homogentisic acid has been researched along with Disease Models, Animal in 9 studies
Homogentisic Acid: Dihydroxyphenylacetic acid with hydroxyls at the 2 and 5 positions of the phenyl ring.
homogentisic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents at the 2- and 5-positions.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alkaptonuria is a rare autosomal recessive disorder characterized by homogentisic aciduria, ochronosis, and arthritis." | 7.70 | A novel therapeutic trial of homogentisic aciduria in a murine model of alkaptonuria. ( Maeda, Y; Oda, K; Suzuki, T; Suzuki, Y; Yoshikawa, Y, 1999) |
| "Alkaptonuria is an inherited disease caused by homogentisate 1,2-dioxygenase (HGD) deficiency." | 5.51 | Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria. ( Bou-Gharios, G; Gallagher, JA; Hughes, AT; Hughes, JH; Keenan, CM; Liu, K; Milan, AM; Norman, BP; Plagge, A; Ranganath, LR; Sakai, T; Sutherland, H; Wilson, PJM, 2019) |
| "Alkaptonuria is a rare autosomal recessive disorder characterized by homogentisic aciduria, ochronosis, and arthritis." | 3.70 | A novel therapeutic trial of homogentisic aciduria in a murine model of alkaptonuria. ( Maeda, Y; Oda, K; Suzuki, T; Suzuki, Y; Yoshikawa, Y, 1999) |
| "Alkaptonuria is a human hereditary metabolic disease characterized by a very high urinary excretion of homogentisic acid, an intermediary product in the metabolism of tyrosine, in association with ochronosis and arthritis." | 3.69 | aku, a mutation of the mouse homologous to human alkaptonuria, maps to chromosome 16. ( Coudé, M; Forest, M; Guénet, JL; Kamoun, P; Lalouette, A; Montagutelli, X, 1994) |
| "In contrast, hereditary tyrosinemia type 1, a genetic disease caused by a deficiency of fumarylacetoacetate hydrolase (FAH), induces severe visceral injuries." | 2.42 | Animal models reveal pathophysiologies of tyrosinemias. ( Endo, F; Nakamura, K; Tanaka, Y; Tanoue, A; Tomoeda, K; Tsujimoto, G, 2003) |
| "Alkaptonuria is an inherited disease caused by homogentisate 1,2-dioxygenase (HGD) deficiency." | 1.51 | Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria. ( Bou-Gharios, G; Gallagher, JA; Hughes, AT; Hughes, JH; Keenan, CM; Liu, K; Milan, AM; Norman, BP; Plagge, A; Ranganath, LR; Sakai, T; Sutherland, H; Wilson, PJM, 2019) |
| "Hereditary tyrosinemia type 1 (HT1), which is associated with severe liver and kidney damage, is caused by deficiency of fumarylacetoacetate hydrolase (FAH), the last enzyme of the tyrosine breakdown cascade." | 1.32 | Renal proximal tubular cells acquire resistance to cell death stimuli in mice with hereditary tyrosinemia type 1. ( Berger, R; Grompe, M; Jacobs, SM; Klomp, LW; Luijerink, MC; Malingré, HE; van Beurden, EA; van den Berg, IE, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Davison, AS | 1 |
| Hughes, AT | 2 |
| Milan, AM | 2 |
| Sireau, N | 1 |
| Gallagher, JA | 2 |
| Ranganath, LR | 2 |
| Hughes, JH | 1 |
| Liu, K | 1 |
| Plagge, A | 1 |
| Wilson, PJM | 1 |
| Sutherland, H | 1 |
| Norman, BP | 1 |
| Keenan, CM | 1 |
| Sakai, T | 1 |
| Bou-Gharios, G | 1 |
| Adam, D | 1 |
| Endo, F | 1 |
| Tanaka, Y | 1 |
| Tomoeda, K | 1 |
| Tanoue, A | 1 |
| Tsujimoto, G | 1 |
| Nakamura, K | 1 |
| Luijerink, MC | 1 |
| van Beurden, EA | 1 |
| Malingré, HE | 1 |
| Jacobs, SM | 1 |
| Grompe, M | 2 |
| Klomp, LW | 1 |
| Berger, R | 1 |
| van den Berg, IE | 1 |
| Held, PK | 1 |
| Al-Dhalimy, M | 1 |
| Willenbring, H | 1 |
| Akkari, Y | 1 |
| Jiang, S | 1 |
| Torimaru, Y | 1 |
| Olson, S | 1 |
| Fleming, WH | 1 |
| Finegold, M | 1 |
| Montagutelli, X | 1 |
| Lalouette, A | 1 |
| Coudé, M | 1 |
| Kamoun, P | 1 |
| Forest, M | 1 |
| Guénet, JL | 1 |
| Suzuki, Y | 1 |
| Oda, K | 1 |
| Yoshikawa, Y | 1 |
| Maeda, Y | 1 |
| Suzuki, T | 1 |
| Keeling, ME | 1 |
| McClure, HM | 1 |
| Kibler, RF | 1 |
2 reviews available for homogentisic acid and Disease Models, Animal
| Article | Year |
|---|---|
Alkaptonuria - Many questions answered, further challenges beckon.
Topics: Alkaptonuria; Animals; Cyclohexanones; Disease Models, Animal; Enzyme Inhibitors; Homogentisic Acid; | 2020 |
Animal models reveal pathophysiologies of tyrosinemias.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Animals; Disease Models, Animal; Gene Expression; Homogentisic | 2003 |
7 other studies available for homogentisic acid and Disease Models, Animal
| Article | Year |
|---|---|
Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria.
Topics: Alkaptonuria; Animals; Disease Models, Animal; Gene Knockout Techniques; Homogentisate 1,2-Dioxygena | 2019 |
A father's fight to help his sons - and fix clinical trials.
Topics: Adolescent; Alkaptonuria; Animals; Autopsy; Child; Clinical Trials as Topic; Compassionate Use Trial | 2019 |
Renal proximal tubular cells acquire resistance to cell death stimuli in mice with hereditary tyrosinemia type 1.
Topics: Animals; Caspase 3; Caspase 9; Caspases; Cyclohexanones; Disease Models, Animal; DNA Fragmentation; | 2004 |
In vivo genetic selection of renal proximal tubules.
Topics: Acute Disease; Animals; Bone Marrow Transplantation; Cell Differentiation; Cell Fusion; Chronic Dise | 2006 |
aku, a mutation of the mouse homologous to human alkaptonuria, maps to chromosome 16.
Topics: Alkaptonuria; Animals; Base Sequence; Chromosome Mapping; Crosses, Genetic; Dioxygenases; Disease Mo | 1994 |
A novel therapeutic trial of homogentisic aciduria in a murine model of alkaptonuria.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Alkaptonuria; Animals; Cyclohexanones; Disease Models, Animal; | 1999 |
Alkaptonuria in an orangutan (Pongo pygmaeus).
Topics: Alkaptonuria; Animals; Chromatography, Paper; Disease Models, Animal; Hominidae; Homogentisic Acid | 1973 |