homogentisic acid has been researched along with Arthritis, Degenerative in 7 studies
Homogentisic Acid: Dihydroxyphenylacetic acid with hydroxyls at the 2 and 5 positions of the phenyl ring.
homogentisic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents at the 2- and 5-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alkaptonuria is a very rare disorder in which homogentisic acid accumulates due to a deficiency in the activity of homogentisic acid 1,2 dioxygenase." | 4.31 | Arthroscopic ankle arthrodesis in two alkaptonuria patients. ( Kanazawa, K; Tomonaga, S; Yamamoto, T; Yoshimura, I, 2023) |
| " This discoloration and early degeneration of the cartilage is characteristic for the metabolic disorder alkaptonuria in which homogentisic acid accumulates in the body." | 4.02 | [A male with black cartilage]. ( Verhaar, JAN; Visser, D, 2021) |
| "Alkaptonuria (AKU) is a rare disease characterized by high levels of homogentisic acid (HGA); patients suffer from tissue ochronosis: dark brown pigmentation, especially of joint cartilage, leading to severe early osteoarthropathy." | 3.96 | Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage. ( Bittl, R; Chow, WY; Duer, MJ; Gallagher, JA; Norman, BP; Oschkinat, H; Ranganath, LR; Roberts, NB; Teutloff, C, 2020) |
| "Alkaptonuria is a rare autosomal recessive condition resulting from inability to breakdown homogentisic acid (HGA), an intermediate in tyrosine degradation." | 3.83 | A role for interleukins in ochronosis in a chondrocyte in vitro model of alkaptonuria. ( Bukhari, M; Jackson, DJ; Mistry, JB; Taylor, AM, 2016) |
| "Alkaptonuria is a genetic disorder of tyrosine metabolism, resulting in elevated circulating concentrations of homogentisic acid." | 3.77 | The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria. ( Boyde, A; Davidson, JS; Gallagher, JA; Hunt, JA; Jarvis, JC; Ranganath, LR; Taylor, AM; Wilson, PJ, 2011) |
| "Alkaptonuria is a disease often forgotten because of its rarity." | 2.82 | Ochronotic arthropathy in the context of spondyloarthritis differential diagnosis: a case-based review. ( Batalov, A; Batalov, Z; Karalilova, R; Kostova, T, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 4 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| Kostova, T | 1 |
| Batalov, Z | 1 |
| Karalilova, R | 1 |
| Batalov, A | 1 |
| Tomonaga, S | 1 |
| Yoshimura, I | 1 |
| Kanazawa, K | 1 |
| Yamamoto, T | 1 |
| Chow, WY | 1 |
| Norman, BP | 1 |
| Roberts, NB | 1 |
| Ranganath, LR | 2 |
| Teutloff, C | 1 |
| Bittl, R | 1 |
| Duer, MJ | 1 |
| Gallagher, JA | 2 |
| Oschkinat, H | 1 |
| Visser, D | 1 |
| Verhaar, JAN | 1 |
| Mistry, JB | 1 |
| Jackson, DJ | 1 |
| Bukhari, M | 1 |
| Taylor, AM | 2 |
| Boyde, A | 1 |
| Wilson, PJ | 1 |
| Jarvis, JC | 1 |
| Davidson, JS | 1 |
| Hunt, JA | 1 |
| Cobey, MC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Determining Individualised Gait Modification Strategies to Reduce Knee Joint Moments in Alkaptonuria Patients Using Real-time Feedback[NCT04142671] | 30 participants (Anticipated) | Interventional | 2021-10-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for homogentisic acid and Arthritis, Degenerative
| Article | Year |
|---|---|
Ochronotic arthropathy in the context of spondyloarthritis differential diagnosis: a case-based review.
Topics: Aged; Alkaptonuria; Ascorbic Acid; Cartilage Diseases; Dioxygenases; Homogentisic Acid; Humans; Join | 2022 |
6 other studies available for homogentisic acid and Arthritis, Degenerative
| Article | Year |
|---|---|
Arthroscopic ankle arthrodesis in two alkaptonuria patients.
Topics: Alkaptonuria; Ankle; Arthrodesis; Cartilage Diseases; Homogentisic Acid; Humans; Osteoarthritis | 2023 |
Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage.
Topics: Alkaptonuria; Cartilage, Articular; Electron Spin Resonance Spectroscopy; Homogentisic Acid; Humans; | 2020 |
[A male with black cartilage].
Topics: Alkaptonuria; Arthroplasty, Replacement, Knee; Cartilage; Color; Homogentisic Acid; Humans; Incident | 2021 |
A role for interleukins in ochronosis in a chondrocyte in vitro model of alkaptonuria.
Topics: Alkaptonuria; Cell Line; Chondrocytes; Homogentisic Acid; Humans; Interleukin-10; Interleukin-6; Och | 2016 |
The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria.
Topics: Alkaptonuria; Bone and Bones; Calcinosis; Cartilage, Articular; Disease Progression; Extracellular M | 2011 |
Ochronosis. A case report.
Topics: Female; Follow-Up Studies; Homogentisic Acid; Humans; Middle Aged; Ochronosis; Osteoarthritis | 1972 |