homogentisic acid has been researched along with Aortic Valve Stenosis in 8 studies
Homogentisic Acid: Dihydroxyphenylacetic acid with hydroxyls at the 2 and 5 positions of the phenyl ring.
homogentisic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents at the 2- and 5-positions.
Aortic Valve Stenosis: A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alkaptonuria is an autosomal recessive disorder of tyrosine metabolism, which results in accumulation of unmetabolized homogentisic acid and its oxidized product in various tissues, including the heart." | 4.89 | Alkaptonuria-associated aortic stenosis. ( Goldstein, J; Lok, ZS; Smith, JA, 2013) |
| "Alkaptonuria, or ochronosis, a rare autosomal recessive metabolic disorder, causes an excess of homogentisic acid that results in dark pigmentation, calcification, and inflammation of cartilaginous and other tissues." | 3.83 | Alkaptonuria Presenting with Impressive Osteoarticular Changes and Severe Aortic Stenosis. ( Monferrer, R; Roca, B; Roca, M, 2016) |
| "Alkaptonuria is a rare inherited disorder of tyrosine metabolism, which results in deposition of homogentisic acid in the connective tissues." | 3.79 | Choice of valve prosthesis in a rare clinical condition: aortic stenosis due to alkaptonuria. ( Cullen, H; Markman, P; Thakur, S, 2013) |
| "Alkaptonuria is a rare metabolic disorder of tyrosine catabolism in which homogentisic acid (HGA) accumulates and is deposited throughout the spine, large joints, cardiovascular system, and various tissues throughout the body." | 3.78 | Aortic stenosis and vascular calcifications in alkaptonuria. ( Chen, MY; Gahl, WA; Hannoush, H; Introne, WJ; Kayser, MA; Lee, SJ; O'Brien, K; Sachdev, V; Suwannarat, P, 2012) |
| " Alkaptonuria can result in accumulation of homogentisic acid." | 3.77 | Black aorta in a patient with alkaptonuria (ochronosis). ( Casali, G; Concistrè, G; Fiorani, B; Loforte, A; Musumeci, F; Ranocchi, F, 2011) |
| "Alkaptonuria is a rare metabolic disease in which homogentisic acid deposits occur in various body tissues." | 3.70 | Aortic stenosis and coronary artery disease caused by alkaptonuria, a rare genetic metabolic syndrome. ( Stefanadis, C; Toutouzas, P; Triantafillidi, H; Vavuranakis, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (87.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diab, N | 1 |
| Zeh, W | 1 |
| Beyersdorf, F | 1 |
| Lok, ZS | 1 |
| Goldstein, J | 1 |
| Smith, JA | 1 |
| Rizzo, S | 1 |
| Basso, C | 1 |
| Bottio, T | 1 |
| Roca, B | 1 |
| Roca, M | 1 |
| Monferrer, R | 1 |
| Concistrè, G | 1 |
| Fiorani, B | 1 |
| Ranocchi, F | 1 |
| Casali, G | 1 |
| Loforte, A | 1 |
| Musumeci, F | 1 |
| Hannoush, H | 1 |
| Introne, WJ | 1 |
| Chen, MY | 1 |
| Lee, SJ | 1 |
| O'Brien, K | 1 |
| Suwannarat, P | 1 |
| Kayser, MA | 1 |
| Gahl, WA | 1 |
| Sachdev, V | 1 |
| Thakur, S | 1 |
| Markman, P | 1 |
| Cullen, H | 1 |
| Vavuranakis, M | 1 |
| Triantafillidi, H | 1 |
| Stefanadis, C | 1 |
| Toutouzas, P | 1 |
1 review available for homogentisic acid and Aortic Valve Stenosis
| Article | Year |
|---|---|
Alkaptonuria-associated aortic stenosis.
Topics: Aged; Alkaptonuria; Aortic Valve; Aortic Valve Stenosis; Heart Valve Prosthesis; Heart Valve Prosthe | 2013 |
7 other studies available for homogentisic acid and Aortic Valve Stenosis
| Article | Year |
|---|---|
Black Aortic Valve Stenosis Reveals a Rare Disorder of Tyrosine Metabolism.
Topics: Aged; Aortic Valve Stenosis; Cardiac Surgical Procedures; Heart Valve Prosthesis; Homogentisic Acid; | 2018 |
A 61-year-old man with hyperpigmentation. Ochronosis.
Topics: Aortic Valve; Aortic Valve Stenosis; Biopsy; Heart Valve Prosthesis Implantation; Homogentisic Acid; | 2015 |
Alkaptonuria Presenting with Impressive Osteoarticular Changes and Severe Aortic Stenosis.
Topics: Aged; Alkaptonuria; Aortic Valve Stenosis; Arthroplasty, Replacement, Hip; Chondrocalcinosis; Diseas | 2016 |
Black aorta in a patient with alkaptonuria (ochronosis).
Topics: Alkaptonuria; Aortic Valve Stenosis; Female; Heart Valve Prosthesis Implantation; Homogentisic Acid; | 2011 |
Aortic stenosis and vascular calcifications in alkaptonuria.
Topics: Adult; Aged; Aged, 80 and over; Alkaptonuria; Aortic Valve Stenosis; Cardiovascular System; Echocard | 2012 |
Choice of valve prosthesis in a rare clinical condition: aortic stenosis due to alkaptonuria.
Topics: Aged; Alkaptonuria; Aortic Valve Stenosis; Heart Valve Prosthesis; Homogentisic Acid; Humans; Male; | 2013 |
Aortic stenosis and coronary artery disease caused by alkaptonuria, a rare genetic metabolic syndrome.
Topics: Alkaptonuria; Aortic Valve Stenosis; Coronary Disease; Homogentisic Acid; Humans; Male; Middle Aged; | 1998 |