrix alteration in alkaptonuric cartilage. ( Alves, LS; Cicaloni, V; Crevenna, AH; Galderisi, S; Geminiani, M; Milella, MS; Millucci, L; Salvini, L; Santucci, A; Spiga, O; Tinti, C; Tinti, L; Vieira, OV, 2021) |
| " This discoloration and early degeneration of the cartilage is characteristic for the metabolic disorder alkaptonuria in which homogentisic acid accumulates in the body." | 4.02 | [A male with black cartilage]. ( Verhaar, JAN; Visser, D, 2021) |
| " Morbidity of AKU is secondary to high circulating homogentisic acid (HGA) and ochronosis." | 3.96 | Homogentisic acid is not only eliminated by glomerular filtration and tubular secretion but also produced in the kidney in alkaptonuria. ( Arnoux, JB; Braconi, D; Bygott, H; Davison, AS; Fitzgerald, R; Gallagher, JA; Genovese, F; Glasova, H; Hughes, AT; Hughes, JH; Imrich, R; Jarvis, JC; Khedr, M; Laan, D; Le Quan Sang, KH; Luangrath, E; Mankowitz, L; Milan, AM; Norman, BP; Olsson, B; Psarelli, EE; Ranganath, LR; Rhodes, NP; Rudebeck, M; Santucci, A; Shweihdi, E; Sireau, N; Stančík, R; van Kan, C; Zatkova, A, 2020) |
| "Alkaptonuria (AKU) is a rare disease correlated with deficiency of the enzyme homogentisate 1,2 dioxygenase, which causes homogentisic acid (HGA) accumulation." | 3.96 | Homogentisic acid affects human osteoblastic functionality by oxidative stress and alteration of the Wnt/β-catenin signaling pathway. ( Bernardini, G; Giustarini, D; Marzocchi, B; Millucci, L; Rossi, R; Santucci, A; Schiavone, ML, 2020) |
| "Alkaptonuria (AKU) is a disease caused by a deficient homogentisate 1,2-dioxygenase activity leading to systemic accumulation of homogentisic acid (HGA), that forms a melanin-like polymer that progressively deposits onto connective tissues causing a pigmentation called "ochronosis" and tissue degeneration." | 3.91 | Homogentisic acid induces morphological and mechanical aberration of ochronotic cartilage in alkaptonuria. ( Bernardini, G; Braconi, D; Consumi, M; Galderisi, S; Giorgetti, G; Leone, G; Lupetti, P; Magnani, A; Marzocchi, B; Millucci, L; Santucci, A; Spiga, O; Viti, C, 2019) |
| "Endogenous ochronosis (EO) or alkaptonuria is an inherited autosomal recessive disease caused by the insufficiency of the enzyme homogentisic acid dioxygenase." | 3.91 | Endogenous ochronosis: when clinical suspicion prevails over histopathology. ( García-Briz, MI; Gegúndez-Hernández, H; Mateu-Puchades, A; Moneva-Léniz, LM; Pose-Lapausa, P; Sánchez-Martínez, EM, 2019) |
| "Nitisinone decreases homogentisic acid (HGA), but has not been shown to modify progression of Alkaptonuria (AKU)." | 3.88 | Nitisinone arrests ochronosis and decreases rate of progression of Alkaptonuria: Evaluation of the effect of nitisinone in the United Kingdom National Alkaptonuria Centre. ( Barton, GJ; Briggs, M; Cox, TF; Daroszewska, A; Davison, AS; Devine, JM; Dillon, JP; Fisher, M; Gallagher, JA; Griffin, R; Harrold, J; Hughes, AT; Hughes, G; Jarvis, JC; Jones, A; Judd, S; Khedr, M; Loftus, N; McCormick, M; Milan, AM; Psarelli, EE; Ranganath, LR; Sireau, N; Taylor, S; Usher, JL; Vinjamuri, S; West, E, 2018) |
| "Alkaptonuria (AKU) is an ultra-rare inborn error of metabolism characterized by homogentisic acid (HGA) accumulation due to a deficient activity of the homogentisate 1." | 3.85 | Homogentisic acid induces aggregation and fibrillation of amyloidogenic proteins. ( Bernardini, G; Bernini, A; Braconi, D; Lupetti, P; Marzocchi, B; Millucci, L; Niccolai, N; Santucci, A; Spiga, O, 2017) |
| "Alkaptonuria is a rare autosomal recessive condition resulting from inability to breakdown homogentisic acid (HGA), an intermediate in tyrosine degradation." | 3.83 | A role for interleukins in ochronosis in a chondrocyte in vitro model of alkaptonuria. ( Bukhari, M; Jackson, DJ; Mistry, JB; Taylor, AM, 2016) |
| "Alkaptonuria is a rare metabolic disease caused by a partial or total deficiency of homogentisic acid oxidase, which results in excess homogentisic acid (HGA) levels." | 3.83 | Long-term result of arthroplasty in the treatment of a case of ochronotic arthropathy. ( Karaaslan, F; Karaoğlu, S; Mermerkaya, MU, 2016) |
| "Alkaptonuria is an ultra-rare autosomal recessive disease developed from the lack of homogentisate 1,2-dioxygenase (HGD) activity, causing an accumulation in connective tissues of homogentisic acid (HGA) and its oxidized derivatives in polymerized form." | 3.81 | Homogentisate 1,2 dioxygenase is expressed in brain: implications in alkaptonuria. ( Bernardini, G; Braconi, D; Geminiani, M; Laschi, M; Lupetti, P; Manetti, F; Millucci, L; Santucci, A; Vannuccini, E, 2015) |
| "Alkaptonuria is a rare inherited disorder of tyrosine metabolism, which results in deposition of homogentisic acid in the connective tissues." | 3.79 | Choice of valve prosthesis in a rare clinical condition: aortic stenosis due to alkaptonuria. ( Cullen, H; Markman, P; Thakur, S, 2013) |
| "Alkaptonuria (AKU) is due to excessive homogentisic acid accumulation in body fluids due to lack of enzyme homogentisate dioxygenase leading in turn to varied clinical manifestations mainly by a process of conversion of HGA to a polymeric melanin-like pigment known as ochronosis." | 3.77 | A quantitative assessment of alkaptonuria: testing the reliability of two disease severity scoring systems. ( Cox, TF; Ranganath, L, 2011) |
| "Alkaptonuria (AKU) is an autosomal recessive disorder caused by a deficiency of homogentisate 1,2 dioxygenase (HGD) and characterized by homogentisic aciduria, ochronosis, and ochronotic arthritis." | 3.77 | An update on molecular genetics of Alkaptonuria (AKU). ( Zatkova, A, 2011) |
| " Alkaptonuria can result in accumulation of homogentisic acid." | 3.77 | Black aorta in a patient with alkaptonuria (ochronosis). ( Casali, G; Concistrè, G; Fiorani, B; Loforte, A; Musumeci, F; Ranocchi, F, 2011) |
| "Alkaptonuria (AKU) is a genetic disorder caused by lack of the enzyme responsible for breaking down homogentisic acid (HGA), an intermediate in tyrosine metabolism." | 3.77 | Development of an in vitro model to investigate joint ochronosis in alkaptonuria. ( Davidson, JS; Fraser, WD; Gallagher, JA; Jarvis, JC; Ranganath, LR; Santucci, A; Taylor, AM; Tinti, L; Wilson, PJ; Wlodarski, B, 2011) |
| "Increased circulating homogentisic acid in body fluids occurs in alkaptonuria (AKU) due to lack of enzyme homogentisate dioxygenase leading in turn to conversion of HGA to a pigmented melanin-like polymer, known as ochronosis." | 3.77 | Natural history of alkaptonuria revisited: analyses based on scoring systems. ( Cox, TF; Ranganath, LR, 2011) |
| " Such a deficiency leads to the accumulation of homogentisic acid (HGA) and its oxidized/polymerized products in connective tissues, where melanin-like pigments accumulate (ochronosis)." | 3.77 | Redox-proteomics of the effects of homogentisic acid in an in vitro human serum model of alkaptonuric ochronosis. ( Bernardini, G; Bianchini, C; Braconi, D; Laschi, M; Millucci, L; Santucci, A; Spreafico, A, 2011) |
| "Alkaptonuria is a genetic disorder of tyrosine metabolism, resulting in elevated circulating concentrations of homogentisic acid." | 3.77 | The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria. ( Boyde, A; Davidson, JS; Gallagher, JA; Hunt, JA; Jarvis, JC; Ranganath, LR; Taylor, AM; Wilson, PJ, 2011) |
| " This leads to the accumulation of homogentisic acid (HGA) and its oxidized/polymerized products in connective tissues, which in turn become characterized by the presence of melanin-like pigments (ochronosis)." | 3.76 | Evaluation of anti-oxidant treatments in an in vitro model of alkaptonuric ochronosis. ( Amato, L; Bernardini, G; Braconi, D; Cavallo, G; Laschi, M; Marcolongo, R; Millucci, L; Santucci, A; Spreafico, A, 2010) |
| " Homogentisic acid was present in the patient's urine sample, suggesting him to be suffering from Alkaptonuria." | 3.76 | Chronic low backache and stiffness may not be due ankylosing spondylitis. ( Ahmed, S; Ali, N; Shah, Z, 2010) |
| " Urine homogentisic acid level was elevated, which is diagnostic for alkaptonuria." | 3.76 | Alkaptonuria. ( Anolik, R; Pomeranz, MK; Yancovitz, M, 2010) |
| "All affected individuals presented with typical features of AKU including darkening of the urine, ochronosis, arthropathy, and elevated urinary excretion of homogentisic acid." | 3.74 | Three-generational alkaptonuria in a non-consanguineous family. ( Engel, K; Haas, D; Lee-Kirsch, MA; Oexle, K; Tinschert, S, 2008) |
| "Alkaptonuria is a rare disorder of metabolism caused by deficiency of homogentisic acid oxidase enzyme and characterized by triad of homogentisic aciduria (dark urine), relentlessly progressive arthritis and ochronosis." | 3.74 | Alkaptonuria and intramedullary calcification. ( Dhiman, DS; Gupta, D; Kaushal, SS; Mahesh, DM; Negi, A; Raina, S; Sharma, S, 2008) |
| "The deficiency of homogentisic acid oxidase, an enzyme that is mainly found in hepatocytes, is associated with alkaptonuria and ochronosis." | 3.73 | Ochronotic arthropathy: disappearance of alkaptonuria after liver transplantation for hepatitis B-related cirrhosis. ( Argin, M; Inal, V; Kobak, AC; Kobak, S; Oder, G, 2005) |
| "Alkaptonuria is a rare, autosomal recessive metabolic disorder in which the homogentisic acid oxidase activity is absent." | 3.73 | Ochronosis and lumbar disc herniation. ( Daneyemez, M; Gürkanlar, D; Solmaz, I; Temiz, C, 2006) |
| " Observation of blue-gray pigmentation around his nose and ears suggested a diagnosis of ochronosis, which was confirmed by the detection of high levels of homogentisic acid in the urine and dark urine color following alkalization." | 3.72 | [Ankylosis of the spine in a case with ochronosis]. ( Bezer, M; Güven, O; Kocaoğlu, B, 2003) |
| "Ochronosis is a musculoskeletal manifestation of alkaptonuria, a rare hereditary metabolic disorder characterised by the absence of the enzyme homogentisic acid oxidase and associated with various systemic abnormalities related to the deposition of homogentisic acid pigment (ochronotic pigment)." | 3.70 | Bilateral hip arthroplasty for ochronotic arthropathy. ( Aynaci, O; Onder, C; Turhan, AU, 2000) |
| "A 75-year-old man was diagnosed with alcaptonuria by direct identification of homogentisic acid in the urine using gas chromatography-mass spectrometry." | 3.69 | Alcaptonuria: a case complicated with valvular heart disease and immunodeficiency. ( Fuji-i, H; Kakinuma, H; Kawaguchi, T; Koga, S; Mori, S; Nakakuma, H; Suzushima, H; Takatsuki, K; Tsuji, N, 1994) |
| "Alkaptonuria is a disease often forgotten because of its rarity." | 2.82 | Ochronotic arthropathy in the context of spondyloarthritis differential diagnosis: a case-based review. ( Batalov, A; Batalov, Z; Karalilova, R; Kostova, T, 2022) |
| "Ochronosis is the process in alkaptonuria (AKU) that causes all the debilitating morbidity." | 2.61 | Ochronotic pigmentation is caused by homogentisic acid and is the key event in alkaptonuria leading to the destructive consequences of the disease-A review. ( Gallagher, JA; Norman, BP; Ranganath, LR, 2019) |
| "The alkaptonuria was diagnosed after histopathological examination of the black disc material." | 2.49 | Alkaptonuric patient presenting with "black" disc: a case report. ( Ergüngör, MF; Günaydin, A; Kahveci, R; Temiz, A, 2013) |
| "Alkaptonuria is a degenerative arthropathy that leads to reduction of functional ability." | 1.72 | [Ochronosis: A case report]. ( Erraoui, K; Janani, S; Nassar, K, 2022) |
| "Alkaptonuria is a rare autosomal recessive disease." | 1.62 | [Severe spine lesion following alkaptonuria. Case report]. ( Bludov, AB; Gorozhanin, AV; Krylov, AS; Kuzin, AV; Kuzin, DA; Radenska-Lopovok, SG; Smirnov, AV, 2021) |
| "Alkaptonuria is a rare autosomal recessive disorder of inborn errors of metabolism." | 1.32 | Alkaptonuria caused by compound heterozygote mutations. ( Aytuğ, AF; Elçioğlu, M; Elçioğlu, NH; Ergun, T; Gürbüz, O; Kotiloğlu, E; Müller, CR, 2003) |
| "Alkaptonuric ochronosis is rare disorder of tyrosin catabolism with an autosomal recessive trait." | 1.31 | [Ochronosis: a case report with multisystemic affectation, including pericardium]. ( Cobos Soler, FJ; Molero Cabrilla, R, 2002) |
| "Alcaptonuria is a rare (incidence approx." | 1.29 | [Alkaptonuria and ochronotic arthropathy. Arthroscopic and intraoperative findings in implantation of a knee joint surface replacing prosthesis]. ( Lubinus, HH; Lubinus, P; Ramsperger, R, 1994) |
| "Homogentisic acid was detectable in the urine by thin layer chromatography, and asymptomatic spondylosis with intervertebral disc calcification was found." | 1.27 | Knee arthropathy in ochronosis: diagnosis by arthroscopy with ultrastructural features. ( Lurie, DP; Musil, G, 1984) |
| "Alkaptonuria is found relatively frequently in Slovakia, Eastern Czechoslovakia (1 in 25,000 inhabitants)." | 1.26 | Alkaptonuria. ( Srsen, S, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (21.74) | 18.7374 |
| 1990's | 5 (5.43) | 18.2507 |
| 2000's | 19 (20.65) | 29.6817 |
| 2010's | 29 (31.52) | 24.3611 |
| 2020's | 19 (20.65) | 2.80 |
| Authors | Studies |
|---|---|
| Soltysova, A | 1 |
| Kuzin, A | 1 |
| Samarkina, E | 1 |
| Zatkova, A | 4 |
| Gorozhanin, AV | 1 |
| Kuzin, AV | 1 |
| Bludov, AB | 1 |
| Radenska-Lopovok, SG | 1 |
| Smirnov, AV | 1 |
| Kuzin, DA | 1 |
| Krylov, AS | 1 |
| Bernini, A | 2 |
| Petricci, E | 1 |
| Atrei, A | 1 |
| Baratto, MC | 1 |
| Manetti, F | 2 |
| Santucci, A | 13 |
| Roopnarinesingh, RC | 1 |
| Donlon, NE | 1 |
| Reynolds, JV | 1 |
| Galderisi, S | 3 |
| Milella, MS | 2 |
| Rossi, M | 1 |
| Cicaloni, V | 2 |
| Rossi, R | 2 |
| Giustarini, D | 2 |
| Spiga, O | 4 |
| Tinti, L | 4 |
| Salvini, L | 2 |
| Tinti, C | 2 |
| Braconi, D | 9 |
| Millucci, L | 10 |
| Lupetti, P | 4 |
| Prischi, F | 1 |
| Bernardini, G | 9 |
| Erraoui, K | 1 |
| Nassar, K | 1 |
| Janani, S | 1 |
| Kostova, T | 1 |
| Batalov, Z | 1 |
| Karalilova, R | 1 |
| Batalov, A | 1 |
| de Azevedo Magalhaes, O | 1 |
| Abdel Rahman Abu Hwas, D | 1 |
| Imrich, R | 2 |
| Lukacova, O | 1 |
| Sedlakova, J | 1 |
| Zanova, E | 1 |
| Vlcek, M | 1 |
| Penesova, A | 1 |
| Radikova, Z | 1 |
| Havranova, A | 1 |
| Ranganath, L | 2 |
| Zaib, S | 1 |
| Rana, N | 1 |
| Hussain, N | 1 |
| Ogaly, HA | 1 |
| Dera, AA | 1 |
| Khan, I | 1 |
| Ranganath, LR | 7 |
| Milan, AM | 2 |
| Hughes, AT | 2 |
| Khedr, M | 3 |
| Davison, AS | 2 |
| Shweihdi, E | 1 |
| Norman, BP | 2 |
| Hughes, JH | 1 |
| Bygott, H | 1 |
| Luangrath, E | 1 |
| Fitzgerald, R | 1 |
| Psarelli, EE | 2 |
| van Kan, C | 1 |
| Laan, D | 1 |
| Olsson, B | 1 |
| Rudebeck, M | 1 |
| Mankowitz, L | 1 |
| Sireau, N | 2 |
| Arnoux, JB | 1 |
| Le Quan Sang, KH | 1 |
| Jarvis, JC | 4 |
| Genovese, F | 1 |
| Glasova, H | 1 |
| Stančík, R | 1 |
| Rhodes, NP | 1 |
| Gallagher, JA | 7 |
| Schiavone, ML | 1 |
| Marzocchi, B | 3 |
| Vinjamuri, S | 2 |
| Geminiani, M | 2 |
| Vieira, OV | 1 |
| Alves, LS | 1 |
| Crevenna, AH | 1 |
| Pinto, WBVR | 1 |
| Farias, IB | 1 |
| Badia, BML | 1 |
| Vieira de Albuquerque Filho, JM | 1 |
| Machado, RIL | 1 |
| de Souza, PVS | 1 |
| Oliveira, ASB | 1 |
| Visser, D | 1 |
| Verhaar, JAN | 1 |
| Chu, P | 1 |
| Cuellar, MC | 1 |
| Bracken, SJ | 1 |
| Tarrant, TK | 1 |
| Khalil, R | 1 |
| Ali, D | 1 |
| Mwafi, N | 1 |
| Alsaraireh, A | 1 |
| Obeidat, L | 1 |
| Albsoul, E | 1 |
| Al Sbou', I | 1 |
| Kumps, C | 1 |
| Stanovici, J | 1 |
| Chaibi, E | 1 |
| Campos-Xavier, B | 1 |
| Pavlidou, DC | 1 |
| Tran, C | 1 |
| Usher, JL | 1 |
| Taylor, S | 1 |
| Loftus, N | 1 |
| Daroszewska, A | 1 |
| West, E | 1 |
| Jones, A | 1 |
| Briggs, M | 1 |
| Fisher, M | 1 |
| McCormick, M | 1 |
| Judd, S | 1 |
| Griffin, R | 1 |
| Cox, TF | 3 |
| Dillon, JP | 1 |
| Devine, JM | 1 |
| Hughes, G | 1 |
| Harrold, J | 1 |
| Barton, GJ | 1 |
| Leone, G | 1 |
| Consumi, M | 1 |
| Viti, C | 1 |
| Giorgetti, G | 1 |
| Magnani, A | 1 |
| Sánchez-Martínez, EM | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Determining Individualised Gait Modification Strategies to Reduce Knee Joint Moments in Alkaptonuria Patients Using Real-time Feedback[NCT04142671] | 30 participants (Anticipated) | Interventional | 2021-10-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for homogentisic acid and Ochronosis
| Article | Year |
|---|---|
Ochronotic arthropathy in the context of spondyloarthritis differential diagnosis: a case-based review.
Topics: Aged; Alkaptonuria; Ascorbic Acid; Cartilage Diseases; Dioxygenases; Homogentisic Acid; Humans; Join | 2022 |
A Mimic of Ankylosing Spondylitis, Ochronosis: Case Report and Review of the Literature.
Topics: Alkaptonuria; Animals; Homogentisic Acid; Humans; Ochronosis; Spondylitis, Ankylosing | 2021 |
Ochronotic pigmentation is caused by homogentisic acid and is the key event in alkaptonuria leading to the destructive consequences of the disease-A review.
Topics: Alkaptonuria; Animals; Cartilage; Chondrocytes; Homogentisic Acid; Humans; Mice; Ochronosis; Oxidati | 2019 |
Alkaptonuric patient presenting with "black" disc: a case report.
Topics: Alkaptonuria; Color; Diagnosis, Differential; Female; Homogentisic Acid; Humans; Intervertebral Disc | 2013 |
Alkaptonuria: a very rare metabolic disorder.
Topics: Alkaptonuria; Homogentisic Acid; Humans; Melanins; Ochronosis | 2013 |
Oxidative stress and mechanisms of ochronosis in alkaptonuria.
Topics: Alkaptonuria; Homogentisic Acid; Humans; Ochronosis; Oxidative Stress | 2015 |
Endogenous ochronosis with a predominant acrokeratoelastoidosis-like presentation.
Topics: Acrodermatitis; Adult; Biopsy, Needle; Diagnosis, Differential; Elasticity; Female; Follow-Up Studie | 2008 |
Alkaptonuria presenting with ochronotic spondyloarthropathy.
Topics: Alkaptonuria; Antioxidants; Ascorbic Acid; Female; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; | 2008 |
Ochronosis in differential diagnosis of patients with chronic backache: a review of the literature.
Topics: Alkaptonuria; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Ascorbic Acid; Back Pain; Calcino | 2007 |
The clinical manifestations of ochronosis: a review.
Topics: Cardiovascular Diseases; Homogentisic Acid; Humans; Joint Diseases; Ochronosis; Pigmentation Disorde | 1995 |
[Alkaptonuria (homogentisic aciduria)].
Topics: Alkaptonuria; Arthritis; Diagnosis, Differential; Dioxygenases; Homogentisate 1,2-Dioxygenase; Homog | 1998 |
[Ochronotic arthropathy].
Topics: Alkaptonuria; Ascorbic Acid; Cartilage, Articular; Homogentisic Acid; Humans; Joint Diseases; Ochron | 1973 |
80 other studies available for homogentisic acid and Ochronosis
| Article | Year |
|---|---|
Alkaptonuria in Russia.
Topics: Alkaptonuria; Exons; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Humans; Joint Diseases; Ochro | 2022 |
[Severe spine lesion following alkaptonuria. Case report].
Topics: Aged; Alkaptonuria; Homogentisic Acid; Humans; Intervertebral Disc; Ochronosis; Spinal Diseases | 2021 |
A molecular spectroscopy approach for the investigation of early phase ochronotic pigment development in Alkaptonuria.
Topics: Acetates; Adult; Aged; Alkaptonuria; Benzoquinones; Case-Control Studies; Dynamic Light Scattering; | 2021 |
Alkaptonuria: clinical manifestations and an updated approach to treatment of a rare disease.
Topics: Alkaptonuria; Cartilage, Articular; Homogentisic Acid; Humans; Ochronosis; Rare Diseases | 2021 |
Homogentisic acid induces autophagy alterations leading to chondroptosis in human chondrocytes: Implications in Alkaptonuria.
Topics: Alkaptonuria; Apoptosis; Autophagy; Biomarkers; Cartilage, Articular; Cell Line; Chondrocytes; Homog | 2022 |
[Ochronosis: A case report].
Topics: Aged; Alkaptonuria; Homogentisic Acid; Humans; Knee Joint; Ochronosis; Radiography | 2022 |
Descemet's membrane folds in ochronosis: a case report.
Topics: Aged; Aged, 80 and over; Cornea; Descemet Membrane; Homogentisic Acid; Humans; Male; Ochronosis; Vis | 2022 |
Nutritional interventions for patients with alkaptonuria: A minireview.
Topics: Alkaptonuria; Homogentisic Acid; Humans; Ochronosis; Tyrosine; Tyrosinemias | 2023 |
Identification of Potential Inhibitors for the Treatment of Alkaptonuria Using an Integrated In Silico Computational Strategy.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Alkaptonuria; Homogentisic Acid; Humans; Molecular Docking Simu | 2023 |
Homogentisic acid is not only eliminated by glomerular filtration and tubular secretion but also produced in the kidney in alkaptonuria.
Topics: Adult; Alkaptonuria; Case-Control Studies; Creatinine; Female; Glomerular Filtration Rate; Homogenti | 2020 |
Homogentisic acid affects human osteoblastic functionality by oxidative stress and alteration of the Wnt/β-catenin signaling pathway.
Topics: Alkaptonuria; beta Catenin; Bone and Bones; Cells, Cultured; Homogentisic Acid; Humans; Inflammation | 2020 |
Characterizing the alkaptonuria joint and spine phenotype and assessing the effect of homogentisic acid lowering therapy in a large cohort of 87 patients.
Topics: Aged; Alkaptonuria; Cohort Studies; Cyclohexanones; Female; Homogentisic Acid; Humans; Joints; Linea | 2021 |
Homogentisic acid induces cytoskeleton and extracellular matrix alteration in alkaptonuric cartilage.
Topics: Actins; Alkaptonuria; Cartilage, Articular; Chondrocytes; Cytoskeleton; Extracellular Matrix; Homoge | 2021 |
Cervical Spondylotic Myelopathy Secondary to Ochronotic Vertebral Arthropathy.
Topics: Adult; Alkaptonuria; Bone Diseases, Metabolic; Cervical Vertebrae; Gait Disorders, Neurologic; Homog | 2021 |
[A male with black cartilage].
Topics: Alkaptonuria; Arthroplasty, Replacement, Knee; Cartilage; Color; Homogentisic Acid; Humans; Incident | 2021 |
Variant Analysis of Alkaptonuria Families with Significant Founder Effect in Jordan.
Topics: Adolescent; Adult; Alkaptonuria; Child; Child, Preschool; Exons; Family Health; Female; Founder Effe | 2021 |
Black cartilage: Incidentally discovered articular ochronosis during arthroplasty.
Topics: Alkaptonuria; Arthroplasty, Replacement, Knee; Cartilage; Homogentisic Acid; Humans; Incidental Find | 2021 |
Nitisinone arrests ochronosis and decreases rate of progression of Alkaptonuria: Evaluation of the effect of nitisinone in the United Kingdom National Alkaptonuria Centre.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Alkaptonuria; Cyclohexanones; Disease Progression; Female; Homo | 2018 |
Homogentisic acid induces morphological and mechanical aberration of ochronotic cartilage in alkaptonuria.
Topics: Alkaptonuria; Cartilage, Articular; Chondrocytes; Homogentisic Acid; Humans; Ochronosis; Oxidation-R | 2019 |
Endogenous ochronosis: when clinical suspicion prevails over histopathology.
Topics: Alkaptonuria; Female; Homogentisic Acid; Humans; Hyperpigmentation; Joint Diseases; Middle Aged; Och | 2019 |
Glaucoma With Alkaptonuria as a Result of Pigment Accumulation.
Topics: Aged; Alkaptonuria; Conjunctival Diseases; Glaucoma, Open-Angle; Gonioscopy; Homogentisic Acid; Huma | 2019 |
Clinical and in vivo confocal microscopic findings of a patient with ocular ochronosis.
Topics: Adult; Alkaptonuria; Conjunctival Diseases; Corneal Diseases; Corneal Pachymetry; Descemet Membrane; | 2014 |
Homogentisate 1,2 dioxygenase is expressed in brain: implications in alkaptonuria.
Topics: Alkaptonuria; Animals; Blood-Brain Barrier; Blotting, Western; Brain; Cell Line, Tumor; Homogentisat | 2015 |
A 61-year-old man with hyperpigmentation. Ochronosis.
Topics: Aortic Valve; Aortic Valve Stenosis; Biopsy; Heart Valve Prosthesis Implantation; Homogentisic Acid; | 2015 |
A role for interleukins in ochronosis in a chondrocyte in vitro model of alkaptonuria.
Topics: Alkaptonuria; Cell Line; Chondrocytes; Homogentisic Acid; Humans; Interleukin-10; Interleukin-6; Och | 2016 |
Tyrosinase, could it be a missing link in ochronosis in alkaptonuria?
Topics: Alkaptonuria; Animals; Catechol Oxidase; Collagen; Genes, Recessive; Homogentisic Acid; Humans; Mela | 2016 |
Long-term result of arthroplasty in the treatment of a case of ochronotic arthropathy.
Topics: Alkaptonuria; Arthroplasty, Replacement, Knee; Chronic Pain; Homogentisic Acid; Humans; Knee Joint; | 2016 |
Homogentisic acid induces aggregation and fibrillation of amyloidogenic proteins.
Topics: Alkaptonuria; alpha-Synuclein; Amyloid beta-Peptides; Amyloidogenic Proteins; Amyloidosis; Atrial Na | 2017 |
Exogenous Ochronosis in Facial Melasma.
Topics: Dermoscopy; Facial Dermatoses; Female; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Humans; Hyd | 2017 |
[Ocular ochronosis. A case report].
Topics: Biopsy; Calcinosis; Conjunctiva; Homogentisic Acid; Humans; Intervertebral Disc; Low Back Pain; Lumb | 2008 |
Alkaptonuria and intramedullary calcification.
Topics: Alkaptonuria; Calcinosis; Disease Progression; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Hum | 2008 |
Three-generational alkaptonuria in a non-consanguineous family.
Topics: Adult; Aged; Alkaptonuria; Biomarkers; DNA Mutational Analysis; Female; Gene Frequency; Genetic Pred | 2008 |
Evaluation of anti-oxidant treatments in an in vitro model of alkaptonuric ochronosis.
Topics: Acetylcysteine; Alkaptonuria; Antioxidants; Ascorbic Acid; Cells, Cultured; Coumaric Acids; Homogent | 2010 |
Evaluation of antioxidant drugs for the treatment of ochronotic alkaptonuria in an in vitro human cell model.
Topics: Acetylcysteine; Alkaptonuria; Antioxidants; Apoptosis; Ascorbic Acid; Cartilage, Articular; Cell Pro | 2010 |
Chronic low backache and stiffness may not be due ankylosing spondylitis.
Topics: Adult; Alkaptonuria; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Homogentisic Acid; Huma | 2010 |
Development of an in vitro model to investigate joint ochronosis in alkaptonuria.
Topics: Alkaptonuria; Cells, Cultured; Homogentisic Acid; Humans; Joint Diseases; Models, Biological; Ochron | 2011 |
Alkaptonuria.
Topics: Aged; Alkaptonuria; Arthritis; Cyclohexanones; Female; Homogentisic Acid; Humans; Joint Diseases; Ni | 2010 |
Black aorta in a patient with alkaptonuria (ochronosis).
Topics: Alkaptonuria; Aortic Valve Stenosis; Female; Heart Valve Prosthesis Implantation; Homogentisic Acid; | 2011 |
An update on molecular genetics of Alkaptonuria (AKU).
Topics: Alkaptonuria; Chromosome Mapping; Chromosomes, Human, Pair 3; DNA Mutational Analysis; Dominican Rep | 2011 |
A quantitative assessment of alkaptonuria: testing the reliability of two disease severity scoring systems.
Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Alkaptonuria; Causality; Cohort Studie | 2011 |
Natural history of alkaptonuria revisited: analyses based on scoring systems.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Adolescent; Adult; Aged; Aged, 80 and over; Alkaptonuria; Arthr | 2011 |
Redox-proteomics of the effects of homogentisic acid in an in vitro human serum model of alkaptonuric ochronosis.
Topics: Alkaptonuria; Benzoquinones; Glutathione Peroxidase; Glutathione Reductase; Homogentisic Acid; Human | 2011 |
Clinical images: Magnetic resonance imaging appearance of alkaptonuria.
Topics: Alkaptonuria; Diagnosis, Differential; Gas Chromatography-Mass Spectrometry; Homogentisic Acid; Huma | 2012 |
The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria.
Topics: Alkaptonuria; Bone and Bones; Calcinosis; Cartilage, Articular; Disease Progression; Extracellular M | 2011 |
Choice of valve prosthesis in a rare clinical condition: aortic stenosis due to alkaptonuria.
Topics: Aged; Alkaptonuria; Aortic Valve Stenosis; Heart Valve Prosthesis; Homogentisic Acid; Humans; Male; | 2013 |
[Ochronosis: a case report with multisystemic affectation, including pericardium].
Topics: Aged; Aged, 80 and over; Alkaptonuria; Calcinosis; Dioxygenases; Female; Heart Diseases; Homogentisa | 2002 |
Alkaptonuria caused by compound heterozygote mutations.
Topics: Adult; Alkaptonuria; Biopsy; Exons; Face; Heterozygote; Homogentisic Acid; Humans; Male; Ochronosis; | 2003 |
Atmospheric oxidation of homogentisic acid: spectrophotometric studies.
Topics: Gentisates; Homogentisic Acid; Ochronosis; Oxidation-Reduction | 1957 |
Studies on ochronosis. I. The distribution of homogentisic acid in guinea pigs.
Topics: Animals; Guinea Pigs; Homogentisic Acid; Ochronosis; Phenylacetates | 1962 |
Studies on ochronosis. 2. Effects of injection of homogentisic acid and ochronotic pigment in experimental animals.
Topics: Animals; Homogentisic Acid; Injections; Ochronosis; Phenylacetates | 1962 |
Ochronotic arthropathy: arthroscopic findings in the shoulder and the knee.
Topics: Adult; Arthroscopy; Cartilage, Articular; Collagen; Collagen Diseases; Homogentisic Acid; Humans; Jo | 2003 |
[Ankylosis of the spine in a case with ochronosis].
Topics: Adult; Ankylosis; Calcinosis; Diagnosis, Differential; Homogentisic Acid; Humans; Low Back Pain; Lum | 2003 |
Pigmented conjunctival lesions as initial manifestation of ochronosis.
Topics: Alkaptonuria; Conjunctival Diseases; Homogentisic Acid; Humans; Male; Middle Aged; Ochronosis; Pigme | 2004 |
Cutaneous markers in ochronosis.
Topics: Adult; Biomarkers; Chromatography, High Pressure Liquid; Female; Homogentisic Acid; Humans; Ochronos | 2005 |
Hip arthroplasty for ochronosis.
Topics: Aged; Arthralgia; Arthroplasty, Replacement, Hip; Bone Cements; Female; Homogentisic Acid; Humans; M | 2005 |
Ochronotic arthropathy: disappearance of alkaptonuria after liver transplantation for hepatitis B-related cirrhosis.
Topics: Alkaptonuria; Female; Follow-Up Studies; Hepatitis C; Homogentisic Acid; Humans; Liver Cirrhosis; Li | 2005 |
Ochronosis and lumbar disc herniation.
Topics: Alkaptonuria; Coloring Agents; Connective Tissue Diseases; Diskectomy; Homogentisate 1,2-Dioxygenase | 2006 |
Lower-back pain, intervertebral-disc calcification and scleral pigmentation.
Topics: Calcinosis; Cheek; Hand; Homogentisic Acid; Humans; Intervertebral Disc; Low Back Pain; Male; Middle | 2006 |
Alcaptonuria detected in the sixth decade of life.
Topics: Alkaptonuria; Homogentisic Acid; Humans; Male; Middle Aged; Ochronosis | 1984 |
Knee arthropathy in ochronosis: diagnosis by arthroscopy with ultrastructural features.
Topics: Arthritis; Arthroscopy; Chromatography, Thin Layer; Female; Homogentisic Acid; Humans; Knee Joint; M | 1984 |
Alcaptonuria: a case complicated with valvular heart disease and immunodeficiency.
Topics: Aged; Alkaptonuria; Gas Chromatography-Mass Spectrometry; Heart Valve Diseases; Homogentisic Acid; H | 1994 |
[Alkaptonuria and ochronotic arthropathy. Arthroscopic and intraoperative findings in implantation of a knee joint surface replacing prosthesis].
Topics: Alkaptonuria; Arthritis; Female; Homogentisic Acid; Humans; Knee Prosthesis; Middle Aged; Ochronosis | 1994 |
Bilateral hip arthroplasty for ochronotic arthropathy.
Topics: Arthroplasty, Replacement, Hip; Female; Hip Prosthesis; Homogentisic Acid; Humans; Kyphosis; Lordosi | 2000 |
[Diagnostic image (45). Ochronosis].
Topics: Aged; Dioxygenases; Ear Cartilage; Female; Genetic Predisposition to Disease; Homogentisate 1,2-Diox | 2001 |
Bluish patches on the ears and axillae with dark urine: ochronosis and alkaptonuria.
Topics: Alkaptonuria; Female; Homogentisic Acid; Humans; Lumbosacral Region; Middle Aged; Ochronosis; Radiog | 2001 |
Biochemical identification of homogentisic acid pigment in an ochronotic egyptian mummy.
Topics: Cartilage; History, Ancient; Homogentisic Acid; Mummies; Ochronosis; Paleopathology; Pelvic Bones; R | 1977 |
Characterization of mummy bone ochronotic pigment.
Topics: Aged; Alkaptonuria; Bone and Bones; Egypt, Ancient; History, Ancient; Homogentisic Acid; Humans; Mal | 1978 |
[Metabolic studies in brothers affected by alcaptonuria (ochronosis)].
Topics: Adult; Homogentisic Acid; Humans; Male; Ochronosis; Pedigree | 1978 |
Alkaptonuria with extensive ochronosis.
Topics: Alkaptonuria; Female; Homogentisic Acid; Humans; Kidney Diseases; Middle Aged; Ochronosis | 1979 |
Alkaptonuria.
Topics: Adolescent; Adult; Aged; Alkaptonuria; Child; Child, Preschool; Czechoslovakia; Female; Homogentisic | 1979 |
Ochronotic arthropathy. I. Clinicopathologic studies.
Topics: Adult; Alkaptonuria; Arthritis; Cartilage, Articular; Female; Homogentisic Acid; Humans; Male; Middl | 1977 |
[Case of ochronosis].
Topics: Adult; Homogentisic Acid; Humans; Male; Ochronosis; Oxygenases | 1976 |
Ascorbic acid and alkaptonuria.
Topics: Alkaptonuria; Animals; Ascorbic Acid; Dioxygenases; Homogentisate 1,2-Dioxygenase; Homogentisic Acid | 1992 |
Ochronosislike pigmentation from hydroquinone bleaching creams.
Topics: Homogentisic Acid; Humans; Hydroquinones; Ochronosis | 1985 |
A histological, histochemical and ultrastructural study of dermal ochronosis.
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Alkaptonuria; Biopsy; Collagen; Female; Homogentisi | 1971 |
Ochronotic arthropathy: an electron microscopical study with a view on pathogenesis.
Topics: Cartilage, Articular; Cell Nucleus; Cytoplasm; Homogentisic Acid; Humans; Joint Diseases; Knee Joint | 1974 |
[Changes in the synovial membrane and synovial fluid in ochronosis].
Topics: Homogentisic Acid; Humans; Joint Diseases; Male; Middle Aged; Ochronosis; Synovial Fluid; Synovial M | 1972 |
[Alkaptonuria and ochronosis].
Topics: Alkaptonuria; Chemical Phenomena; Chemistry; Diagnosis, Differential; Female; Germany, West; Homogen | 1972 |
Ochronosis. A case report.
Topics: Female; Follow-Up Studies; Homogentisic Acid; Humans; Middle Aged; Ochronosis; Osteoarthritis | 1972 |
[2 cases of ochronosis].
Topics: Adult; Age Factors; Diagnosis, Differential; Female; Genes, Recessive; Homogentisic Acid; Humans; Mi | 1971 |