homocysteine has been researched along with Neural Tube Defects in 214 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 55 (25.70) | 18.2507 |
| 2000's | 111 (51.87) | 29.6817 |
| 2010's | 44 (20.56) | 24.3611 |
| 2020's | 4 (1.87) | 2.80 |
| Authors | Studies |
|---|---|
| Arthurs, AL; Jankovic-Karasoulos, T; Roberts, CT; Smith, MD; Williamson, JM | 1 |
| Finnell, RH; Hou, J; Huang, L; Jin, L; Lin, Y; Liu, Z; Ma, J; Mei, X; Nie, J; Qi, D; Saiyin, H; Si, W; Wang, H; Wang, J; Xu, W; Xue, Y; Ye, J; Zhang, T; Zhao, J; Zhao, S; Zhao, Y; Zhu, P | 1 |
| Refsum, H; Smith, AD | 1 |
| Bao, Y; Gu, YH; Guo, J; Matsuura, M; Qiu, Z; Ushijima, M; Wang, F; Xie, X; Zhang, Q; Zhang, T; Zheng, P | 1 |
| Arora, J; Deb, R; Garg, G; Kumar Kalla, A; Nava Saraswathy, K; Saksena, D; Samtani, R; Sharma, N | 1 |
| Bankura, B; Das, M; Munian, D; Paul, S; Sadhukhan, S | 1 |
| Bai, B; Cao, H; Ding, G; Huo, J; Mei, X; Qiu, Z; Wan, C; Wang, H; Wang, L; Wang, S; Wang, Z; Wu, J; Xie, Q; Zhang, M; Zhang, Q; Zhang, T; Zhao, J; Zhao, S | 1 |
| Aloui, M; Baara, A; Ben Fradj, MK; Ben Halima, M; Ben Jemaa, N; Ben Wafi, S; Boulares, M; Feki, M; Gaigi, SS; Jemaa, R; Kallel, A; Lassoued, M; Mahjoubi, I; Marrakchi, R; Midani, F; Nasri, K; Omar, S; Soussi, M | 1 |
| Böttiger, AK; Farkas, SA; Finnell, RH; Isaksson, HS; Nilsson, TK; Ren, A | 1 |
| Ammar, D; Kobus, K; Müller, YM; Nazari, EM | 1 |
| Dornan, J; Marshall, B; McNulty, B; McNulty, H; Molloy, AM; Pentieva, K; Scott, JM; Ward, M | 1 |
| Hoey, L; McNulty, H; Pentieva, K; Strain, J; Ward, M | 1 |
| Deshmukh, U; Katre, P; Yajnik, CS | 1 |
| Ali, NS; Michels, KB; Osterhues, A | 1 |
| Benoist, JF; Blom, HJ; Imbard, A | 1 |
| Bhargava, S; Tyagi, SC | 1 |
| Koletzko, B; Obeid, R; Pietrzik, K | 1 |
| Acosta, D; Cadenas-Benitez, NM; Cerrillos, L; Gomez de Terreros, I; Gonzalez-Meneses, A; Neth, O; Praena-Fernandez, JM; Yanes-Sosa, F; Ybot-González, P | 1 |
| Guan, Z; Niu, B; Wang, J; Wang, X; Wang, Z; Xie, Q; Zhang, T; Zhao, X; Zhu, Z | 1 |
| Kumar, P; Mishra, OP; Rai, V; Yadav, SK; Yadav, U | 1 |
| Fathe, K; Finnell, RH; Person, MD | 1 |
| Li, YL; Tang, KF; Wang, HY | 1 |
| de Groh, M; MacFarlane, AJ; Zinck, JW | 1 |
| Aloui, M; Ben Fradj, MK; Ben Jemaa, N; Elmay, MV; Feki, M; Gaigi, SS; Kaabechi, N; Marrakchi, R; Masmoudi, A; Nasri, K; Omar, S; Touati, A | 1 |
| Balahoroğlu, R; Demir, N; Kaba, S; Karaman, K; Peker, E; Tuncer, O; Üstyol, L | 1 |
| Cabrera, RM; Denny, KJ; Finnell, RH; Jeanes, A; Kelly, CF; Kumar, V; Taylor, SM; Witham, KL; Woodruff, TM | 1 |
| Arıkan Terzi, ES; Aslan, A; Eser, B; Eser, O; Kocabaş, V; Ozdemir Erdogan, M; Solak, M; Yildiz, SH | 1 |
| Arisoy, R; Aydin, H; B Geçkinli, B; Çetinkaya, A; Demirci, O; Erdoğdu, E; Karaman, A; Şimşek, H | 1 |
| Du, Y; Li, W; Wan, Z; Yang, M | 1 |
| Ammar, D; Bourckhardt, GF; Kobus-Bianchini, K; Müller, YMR; Nazari, EM | 1 |
| Rogers, EJ | 1 |
| Chen, G; Gu, X; Lin, L; Pei, L; Wang, F; Wu, J; Xin, R; Zhang, T; Zheng, X | 1 |
| Chen, G; Liang, QL; Luo, GA; Song, XM; Wang, Y; Wang, YM; Wu, JX; Yang, HH; Zhang, HY; Zhang, T; Zheng, XY | 1 |
| Brouwer, IA; Clarke, R; Katan, MB; Verhoef, P; Winkels, RM | 1 |
| Selhub, J | 1 |
| Blom, HJ; Burren, KA; Copp, AJ; Greene, ND; Kok, RM; Massa, V; Savery, D; Scott, JM | 1 |
| Carter, TC; Mills, JL | 1 |
| Abdollahi, Z; Djazayeri, A; Elmadfa, I; Freisling, H; Mazandarani, FS; Mohamed, K; Sadeghian, S | 1 |
| House, JD; Sevenhuysen, GP; Shuaibi, AM | 1 |
| Brender, JD; Canfield, MA; Felkner, M; Suarez, L; Sun, Q | 1 |
| Ohrvik, VE; Olsson, JC; Sundberg, BE; Witthöft, CM | 1 |
| Brody, LC; Kirke, PN; Mills, JL; Molloy, AM; Scott, JM | 1 |
| Blom, HJ | 2 |
| Dary, O | 1 |
| Bakker, DJ; de Jong-van den Berg, LT; Fokkema, MR | 1 |
| Murphy, MM; Scott, JM; Varela-Moreiras, G | 1 |
| Stover, PJ | 1 |
| Berthold, HK; Brämswig, S; Lamers, Y; Pietrzik, K; Prinz-Langenohl, R; Tobolski, O; Wintergerst, E | 1 |
| Guan, J; Le, J; Pei, L; Wang, F; Wang, L; Wu, L; Zhang, T; Zhao, H; Zheng, X; Zou, J | 1 |
| Buyukbas, S; Cosar, E; Erdogan, MO; Eser, B; Eser, O; Koken, R; Solak, M; Yildiz, SH | 1 |
| Alanbay, I; Atay, V; Başer, I; Beyan, C; Ceyhan, ST; Kaptan, K; Yaman, H | 1 |
| Blom, HJ; Smulders, Y | 1 |
| Carroll, WD; Emes, RD; Farrell, WE; Fryer, AA; Haworth, KE; Ismail, KM; Mein, C | 1 |
| Duffy, M; Dunne, A; Finnegan, O; McNulty, H; Molloy, AM; Pentieva, K; Scott, JM; Strain, J; Tighe, P; Ward, M | 1 |
| Verhoef, P | 1 |
| Fernandez-Ballart, JD; Murphy, MM | 1 |
| Brody, LC; Conley, M; Kirke, PN; Mc Donnell, R; Mills, JL; Molloy, AM; Scott, JM; Sutton, M; Troendle, JF | 1 |
| Liang, S; Ren, YY | 1 |
| Chew, SC; Khor, GL; Loh, SP | 1 |
| Abdollahi, Z; Djazayery, A; Elmadfa, I; Golalipour, MJ; Sadeghian Sharif, S; Sadighi, J; Salehi, F | 1 |
| Chandak, GR; Gayathri, P; Ghule, S; Godbole, K; Kanitkar-Damle, A; Memane, N; Sasirekha, BV; Sheth, J; Suresh, S; Yajnik, CS | 1 |
| Bart, S; Diefenbach, K; Marr, J; Sampson-Landers, C; Trummer, D | 1 |
| Allen, RH; Beaudin, AE; Perry, CA; Stabler, SP; Stover, PJ | 1 |
| Cui, ZL; Gu, Q; Li, Y; Luo, XP | 1 |
| Trimmer, EE | 1 |
| Fajardo, V; Varela-Moreiras, G | 1 |
| Aitken, W; Chisholm, A; Harper, MJ; Mann, JI; Riddell, LJ; Rossaak, JI; Venn, BJ; Williams, SM | 1 |
| Rader, JI | 1 |
| Finnell, RH; Lammer, EJ; Shaw, GM; Volcik, KA | 1 |
| Bagley, P; Bottiglieri, T; Frosst, P; Hiou-Tim, F; Lussier-Cacan, S; Rozen, R; Selhub, J; Tran, P | 1 |
| Bruce, A; Jägerstad, M; Johansson, M; Witthöft, CM | 1 |
| Gregory, JF; Quinlivan, EP | 1 |
| Afman, LA; Blom, HJ; Trijbels, FJ | 1 |
| Copp, AJ; Dunlevy, LE; Greene, ND | 1 |
| Green, TJ; Mann, JI; Moser, R; Venn, BJ | 1 |
| Cabrillo, E; de la Calle, M; Herranz, A; Magdaleno, F; Sancha, M; Usandizaga, R | 1 |
| Afman, LA; Blom, HJ; Kluijtmans, LA; Lievers, KJ; Trijbels, FJ | 1 |
| Adank, C; Briars, B; Green, TJ; Skeaff, CM | 1 |
| Chen, X; Hu, B; Li, Y; Zhao, X | 1 |
| Epeldegui, M; Maestro de las Casas, C; Pérez-Miguelsanz, J; Tudela, C; Varela-Moreiras, G | 1 |
| Hague, WM | 1 |
| Finnell, RH; Tang, LS | 1 |
| Gibert, MJ; Martín, I; Obrador, A; Pastor, M | 1 |
| Afman, LA; Blom, HJ; Van der Put, NM; Van Straaten, HW | 1 |
| Holmes, VA | 1 |
| Blacquire, KD; Leanza, CM; Miller, RR; Phillips, EE | 1 |
| Czeizel, E; Kalina, A | 1 |
| Anello, G; Bosco, P; Brunaud, L; Candito, M; Ferri, R; Guéant, JL; Guéant-Rodriguez, RM; Namour, B; Romano, A; Romano, C | 1 |
| Abeles, R; Gold, V; Michael, E; Nachmany, A; Weil, M | 1 |
| Boot, MJ; Gittenberger-de Groot, AC; Poelmann, RE; Steegers-Theunissen, RP; van Iperen, L | 1 |
| Lamers, Y; Moser, R; Pietrzik, K; Prinz-Langenohl, R | 1 |
| Burn, J; Jonas, PA; Laffling, AJ; Lynch, SA; Pearce, MS; Relton, CL; Tawn, EJ; Wilding, CS | 1 |
| Cook, M; Hoess, K; Jensen, LE; Mitchell, LE; Thorn, CF; Wall, AM; Whitehead, AS | 1 |
| Félix, TM; Giugliani, R; Leistner, S | 1 |
| Clark, P; Ellison, J; Greer, IA; Walker, ID | 1 |
| Ueland, PM; Vollset, SE | 1 |
| Besalduch, A; Gibert, MJ; Martín, I; Noguera, A; Obrador, A; Pintos, C | 1 |
| Qiu, XQ; Shen, LP | 1 |
| Green, TJ; Rockell, JE; Skeaff, CM; Venn, BJ | 1 |
| Castenmiller, JJ; de Jong, RJ; Siebelink, E; van den Berg, H; van Vliet, T; Verwei, M; West, CE | 1 |
| Bruno, EJ; Ziegenfuss, TN | 1 |
| Cotter, A; Daly, S; Molloy, AE; Scott, J | 1 |
| Moore, JL | 1 |
| Bienengraeber, V; Fanghaenel, J; Gundlach, KK; Weingaertner, J | 1 |
| Afman, LA; Brouns, MR; Hekking, JW; Köhler, ES; van Straaten, HW; Vanhauten, BA | 1 |
| Lee, JA; Lee, JI; Lim, HS | 1 |
| Colaizzo, D; Corrao, AM; Di Girgenti, C; Grandone, E; Margaglione, M; Martinelli, P; Paladini, D; Pellegrino, M; Sardella, L; Vecchione, G; Zelante, L | 1 |
| Li, D; Liu, Y; Pickell, L; Rozen, R | 1 |
| Potter, JD; Ulrich, CM | 1 |
| Bongain, A; Candito, M; Guéant, JL; Naimi, M; Van Obberghen, E | 1 |
| Afman, LA; Blom, HJ; Heil, SG; van der Linden, IJ | 1 |
| Picciano, MF; Tamura, T | 1 |
| Benedict, S; Nagelkerke, N; Padmanabhan, R; Shafiullah, M | 1 |
| Blom, HJ; den Heijer, M; Finnell, RH; Shaw, GM | 1 |
| Gunnell, D; Lewis, S; Smith, GD; Zammit, S | 1 |
| Carter, M; Colmenares, C; Ernest, S; Hosack, A; Lerner, N; Nadeau, JH; Pao, YH; Rosenblatt, DS; Ross, ME; Shao, H | 1 |
| Boisson, C; Candito, M; Gaucherand, P; Guéant, JL; Luton, D; Naimi, M; Rudigoz, JC; Van Obberghen, E | 1 |
| El-Bassyouni, HT; El-Kamah, G; Farag, MK; Gaber, KR; Soliman, SE | 1 |
| Benevenga, NJ | 1 |
| Askin, N; Dunne, A; Flynn, CA; Hoey, L; McNulty, H; Molloy, AM; Pentieva, K; Scott, JM; Strain, J; Ward, M | 1 |
| Kim, YI; Refsum, H; Smith, AD | 1 |
| Blayau, M; Boisson, C; Brustié, C; Candito, M; Fillion-Emery, N; Francannet, C; Gaucherand, P; Gérard, P; Guéant, JL; Guéant-Rodriguez, RM; Guidicelli, B; Heckenroth, H; Herbeth, B; Journel, H; Luton, D; Muller, F; Oury, JF; Poulain, P; Rivet, R; Roszyk, L; Roux, F; Rudigoz, RC; Saura, R; Staccini, P; Van Obberghen, E; Vernhet, I | 1 |
| Hustad, S; Ueland, PM | 1 |
| Bala, M; Jhanwar, A; Kharab, S; Pandey, RM; Ratan, SK; Rattan, KN; Singh, V; Singhal, S | 1 |
| Blom, H; Cole, KJ; Peeters, MC; Rousseau, AM; Seller, MJ; van Straaten, HW | 1 |
| Ubbink, JB | 1 |
| Blom, HJ; Copius Peereboom-Stegeman, JH; Deabreu, RA; Eskes, TK; Noordhoek, J; Trijbels, FJ; Vanaerts, LA | 1 |
| Conley, MR; Kirke, PN; Lee, YJ; McPartlin, JM; Mills, JL; Scott, JM; Weir, DG | 1 |
| Blom, HJ; Boers, GH; Borm, GF; Eskes, TK; Nijhuis, JG; Steegers-Theunissen, RP; Thomas, CM | 1 |
| Butterworth, CE | 1 |
| Blom, HJ; Boers, GH; Borm, GF; Eskes, TK; Finkelstein, JD; Steegers-Theunissen, RP; Thomas, CM; Trijbels, FJ; Wouters, MG | 1 |
| Hartley, R; Levene, MI; Lucock, MD; Schorah, CJ; Wild, J | 1 |
| Eskes, TK; Steegers-Theunissen, RP | 1 |
| Eskes, TK; Smithells, RW; Steegers-Theunissen, RP | 1 |
| Motulsky, AG | 1 |
| Conley, MR; Kirke, PN; Lee, YJ; McPartlin, JM; Mills, JL; Molloy, AM; Scott, JM; Weir, DG | 1 |
| Davis, RE | 1 |
| Sobra, J | 1 |
| Evans, AE; Gey, KF; Harmon, DL; McCrum, EE; McMaster, D; Whitehead, AS; Woodside, JV; Yarnell, JW; Young, IS | 1 |
| Conley, MR; Mills, JL | 1 |
| Ratashak, SA; Rosenquist, TH; Selhub, J | 1 |
| Allen, WP | 1 |
| St Clair, L; Swain, RA | 1 |
| Gallagher, PM; Kirke, PN; Mills, JL; Molloy, A; Ramsbottom, D; Scott, JM; Weir, DG; Whitehead, AS | 1 |
| Eskes, TK | 5 |
| Cole, DE; Evrovski, J; Miner, SE | 1 |
| Fowler, B | 1 |
| Bakker, RC; Brandjes, DP | 1 |
| Banerjee, R; Blom, HJ; Eskes, TK; Heil, SG; Kluijtmans, LA; Trijbels, JM; van der Molen, EF; van der Put, NM; Van Oppenraaij-Emmerzaal, D | 1 |
| Brouwer, IA; de Bree, A; Steegers-Theunissen, RP; van Dusseldorp, M; van het Hof, KH | 1 |
| Aubard, Y; Baudet, JH; Chinchilla, AM; Piver, P | 1 |
| Blom, HJ; Eskes, TK; Gabreëls, F; Smeitink, JA; Stevens, EM; Trijbels, FJ; van den Heuvel, LP; van der Put, NM | 1 |
| Copp, AJ | 1 |
| Boddie, AM; Dembure, PP; Elsas, LJ; Fisher, AJ; Macmahon, W; Saxe, D; Steen, MT; Sullivan, KM | 1 |
| Hishida, R; Nau, H | 1 |
| Hu, Y; Li, L; Zhan, S | 1 |
| Beresford, SA; Hickok, DE; Monsen, ER; Neuhouser, ML | 1 |
| Glade, MJ | 1 |
| Scott, JM; Weir, DG | 1 |
| Bester, MJ; Blom, HJ; Christianson, A; Delport, R; Potgieter, H; Ubbink, JB; Van Allen, MI; van der Merwe, A; Venter, PA; Vermaak, WJ | 1 |
| Alikaşifoğlu, M; Anar, B; Boduroğlu, K; Tunçbilek, E | 1 |
| Bailey, LB; Gregory, JF | 1 |
| Arbour, L; Christensen, B; Forbes, P; Gilfix, BM; Gravel, RA; Leclerc, D; Platt, R; Rosenblatt, DS; Rozen, R; Sabbaghian, N; Tran, P | 1 |
| Bui, TH; Jörgensen, C; Kihlberg, R; Söderhjelm, L | 1 |
| Norberg, B | 1 |
| Cole, DE; Langman, LJ | 1 |
| Rosenblatt, DS | 1 |
| Acton, S; Cliver, S; Johanning, GL; Johnston, KE; Owen, J; Tamura, T; Wenstrom, KD | 1 |
| Acton, S; Johanning, GL; Johnston, KE; Owen, J; Tamura, T; Wenstrom, KD | 1 |
| McCarron, P; Smith, GD; Stone, DH | 1 |
| Emblem, BM; Gjessing, HK; Irgens, LM; Monsen, AL; Refsum, H; Tverdal, A; Ueland, PM; Vollset, SE | 1 |
| Green, T; O'Connor, DL; Picciano, MF | 1 |
| Jennings, R; Madsen, JR; Manning, SM | 1 |
| Molloy, AM; Scott, JM; Weir, DG | 1 |
| Finkelstein, JD | 1 |
| Donnelly, JG; Isotalo, PA; Wells, GA | 1 |
| Cortés, F; de la Maza, MP; Hirsch, S | 1 |
| Blom, HJ; van der Put, NM | 1 |
| Brouwer, IA | 1 |
| Kruger, WD | 1 |
| Daskalakis, I; Lucock, M | 1 |
| Aubard, Y; Cantaloube, M; Darodes, N | 1 |
| Wald, NJ | 1 |
| Blom, HJ; Brouwer, IA; Eskes, TK; Hautvast, JG; Steegers-Theunissen, RP; Thomas, CM; van Dusseldorp, M; van Rooij, IA | 1 |
| Baker, PJ; Banerjee, R; Brody, LC; Garrett, L; Harris, M; Liu, ML; Shane, B; Stitzel, M; Swanson, DA; Wu, J | 1 |
| Beilby, J; Rossi, E | 1 |
| Afman, LA; Blom, HJ; Thomas, CM; Trijbels, JM; Van Der Put, NM | 1 |
| Finnell, RH; Rosenquist, TH | 1 |
| Böddeker, I; Koch, MC; Ngo, ET; Richter, B; Röper, B; Stegmann, K | 1 |
| Caudill, MA; Cogger, EA; Esfahani, ST; Le, T; Moonie, SA | 1 |
| Blom, HJ; Trijbels, FJ; van der Put, NM; van Straaten, HW | 1 |
| Hansen, M; Jensen, M; Madsen, LT; Samman, S; Sandström, B; Sørensen, SS | 1 |
| Blasco, C; Fabre, E; Gallo, M; González De Agüero, R; Juste, G; Lou, AC; Reyes-Engel, A; Romero, MS; Sobreviela, M | 1 |
| Refsum, H | 1 |
| Krishnaswamy, K; Madhavan Nair, K | 1 |
| Molloy, AM; Scott, JM | 1 |
| Beresford, SA; Neuhouser, ML | 1 |
| Finnell, RH; Gelineau-van Waes, J; Le, CX; Lu, X; Spiegelstein, O; Vorce, RL; Wlodarczyk, B | 1 |
| Andreussi, L; Arata, L; Calevo, MG; Cama, A; Capra, V; De Marco, P; Finnell, RH; Merello, E; Moroni, A | 1 |
| Chen, X; Hao, L; Li, Z; Liu, M; Liu, X; Tang, Y | 1 |
| Cunha, AL; Guerra-Shinohara, EM; Hirata, MH; Hirata, RD; Kim, CA; Nonoyama, K | 1 |
| Molloy, AM | 1 |
| Chen, X; Li, Y; Li, Z; Zhang, C | 1 |
| Chen, X; Li, Y; Li, Z; Qi, P | 1 |
| Sillender, M | 1 |
| Burgoon, JM; Nadeau, M; Sadler, TW; Selhub, J | 1 |
| Chen, X; Li, Y; Li, Z; Meng, Z | 1 |
| Leyva, M | 1 |
| Boers, GH; Eskes, TK; Steegers-Theunissen, RP; Trijbels, FJ | 1 |
77 review(s) available for homocysteine and Neural Tube Defects
| Article | Year |
|---|---|
High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Carbon; Choline; Diabetes, Gestational; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Micronutrients; Neural Tube Defects; Pregnancy; Thymidylate Synthase; Vitamin B 12 | 2022 |
Homocysteine - from disease biomarker to disease prevention.
Topics: Adult; Aged; Biomarkers; Child; Cognitive Dysfunction; Homocysteine; Humans; Macular Degeneration; Neural Tube Defects; Stroke; Vitamin B Complex | 2021 |
The role of folic acid fortification in neural tube defects: a review.
Topics: Biological Availability; Choline; Edible Grain; Female; Folic Acid; Folic Acid Antagonists; Food, Fortified; Homocysteine; Humans; Neural Tube Defects; Nutritional Requirements; Pregnancy; Recommended Dietary Allowances; United States; Vitamin B 12 | 2013 |
Neural tube defects, folic acid and methylation.
Topics: Animals; Choline; Folic Acid; Homocysteine; Humans; Methylation; Neural Tube Defects; Neurulation; Vitamin B 12; Vitamin B Complex | 2013 |
Nutriepigenetic regulation by folate-homocysteine-methionine axis: a review.
Topics: Animals; Epigenesis, Genetic; Fatigue Syndrome, Chronic; Folic Acid; Folic Acid Deficiency; Gene-Environment Interaction; Homocysteine; Humans; Methionine; Neural Tube Defects; Progeria | 2014 |
Critical evaluation of lowering the recommended dietary intake of folate.
Topics: Anemia; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Genetic Markers; Homocysteine; Humans; Life Style; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Genetic; Pregnancy; Pregnancy Complications; Recommended Dietary Allowances; Treatment Outcome | 2014 |
"Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis".
Topics: Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Odds Ratio; Polymorphism, Single Nucleotide; Pregnancy; Publication Bias; Risk Factors | 2015 |
Quantitative assessment of maternal biomarkers related to one-carbon metabolism and neural tube defects.
Topics: Biomarkers; Carbon; Case-Control Studies; Confidence Intervals; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Vitamin B 12 | 2015 |
Elevated homocysteine levels in mothers with neural tube defects: a systematic review and meta-analysis.
Topics: Case-Control Studies; Female; Folic Acid; Hematinics; Homocysteine; Humans; Neural Tube Defects; Pregnancy | 2017 |
Public health significance of elevated homocysteine.
Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Dementia; Diet; Female; Folic Acid; Fractures, Bone; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Neural Tube Defects; Pregnancy; Public Health; Risk Factors; Vitamin B 12; Vitamin B 6 | 2008 |
The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects.
Topics: Clinical Trials as Topic; DNA Mutational Analysis; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Metabolic Networks and Pathways; Models, Biological; Neural Tube Defects; Polymorphism, Genetic; Pregnancy; Research | 2009 |
Folic acid, methylation and neural tube closure in humans.
Topics: Female; Folic Acid; Genetic Variation; Homocysteine; Humans; Metabolic Networks and Pathways; Methylation; Methyltransferases; Models, Biological; Neural Tube; Neural Tube Defects; Pregnancy | 2009 |
Nutritional interpretation of folic acid interventions.
Topics: Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Neural Tube Defects | 2009 |
Cobalamin, folic acid, and homocysteine.
Topics: Adult; Aged; Cardiovascular Diseases; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Neural Tube Defects; Nutritional Requirements; Nutritional Status; Pregnancy; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex | 2009 |
Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects.
Topics: Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Models, Biological; Neural Tube Defects; Pregnancy; Risk Factors | 2011 |
Homocysteine in pregnancy.
Topics: Animals; Biomarkers; Female; Fetal Development; Fetal Growth Retardation; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Placenta; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Reproduction | 2011 |
[Genes involved in folate metabolim and neural tube defects].
Topics: Female; Folic Acid; Folic Acid Transporters; Genetic Predisposition to Disease; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Single Nucleotide; Pregnancy; Reduced Folate Carrier Protein; Risk Factors | 2011 |
Methylenetetrahydrofolate reductase: biochemical characterization and medical significance.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Arabidopsis; Cardiovascular Diseases; Catalysis; Escherichia coli; Homocysteine; Humans; Hyperhomocysteinemia; Leishmania major; Mental Disorders; Methylenetetrahydrofolate Reductase (NADPH2); Models, Molecular; Molecular Sequence Data; Neoplasms; Neural Tube Defects; Polymorphism, Single Nucleotide; Sequence Alignment; Tetrahydrofolates | 2013 |
Folic acid fortification, folate status and plasma homocysteine.
Topics: Cohort Studies; Folic Acid; Homocysteine; Humans; Neural Tube Defects | 2002 |
Effect of food fortification on folic acid intake in the United States.
Topics: Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Linear Models; Male; Neural Tube Defects; Nutritional Status; United States; United States Food and Drug Administration | 2003 |
Homocysteine, folic acid and B-group vitamins in obstetrics and gynaecology.
Topics: Abortion, Spontaneous; Congenital Abnormalities; Contraceptives, Oral, Hormonal; Female; Fetal Death; Fetal Growth Retardation; Folic Acid; Gynecology; Homocysteine; Humans; Menopause; Neural Tube Defects; Obstetrics; Pre-Eclampsia; Pregnancy; Uterine Cervical Dysplasia; Vitamin B Complex | 2003 |
Homocysteine and pregnancy.
Topics: Female; Homocysteine; Humans; Hyperhomocysteinemia; Neural Tube Defects; Placenta Diseases; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Hematologic | 2003 |
Changes in haemostasis during normal pregnancy: does homocysteine play a role in maintaining homeostasis?
Topics: Female; Folic Acid; Homeostasis; Homocysteine; Humans; Hyperhomocysteinemia; Neural Tube Defects; Placenta Diseases; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Hematologic; Thromboembolism | 2003 |
[Public health control of hyperhomocysteinemia and its consequences].
Topics: Alzheimer Disease; Canada; Cardiovascular Diseases; Flour; Folic Acid; Food, Fortified; Hematinics; Homocysteine; Humans; Hungary; Hyperhomocysteinemia; Neoplasms; Neural Tube Defects; Primary Prevention; Public Health; Randomized Controlled Trials as Topic; United Kingdom; United States; Vitamin B Complex; Vitamin B Deficiency | 2003 |
Genetic determinants of folate and vitamin B12 metabolism: a common pathway in neural tube defect and Down syndrome?
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Down Syndrome; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Genetic; Transcobalamins; Vitamin B 12 | 2003 |
[Methylenetetrahydrofolate polymorphism, folic acid, homocysteine associated with neural tube defects].
Topics: Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Genetic | 2004 |
Water-soluble vitamins: research update.
Topics: Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Neural Tube Defects; Niacinamide; Nutritional Requirements; Pregnancy; Riboflavin; Riboflavin Deficiency; Solubility; Thiamine; Thiamine Deficiency; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6; Vitamin B 6 Deficiency; Vitamin B Complex; Vitamin B Deficiency | 2005 |
Homocysteine and folic acid: implications for pregnancy.
Topics: Canada; Female; Folic Acid; Food, Fortified; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; International Cooperation; National Health Programs; Neural Tube Defects; Pre-Eclampsia; Pregnancy; United States | 2005 |
The significance of folic acid for epilepsy patients.
Topics: Anticonvulsants; Epilepsy; Female; Folic Acid; History, 20th Century; Homocysteine; Humans; Male; Methionine; Models, Biological; Neural Tube Defects; Pregnancy; Vascular Diseases | 2005 |
Initial findings on teratological and developmental relationships and differences between neural tube defects and facial clefting. First experimental results.
Topics: Alveolar Process; Animals; Cleft Lip; Cleft Palate; Female; Folic Acid Deficiency; Homocysteine; Neural Tube Defects; Rats; Rats, Inbred Lew; Vitamin B 6 Deficiency | 2005 |
Genetic variation in genes of folate metabolism and neural-tube defect risk.
Topics: Adult; Female; Folic Acid; Genetic Variation; Homocysteine; Humans; Neural Tube Defects; Polymorphism, Genetic; Pregnancy; Risk Factors | 2006 |
Folate and human reproduction.
Topics: Diet; Dietary Supplements; Female; Fetal Development; Fetus; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Lactation; Male; Neural Tube Defects; Nutritional Requirements; Placenta; Pregnancy; Pregnancy Complications; Reproduction | 2006 |
Neural tube defects and folate: case far from closed.
Topics: Animals; Central Nervous System; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Homocysteine; Humans; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects | 2006 |
Schizophrenia and neural tube defects: comparisons from an epidemiological perspective.
Topics: Birth Intervals; Female; Fetal Development; Folic Acid Deficiency; Geography; Homocysteine; Humans; Incidence; Methylenetetrahydrofolate Dehydrogenase (NAD+); Neural Tube Defects; Nutrition Disorders; Phenotype; Pregnancy; Risk Factors; Schizophrenia; Seasons; Starvation | 2007 |
Is an elevated circulating maternal homocysteine concentration a risk factor for neural tube defects?
Topics: Biomarkers; Female; Homocysteine; Humans; Methionine; Methylation; Neural Tube Defects; Pregnancy; Risk Factors | 1995 |
Folate status, women's health, pregnancy outcome, and cancer.
Topics: Adolescent; Adult; Animals; Arteriosclerosis; Female; Folic Acid Deficiency; Homocysteine; Humans; Infant; Maternal-Fetal Exchange; Methionine; Middle Aged; Neural Tube Defects; Papillomaviridae; Pregnancy; Rats; Tumor Virus Infections; Uterine Cervical Neoplasms; Women's Health | 1993 |
Update of new risk factors and prevention of neural-tube defects.
Topics: Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Neural Tube Defects; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency | 1993 |
Nutritional ecogenetics: homocysteine-related arteriosclerotic vascular disease, neural tube defects, and folic acid.
Topics: Arteriosclerosis; Coronary Disease; Female; Folic Acid; Homocysteine; Homocystinuria; Humans; Male; Neural Tube Defects; Nutritional Physiological Phenomena; Polymorphism, Genetic; Risk Factors; Sex Characteristics | 1996 |
Homocysteine and neural tube defects.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Infant, Newborn; Mice; Neural Tube Defects; Pregnancy; Randomized Controlled Trials as Topic; Rats; Vitamin B 12 | 1996 |
[Hyperhomocysteinemia].
Topics: Arteriosclerosis; Cardiovascular Diseases; Coronary Disease; Homocysteine; Humans; Neural Tube Defects | 1996 |
Folic acid to prevent neural tube defects: scientific advances and public health issues.
Topics: Diet; Female; Folic Acid; Genetic Testing; Hematinics; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Prenatal Care; Risk Factors | 1996 |
Folic acid in the prevention of birth defects.
Topics: Congenital Abnormalities; Female; Folic Acid; Homocysteine; Humans; Methionine; Neural Tube Defects; Preconception Care; Pregnancy; Prenatal Care | 1996 |
The role of folic acid in deficiency states and prevention of disease.
Topics: Anemia, Macrocytic; Arteriosclerosis; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Nutritional Physiological Phenomena; Pregnancy | 1997 |
Folates and the fetus.
Topics: Anemia, Megaloblastic; Carbon; Fetus; Folic Acid; Gestational Age; Homocysteine; Humans; Neural Tube Defects; Recurrence | 1997 |
Clinical chemistry and molecular biology of homocysteine metabolism: an update.
Topics: Female; Genotype; Homocysteine; Homocystinuria; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Models, Biological; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Practice Guidelines as Topic; Renal Insufficiency; Vascular Diseases; Vitamin B Deficiency | 1997 |
Disorders of homocysteine metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Amino Acid Metabolism, Inborn Errors; Animals; Cystathionine beta-Synthase; Disease Models, Animal; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases | 1997 |
Hyperhomocysteinaemia and associated disease.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Arteriosclerosis; Female; Homocysteine; Homocystinuria; Homozygote; Humans; Lyases; Metabolism, Inborn Errors; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases; Pregnancy; Pregnancy Complications; Thrombophlebitis | 1997 |
Folate intake in Europe: recommended, actual and desired intake.
Topics: Adult; Europe; Female; Folic Acid; Food; Homocysteine; Humans; Male; Neural Tube Defects; Nutrition Policy; Pregnancy; Risk Factors | 1997 |
[Folates and the neural tube. Review of the literature].
Topics: Animals; Europe; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Methionine; Methylation; Neural Crest; Neural Tube Defects; Preconception Care; Pregnancy; Prenatal Care; Prevalence; Risk Factors | 1997 |
Prevention of neural tube defects: vitamins, enzymes and genes.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cystathionine beta-Synthase; Female; Folic Acid; Homocysteine; Humans; Inositol; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Neurologic Mutants; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Vitamins | 1998 |
Mutated 5,10-methylenetetrahydrofolate reductase and moderate hyperhomocysteinaemia.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Amino Acid Metabolism, Inborn Errors; Arteriosclerosis; Heterozygote; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Oxidoreductases; Thrombosis | 1998 |
Neural tube defects, vitamins and homocysteine.
Topics: Animals; Female; Folic Acid; Homocysteine; Humans; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Rats; Spinal Dysraphism | 1998 |
From birth to conception. Open or closed.
Topics: Congenital Abnormalities; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Netherlands; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Spinal Dysraphism | 1998 |
Open or closed? A world of difference: a history of homocysteine research.
Topics: Animals; Female; Folic Acid; Homocysteine; Humans; Metabolism, Inborn Errors; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Vascular Diseases | 1998 |
Folic acid, homocysteine and one-carbon metabolism: a review of the essential biochemistry.
Topics: Cardiovascular Diseases; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Vitamin B 12 Deficiency | 1998 |
Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement.
Topics: Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Neural Tube Defects; Nutritional Requirements; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Risk Factors; Vascular Diseases | 1999 |
[Folic acid protects against neural tube defects. But how many women of reproductive age have been informed about this fact?].
Topics: Female; Folic Acid; Guidelines as Topic; Health Education; Homocysteine; Humans; Multicenter Studies as Topic; Neural Tube Defects; Nutritional Requirements; Pregnancy; Primary Prevention | 1999 |
Homocysteine.
Topics: Amino Acid Metabolism, Inborn Errors; Female; Homocysteine; Humans; Male; Neural Tube Defects; Vascular Diseases | 1999 |
Maternal folate status and lactation.
Topics: Animals; Animals, Suckling; Arteriosclerosis; Disease Susceptibility; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Infant; Infant, Newborn; Iron Deficiencies; Lactation; Mammals; Milk; Neoplasms; Neural Tube Defects; Neutrophils; Nutritional Requirements; Pregnancy; Pregnancy Complications; Pteroylpolyglutamic Acids; Rats | 1997 |
Pathophysiology, prevention, and potential treatment of neural tube defects.
Topics: Animals; Disease Models, Animal; Embryonic and Fetal Development; Folic Acid; Homocysteine; Humans; Incidence; Nervous System; Neural Tube Defects; Preventive Medicine | 2000 |
Homocysteine, folate enzymes and neural tube defects.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Nutritional Requirements; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Pregnancy Complications; Vitamin B 12 | 1999 |
Homocysteine: a history in progress.
Topics: History, 19th Century; History, 20th Century; Homocysteine; Homocystinuria; Humans; Insulin; Methionine; Neural Tube Defects; North America; Research; S-Adenosylmethionine; Workforce | 2000 |
[The importance of folic acid in current medicine].
Topics: Adult; Cardiovascular Diseases; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Hematinics; Homocysteine; Humans; Infant; Infant, Newborn; Neural Tube Defects; Pregnancy | 2000 |
Neural tube defects and a disturbed folate dependent homocysteine metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic | 2000 |
Vitamins and homocysteine metabolism.
Topics: Folic Acid Deficiency; Homocysteine; Humans; Neural Tube Defects; Nutritional Status; Vascular Diseases; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency; Vitamins | 2000 |
New perspectives on folate status: a differential role for the vitamin in cardiovascular disease, birth defects and other conditions.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Infant, Newborn; Neural Tube Defects | 2000 |
Hyperhomocysteinemia and pregnancy--review of our present understanding and therapeutic implications.
Topics: Abortion, Habitual; Anticoagulants; Female; Fetal Death; Fetal Growth Retardation; Homocysteine; Humans; Neural Tube Defects; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Venous Thrombosis | 2000 |
Folic acid and neural tube defects.
Topics: Biological Availability; Diet; Dose-Response Relationship, Drug; England; Female; Flour; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Myocardial Ischemia; Neural Tube Defects; Nutritive Value; Pregnancy; Pregnancy Complications; Prevalence; Risk Factors; Wales | 2001 |
Number 58: homocysteine and disease.
Topics: Alzheimer Disease; Animals; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Diet; Folic Acid; Homocysteine; Humans; Neural Tube Defects | 2000 |
Genes, folate and homocysteine in embryonic development.
Topics: Animals; Dietary Supplements; Embryonic and Fetal Development; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Pregnancy | 2001 |
Folate, homocysteine and neural tube defects: an overview.
Topics: Animals; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Intestinal Absorption; Methylenetetrahydrofolate Reductase (NADPH2); Models, Chemical; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Prevalence | 2001 |
Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome.
Topics: Congenital Abnormalities; Deficiency Diseases; Developing Countries; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Infant, Newborn; Neural Tube Defects; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Vitamin B 12; Vitamin B 12 Deficiency | 2001 |
Importance of folate in human nutrition.
Topics: Biological Availability; Birth Weight; Cardiovascular Diseases; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; India; Intestinal Absorption; Liver; Male; Meat; Neoplasms; Neural Tube Defects; Nutrition Policy; Nutritional Physiological Phenomena; Pregnancy; Prevalence; Public Health; Vegetables | 2001 |
Folates and prevention of disease.
Topics: Cardiovascular Diseases; Colorectal Neoplasms; Dietary Supplements; Folic Acid; Food, Fortified; Homocysteine; Humans; Mental Disorders; Neural Tube Defects; Treatment Outcome | 2001 |
Folic acid: are current fortification levels adequate?
Topics: Biomarkers; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Neural Tube Defects; Nutritional Requirements; Nutritional Status; Pregnancy; Safety; Treatment Outcome; United States | 2001 |
Folate bioavailability and health.
Topics: Biological Availability; Cardiovascular Diseases; Dietary Supplements; Female; Folic Acid; Food, Fortified; Hematinics; Homocysteine; Humans; Intestinal Absorption; Mental Disorders; Neural Tube Defects; Nutritional Requirements; Nutritional Status; Pregnancy | 2002 |
Folic acid intake and its effects on the prevention of neural tube defects, the masking of vitamin B12 deficiency and the reduction of homocysteine.
Topics: Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Neural Tube Defects; Oklahoma; Pregnancy; Prenatal Care; Primary Prevention; Risk Assessment; United States; United States Food and Drug Administration; Vitamin B 12 Deficiency | 2002 |
20 trial(s) available for homocysteine and Neural Tube Defects
| Article | Year |
|---|---|
Impact of continuing folic acid after the first trimester of pregnancy: findings of a randomized trial of Folic Acid Supplementation in the Second and Third Trimesters.
Topics: Adolescent; Adult; Dietary Supplements; Double-Blind Method; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Male; Neural Tube Defects; Northern Ireland; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Young Adult | 2013 |
Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial.
Topics: Aged; Aging; Bread; Double-Blind Method; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Neural Tube Defects; Nutritional Requirements; Nutritional Status; Vitamin B 12; Vitamin B 12 Deficiency | 2008 |
Effect of 2 pieces of nutritional advice on folate status in Swedish women: a randomized controlled trial.
Topics: Adult; Bread; Edible Grain; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Middle Aged; Neural Tube Defects; Nutrition Policy; Nutritional Requirements; Nutritional Status; Sweden | 2009 |
Controlled study on folate status following folic acid supplementation and discontinuation in women of child-bearing age.
Topics: Adult; Dietary Supplements; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Neural Tube Defects; Plasma; Serum; Young Adult | 2009 |
Supplementation with a multivitamin containing 800 microg of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women.
Topics: Adolescent; Adult; Diet; Diet Records; Dietary Supplements; Double-Blind Method; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Methionine; Micronutrients; Neural Tube Defects; Nutritional Status; Reference Values; Riboflavin; Time Factors; Vitamin B 12; Vitamin B 6; Young Adult | 2009 |
A dose-finding trial of the effect of long-term folic acid intervention: implications for food fortification policy.
Topics: Aged; Dose-Response Relationship, Drug; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Myocardial Ischemia; Neural Tube Defects; Nutrition Policy; Vitamin B 12 | 2011 |
Maternal one-carbon metabolism, MTHFR and TCN2 genotypes and neural tube defects in India.
Topics: Adult; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; India; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Single Nucleotide; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency | 2011 |
Folate status and homocysteine levels during a 24-week oral administration of a folate-containing oral contraceptive: a randomized, double-blind, active-controlled, parallel-group, US-based multicenter study.
Topics: Adolescent; Adult; Androstenes; Calcium; Contraceptives, Oral; Double-Blind Method; Estrogens; Ethinyl Estradiol; Female; Folic Acid; Glutamates; Homocysteine; Humans; Mineralocorticoid Receptor Antagonists; Neural Tube Defects; Treatment Outcome; Young Adult | 2012 |
Assessment of three levels of folic acid on serum folate and plasma homocysteine: a randomised placebo-controlled double-blind dietary intervention trial.
Topics: Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Double-Blind Method; Edible Grain; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Neural Tube Defects; Nutritional Requirements; Placebos; Vitamin B 12 | 2002 |
Study of wheat breakfast rolls fortified with folic acid. The effect on folate status in women during a 3-month intervention.
Topics: Adult; Biological Availability; Bread; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Erythrocytes; Female; Folic Acid; Food Handling; Food, Fortified; Homocysteine; Humans; Middle Aged; Neural Tube Defects; Nutritional Status; Triticum | 2002 |
Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study.
Topics: Adult; Dietary Supplements; Double-Blind Method; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Neural Tube Defects; Placebos; Tetrahydrofolates; Treatment Outcome; Vitamin B 12 Deficiency | 2003 |
Weekly high-dose folic Acid supplementation is effective in lowering serum homocysteine concentrations in women.
Topics: Adolescent; Adult; Dietary Supplements; Double-Blind Method; Drug Administration Schedule; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Treatment Outcome | 2003 |
Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women.
Topics: Adult; Analysis of Variance; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Placebos; Tetrahydrofolates; Treatment Outcome; Vitamin B 12 Deficiency | 2004 |
Effect of supplementation with folic acid throughout pregnancy on plasma homocysteine concentration.
Topics: Adult; Dietary Supplements; Female; Folic Acid; Gestational Age; Homocysteine; Humans; Longitudinal Studies; Neural Tube Defects; Pregnancy; Treatment Outcome | 2004 |
Folic acid fortified milk increases blood folate and lowers homocysteine concentration in women of childbearing age.
Topics: Adolescent; Adult; Animals; Biological Availability; Double-Blind Method; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Middle Aged; Milk; Neural Tube Defects; Nutritional Status | 2005 |
Bioavailability of folic acid from fortified pasteurised and UHT-treated milk in humans.
Topics: Adolescent; Adult; Animals; Biological Availability; Carrier Proteins; Double-Blind Method; Erythrocytes; Female; Folate Receptors, GPI-Anchored; Folic Acid; Food Handling; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Milk; Neural Tube Defects; Receptors, Cell Surface | 2005 |
Effect of time of initiation and dose of prenatal iron and folic acid supplementation on iron and folate nutriture of Korean women during pregnancy.
Topics: Adult; Analysis of Variance; Anemia, Iron-Deficiency; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Iron, Dietary; Korea; Neural Tube Defects; Nutritional Requirements; Nutritional Status; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second; Prenatal Nutritional Physiological Phenomena; Time Factors | 2005 |
Neural tube defects and elevated homocysteine levels in amniotic fluid.
Topics: Adult; Amniotic Fluid; Female; Fetal Diseases; Folic Acid; Gestational Age; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Pregnancy Trimester, Second; Pyridoxine; Vitamin B 12 | 1995 |
Association of the 677C-->T mutation on the methylenetetrahydrofolate reductase gene in Turkish patients with neural tube defects.
Topics: Adult; Alleles; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Testing; Genotype; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Turkey | 1999 |
Folic acid enrichment of bread does not appear to affect zinc absorption in young women.
Topics: Adult; Bread; Cross-Over Studies; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Intestinal Absorption; Neural Tube Defects; Zinc; Zinc Isotopes | 2001 |
117 other study(ies) available for homocysteine and Neural Tube Defects
| Article | Year |
|---|---|
Inhibiting MARSs reduces hyperhomocysteinemia-associated neural tube and congenital heart defects.
Topics: Animals; Female; Heart Defects, Congenital; Homocysteine; Humans; Hyperhomocysteinemia; Infant, Newborn; Male; Methionine-tRNA Ligase; Mice; Mice, Inbred C57BL; Neural Tube Defects; Rats; Rats, Sprague-Dawley; United States | 2020 |
Higher serum homocysteine and lower thyroid hormone levels in pregnant women are associated with neural tube defects.
Topics: Animals; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Mice; Neural Tube Defects; Pregnancy; Pregnant Women; Thyroid Hormones; Thyroxine | 2021 |
Folic acid, dietary habits, and homocysteine levels in relation to neural tube defects: A case-control study in North India.
Topics: Adult; Case-Control Studies; Diet; Diet, Vegetarian; Dietary Supplements; Feeding Behavior; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; India; Infant; Infant Mortality; Middle Aged; Neural Tube Defects; Odds Ratio; Prevalence | 2018 |
Association of FOLH1, DHFR, and MTHFR gene polymorphisms with susceptibility of Neural Tube Defects: A case control study from Eastern India.
Topics: Adult; Alleles; Antigens, Surface; Case-Control Studies; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; India; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neural Tube Defects; Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors; Tetrahydrofolate Dehydrogenase | 2018 |
Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects.
Topics: Adult; Animals; Brain; Chick Embryo; DNA (Cytosine-5-)-Methyltransferases; DNA Helicases; DNA Methyltransferase 3B; Female; HEK293 Cells; Histones; Homocysteine; Humans; Male; Neural Tube Defects; Nuclear Proteins; Transcription Factors; Young Adult | 2018 |
Association of MTHFR C677T, MTHFR A1298C, and MTRR A66G Polymorphisms with Neural Tube Defects in Tunisian Parents.
Topics: Alleles; Fathers; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Homocystinuria; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Muscle Spasticity; Neural Tube Defects; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Pregnancy; Psychotic Disorders; Tunisia | 2019 |
Epigenetic alterations in folate transport genes in placental tissue from fetuses with neural tube defects and in leukocytes from subjects with hyperhomocysteinemia.
Topics: Case-Control Studies; CpG Islands; DNA Methylation; Epigenesis, Genetic; Female; Folate Receptor 1; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Infant, Newborn; Leukocytes; Neural Tube Defects; Placenta; Polymorphism, Single Nucleotide; Pregnancy; Proton-Coupled Folate Transporter; Replication Protein C; RNA, Messenger; Transcription, Genetic | 2013 |
Homocysteine causes disruptions in spinal cord morphology and changes the expression of Pax 1/9 and Sox 9 gene products in the axial mesenchyme.
Topics: Analysis of Variance; Animals; Cell Proliferation; Chick Embryo; DNA Primers; Folic Acid Deficiency; Gene Expression Regulation, Developmental; Homocysteine; Immunohistochemistry; Mesoderm; Neural Tube Defects; Paired Box Transcription Factors; PAX9 Transcription Factor; Reverse Transcriptase Polymerase Chain Reaction | 2013 |
Nutrition throughout life: folate.
Topics: Biological Availability; Cardiovascular Diseases; Drug Stability; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Neural Tube Defects; Nutrition Policy; Nutritional Physiological Phenomena; Nutritional Requirements; Nutritional Status; Pregnancy | 2012 |
Influence of maternal vitamin B12 and folate on growth and insulin resistance in the offspring.
Topics: Adiposity; Adolescent; Adult; Animals; Body Weight; Carbon; Cardiovascular Diseases; Child; Chronic Disease; Diabetes Mellitus; Female; Folic Acid; Folic Acid Deficiency; Growth; Homocysteine; Humans; India; Infant; Infant, Newborn; Insulin Resistance; Maternal Nutritional Physiological Phenomena; Neural Tube Defects; Nutritional Status; Pregnancy; Pregnancy Complications; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2013 |
Association of neural tube defects in children of mothers with MTHFR 677TT genotype and abnormal carbohydrate metabolism risk: a case-control study.
Topics: Adult; Alleles; Carbohydrate Metabolism; Case-Control Studies; Female; Genetic Association Studies; Genotype; Homocysteine; Humans; Incidence; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Neural Tube Defects; Polymorphism, Single Nucleotide; Pregnancy; Risk Factors; Spinal Dysraphism; Young Adult | 2014 |
Quantification of folate metabolites in serum using ultraperformance liquid chromatography tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Limit of Detection; Neural Tube Defects; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry; Tetrahydrofolates | 2014 |
The application of a chemical determination of N-homocysteinylation levels in developing mouse embryos: implication for folate responsive birth defects.
Topics: Animals; Congenital Abnormalities; Disease Models, Animal; Embryo, Mammalian; Embryonic Development; Female; Folic Acid; Folic Acid Deficiency; Genotyping Techniques; Homocysteine; Mice; Neural Tube; Neural Tube Defects | 2015 |
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
Topics: Adult; Biomarkers; Canada; Case-Control Studies; Cross-Sectional Studies; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Genotype; Genotyping Techniques; Health Surveys; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neural Tube Defects; Nutritional Status; Polymorphism, Single Nucleotide; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2015 |
Association of maternal homocysteine and vitamins status with the risk of neural tube defects in Tunisia: A case-control study.
Topics: Adult; Case-Control Studies; Female; Fluorescence Polarization Immunoassay; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Radioimmunoassay; Risk Factors; Tunisia; Vitamins | 2015 |
The levels of vitamın B12, folate and homocysteine in mothers and their babies with neural tube defects.
Topics: Adult; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Middle Aged; Neural Tube Defects; Pregnancy; Prevalence; Risk Factors; Turkey; Vitamin B 12; Young Adult | 2016 |
Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects.
Topics: Animals; Autoantibodies; Blood Proteins; Diet; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Gestational Age; Homocysteine; Humans; Mice; Mice, Inbred C57BL; Neural Tube Defects; Pregnancy; Protein Processing, Post-Translational | 2016 |
Lack of association between the methylenetetrahydropholate reductase gene A1298C polymorphism and neural tube defects in a Turkish study group.
Topics: Adult; Child; Child, Preschool; Female; Gene Frequency; Genetic Association Studies; Genotype; Homocysteine; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube; Neural Tube Defects; Risk Factors; Turkey; Vitamin B 12 | 2016 |
Evaluation of maternal serum folate, vitamin B12, and homocysteine levels andfactor V Leiden, factor II g.20210G>A, and MTHFR variations in prenatallydiagnosed neural tube defects.
Topics: Female; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Pregnancy; Prothrombin; Vitamin B 12 | 2016 |
Homocysteine-induced changes in cell proliferation and differentiation in the chick embryo spinal cord: implications for mechanisms of neural tube defects (NTD).
Topics: Animals; Cell Differentiation; Cell Proliferation; Chick Embryo; Histones; Homocysteine; Neural Tube Defects; Neurons; Proliferating Cell Nuclear Antigen; Spinal Cord; Tubulin; Tumor Suppressor Protein p53 | 2017 |
Has enhanced folate status during pregnancy altered natural selection and possibly Autism prevalence? A closer look at a possible link.
Topics: Autistic Disorder; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Genetic; Pregnancy; Selection, Genetic | 2008 |
Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China.
Topics: Adult; Case-Control Studies; China; Diet; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Luminescent Measurements; Maternal Nutritional Physiological Phenomena; Neural Tube Defects; Pregnancy; Pregnant Women; Risk Factors; Ultrasonography; Vitamin B 12; Young Adult | 2009 |
Neural tube defects and disturbed maternal folate- and homocysteine-mediated one-carbon metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Carbon; Case-Control Studies; Chi-Square Distribution; Chromatography; Female; Folic Acid; Homocysteine; Humans; Maternal Age; Models, Biological; Neural Tube Defects; Pregnancy; S-Adenosylhomocysteine | 2008 |
Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function.
Topics: Animals; Disease Susceptibility; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Methylation; Mice; Mice, Transgenic; Mutation; Neural Tube Defects; Paired Box Transcription Factors; PAX3 Transcription Factor | 2008 |
Invited commentary: Preventing neural tube defects and more via food fortification?
Topics: Confidence Intervals; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Maryland; Mothers; Neural Tube Defects; Pregnancy; Prenatal Care; United States; Vitamin B Complex | 2009 |
Folate, vitamin B12 and homocysteine status in women of childbearing age: baseline data of folic acid wheat flour fortification in Iran.
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Female; Flour; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Iran; Middle Aged; Neural Tube Defects; Nutritional Status; Outcome and Process Assessment, Health Care; Triticum; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2008 |
Folate status of young Canadian women after folic acid fortification of grain products.
Topics: Adolescent; Biomarkers; Cross-Sectional Studies; Dietary Supplements; Edible Grain; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Neural Tube Defects; Nutritional Requirements; Nutritional Status; United States; Young Adult | 2008 |
Maternal serum homocysteine and risk for neural tube defects in a Texas-Mexico border population.
Topics: Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Mexico; Neural Tube Defects; Pregnancy; Pregnancy Complications; Retrospective Studies; Risk Factors; Texas; Vitamin B 12 | 2009 |
One-carbon metabolism-genome interactions in folate-associated pathologies.
Topics: Animals; Carbon; Child; Developmental Disabilities; Disease Models, Animal; Environment; Folic Acid; Gastrointestinal Neoplasms; Genetic Phenomena; Genome, Human; Homocysteine; Humans; Methionine; Mice; Neural Tube Defects; Purines; Risk Factors; Thymidine Monophosphate | 2009 |
Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects.
Topics: Adult; Base Sequence; DNA Methylation; Educational Status; Embryonic Development; Female; Genome, Human; Homocysteine; Humans; Immunoassay; Long Interspersed Nucleotide Elements; Male; Malnutrition; Molecular Sequence Data; Neural Tube Defects; Open Reading Frames; Parity; Pregnancy; Pregnancy Complications; Risk Factors; Vitamin B 12; Young Adult | 2010 |
C677T polymorphism of the methylenetetrahydrofolate reductase gene does not affect folic acid, vitamin B12, and homocysteine serum levels in Turkish children with neural tube defects.
Topics: Adult; Alleles; Child; Child, Preschool; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Genetic; Turkey; Vitamin B 12 | 2010 |
Serum vitamin B12 and homocysteine levels in pregnant women with neural tube defect.
Topics: Adult; Case-Control Studies; Female; Fetal Diseases; Homocysteine; Humans; Maternal Nutritional Physiological Phenomena; Neural Tube Defects; Pregnancy; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2010 |
Quantitative, high-resolution epigenetic profiling of CpG loci identifies associations with cord blood plasma homocysteine and birth weight in humans.
Topics: Birth Weight; CpG Islands; Epigenesis, Genetic; Female; Fetal Blood; Folic Acid; Gene Expression Profiling; Homocysteine; Humans; Long Interspersed Nucleotide Elements; Male; Neural Tube Defects; Pregnancy; Vitamin B Complex | 2011 |
New insights on the lowest dose for mandatory folic acid fortification?
Topics: Folic Acid; Food, Fortified; Homocysteine; Humans; Neural Tube Defects | 2011 |
Maternal folate, vitamin B12 and homocysteine levels in pregnancies affected by congenital malformations other than neural tube defects.
Topics: Congenital Abnormalities; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Risk Factors; Vitamin B 12 | 2011 |
Association between dietary folate intake and blood status of folate and homocysteine in Malaysian adults.
Topics: Adult; Asian People; Cardiovascular Diseases; Cross-Sectional Studies; Diet; Diet Records; Diet Surveys; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Linear Models; Malaysia; Male; Middle Aged; Neural Tube Defects; Nutritional Status; Sex Factors; Surveys and Questionnaires; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Young Adult | 2011 |
Efficacy of flour fortification with folic acid in women of childbearing age in Iran.
Topics: Adolescent; Adult; Bread; Cross-Sectional Studies; Female; Flour; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Iran; Longitudinal Studies; Middle Aged; Neural Tube Defects; Nutritional Status; Socioeconomic Factors; Vitamin B 12; Young Adult | 2011 |
Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice.
Topics: Aminohydrolases; Animals; Choline; Choline Deficiency; Crosses, Genetic; Disease Models, Animal; Embryo Loss; Female; Fetal Growth Retardation; Folic Acid; Folic Acid Deficiency; Formate-Tetrahydrofolate Ligase; Genes, Lethal; Heterozygote; Homocysteine; Hypoxanthine; Maternal Nutritional Physiological Phenomena; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Mutant Strains; Multienzyme Complexes; Mutagenesis, Insertional; Neural Tube Defects; Pregnancy | 2012 |
Homocysteine, folate, vitamin B12 and B6 in mothers of children with neural tube defects in Xinjiang, China.
Topics: Adult; Biomarkers; Case-Control Studies; China; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Neural Tube Defects; Pregnancy; Prenatal Exposure Delayed Effects; Prenatal Nutritional Physiological Phenomena; Risk Factors; Vitamin B 12; Vitamin B 6 | 2012 |
Efficacy of adding folic acid to foods.
Topics: Cardiovascular Diseases; Diet; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Neoplasms; Neural Tube Defects; Vitamin B 12 Deficiency | 2012 |
Does prenatal screening for 5,10-methylenetetrahydrofolate reductase (MTHFR) mutations in high-risk neural tube defect pregnancies make sense?
Topics: Animals; Female; Fetal Diseases; Folic Acid; Genetic Predisposition to Disease; Genetic Testing; Homocysteine; Humans; Meta-Analysis as Topic; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Knockout; Mutation; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pregnancy; Prenatal Diagnosis | 2002 |
The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr.
Topics: 5' Flanking Region; Animals; Cholates; Disease Models, Animal; Folic Acid; Homocysteine; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors | 2002 |
The H475Y polymorphism in the glutamate carboxypeptidase II gene increases plasma folate without affecting the risk for neural tube defects in humans.
Topics: Adolescent; Adult; Antigens, Surface; Carboxypeptidases; Female; Folic Acid; Glutamate Carboxypeptidase II; Homocysteine; Humans; Male; Middle Aged; Netherlands; Neural Tube Defects; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Risk Factors | 2003 |
Homocysteine is embryotoxic but does not cause neural tube defects in mouse embryos.
Topics: Animals; Central Nervous System; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Fetus; Folic Acid; Homocysteine; Humans; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Neural Tube Defects; Pregnancy; Pregnancy Complications; Somites; Thymidine | 2003 |
Gene-gene interaction between the cystathionine beta-synthase 31 base pair variable number of tandem repeats and the methylenetetrahydrofolate reductase 677C > T polymorphism on homocysteine levels and risk for neural tube defects.
Topics: Adolescent; Adult; Child; Cystathionine beta-Synthase; Female; Gene Frequency; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neural Tube Defects; Polymorphism, Genetic; Tandem Repeat Sequences; Vitamin B 6 | 2003 |
[Relationship between homocysteine-induced apoptosis and teratogenesis in developing avian embryo].
Topics: Animals; Apoptosis; Chick Embryo; Heart Defects, Congenital; Homocysteine; Neural Tube Defects | 1999 |
High exogenous homocysteine modifies eye development in early chick embryos.
Topics: Abnormalities, Drug-Induced; Animals; Antibodies, Monoclonal; Chick Embryo; Eye; Eye Abnormalities; Fibrillin-1; Fibrillins; Homocysteine; Immunohistochemistry; Lens Capsule, Crystalline; Microfilament Proteins; Microphthalmos; Morphogenesis; Neural Tube Defects | 2003 |
Neural and orofacial defects in Folp1 knockout mice [corrected].
Topics: Animals; Carrier Proteins; Craniofacial Abnormalities; Embryonic and Fetal Development; Female; Folate Receptors, GPI-Anchored; Folic Acid; Gene Expression Regulation, Developmental; Genetic Markers; Genotype; Homocysteine; Homozygote; Male; Mice; Mice, Knockout; Neural Tube Defects; Receptors, Cell Surface | 2003 |
[Do folates and homocysteine have a causal relation with neural tube defects?].
Topics: Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Pregnancy | 2003 |
Homocysteine interference in neurulation: a chick embryo model.
Topics: Abnormalities, Multiple; Animals; Chick Embryo; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Homocysteine; Neural Tube Defects; Organ Culture Techniques; Teratogens | 2003 |
Homocysteine-induced changes in brain membrane composition correlate with increased brain caspase-3 activities and reduced chick embryo viability.
Topics: Animals; Apoptosis; Brain; Caspase 3; Caspases; Chick Embryo; Fatty Acids; Homocysteine; Methylation; Neural Tube Defects; Phospholipids | 2003 |
Folic acid rescues nitric oxide-induced neural tube closure defects.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carbon Radioisotopes; Chick Embryo; Culture Techniques; Folic Acid; Hemoglobins; Homocysteine; Models, Biological; Neural Tube Defects; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Tetrahydrofolates; Time Factors | 2004 |
Homocysteine induces endothelial cell detachment and vessel wall thickening during chick embryonic development.
Topics: Animals; Blood Vessels; Branchial Region; Cell Adhesion; Cell Lineage; Cell Movement; Chick Embryo; Endothelin-1; Endothelium, Vascular; Extracellular Matrix; Fibrillin-2; Fibrillins; Fibronectins; Homocysteine; Microfilament Proteins; Muscle, Smooth, Vascular; Neural Crest; Neural Tube Defects; Specific Pathogen-Free Organisms | 2004 |
Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population.
Topics: Case-Control Studies; Epistasis, Genetic; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Neural Tube Defects; Polymorphism, Genetic; United Kingdom | 2004 |
A common ABCC2 promoter polymorphism is not a determinant of the risk of spina bifida.
Topics: ATP-Binding Cassette Transporters; Folic Acid; Genetic Variation; Homocysteine; Humans; Likelihood Functions; Linear Models; Multidrug Resistance-Associated Protein 2; Neural Tube Defects; Pedigree; Polymorphism, Genetic; Promoter Regions, Genetic; Retrospective Studies; Risk Factors; Spinal Dysraphism | 2004 |
Metabolic effects and the methylenetetrahydrofolate reductase (MTHFR) polymorphism associated with neural tube defects in southern Brazil.
Topics: Adolescent; Adult; Brazil; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Genetic; Vitamin B 12 | 2004 |
Homocysteine and folate in pregnancy.
Topics: Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; Prenatal Diagnosis; Reference Values | 2004 |
Oxidative stress in mothers who have conceived fetus with neural tube defects: the role of aminothiols and selenium.
Topics: Adult; Case-Control Studies; Cysteine; Dipeptides; Female; Folic Acid; Glutathione; Homocysteine; Humans; Infant, Newborn; Methionine; Mothers; Neural Tube Defects; Oxidation-Reduction; Oxidative Stress; Selenium; Sulfhydryl Compounds | 2004 |
Morphogenetic movements during cranial neural tube closure in the chick embryo and the effect of homocysteine.
Topics: Actin Cytoskeleton; Actins; Animals; Cell Movement; Central Nervous System; Chick Embryo; Homocysteine; Methylation; Neural Tube Defects; Skull | 2005 |
Homocysteine metabolism in families from southern Italy with neural tube defects: role of genetic and nutritional determinants.
Topics: Adolescent; Adult; Case-Control Studies; Child, Preschool; Female; Genetic Predisposition to Disease; Homocysteine; Humans; Infant; Italy; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Neural Tube Defects; Nutritional Status; White People | 2006 |
Impact of methylenetetrahydrofolate reductase deficiency and low dietary folate on the development of neural tube defects in splotch mice.
Topics: Animals; Female; Folic Acid Deficiency; Gestational Age; Heterozygote; Homocysteine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Mutant Strains; Neural Tube Defects; Paired Box Transcription Factors; PAX3 Transcription Factor; Pregnancy | 2006 |
Folate supplementation: too much of a good thing?
Topics: Carcinogens; Cardiovascular Diseases; Dietary Supplements; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Neoplasms; Neural Tube Defects; Preconception Care; Vitamin B Complex | 2006 |
Antiepileptic drugs: a case report in a pregnancy with a neural tube defect.
Topics: Adult; Anticonvulsants; Female; Folic Acid; Homocysteine; Humans; Lamotrigine; Myoclonic Epilepsy, Juvenile; Neural Tube Defects; Pregnancy; Pregnancy Complications; Pregnancy, Multiple; Triazines; Triplets; Vitamin B Complex | 2006 |
Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Female; Fetal Growth Retardation; Folic Acid; Gestational Age; Homocysteine; Homocystine; Mice; Neural Tube Defects; Pregnancy; Random Allocation; Teratogens; Valproic Acid; Vitamin B 12 | 2006 |
Parallel changes in metabolite and expression profiles in crooked-tail mutant and folate-reduced wild-type mice.
Topics: Animals; DNA-Binding Proteins; Female; Folic Acid; Folic Acid Deficiency; Gene Expression Profiling; Homocysteine; Homozygote; Mice; Mice, Mutant Strains; Neural Tube Defects; Proto-Oncogene Proteins | 2006 |
Plasma vitamin values and antiepileptic therapy: case reports of pregnancy outcomes affected by a neural tube defect.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Valproic Acid; Vitamin B 12; Vitamin B 6 | 2007 |
Maternal vitamin B12 and the risk of fetal neural tube defects in Egyptian patients.
Topics: Case-Control Studies; Egypt; Female; Folic Acid; Homocysteine; Humans; Maternal Nutritional Physiological Phenomena; Neural Tube Defects; Odds Ratio; Pregnancy; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2007 |
Consideration of betaine and one-carbon sources of N5-methyltetrahydrofolate for use in homocystinuria and neural tube defects.
Topics: Betaine; Dietary Supplements; Folic Acid; Homocysteine; Homocystinuria; Humans; Methionine; Methylation; Neural Tube Defects; Nutritional Physiological Phenomena; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B Complex | 2007 |
Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Neural Tube Defects; Nutrition Policy; Nutritional Status; Vitamin B 12; Vitamin B 6 | 2007 |
Is folic acid good for everyone?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Cognition; Epigenesis, Genetic; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Neoplasms; Neural Tube Defects; Nutrition Policy; Nutritional Requirements; Public Health; Vitamin B 12 Deficiency | 2008 |
Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; France; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Nutritional Status; Polymorphism, Genetic; Pregnancy; Prospective Studies; Risk Factors; Vitamin B Complex | 2008 |
Homocysteine and folate status in an era of folic acid fortification: balancing benefits, risks, and B-vitamins.
Topics: Cleft Lip; Cleft Palate; Folic Acid; Food, Fortified; Homocysteine; Humans; Neural Tube Defects; Nutrition Surveys; Risk Assessment; Vitamin B Complex | 2008 |
Evaluation of the levels of folate, vitamin B12, homocysteine and fluoride in the parents and the affected neonates with neural tube defect and their matched controls.
Topics: Biomarkers; Female; Fluorides; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Incidence; India; Infant, Newborn; Male; Neural Tube Defects; Parents; Prognosis; Retrospective Studies; Risk Factors; Vitamin B 12 | 2008 |
Dietary methionine does not reduce penetrance in curly tail mice but causes a phenotype-specific decrease in embryonic growth.
Topics: Animals; Diet; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Female; Homocysteine; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Mutant Strains; Neural Tube Defects; Phenotype; Pregnancy; Weight Gain | 1995 |
Prevention of neural tube defects by and toxicity of L-homocysteine in cultured postimplantation rat embryos.
Topics: Adenosylhomocysteinase; Animals; Catalase; Copper; Copper Sulfate; Culture Techniques; Drug Interactions; Embryonic and Fetal Development; Embryonic Development; Female; Homocysteine; Homocystine; Hydrolases; Methionine; Neural Tube Defects; Oxidation-Reduction; Pregnancy; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Stereoisomerism; Teratogens; Vitamin B 12 | 1994 |
Homocysteine metabolism in pregnancies complicated by neural-tube defects.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Analysis of Variance; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Methylation; Methylmalonic Acid; Neural Tube Defects; Pregnancy; Vitamin B 12 | 1995 |
Maternal hyperhomocysteinemia: a risk factor for neural-tube defects?
Topics: Adult; Anencephaly; Cystathionine beta-Synthase; Encephalocele; Female; Folic Acid; Homocysteine; Humans; Meningomyelocele; Methionine; Neural Tube Defects; Pregnancy; Pregnancy Complications; Risk Factors | 1994 |
The methylfolate axis in neural tube defects: in vitro characterisation and clinical investigation.
Topics: Animals; Anticonvulsants; Female; Folic Acid; Homocysteine; Humans; In Vitro Techniques; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Rats; Rats, Wistar; Tetrahydrofolates | 1994 |
Primary prevention of neural-tube defects with folic acid.
Topics: Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Nutritional Physiological Phenomena; Pregnancy; Primary Prevention | 1994 |
Abnormal folate metabolism and neural tube defects.
Topics: Adult; Erythrocytes; Female; Folic Acid; Homocysteine; Homozygote; Humans; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors | 1996 |
The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Neural Tube Defects; Oxidoreductases; Phenotype; Risk Factors; Vascular Diseases; Vitamin B 12 | 1996 |
Homocysteine induces congenital defects of the heart and neural tube: effect of folic acid.
Topics: Animals; Chick Embryo; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryonic and Fetal Development; Folic Acid; Gastrula; Heart Defects, Congenital; Homocysteine; Mice; Neural Tube Defects; Teratogens | 1996 |
Are common mutations of cystathionine beta-synthase involved in the aetiology of neural tube defects?
Topics: Cystathionine beta-Synthase; DNA Transposable Elements; Female; Gene Frequency; Haplotypes; Heterozygote; Homocysteine; Homozygote; Humans; Infant, Newborn; Ireland; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Pregnancy; Risk Factors; Sequence Analysis, DNA | 1997 |
Sequence analysis of the coding region of human methionine synthase: relevance to hyperhomocysteinaemia in neural-tube defects and vascular disease.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Arterial Occlusive Diseases; Female; Genotype; Homocysteine; Humans; Male; Molecular Sequence Data; Mutation; Neural Tube Defects; Odds Ratio; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Cardiovascular; Sequence Analysis, DNA | 1997 |
A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?
Topics: Adenine; Adult; Cytosine; Female; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Prevalence; Pyridoxine; Vitamin B 12 | 1998 |
Neural-tube defects are associated with low concentrations of cobalamin (vitamin B12) in amniotic fluid.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amniocentesis; Amniotic Fluid; Case-Control Studies; Cysteine; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Methionine; Methylation; Neural Tube Defects; Pilot Projects; Pregnancy; Reference Values; Vitamin B 12 | 1998 |
VPA-induced neural tube defects in mice. I. Altered metabolism of sulfur amino acids and glutathione.
Topics: Abnormalities, Drug-Induced; Amino Acids; Animals; Anticonvulsants; Female; Folic Acid; Glutathione; Homocysteine; Liver; Methionine; Mice; Neural Tube Defects; Pregnancy; Valproic Acid | 1998 |
[A correlation study on homocysteine metabolism in pregnant women and neural tube defects in urban and rural areas].
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Random Allocation; Rural Health; Urban Health; Vitamin B 12 | 1997 |
Absorption of dietary and supplemental folate in women with prior pregnancies with neural tube defects and controls.
Topics: Absorption; Adult; Biological Availability; Diet; Dietary Supplements; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Pteroylpolyglutamic Acids; Vitamin B 12; Zinc | 1998 |
Workshop on Folate, B12, and Choline. Sponsored by the Panel on Folate and other B vitamins of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine, Washington, D.C., March 3-4,
Topics: Biological Availability; Biomarkers; Cardiovascular Diseases; Choline; Congenital Abnormalities; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Male; Neoplasms; Neural Tube Defects; Nutrition Policy; Nutritional Status; Vitamin B 12; Vitamin B 12 Deficiency | 1999 |
Folate status, homocysteine metabolism, and methylene tetrahydrofolate reductase genotype in rural South African blacks with a history of pregnancy complicated by neural tube defects.
Topics: Adult; Black People; DNA; Female; Folic Acid; Genotype; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Dehydrogenase (NADP); Neural Tube Defects; Nutritional Status; Pregnancy; Pregnancy Complications; Rural Population; South Africa | 1999 |
Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Child; Child, Preschool; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Prevalence; Risk; Vitamin B 12 | 1999 |
Turn of tide for oral vitamin B12 treatment.
Topics: Administration, Oral; Aged; Biological Availability; Biomarkers; England; Female; Homocysteine; Humans; Infusions, Intravenous; Methylmalonic Acid; Neural Tube Defects; Pregnancy; Pregnancy Complications; Sweden; Vitamin B 12; Vitamin B 12 Deficiency | 1999 |
Folate and homocysteine metabolism and gene polymorphisms in the etiology of Down syndrome.
Topics: Down Syndrome; Female; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Nutritional Physiological Phenomena; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pregnancy | 1999 |
Amniotic fluid homocysteine levels, 5,10-methylenetetrahydrafolate reductase genotypes, and neural tube closure sites.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Alanine; Amino Acid Substitution; Amniotic Fluid; Female; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases; Point Mutation; Pregnancy; Valine | 2000 |
Role of amniotic fluid homocysteine level and of fetal 5, 10-methylenetetrahydrafolate reductase genotype in the etiology of neural tube defects.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Alanine; Amino Acid Substitution; Amniotic Fluid; Female; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases; Point Mutation; Pregnancy; Valine | 2000 |
Similarities in the epidemiology of neural tube defects and coronary heart disease: is homocysteine the missing link?
Topics: Coronary Disease; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Ireland; Male; Neural Tube Defects; Public Health; United Kingdom | 1999 |
Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study.
Topics: Abruptio Placentae; Adult; Aged; Biomarkers; Clubfoot; Congenital Abnormalities; Female; Fetal Death; Fetal Growth Retardation; Folic Acid Deficiency; Homocysteine; Humans; Infant, Newborn; Infant, Very Low Birth Weight; Male; Middle Aged; Neural Tube Defects; Norway; Obstetric Labor, Premature; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Registries; Risk Factors | 2000 |
Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: an examination of C677T and A1298C mutations.
Topics: Abortion, Habitual; Alleles; Female; Fetal Blood; Fetal Death; Fetus; Gene Frequency; Genes, Essential; Genes, Lethal; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Phenotype; Point Mutation; Polymorphism, Genetic; Pregnancy; Pregnancy Outcome | 2000 |
Folic acid, folate and homocysteine: human intervention studies.
Topics: Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Pregnancy | 2000 |
Homocysteine-lowering effect of 500 microg folic acid every other day versus 250 microg/day.
Topics: Adolescent; Adult; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Time Factors | 2000 |
Targeted disruption of the methionine synthase gene in mice.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Base Sequence; Cardiovascular Diseases; DNA Primers; Embryonic and Fetal Development; Female; Folic Acid; Gene Targeting; Heterozygote; Homocysteine; Homozygote; Humans; Methionine; Mice; Mice, Knockout; Neural Tube Defects; Pregnancy; Risk Factors; Vitamin B 12 Deficiency | 2001 |
Homocysteine and human reproduction.
Topics: Culture Techniques; Female; Folic Acid; History, 17th Century; History, 20th Century; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Reproduction | 2000 |
Reduced vitamin B12 binding by transcobalamin II increases the risk of neural tube defects.
Topics: Adult; Case-Control Studies; Chromatography, High Pressure Liquid; Electrophoresis, Agar Gel; Female; Homocysteine; Humans; Middle Aged; Neural Tube Defects; Polymerase Chain Reaction; Polymorphism, Genetic; Pregnancy; Risk Factors; Statistics as Topic; Transcobalamins; Vitamin B 12 | 2001 |
Interaction of folate and homocysteine pathway genotypes evaluated in susceptibility to neural tube defects (NTD) in a German population.
Topics: Alleles; Case-Control Studies; Cystathionine beta-Synthase; Female; Folic Acid; Gene Frequency; Genotype; Germany; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Risk Factors | 2001 |
Folate status in women of childbearing age residing in Southern California after folic acid fortification.
Topics: Adolescent; Adult; California; Cross-Sectional Studies; Erythrocytes; Female; Folic Acid; Food, Fortified; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neural Tube Defects; Nutritional Requirements; Nutritional Status; Oxidoreductases Acting on CH-NH Group Donors; Social Class | 2001 |
[Effects of levofolinic acid on plasma homocysteine concentrations in healthy and young women in preconceptional care].
Topics: Adult; Female; Homocysteine; Humans; Leucovorin; Neural Tube Defects; Preconception Care | 2001 |
Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice.
Topics: Animals; Arsenates; Arsenicals; Arsenites; Cacodylic Acid; Carrier Proteins; Dose-Response Relationship, Drug; Female; Fetal Resorption; Folate Receptors, GPI-Anchored; Folic Acid Deficiency; Genetic Predisposition to Disease; Genotype; Homocysteine; Mice; Mice, Knockout; Neural Tube Defects; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, Cell Surface; Teratogens | 2001 |
Polymorphisms in genes involved in folate metabolism as risk factors for NTDs.
Topics: Adult; Carrier Proteins; Case-Control Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Italy; Male; Membrane Proteins; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pregnancy | 2001 |
[Relationship between folate, vitamin B12, total plasma homocysteine and mutation of reductase].
Topics: Adult; Female; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Vitamin B 12 | 2000 |
Metabolic effects of C677T and A1298C mutations at the MTHFR gene in Brazilian children with neural tube defects.
Topics: Adolescent; Adult; Alleles; Brazil; Child; Child, Preschool; Female; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation, Missense; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Vitamins | 2002 |
[Time-effect relationship between the positional microinjection of HCY-2 gene and the neural tube teratogenesis of chick embryos].
Topics: Animals; Chick Embryo; Gene Transfer Techniques; Homocysteine; Microinjections; Neural Tube Defects; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 1999 |
[Homocysteine-induced neural tube defects in chick embryos and protection of folic acid].
Topics: Animals; Apoptosis; Chick Embryo; Folic Acid; Homocysteine; Neural Tube Defects; Teratogens | 1998 |
Fortification of flour with folic acid. Fortification is needed now.
Topics: Flour; Folic Acid; Food, Fortified; Homocysteine; Humans; Neural Tube Defects | 2002 |
Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model.
Topics: Animals; Body Weight; Cleft Palate; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Homocysteine; Male; Mice; Mice, Inbred ICR; Neural Tube Defects; Pregnancy | 2002 |
[Effects of HCY-2 gene transfer on the development of chick neural tube].
Topics: Animals; Chick Embryo; DNA, Complementary; Gene Transfer Techniques; Homocysteine; Neural Crest; Neural Tube Defects | 1999 |
Neural-tube defects and derangement of homocysteine metabolism.
Topics: Female; Homocysteine; Homocystinuria; Humans; Infant, Newborn; Neural Tube Defects; Pregnancy | 1991 |