homogentisic acid has been researched along with Joint Diseases in 14 studies
Homogentisic Acid: Dihydroxyphenylacetic acid with hydroxyls at the 2 and 5 positions of the phenyl ring.
homogentisic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents at the 2- and 5-positions.
Joint Diseases: Diseases involving the JOINTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ochronosis is a rare disease caused by an inherited lack of homogentisic acid oxidase." | 4.79 | The clinical manifestations of ochronosis: a review. ( De Clerck, LS; Francx, LM; Stevens, WJ; Van Offel, JF, 1995) |
| "Alkaptonuria is characterized by the accumulation of homogentisic acid (HGA), part of which is excreted in the urine but the excess HGA forms a dark brown ochronotic pigment that deposits in the connective tissue (ochronosis), eventually leading to early-onset severe arthropathy." | 4.12 | Alkaptonuria in Russia. ( Kuzin, A; Samarkina, E; Soltysova, A; Zatkova, A, 2022) |
| "Endogenous ochronosis (EO) or alkaptonuria is an inherited autosomal recessive disease caused by the insufficiency of the enzyme homogentisic acid dioxygenase." | 3.91 | Endogenous ochronosis: when clinical suspicion prevails over histopathology. ( García-Briz, MI; Gegúndez-Hernández, H; Mateu-Puchades, A; Moneva-Léniz, LM; Pose-Lapausa, P; Sánchez-Martínez, EM, 2019) |
| "Alkaptonuria (AKU) is a genetic disorder caused by lack of the enzyme responsible for breaking down homogentisic acid (HGA), an intermediate in tyrosine metabolism." | 3.77 | Development of an in vitro model to investigate joint ochronosis in alkaptonuria. ( Davidson, JS; Fraser, WD; Gallagher, JA; Jarvis, JC; Ranganath, LR; Santucci, A; Taylor, AM; Tinti, L; Wilson, PJ; Wlodarski, B, 2011) |
| "Alkaptonuria (AKU) is an autosomal recessive disorder caused by a deficiency of homogentisate 1,2 dioxygenase (HGD) and characterized by homogentisic aciduria, ochronosis, and ochronotic arthritis." | 3.77 | An update on molecular genetics of Alkaptonuria (AKU). ( Zatkova, A, 2011) |
| " Urine homogentisic acid level was elevated, which is diagnostic for alkaptonuria." | 3.76 | Alkaptonuria. ( Anolik, R; Pomeranz, MK; Yancovitz, M, 2010) |
| "Alkaptonuria is a disease often forgotten because of its rarity." | 2.82 | Ochronotic arthropathy in the context of spondyloarthritis differential diagnosis: a case-based review. ( Batalov, A; Batalov, Z; Karalilova, R; Kostova, T, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Soltysova, A | 1 |
| Kuzin, A | 1 |
| Samarkina, E | 1 |
| Zatkova, A | 2 |
| Kostova, T | 1 |
| Batalov, Z | 1 |
| Karalilova, R | 1 |
| Batalov, A | 1 |
| Kumps, C | 1 |
| Stanovici, J | 1 |
| Chaibi, E | 1 |
| Campos-Xavier, B | 1 |
| Pavlidou, DC | 1 |
| Tran, C | 1 |
| Sánchez-Martínez, EM | 1 |
| García-Briz, MI | 1 |
| Moneva-Léniz, LM | 1 |
| Gegúndez-Hernández, H | 1 |
| Pose-Lapausa, P | 1 |
| Mateu-Puchades, A | 1 |
| Tinti, L | 1 |
| Taylor, AM | 1 |
| Santucci, A | 1 |
| Wlodarski, B | 1 |
| Wilson, PJ | 1 |
| Jarvis, JC | 1 |
| Fraser, WD | 1 |
| Davidson, JS | 1 |
| Ranganath, LR | 1 |
| Gallagher, JA | 1 |
| Yancovitz, M | 1 |
| Anolik, R | 1 |
| Pomeranz, MK | 1 |
| Thacker, M | 1 |
| Garude, S | 1 |
| Puri, A | 1 |
| Ogata, J | 1 |
| Tamura, K | 1 |
| Miyanishi, K | 1 |
| Minami, K | 1 |
| Haranishi, Y | 1 |
| Tsubaki, T | 1 |
| Van Offel, JF | 1 |
| De Clerck, LS | 1 |
| Francx, LM | 1 |
| Stevens, WJ | 1 |
| Friis, J | 1 |
| Kutty, MK | 1 |
| Iqbal, QM | 1 |
| Teh, EC | 1 |
| Lumpur, K | 1 |
| Duliapin, VA | 1 |
| Chepoĭ, VM | 1 |
3 reviews available for homogentisic acid and Joint Diseases
| Article | Year |
|---|---|
Ochronotic arthropathy in the context of spondyloarthritis differential diagnosis: a case-based review.
Topics: Aged; Alkaptonuria; Ascorbic Acid; Cartilage Diseases; Dioxygenases; Homogentisic Acid; Humans; Join | 2022 |
The clinical manifestations of ochronosis: a review.
Topics: Cardiovascular Diseases; Homogentisic Acid; Humans; Joint Diseases; Ochronosis; Pigmentation Disorde | 1995 |
[Ochronotic arthropathy].
Topics: Alkaptonuria; Ascorbic Acid; Cartilage, Articular; Homogentisic Acid; Humans; Joint Diseases; Ochron | 1973 |
11 other studies available for homogentisic acid and Joint Diseases
| Article | Year |
|---|---|
Alkaptonuria in Russia.
Topics: Alkaptonuria; Exons; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Humans; Joint Diseases; Ochro | 2022 |
Black cartilage: Incidentally discovered articular ochronosis during arthroplasty.
Topics: Alkaptonuria; Arthroplasty, Replacement, Knee; Cartilage; Homogentisic Acid; Humans; Incidental Find | 2021 |
Endogenous ochronosis: when clinical suspicion prevails over histopathology.
Topics: Alkaptonuria; Female; Homogentisic Acid; Humans; Hyperpigmentation; Joint Diseases; Middle Aged; Och | 2019 |
Development of an in vitro model to investigate joint ochronosis in alkaptonuria.
Topics: Alkaptonuria; Cells, Cultured; Homogentisic Acid; Humans; Joint Diseases; Models, Biological; Ochron | 2011 |
Alkaptonuria.
Topics: Aged; Alkaptonuria; Arthritis; Cyclohexanones; Female; Homogentisic Acid; Humans; Joint Diseases; Ni | 2010 |
An update on molecular genetics of Alkaptonuria (AKU).
Topics: Alkaptonuria; Chromosome Mapping; Chromosomes, Human, Pair 3; DNA Mutational Analysis; Dominican Rep | 2011 |
Ochronotic arthropathy: arthroscopic findings in the shoulder and the knee.
Topics: Adult; Arthroscopy; Cartilage, Articular; Collagen; Collagen Diseases; Homogentisic Acid; Humans; Jo | 2003 |
[Anesthesia in a patient with alkaptonuric ochronosis for total hip arthroplasty].
Topics: Aged; Alkaptonuria; Anesthesia, Epidural; Anesthesia, General; Anesthesia, Spinal; Arthroplasty, Rep | 2008 |
Alcaptonuria (Ochronosis).
Topics: Alkaptonuria; Homogentisic Acid; Humans; Joint Diseases; Oxygenases; Spinal Diseases | 1973 |
Ochronotic arthropathy: an electron microscopical study with a view on pathogenesis.
Topics: Cartilage, Articular; Cell Nucleus; Cytoplasm; Homogentisic Acid; Humans; Joint Diseases; Knee Joint | 1974 |
[Changes in the synovial membrane and synovial fluid in ochronosis].
Topics: Homogentisic Acid; Humans; Joint Diseases; Male; Middle Aged; Ochronosis; Synovial Fluid; Synovial M | 1972 |