homocysteine and Down Syndrome

homocysteine has been researched along with Down Syndrome in 52 studies

Research

Studies (52)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (9.62)	18.7374
1990's	7 (13.46)	18.2507
2000's	26 (50.00)	29.6817
2010's	13 (25.00)	24.3611
2020's	1 (1.92)	2.80

Authors

Authors	Studies
Antonaros, F; Caracausi, M; Carosi Diatricch, L; Cicchini, E; Cocchi, G; Feliciello, A; Lanfranchi, S; Locatelli, C; Mannini, E; Martelli, A; Olivucci, G; Onnivello, S; Pelleri, MC; Piovesan, A; Pulina, F; Ramacieri, G; Strippoli, P; Vianello, R; Vione, B; Vitale, L	1
Jiajin, L; Junxiao, C; Shuyan, C; Xiudi, W; Ying, W	1
Biselli, JM; Carvalho, VM; Eberlin, MN; Goloni-Bertollo, EM; Haddad, R; Marucci, GH; Mendes, CC; Oliveira, LD; Pavarino, ÉC; Raimundo, AM; Riccio, MF; Vannucchi, H; Zampieri, BL	1
Anello, G; Antonucci, I; Barone, C; Bosco, P; Coppedè, F; Denaro, M; Lorenzoni, V; Migliore, L; Romano, C; Stuppia, L	1
Gupta, V; Jaiswal, SK; Kumar, A; Mishra, OP; Rai, AK; Raman, R; Sukla, KK	1
Chen, J; He, J; Li, T; Liu, Y; Song, C; Wang, Y; Xiong, F	1
Benejam, B; Blanco-Hinojo, L; Bléhaut, H; Catuara-Solarz, S; Cuenca-Royo, A; de la Torre, R; de Sola, S; Del Hoyo, L; Delabar, JM; Dierssen, M; Dueñas-Espín, I; Espadaler, JM; Farré, M; Fitó, M; Hernandez, G; Janel, N; Langohr, K; Principe, A; Pujol, J; Rodriguez, J; Sanchez-Benavides, G; Videla, S; Xicota, L	1
Chauhan, A; Jaiswal, SK; Kumar, A; Lakhotia, AR; Rai, AK; Sukla, KK	1
Oláh, E; V Oláh, A; Varga, P	1
Arora, S; Gulati, S; Kabra, M; Kohli, U; Pandey, RM; Ramakrishnan, L	1
Alves da Silva, AF; Biselli, JM; Carvalho, VM; Eberlin, MN; Goloni-Bertollo, EM; Haddad, R; Machado, FB; Medina-Acosta, E; Pavarino-Bertelli, EC; Vannucchi, H; Zampieri, BL	1
Ahmed, HH; Dardir, AA; El-Sayed, EM; Ezzat, A; Hashish, AF; Meguid, NA	1
Cheng, PJ; Chueh, HY; Hsieh, TT; Huang, SY; Shaw, SW	1
Biselli, JM; Carvalho, VM; Eberlin, MN; Goloni-Bertollo, EM; Haddad, R; Mendes, CC; Pavarino-Bertelli, EC; Riccio, MF; Vannucchi, H; Zampieri, BL	1
Bertollo, EM; Biselli, JM; Carvalho, VM; Eberlin, MN; Haddad, R; Marucci, GH; Pavarino, EC; Riccio, MF; Valentin, S; Vannucchi, H; Zampieri, BL	1
Biselli, JM; Carvalho, VM; Eberlin, MN; Fonseca, MF; Goloni-Bertollo, EM; Haddad, R; Pavarino, EC; Vannucchi, H; Zampieri, BL	1
Duncan, TM; Nijhout, HF; Reed, MC	1
Anello, G; Barone, C; Bosco, P; Caraci, F; Guéant, JL; Guéant-Rodriguez, RM; Namour, F; Romano, A; Romano, C	1
Anello, G; Bosco, P; Brunaud, L; Candito, M; Ferri, R; Guéant, JL; Guéant-Rodriguez, RM; Namour, B; Romano, A; Romano, C	1
Baviera, G; Corrado, F; D'Anna, R; Granese, D; Ientile, R; Stella, NC	1
Jill James, S	1
Aoyagi, K; Arisawa, K; Kondoh, T; Mine, M; Ohgi, S; Takamura, N; Yamashita, S	1
Barbé, F; Bléhaut, H; Chango, A; Fillon-Emery, N; Herbeth, B; Lambert, D; Mircher, C; Nicolas, JP; Réthoré, MO; Rosenblatt, DS	1
Bléhaut, H; Chango, A; Fillon-Emery, N; Nicolas, JP; Willequet, F	1
Anello, G; Barone, C; Bosco, P; Gérard, P; Guéant, JL; Guéant-Rodríguez, RM; Romano, A; Romano, C	1
Alvarez Perez, AB; Brunoni, D; D'Almeida, V; da Silva, LR; Galdieri, Lde C; Longhitano, SB; Ribeiro Porto, MP; Vergani, N	1
Bléhaut, H; Chango, A; Fillon-Emery, N; Herbeth, B; James, SJ; Lambert, D; Mircher, C; Nicolas, JP; Réthoré, MO	1
Eskes, TK	1
Bermejo, E; Castro, M; Desviat, LR; Leal, F; Mansilla, E; Martínez-Fernández, ML; Martínez-Frías, ML; Pérez, B; Prieto, D; Rodríguez, L; Rodríguez-Pinilla, E; Ugarte, M	1
Andria, G; Granese, B; Mastroiacovo, P; Pepe, A; Salomè, S; Sammartino, A; Scala, I; Sebastio, G; Sellitto, M	1
Abdennebi-Najar, L; Chango, A; Do, S; Ferré, S; Guéant, JL; Nicolas, JP; Tessier, F; Willequet, F	1
Coppus, AW; Egger, JI; Fekkes, D; Tuinier, S; van Duijn, CM; Verhoeven, WM	1
Astrea, G; Bargagna, S; Bonelli, A; Colognato, R; Coppedè, F; Migliore, L; Siciliano, G	1
Wang, W; Wang, Xy; Xie, W	1
Biselli, JM; Eberlin, MN; Goloni-Bertollo, EM; Haddad, R; Pavarino-Bertelli, EC	1
Biselli, JM; Eberlin, MN; Goloni-Bertollo, EM; Haddad, R; Pavarino-Bertelli, EC; Zampieri, BL	1
Martínez-Frías, ML	1
Buck, SA; Gurney, JG; Matherly, LH; Ravindranath, Y; Stout, ML; Taub, JW	1
Sass, JO; Skladal, D; Viertler, E	1
Rosenblatt, DS	1
Gaylor, DW; Gibson, JB; Hine, RJ; James, SJ; Melnyk, S; Pogribna, M; Pogribny, IP; Swenson, DH; Tafoya, DL; Wilson, VL; Yi, P	1
Trissler, RJ	1
Chango, A; James, SJ; Melnyk, S; Pogribna, M; Pogribny, I; Yi, P	1
Conley, M; Johnson, Z; Kirke, PN; Mills, JL; Molloy, AM; O'Leary, VB; Parle-McDermott, A; Scott, JM	1
Kjellström, T; Nordström, M	1
de Blois, MC; Lejeune, J; Peeters, M; Rethore, MO	1
Christensen, B; Refsum, H; Ueland, PM	1
Brattström, L; Hultberg, B; Israelsson, B; Tengborn, L	1
Brattström, L; Brun, A; Englund, E	1
Allard, D; Ceballos, I; Chadefaux, B; Coude, M; Hamet, M; Kamoun, P; Poissonnier, M	1
Borghi, E; Borowy, F; de Blois, MC; Lejeune, J; Maunoury-Burolla, C; Mir, M; Nicolle, L; Recan, D; Rethoré, MO	1
Allard, D; Ceballos, I; Chadefaux, B; Jérôme, H	1

Reviews

5 review(s) available for homocysteine and Down Syndrome

Article	Year
The MTRR 66A>G polymorphism and maternal risk of birth of a child with Down syndrome in Caucasian women: a case-control study and a meta-analysis. Molecular biology reports, 2014, Volume: 41, Issue:9 Topics: Adult; Aged; Alleles; Biomarkers; Case-Control Studies; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Genotyping Techniques; Heterozygote; Homocysteine; Humans; Logistic Models; Middle Aged; Mothers; Polymorphism, Single Nucleotide; Risk Factors; Vitamin B 12; White People	2014
[Biochemical alterations in patients with Down syndrome]. Orvosi hetilap, 2008, Jun-29, Volume: 149, Issue:26 Topics: Acetylglucosaminidase; Adult; Alzheimer Disease; Antioxidants; Bilirubin; Blood Proteins; Cystathionine beta-Synthase; Disease Progression; Down Syndrome; Ferritins; Folic Acid; Homocysteine; Humans; Learning; Nootropic Agents; Quality of Life; S100 Proteins; Serum Albumin; Superoxide Dismutase; Transferrin; Vitamin B 12	2008
Genetic determinants of folate and vitamin B12 metabolism: a common pathway in neural tube defect and Down syndrome? Clinical chemistry and laboratory medicine, 2003, Volume: 41, Issue:11 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Down Syndrome; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Genetic; Transcobalamins; Vitamin B 12	2003
Abnormal folate metabolism in mothers with Down syndrome offspring: review of the literature. European journal of obstetrics, gynecology, and reproductive biology, 2006, Feb-01, Volume: 124, Issue:2 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; DNA; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Homocysteine; Homocystinuria; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Mutation	2006
The biochemical structure and function of methylenetetrahydrofolate reductase provide the rationale to interpret the epidemiological results on the risk for infants with Down syndrome. American journal of medical genetics. Part A, 2008, Jun-01, Volume: 146A, Issue:11 Topics: Cystathionine beta-Synthase; Down Syndrome; Female; Flavin-Adenine Dinucleotide; Flavins; Folic Acid Deficiency; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Risk Factors; S-Adenosylmethionine; Structure-Activity Relationship	2008

Trials

1 trial(s) available for homocysteine and Down Syndrome

Article	Year
Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial. The Lancet. Neurology, 2016, Volume: 15, Issue:8 Topics: Adaptation, Psychological; Adult; Catechin; Cholesterol; Cognition Disorders; Cognitive Behavioral Therapy; Double-Blind Method; Down Syndrome; Female; Follow-Up Studies; Homocysteine; Humans; Inhibition, Psychological; Male; Neuroprotective Agents; Recognition, Psychology; Retrospective Studies; Spain; Treatment Outcome; Young Adult	2016

Article

Year

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial.

The Lancet. Neurology, 2016, Volume: 15, Issue:8

Topics: Adaptation, Psychological; Adult; Catechin; Cholesterol; Cognition Disorders; Cognitive Behavioral Therapy; Double-Blind Method; Down Syndrome; Female; Follow-Up Studies; Homocysteine; Humans; Inhibition, Psychological; Male; Neuroprotective Agents; Recognition, Psychology; Retrospective Studies; Spain; Treatment Outcome; Young Adult

2016

Other Studies

46 other study(ies) available for homocysteine and Down Syndrome

Article	Year
One-carbon pathway and cognitive skills in children with Down syndrome. Scientific reports, 2021, 02-19, Volume: 11, Issue:1 Topics: Biomarkers; Carbon; Child; Cognition; Down Syndrome; Energy Metabolism; Fasting; Female; Homocysteine; Humans; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2)	2021
Genetic polymorphisms in folate metabolism as risk for Down syndrome in the southern China. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2019, Volume: 32, Issue:12 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Asian People; Case-Control Studies; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Risk Factors; Young Adult	2019
DHFR 19-bp deletion and SHMT C1420T polymorphisms and metabolite concentrations of the folate pathway in individuals with Down syndrome. Genetic testing and molecular biomarkers, 2013, Volume: 17, Issue:4 Topics: Adolescent; Adult; Child; Child, Preschool; Down Syndrome; Female; Folic Acid; Gene Deletion; Gene Frequency; Genotype; Glycine Hydroxymethyltransferase; Homocysteine; Humans; Infant; Male; Methylmalonic Acid; Polymorphism, Genetic; Tetrahydrofolate Dehydrogenase; Young Adult	2013
Role of folate-homocysteine pathway gene polymorphisms and nutritional cofactors in Down syndrome: A triad study. Human reproduction (Oxford, England), 2015, Volume: 30, Issue:8 Topics: Adult; Alleles; Diet; Down Syndrome; Female; Folic Acid; Gene-Environment Interaction; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Status; Polymorphism, Single Nucleotide; Pregnancy; Risk Factors	2015
Effect of the one‑carbon unit cycle on overall DNA methylation in children with Down's syndrome. Molecular medicine reports, 2015, Volume: 12, Issue:6 Topics: Age Factors; Biomarkers; Carbon; Child; Child, Preschool; DNA Methylation; Down Syndrome; Female; Folic Acid; Homocysteine; Humans; Male; Vitamin B 12	2015
Choline metabolic pathway gene polymorphisms and risk for Down syndrome: An association study in a population with folate-homocysteine metabolic impairment. European journal of clinical nutrition, 2017, Volume: 71, Issue:1 Topics: Adult; Betaine-Homocysteine S-Methyltransferase; Case-Control Studies; Child; Choline; Choline Dehydrogenase; Down Syndrome; Female; Folic Acid; Genetic Association Studies; Genotype; Homocysteine; Humans; Metabolic Networks and Pathways; Mothers; Odds Ratio; Phosphatidylethanolamine N-Methyltransferase; Polymorphism, Single Nucleotide; Risk Factors	2017
Prevalence of MTHFR C677T polymorphism in north Indian mothers having babies with Trisomy 21 Down syndrome. Down's syndrome, research and practice : the journal of the Sarah Duffen Centre, 2008, Volume: 12, Issue:2 Topics: Adult; Diet; DNA; Down Syndrome; Female; Folic Acid; Gene Frequency; Homocysteine; Humans; India; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; Vitamins; Young Adult	2008
Double aneuploidy (48,XXY,+21) of maternal origin in a child born to a 13-year-old mother: evaluation of the maternal folate metabolism. Genetic counseling (Geneva, Switzerland), 2009, Volume: 20, Issue:3 Topics: Adolescent; Alleles; Aneuploidy; Brazil; Chromosomes, Human, X; Chromosomes, Human, Y; DNA Mutational Analysis; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Carrier Screening; Genotype; Heart Defects, Congenital; Homocysteine; Homozygote; Humans; Infant; Klinefelter Syndrome; Male; Meiosis; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Nondisjunction, Genetic; Polymorphism, Genetic; Pregnancy; Pregnancy in Adolescence; Sex Chromosome Aberrations; Trisomy	2009
Homocysteine and oxidative stress in Egyptian children with Down syndrome. Clinical biochemistry, 2010, Volume: 43, Issue:12 Topics: Adult; Ascorbic Acid; Child; Child, Preschool; Copper; Down Syndrome; Female; Folic Acid; Homocysteine; Humans; Male; Oxidative Stress; Thiobarbituric Acid Reactive Substances; Tocopherols; Zinc	2010
Maternal homocysteine level and markers used in first-trimester screening for fetal Down syndrome. Reproductive sciences (Thousand Oaks, Calif.), 2010, Volume: 17, Issue:12 Topics: Adult; Biomarkers; Chorionic Gonadotropin, beta Subunit, Human; Down Syndrome; Female; Gestational Age; Homocysteine; Humans; Nuchal Translucency Measurement; Pregnancy; Pregnancy-Associated Plasma Protein-A; Prenatal Diagnosis	2010
19-base pair deletion polymorphism of the dihydrofolate reductase (DHFR) gene: maternal risk of Down syndrome and folate metabolism. Sao Paulo medical journal = Revista paulista de medicina, 2010, Volume: 128, Issue:4 Topics: Adolescent; Chi-Square Distribution; Child; Cross-Sectional Studies; Down Syndrome; Female; Folic Acid; Gene Frequency; Homocysteine; Humans; Methylmalonic Acid; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Factors; Tetrahydrofolate Dehydrogenase	2010
Polymorphism C1420T of Serine hydroxymethyltransferase gene on maternal risk for Down syndrome. Molecular biology reports, 2012, Volume: 39, Issue:3 Topics: DNA Primers; Down Syndrome; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Glycine Hydroxymethyltransferase; Homocysteine; Humans; Inheritance Patterns; Logistic Models; Methylmalonic Acid; Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors	2012
Genetic polymorphisms modulate the folate metabolism of Brazilian individuals with Down syndrome. Molecular biology reports, 2012, Volume: 39, Issue:10 Topics: Adolescent; Adult; Brazil; Child; Child, Preschool; Chromosomes, Human, Pair 21; Down Syndrome; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genotype; Homocysteine; Humans; Infant; Linear Models; Male; Methylmalonic Acid; Polymorphism, Genetic; Sequence Analysis, DNA; Vitamin B 12 Deficiency; Young Adult	2012
The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model. Molecular nutrition & food research, 2013, Volume: 57, Issue:4 Topics: Cystathionine beta-Synthase; Down Syndrome; Folic Acid; Folic Acid Deficiency; Half-Life; Homocysteine; Humans; Methionine; Methylation; Models, Theoretical; Nutrition Surveys; Nutritional Status; Oxidative Stress; S-Adenosylmethionine; Vitamin B 12 Deficiency; Vitamin B Complex; Vitamins	2013
Methionine synthase (MTR) 2756 (A --> G) polymorphism, double heterozygosity methionine synthase 2756 AG/methionine synthase reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having a child with Down syndrome. American journal of medical genetics. Part A, 2003, Sep-01, Volume: 121A, Issue:3 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Alleles; Case-Control Studies; Child; Down Syndrome; Female; Ferredoxin-NADP Reductase; Flavoproteins; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heterozygote; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk Factors; Sicily	2003
Plasma homocysteine in early and late pregnancies complicated with preeclampsia and isolated intrauterine growth restriction. Acta obstetricia et gynecologica Scandinavica, 2004, Volume: 83, Issue:2 Topics: Adult; Case-Control Studies; Cohort Studies; Down Syndrome; Female; Fetal Growth Retardation; Homocysteine; Humans; Hyperhomocysteinemia; Longitudinal Studies; Mass Screening; Pre-Eclampsia; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, Second; Risk Factors	2004
Maternal metabolic phenotype and risk of Down syndrome: beyond genetics. American journal of medical genetics. Part A, 2004, May-15, Volume: 127A, Issue:1 Topics: Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Homocysteine; Humans; Maternal Nutritional Physiological Phenomena; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Risk Factors; Vitamin B 12 Deficiency	2004
Abnormal folic acid-homocysteine metabolism as maternal risk factors for Down syndrome in Japan. European journal of nutrition, 2004, Volume: 43, Issue:5 Topics: Adult; Down Syndrome; Female; Folic Acid; Homocysteine; Humans; Japan; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Risk Factors; Vitamin B 12; Vitamin B 6	2004
Homocysteine concentrations in adults with trisomy 21: effect of B vitamins and genetic polymorphisms. The American journal of clinical nutrition, 2004, Volume: 80, Issue:6 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Administration, Oral; Adolescent; Adult; Case-Control Studies; Cystathionine beta-Synthase; Dietary Supplements; Down Syndrome; Drug Synergism; Female; Ferredoxin-NADP Reductase; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Male; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Reduced Folate Carrier Protein; Vitamin B 12; Vitamin B 6	2004
The single nucleotide polymorphism (80G-->A) of reduced folate carrier gene in trisomy 21. The American journal of clinical nutrition, 2004, Volume: 80, Issue:6 Topics: Adolescent; Adult; Down Syndrome; Female; Heterozygote; Homocysteine; Homozygote; Humans; Male; Membrane Transport Proteins; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein	2004
Homocysteine and related genetic polymorphisms in Down's syndrome IQ. Journal of neurology, neurosurgery, and psychiatry, 2005, Volume: 76, Issue:5 Topics: Alleles; Alzheimer Disease; Apolipoproteins E; Diagnostic and Statistical Manual of Mental Disorders; Down Syndrome; Folic Acid; Homocysteine; Humans; Intelligence; Karyotyping; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Transcobalamins; Vitamin B 12	2005
Relationship between polymorphisms in genes involved in homocysteine metabolism and maternal risk for Down syndrome in Brazil. American journal of medical genetics. Part A, 2005, Jun-15, Volume: 135, Issue:3 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Alleles; Case-Control Studies; Cystathionine beta-Synthase; Down Syndrome; Enzymes; Family Health; Female; Ferredoxin-NADP Reductase; Gene Frequency; Genotype; Homocysteine; Humans; Linkage Disequilibrium; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Polymorphism, Genetic; Risk Factors	2005
No association between common polymorphisms in genes of folate and homocysteine metabolism and the risk of Down's syndrome among French mothers. The British journal of nutrition, 2005, Volume: 94, Issue:2 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; France; Genotype; Homocysteine; Humans; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Polymorphism, Genetic; Reduced Folate Carrier Protein; Risk Factors	2005
Maternal polymorphisms 677C-T and 1298A-C of MTHFR, and 66A-G MTRR genes: is there any relationship between polymorphisms of the folate pathway, maternal homocysteine levels, and the risk for having a child with Down syndrome? American journal of medical genetics. Part A, 2006, May-01, Volume: 140, Issue:9 Topics: Case-Control Studies; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Genotype; Homocysteine; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Mutation; Polymorphism, Single Nucleotide; Regression Analysis; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine	2006
Analysis of seven maternal polymorphisms of genes involved in homocysteine/folate metabolism and risk of Down syndrome offspring. Genetics in medicine : official journal of the American College of Medical Genetics, 2006, Volume: 8, Issue:7 Topics: Adult; Case-Control Studies; Chromosome Aberrations; Down Syndrome; Female; Folic Acid; Gene Frequency; Genotype; Haplotypes; Homocysteine; Humans; Maternal Age; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Models, Biological; Polymorphism, Genetic; Risk Factors	2006
Quantitative methylation-sensitive arbitrarily primed PCR method to determine differential genomic DNA methylation in Down Syndrome. Biochemical and biophysical research communications, 2006, Oct-20, Volume: 349, Issue:2 Topics: Adolescent; Adult; Case-Control Studies; DNA Fragmentation; DNA Methylation; Down Syndrome; Female; Genetic Techniques; Homocysteine; Humans; Male; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction	2006
Plasma amino acids and neopterin in healthy persons with Down's syndrome. Journal of neural transmission (Vienna, Austria : 1996), 2007, Volume: 114, Issue:8 Topics: Aged; Amino Acid Metabolism, Inborn Errors; Amino Acids; Biomarkers; Comorbidity; Dopamine; Down Syndrome; Female; Homocysteine; Homovanillic Acid; Humans; Immune System Diseases; Immunity, Cellular; Male; Methionine; Middle Aged; Neopterin; Taurine; Up-Regulation	2007
Polymorphisms in folate and homocysteine metabolizing genes and chromosome damage in mothers of Down syndrome children. American journal of medical genetics. Part A, 2007, Sep-01, Volume: 143A, Issue:17 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Down Syndrome; Female; Folic Acid; Homocysteine; Humans; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Micronuclei, Chromosome-Defective; Middle Aged; Mothers; Polymorphism, Genetic	2007
[The relationship between polymorphism of gene involved in folate metabolism, homocysteine level and risk of Down syndrome]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 2007, Volume: 24, Issue:5 Topics: Adult; Alleles; Base Sequence; Case-Control Studies; Down Syndrome; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Polymorphism, Genetic; Pregnancy	2007
The MTR A2756G polymorphism is associated with an increase of plasma homocysteine concentration in Brazilian individuals with Down syndrome. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2008, Volume: 41, Issue:1 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Analysis of Variance; Brazil; Chi-Square Distribution; Child; Child, Preschool; Down Syndrome; Female; Gene Frequency; Heterozygote; Homocysteine; Humans; Infant; Male; Mass Spectrometry; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic	2008
Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil. Genetics and molecular research : GMR, 2008, Jan-22, Volume: 7, Issue:1 Topics: Adolescent; Adult; Alleles; Brazil; Case-Control Studies; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Haplotypes; Homocysteine; Humans; Logistic Models; Maternal Age; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mothers; Polymorphism, Genetic; Reduced Folate Carrier Protein; Risk Factors; Statistics as Topic	2008
Enhanced metabolism of 1-beta-D-arabinofuranosylcytosine in Down syndrome cells: a contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia. Blood, 1996, Apr-15, Volume: 87, Issue:8 Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cell Line, Transformed; Cells, Cultured; Child; Child, Preschool; Chromosomes, Human, Pair 21; Cystathionine beta-Synthase; Cytarabine; Deoxycytosine Nucleotides; Disease-Free Survival; Down Syndrome; Female; Herpesvirus 4, Human; Homocysteine; Humans; Infant; Infant, Newborn; Leukemia, Megakaryoblastic, Acute; Leukemia, Myeloid; Male; Methotrexate; Myelodysplastic Syndromes; Neoplastic Stem Cells; Remission, Spontaneous; Survival Rate	1996
Methionine loading in a Down's syndrome patient with cerebral infarction. Annals of clinical biochemistry, 1999, Volume: 36 ( Pt 2) Topics: Adult; Cerebral Infarction; Down Syndrome; Homocysteine; Humans; Male; Methionine; Thiobarbituric Acid Reactive Substances	1999
Folate and homocysteine metabolism and gene polymorphisms in the etiology of Down syndrome. The American journal of clinical nutrition, 1999, Volume: 70, Issue:4 Topics: Down Syndrome; Female; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Nutritional Physiological Phenomena; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pregnancy	1999
Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome. The American journal of clinical nutrition, 1999, Volume: 70, Issue:4 Topics: Adult; Alcohol Drinking; Case-Control Studies; Chromatography, High Pressure Liquid; Deoxyribonucleases, Type II Site-Specific; Diet Surveys; Diet, Reducing; Dietary Supplements; DNA; Down Syndrome; Electrophoresis, Agar Gel; Female; Folic Acid; Genotype; Homocysteine; Humans; Methionine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymerase Chain Reaction; Risk Factors; Surveys and Questionnaires	1999
Folic acid and Down syndrome. Journal of the American Dietetic Association, 2000, Volume: 100, Issue:2 Topics: Dietary Supplements; Down Syndrome; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors	2000
Homocysteine metabolism in children with Down syndrome: in vitro modulation. American journal of human genetics, 2001, Volume: 69, Issue:1 Topics: Adenosine; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Cystathionine; Cystathionine beta-Synthase; Cysteine; DNA Methylation; Down Syndrome; Glutathione; Homocysteine; Humans; Leucovorin; Lymphocytes; Methionine; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine; Sarcosine; Superoxide Dismutase; Thymidine; Vitamin B 12	2001
MTRR and MTHFR polymorphism: link to Down syndrome? American journal of medical genetics, 2002, Jan-15, Volume: 107, Issue:2 Topics: Alleles; Case-Control Studies; Child; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Vitamin B 12	2002
Age dependency of cystathionine beta-synthase activity in human fibroblasts in homocyst(e)inemia and atherosclerotic vascular disease. Atherosclerosis, 1992, Volume: 94, Issue:2-3 Topics: Adult; Aged; Aging; Arteriosclerosis; Cells, Cultured; Cystathionine beta-Synthase; Down Syndrome; Female; Fibroblasts; Homocysteine; Homocystinuria; Humans; Male; Middle Aged; Skin	1992
Homocysteine and the methotrexate toxicity in trisomy 21. Cancer chemotherapy and pharmacology, 1991, Volume: 27, Issue:4 Topics: Adenosine; Down Syndrome; Homocysteine; Humans; Lymphocytes; Methotrexate	1991
Methotrexate sensitivity in Down's syndrome: a hypothesis. Cancer chemotherapy and pharmacology, 1990, Volume: 25, Issue:5 Topics: Down Syndrome; Drug Tolerance; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma	1990
Homocysteine, factor VII and antithrombin III in subjects with different gene dosage for cystathionine beta-synthase. Journal of inherited metabolic disease, 1989, Volume: 12, Issue:4 Topics: Antithrombin III; Cystathionine beta-Synthase; Dosage Compensation, Genetic; Down Syndrome; Factor VII; Female; Homocysteine; Homozygote; Humans; Hydro-Lyases; Male; Methionine	1989
Does Down syndrome support homocysteine theory of arteriosclerosis? Lancet (London, England), 1987, Feb-14, Volume: 1, Issue:8529 Topics: Adult; Aged; Arteriosclerosis; Cystathionine beta-Synthase; Down Syndrome; Homocysteine; Humans; Hydro-Lyases; Middle Aged	1987
Is absence of atheroma in Down syndrome due to decreased homocysteine levels? Lancet (London, England), 1988, Sep-24, Volume: 2, Issue:8613 Topics: Arteriosclerosis; Child; Down Syndrome; Homocysteine; Humans	1988
[Metabolism of monocarbons and trisomy 21: sensitivity to methotrexate]. Annales de genetique, 1986, Volume: 29, Issue:1 Topics: Cells, Cultured; Dose-Response Relationship, Drug; Down Syndrome; Homocysteine; Humans; Lymphocytes; Methionine; Methotrexate; Mitotic Index; Purines	1986
[Effects of gene localization and its metabolic significance in trisomy 21]. Bulletin de l'Academie nationale de medecine, 1985, Volume: 169, Issue:9 Topics: Chromosome Mapping; Chromosomes, Human, 21-22 and Y; Cystathionine; Cystathionine beta-Synthase; Down Syndrome; Fibroblasts; Homocysteine; Homocystinuria; Humans; Methionine	1985