homogentisic acid has been researched along with Disease Exacerbation in 5 studies
Homogentisic Acid: Dihydroxyphenylacetic acid with hydroxyls at the 2 and 5 positions of the phenyl ring.
homogentisic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents at the 2- and 5-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nitisinone decreases homogentisic acid (HGA), but has not been shown to modify progression of Alkaptonuria (AKU)." | 7.88 | Nitisinone arrests ochronosis and decreases rate of progression of Alkaptonuria: Evaluation of the effect of nitisinone in the United Kingdom National Alkaptonuria Centre. ( Barton, GJ; Briggs, M; Cox, TF; Daroszewska, A; Davison, AS; Devine, JM; Dillon, JP; Fisher, M; Gallagher, JA; Griffin, R; Harrold, J; Hughes, AT; Hughes, G; Jarvis, JC; Jones, A; Judd, S; Khedr, M; Loftus, N; McCormick, M; Milan, AM; Psarelli, EE; Ranganath, LR; Sireau, N; Taylor, S; Usher, JL; Vinjamuri, S; West, E, 2018) |
| "Nitisinone decreases homogentisic acid (HGA), but has not been shown to modify progression of Alkaptonuria (AKU)." | 3.88 | Nitisinone arrests ochronosis and decreases rate of progression of Alkaptonuria: Evaluation of the effect of nitisinone in the United Kingdom National Alkaptonuria Centre. ( Barton, GJ; Briggs, M; Cox, TF; Daroszewska, A; Davison, AS; Devine, JM; Dillon, JP; Fisher, M; Gallagher, JA; Griffin, R; Harrold, J; Hughes, AT; Hughes, G; Jarvis, JC; Jones, A; Judd, S; Khedr, M; Loftus, N; McCormick, M; Milan, AM; Psarelli, EE; Ranganath, LR; Sireau, N; Taylor, S; Usher, JL; Vinjamuri, S; West, E, 2018) |
| "Increased circulating homogentisic acid in body fluids occurs in alkaptonuria (AKU) due to lack of enzyme homogentisate dioxygenase leading in turn to conversion of HGA to a pigmented melanin-like polymer, known as ochronosis." | 3.77 | Natural history of alkaptonuria revisited: analyses based on scoring systems. ( Cox, TF; Ranganath, LR, 2011) |
| "Alkaptonuria is a genetic disorder of tyrosine metabolism, resulting in elevated circulating concentrations of homogentisic acid." | 3.77 | The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria. ( Boyde, A; Davidson, JS; Gallagher, JA; Hunt, JA; Jarvis, JC; Ranganath, LR; Taylor, AM; Wilson, PJ, 2011) |
| "Alkaptonuria is a rare disorder of metabolism caused by deficiency of homogentisic acid oxidase enzyme and characterized by triad of homogentisic aciduria (dark urine), relentlessly progressive arthritis and ochronosis." | 3.74 | Alkaptonuria and intramedullary calcification. ( Dhiman, DS; Gupta, D; Kaushal, SS; Mahesh, DM; Negi, A; Raina, S; Sharma, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ranganath, LR | 3 |
| Khedr, M | 1 |
| Milan, AM | 1 |
| Davison, AS | 1 |
| Hughes, AT | 1 |
| Usher, JL | 1 |
| Taylor, S | 1 |
| Loftus, N | 1 |
| Daroszewska, A | 1 |
| West, E | 1 |
| Jones, A | 1 |
| Briggs, M | 1 |
| Fisher, M | 1 |
| McCormick, M | 1 |
| Judd, S | 1 |
| Vinjamuri, S | 1 |
| Griffin, R | 1 |
| Psarelli, EE | 1 |
| Cox, TF | 2 |
| Sireau, N | 1 |
| Dillon, JP | 1 |
| Devine, JM | 1 |
| Hughes, G | 1 |
| Harrold, J | 1 |
| Barton, GJ | 1 |
| Jarvis, JC | 2 |
| Gallagher, JA | 2 |
| Adam, D | 1 |
| Raina, S | 1 |
| Mahesh, DM | 1 |
| Kaushal, SS | 1 |
| Gupta, D | 1 |
| Dhiman, DS | 1 |
| Negi, A | 1 |
| Sharma, S | 1 |
| Taylor, AM | 1 |
| Boyde, A | 1 |
| Wilson, PJ | 1 |
| Davidson, JS | 1 |
| Hunt, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Determining Individualised Gait Modification Strategies to Reduce Knee Joint Moments in Alkaptonuria Patients Using Real-time Feedback[NCT04142671] | 30 participants (Anticipated) | Interventional | 2021-10-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for homogentisic acid and Disease Exacerbation
| Article | Year |
|---|---|
Nitisinone arrests ochronosis and decreases rate of progression of Alkaptonuria: Evaluation of the effect of nitisinone in the United Kingdom National Alkaptonuria Centre.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Alkaptonuria; Cyclohexanones; Disease Progression; Female; Homo | 2018 |
A father's fight to help his sons - and fix clinical trials.
Topics: Adolescent; Alkaptonuria; Animals; Autopsy; Child; Clinical Trials as Topic; Compassionate Use Trial | 2019 |
Alkaptonuria and intramedullary calcification.
Topics: Alkaptonuria; Calcinosis; Disease Progression; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Hum | 2008 |
Natural history of alkaptonuria revisited: analyses based on scoring systems.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Adolescent; Adult; Aged; Aged, 80 and over; Alkaptonuria; Arthr | 2011 |
The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria.
Topics: Alkaptonuria; Bone and Bones; Calcinosis; Cartilage, Articular; Disease Progression; Extracellular M | 2011 |