homogentisic acid has been researched along with Hyperpigmentation in 2 studies
Homogentisic Acid: Dihydroxyphenylacetic acid with hydroxyls at the 2 and 5 positions of the phenyl ring.
homogentisic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents at the 2- and 5-positions.
Hyperpigmentation: Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alkaptonuria (AKU) is an ultra-rare genetic disease, in which the accumulation of a toxic metabolite, homogentisic acid (HGA) leads to the systemic development of ochronotic aggregates." | 7.85 | Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria. ( Bernardini, G; Braconi, D; Gambassi, S; Geminiani, M; Knight, MM; Manetti, F; Millucci, L; Orlandini, M; Petricci, E; Santucci, A; Taddei, M; Thompson, CL; Thorpe, SD, 2017) |
| "Endogenous ochronosis (EO) or alkaptonuria is an inherited autosomal recessive disease caused by the insufficiency of the enzyme homogentisic acid dioxygenase." | 3.91 | Endogenous ochronosis: when clinical suspicion prevails over histopathology. ( García-Briz, MI; Gegúndez-Hernández, H; Mateu-Puchades, A; Moneva-Léniz, LM; Pose-Lapausa, P; Sánchez-Martínez, EM, 2019) |
| "Alkaptonuria (AKU) is an ultra-rare genetic disease, in which the accumulation of a toxic metabolite, homogentisic acid (HGA) leads to the systemic development of ochronotic aggregates." | 3.85 | Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria. ( Bernardini, G; Braconi, D; Gambassi, S; Geminiani, M; Knight, MM; Manetti, F; Millucci, L; Orlandini, M; Petricci, E; Santucci, A; Taddei, M; Thompson, CL; Thorpe, SD, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sánchez-Martínez, EM | 1 |
| García-Briz, MI | 1 |
| Moneva-Léniz, LM | 1 |
| Gegúndez-Hernández, H | 1 |
| Pose-Lapausa, P | 1 |
| Mateu-Puchades, A | 1 |
| Gambassi, S | 1 |
| Geminiani, M | 1 |
| Thorpe, SD | 1 |
| Bernardini, G | 1 |
| Millucci, L | 1 |
| Braconi, D | 1 |
| Orlandini, M | 1 |
| Thompson, CL | 1 |
| Petricci, E | 1 |
| Manetti, F | 1 |
| Taddei, M | 1 |
| Knight, MM | 1 |
| Santucci, A | 1 |
2 other studies available for homogentisic acid and Hyperpigmentation
| Article | Year |
|---|---|
Endogenous ochronosis: when clinical suspicion prevails over histopathology.
Topics: Alkaptonuria; Female; Homogentisic Acid; Humans; Hyperpigmentation; Joint Diseases; Middle Aged; Och | 2019 |
Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria.
Topics: Alkaptonuria; Anilides; Cells, Cultured; Chondrocytes; Cilia; Dose-Response Relationship, Drug; Hedg | 2017 |