homogentisic acid has been researched along with Calcinosis in 7 studies
Homogentisic Acid: Dihydroxyphenylacetic acid with hydroxyls at the 2 and 5 positions of the phenyl ring.
homogentisic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents at the 2- and 5-positions.
Calcinosis: Pathologic deposition of calcium salts in tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A diagnosis of ochronosis was made by the observation of bluish-brown pigmentation in the nose and ears, dark urine colors following alkalization, and high levels of homogentisic acid in the urine." | 4.84 | Ochronosis in differential diagnosis of patients with chronic backache: a review of the literature. ( Capkin, E; Karkucak, M; Serdaroğlu, M; Tosun, M; Yayli, S, 2007) |
| "Alkaptonuria is a genetic disorder of tyrosine metabolism, resulting in elevated circulating concentrations of homogentisic acid." | 3.77 | The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria. ( Boyde, A; Davidson, JS; Gallagher, JA; Hunt, JA; Jarvis, JC; Ranganath, LR; Taylor, AM; Wilson, PJ, 2011) |
| "Alkaptonuria is a rare disorder of metabolism caused by deficiency of homogentisic acid oxidase enzyme and characterized by triad of homogentisic aciduria (dark urine), relentlessly progressive arthritis and ochronosis." | 3.74 | Alkaptonuria and intramedullary calcification. ( Dhiman, DS; Gupta, D; Kaushal, SS; Mahesh, DM; Negi, A; Raina, S; Sharma, S, 2008) |
| " Observation of blue-gray pigmentation around his nose and ears suggested a diagnosis of ochronosis, which was confirmed by the detection of high levels of homogentisic acid in the urine and dark urine color following alkalization." | 3.72 | [Ankylosis of the spine in a case with ochronosis]. ( Bezer, M; Güven, O; Kocaoğlu, B, 2003) |
| "Alkaptonuric ochronosis is rare disorder of tyrosin catabolism with an autosomal recessive trait." | 1.31 | [Ochronosis: a case report with multisystemic affectation, including pericardium]. ( Cobos Soler, FJ; Molero Cabrilla, R, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (85.71) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ben Rayana, N | 1 |
| Chahed, N | 1 |
| Khochtali, S | 1 |
| Ghorbel, M | 1 |
| Hamdi, R | 1 |
| Rouis, M | 1 |
| Bouajina, I | 1 |
| Hamida, FB | 1 |
| Raina, S | 1 |
| Mahesh, DM | 1 |
| Kaushal, SS | 1 |
| Gupta, D | 1 |
| Dhiman, DS | 1 |
| Negi, A | 1 |
| Sharma, S | 1 |
| Taylor, AM | 1 |
| Boyde, A | 1 |
| Wilson, PJ | 1 |
| Jarvis, JC | 1 |
| Davidson, JS | 1 |
| Hunt, JA | 1 |
| Ranganath, LR | 1 |
| Gallagher, JA | 1 |
| Cobos Soler, FJ | 1 |
| Molero Cabrilla, R | 1 |
| Bezer, M | 1 |
| Kocaoğlu, B | 1 |
| Güven, O | 1 |
| Sharma, A | 1 |
| Sharma, SK | 1 |
| Wanchu, A | 1 |
| Kumar, M | 1 |
| Singh, S | 1 |
| Bambery, P | 1 |
| Capkin, E | 1 |
| Karkucak, M | 1 |
| Yayli, S | 1 |
| Serdaroğlu, M | 1 |
| Tosun, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Determining Individualised Gait Modification Strategies to Reduce Knee Joint Moments in Alkaptonuria Patients Using Real-time Feedback[NCT04142671] | 30 participants (Anticipated) | Interventional | 2021-10-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for homogentisic acid and Calcinosis
| Article | Year |
|---|---|
Ochronosis in differential diagnosis of patients with chronic backache: a review of the literature.
Topics: Alkaptonuria; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Ascorbic Acid; Back Pain; Calcino | 2007 |
6 other studies available for homogentisic acid and Calcinosis
| Article | Year |
|---|---|
[Ocular ochronosis. A case report].
Topics: Biopsy; Calcinosis; Conjunctiva; Homogentisic Acid; Humans; Intervertebral Disc; Low Back Pain; Lumb | 2008 |
Alkaptonuria and intramedullary calcification.
Topics: Alkaptonuria; Calcinosis; Disease Progression; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Hum | 2008 |
The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria.
Topics: Alkaptonuria; Bone and Bones; Calcinosis; Cartilage, Articular; Disease Progression; Extracellular M | 2011 |
[Ochronosis: a case report with multisystemic affectation, including pericardium].
Topics: Aged; Aged, 80 and over; Alkaptonuria; Calcinosis; Dioxygenases; Female; Heart Diseases; Homogentisa | 2002 |
[Ankylosis of the spine in a case with ochronosis].
Topics: Adult; Ankylosis; Calcinosis; Diagnosis, Differential; Homogentisic Acid; Humans; Low Back Pain; Lum | 2003 |
Lower-back pain, intervertebral-disc calcification and scleral pigmentation.
Topics: Calcinosis; Cheek; Hand; Homogentisic Acid; Humans; Intervertebral Disc; Low Back Pain; Male; Middle | 2006 |