homocysteine has been researched along with Disease Models, Animal in 313 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (1.60) | 18.7374 |
| 1990's | 11 (3.51) | 18.2507 |
| 2000's | 119 (38.02) | 29.6817 |
| 2010's | 153 (48.88) | 24.3611 |
| 2020's | 25 (7.99) | 2.80 |
| Authors | Studies |
|---|---|
| Al-Shabrawey, M; DeAngelis, MM; Kim, IK; Kira, D; Mohamed, R; Owen, LA; Rajpurohit, P; Samra, YA; Shakoor, A; Sheibani, N; Tawfik, A | 1 |
| Cao, J; Geng, HR; Lin, Y; Liu, L; Qiao, YN; Qu, YY; Xu, W; Zhang, X; Zhao, JY | 1 |
| Ding, N; Dong, X; Gu, L; Jiang, Y; Liu, D; Wang, Y; Xu, L; Yang, A; Zhang, H | 1 |
| De la Cruz-López, F; De la Torre-Iturbe, S; Flores, G; Garcés-Ramírez, L; Vázquez-Roque, RA | 1 |
| Akahoshi, N; Ishii, I; Ito, S; Kamata, S; Kamichatani, W; Koizumi, M; Miura, A; Nagata, T; Ohtani, H; Shimonaga, A; Tosaka, Y; Tsushima, M | 1 |
| Igarashi, A; Inoue, S; Kimura, T; Machida, H; Minegishi, Y; Murano, H; Nakano, H; Nemoto, T; Nishiwaki, M; Otaki, Y; Sato, K; Sato, M; Shibata, Y; Tokairin, Y; Watanabe, M; Yamauchi, K; Yang, S | 1 |
| Cui, K; Liu, J; Ruan, Y; Song, J; Tang, Z; Wang, S; Wang, T; Yang, J; Yu, Z | 1 |
| George, AK; Hardin, SJ; Homme, RP; Pushpakumar, S; Singh, M; Tyagi, SC | 1 |
| Corrales, F; Franco, L; Guerrero, L; López-Rodas, G; Martí-Andrés, P; Paradela, A; Pérez, S; Rius-Pérez, S; Sastre, J; Taléns-Visconti, R; Torres, L; Torres-Cuevas, I | 1 |
| Chai, SB; Chen, Y; Hou, YL; Liu, X; Ni, XQ; Ning, ZP; Qi, YF; Ren, JL; Tang, CS; Wu, N; Xue, CD; Yu, YR; Zhang, LS; Zhu, Q | 1 |
| Cong, Y; Liu, H; Zhou, Y | 1 |
| An, DD; Liu, R; Lu, YM; Ohlmeyer, M; Shu, XJ; Wan, L; Wang, JZ; Wang, XC; Wei, H; Westermarck, J; Xie, JZ; Zeng, Y; Zhang, HL | 1 |
| George, AK; Singh, M; Smolenkova, I; Stanisic, D; Tyagi, SC | 1 |
| Castro-Martínez, F; Flores-Flores, M; Moreno-García, L; Nahmad, M | 1 |
| Joshi, S; Kapur, J; Singh, T; Williamson, JM | 1 |
| López, V; Moraga, FA; Uribe, E | 1 |
| Al-Shabrawey, M; Alhusban, S; Kira, D; Mohamed, R; Tawfik, A | 1 |
| Jiang, H; Maclean, KN; Mclagan, BM; Phinney, WN; Roede, JR; Stabler, SP | 1 |
| Cai, J; Chen, Z; Cui, C; Fan, X; Geng, B; Gong, Y; Jiang, S; Xu, W | 1 |
| Balint, B; Blaise, S; Camadro, JM; Guéant, JL; Guéant-Rodriguez, RM; Hergalant, S; Lignières, L; Vanalderwiert, L | 1 |
| Chen, Z; Feng, Y; Liu, F; Tian, Y; Xiong, Y; Xue, W; Yin, S; Yu, D | 1 |
| Adsi, H; Bera, S; Do, TD; Frenkel, D; Gartner, M; Gazit, E; Kreiser, T; Laor Bar-Yosef, D; Levy, D; Oluwatoba, DS; Sade Yazdi, D; Shaham-Niv, S; Sigal, S; Zaguri, D | 1 |
| Chen, Y; Dong, H; Li, Y; Wang, S; Wang, X; Wu, J; Xu, Y; Zhang, B | 1 |
| Barrero, C; Li, JG; Merali, S; Praticò, D | 1 |
| Bublil, EM; Carrillo, RS; Kraus, JP; Majtan, T; Park, I | 1 |
| Azimzadeh, K; Nasrollahi Nargesabad, R; Vousooghi, N | 1 |
| Cui, S; Gao, Y; Huang, G; Li, W; Lv, X; Wang, P | 1 |
| Kruger, WD | 1 |
| Cai, Z; Fu, Y; Kong, W; Liu, Z; Wang, X; Wang, Y; Yu, B; Yu, F; Zhang, L; Zhou, J | 1 |
| Ci, H; Ge, X; Song, W; Tian, G; Zhang, Y | 1 |
| Azad, MAK; Huang, P; Liu, G; Ren, W; Teklebrh, T; Yan, W; Yin, Y; Zhou, X | 1 |
| Dong, Y; Liu, H; Luo, C; Sun, Q; Wang, H; Wang, W; Wu, Y; Xu, J; Zhang, H; Zhou, Y | 1 |
| de S Moreira, D; Figueiró, PW; Guma, FCR; Manfredini, V; Prezzi, CA; Rohden, F; Siebert, C; Wyse, ATS | 1 |
| Hamano, T; Hayashi, K; Ikawa, M; Kanaan, NM; Kuriyama, M; Nakamoto, Y; Shirafuji, N; Yamamura, O; Yen, SH; Yoshida, H | 1 |
| Bao, J; Chen, D; Huang, F; Ke, D; Liu, R; Mahaman, YAR; Salissou, MTM; Wang, JZ; Wang, Q; Wang, X; Wang, Y; Wei, Z; Wu, M; Zhang, B | 1 |
| Barrero, C; Di Meco, A; Li, JG; Merali, S; Praticò, D | 1 |
| Fang, YY; Huo, JN; Li, D; Liu, HX; Ma, XX; Wang, TR; Wang, XX; Wu, QJ; Zhou, YM | 1 |
| Arning, E; Bottiglieri, T; Hoffman, A; Qian, H; Sontag, E; Sontag, JM; Taleski, G; Wasek, B | 1 |
| Chen, M; Gao, X; Li, J | 1 |
| Chopra, K; Dharavath, RN; Sachdeva, AK | 1 |
| Emmerson, JT; Jadavji, NM; MacFarlane, AJ; Shanmugalingam, U; Smith, PD; Willmore, WG | 1 |
| Bao, Z; Cheng, Y; Li, X; Wang, Z; Zhang, B; Zhang, Y; Zhong, X | 1 |
| Barančík, M; Berenyiová, A; Dovinová, I; Hrabárová, E; Jansen, E; Kvandová, M; Majzúnová, M | 1 |
| Alexandrin, VV; Bulgakova, PO; Ivanov, AV; Kubatiev, AA; Nikiforova, KA; Paltsyn, AA; Sviridkina, NB; Virus, ED | 1 |
| Guo, J; Li, Q; Ni, S; Wang, JZ; Yang, Y | 1 |
| Kan, P; Wang, J; Xiang, L; Xu, N; Yang, P; Yao, X; Zhu, Y | 1 |
| Ke, CY; Lee, YJ; Lin, PK; Tien, N | 1 |
| Forgacsova, A; Galba, J; Kovac, A; Mikus, P; Mojzisova, J; Piestansky, J | 1 |
| Caccamo, A; Dave, N; Ferreira, E; Huentelman, MJ; Naymik, M; Oddo, S; Piras, IS; Tran, A; Velazquez, R; Winslow, W | 1 |
| Aiello, P; Bello, C; Canali, R; Carminati, D; Comitato, R; Devirgiliis, C; Guantario, B; Meucci, A; Motta, V; Natella, F; Perozzi, G; Roselli, M; Tidona, F; Trevisi, P; Virgili, F; Zinno, P | 1 |
| Chen, AF; Chen, R; Leng, Y; Ma, Y; Shi, R; Zeng, P; Zhang, Z | 1 |
| Baranovicova, E; Kalenska, D; Lehotsky, J; Tomascova, A | 1 |
| Bossenmeyer-Pourié, C; Daval, JL; Geoffroy, A; Guéant, JL; Helle, D; Pourié, G; Saber-Cherif, L; Umoret, R | 1 |
| Chen, X; Chen, Z; Cui, C; Huang, F; Jiang, X; Niu, J; Sun, J | 1 |
| Drobny, A; Fitzenberger, E; Hellmann, B; Meloh, H; Mueller, AS; van der Klis, JD; Wächtershäuser, E; Wenzel, U | 1 |
| Allan, AM; Brigman, J; Jacobsen, DW; Jindal, A; Miller, JW; Paul, S; Poddar, R; Rajagopal, S; Winter, L | 1 |
| Joshi, SR; Nandi, AA; Wadhwani, NS | 1 |
| Cheng, M; Liang, X; Liu, H; Sai, N; Wang, M; Wang, X; Yang, L; Zhang, X | 1 |
| Burkhanova, GF; Cmarko, L; Gaifullina, AS; Gerasimova, EV; Huang, J; Lazniewska, J; Rivas-Ramirez, P; Rzhepetskyy, Y; Sitdikova, GF; Tomin, A; Weiss, N; Zamponi, GW | 1 |
| Gao, W; Guo, C; Meng, B; Pu, L; Wei, J; Wu, J; Yang, J | 1 |
| Bjekić-Macut, J; Djuric, D; Hrncić, D; Rasić-Marković, A; Stanojlović, O; Susić, V | 1 |
| Meyer, BJ; Milte, CM; Parletta, N | 1 |
| Linask, KK | 1 |
| Albright, KA; Neuman, JC; Schalinske, KL | 1 |
| Blanco-Vaca, F; Escolà-Gil, JC; Jauhiainen, M; Julve, J; Martín-Campos, JM; Osada, J; Quesada, H; Rentería-Obregón, IM; Rodríguez-Millán, E; Sánchez-Quesada, JL | 1 |
| Antl, N; Bulmer, AC; Doberer, D; Ferk, F; Knasmüller, S; Marculescu, R; Mölzer, C; Müllner, E; Najafi, K; Poulsen, HE; Rittmannsberger, B; Schreidl, S; Vitek, L; Wagner, KH; Wallner, M | 1 |
| Obeid, R | 1 |
| Jerome-Majewska, LA; Moreno-Garcia, MA; Rosenblatt, DS | 1 |
| Gray, C; Li, M; Reynolds, CM; Sloboda, DM; Vickers, MH | 1 |
| Colovic, M; Djuric, D; Hrncic, D; Krstic, D; Lekovic, J; Macut, D; Rasic-Markovic, A; Stanojlovic, O; Susic, V | 1 |
| Scherer, E; Schweinberger, BM; Schwieder, L; Sitta, A; Vargas, CR; Wyse, AT | 1 |
| Bisson, JF; Cassel, JC; Jacquelin, C; Javelot, H; Lalonde, R; Lazarus, C; Messaoudi, M; Nejdi, A; Rozan, P; Strazielle, C | 1 |
| Jakubowski, H; Luczak, M; Marczak, L; Suszyńska-Zajczyk, J | 1 |
| Ishii, I | 1 |
| Blom, HJ; Castro, R; Davids, M; Esse, R; Florindo, C; Gupta, S; Imbard, A; Kruger, WD; Quinlivan, EP; Tavares de Almeida, I; Teerlink, T | 1 |
| Barrero, C; Chu, J; Li, JG; Merali, S; Praticò, D | 1 |
| Bahous, RH; Bedell, BJ; Caudill, MA; Deng, L; Grand'maison, M; Jadavji, NM; Malysheva, O; Rozen, R | 1 |
| Azhdari-Zarmehri, H; Dargahi, T; Faraj, A; Fraidouni, N; Haghdoost-Yazdi, H; Sarookhani, M; Yaghoubidoust, MH | 1 |
| Chen, R; Hu, J; Liu, R; Liu, X; Tian, Q; Wang, JZ; Wang, P; Wang, Q; Wang, XC; Xia, Y; Zeng, K | 1 |
| Li, JG; Praticò, D | 1 |
| Cardoso, JF; Cohen, C; Garcia, SB; Vannucchi, H | 1 |
| Qian, L; Zhao, Y | 1 |
| Arning, E; Blokhin, IO; Bottiglieri, T; Dayal, S; Erger, RA; Faraci, FM; Jensen, M; Lentz, SR; Stevens, JW | 1 |
| Cheng, J; Han, DW; Jia, JT; Lai, LN; Li, XJ; Lv, ML; Tian, XX; Zhang, HY; Zhang, LL; Zhao, ZF | 1 |
| Chengfeng, S; Lei, W; Lingjia, Q; Rui, Z; Wei, L; Xinxing, W | 1 |
| Rabinovitz, S; Yehuda, S | 1 |
| Cao, LY; Ding, H; Fan, WJ; Gan, HZ; Mei, Q; Xu, JM | 1 |
| Cui, W; Liu, J; Sun, X; Xie, X; Zhang, D; Zhu, Y | 1 |
| Ferrari, LF; Green, PG; Joseph, EK; Levine, JD | 1 |
| Hu, Z; Jiang, X; Liang, H; Liu, Q; Liu, Y; Shen, Q | 1 |
| Aliani, M; House, JD; Mayengbam, S; Raposo, S | 1 |
| Tyagi, SC; Veeranki, S | 1 |
| Fathe, K; Finnell, RH; Person, MD | 1 |
| Boehm-Sturm, P; Dirnagl, U; Farr, TD; Foddis, M; Füchtemeier, M; Harms, C; Jadavji, NM; Khalil, AA; Lips, J | 1 |
| Cavallaro, RA; Desiderio, C; Di Napoli, A; Fuso, A; Gervasoni, J; Giardina, B; Nicolia, V; Persichilli, S; Scarpa, S | 1 |
| da Costa, KA; Fiorucci, S; Goedken, MJ; Guo, G; Jaeschke, H; Kong, B; Lebofsky, M; Lee, S; Orena, SJ; Renga, B; Rudraiah, S; Smalling, R; Tsuchiya, H; Wang, L; Yang, Z; Zeisel, SH; Zhang, Y | 1 |
| Bora, HK; Kalita, J; Misra, UK; Murthy, RC; Singh, SK | 1 |
| Bamba, M; Hirota, T; Miyajima, A; Muto, T | 1 |
| Luft, FC | 1 |
| Caudill, MA; Deng, L; Jadavji, NM; Malysheva, O; Rozen, R | 1 |
| Colovic, M; Djuric, D; Hrncic, D; Krstic, D; Macut, Dj; Rankov-Petrovic, B; Rasic-Markovic, A; Stanojlovic, O | 1 |
| Benoist, JF; Blom, HJ; de Baulny, HO; de Vriese, AS; Esse, R; Gupta, S; Imbard, A; Kruger, W; Lebon, S; Schiff, M | 1 |
| Selhub, J; Troen, AM | 1 |
| Hainsworth, AH; Weekman, EM; Wilcock, DM; Yeo, NE | 1 |
| Cheng, WW; He, BW; Xu, X; Yang, WJ; Yang, XY | 1 |
| Adamkov, M; Kovalska, L; Kovalska, M; Lehotsky, J; Mahmood, S; Tothova, B | 1 |
| Cabrera, RM; Denny, KJ; Finnell, RH; Jeanes, A; Kelly, CF; Kumar, V; Taylor, SM; Witham, KL; Woodruff, TM | 1 |
| Gao, T; Gong, J; Li, J; Ma, J; Mu, J; Ren, H; Wang, J; Xie, J; Yuan, B; Zheng, S; Zhu, P | 1 |
| Cao, J; Guo, X; He, Y; Jiang, Y; Kong, F; Liu, Z; Ma, S; Tian, J; Wang, Y; Xu, H; Yang, A; Yang, X; Zhang, H; Zhang, M | 1 |
| Croxford, R; Grin, A; Ishiguro, L; Kim, YI; Sohn, KJ; Streutker, CJ; Yang, M | 1 |
| Fang, L; He, C; Li, H; Li, X; Liu, N; Sun, X; Wang, J; Yang, Z | 1 |
| Andreau, K; Blanc, E; Bokobza, C; Daubigney, F; Delabar, JM; Janel, N; Legrand, B; Mortreux, M; Paul, JL; Renon, M; Rouach, H | 1 |
| Bhattacharjee, N; Borah, A; Choudhury, A; Choudhury, S; Mazumder, MK; Paul, R | 1 |
| Andrews, AJ; Gupta, S; Kruger, WD; Kuo, YM; Lee, HO; Li, YS; Slifker, MJ; Wang, L | 1 |
| Chen, Y; Hong, Y; Wang, W; Xiao, Z; Yu, L | 1 |
| Hasegawa, T; Ukai, W | 1 |
| Bhattacharjee, N; Borah, A | 1 |
| Fu, Y; Liang, K; Su, Z; Sun, Y; Tang, W; Wang, X; Wang, Z; Wei, X; Yi, F; Zhang, Y; Zhou, M | 1 |
| Gu, HF; Li, M; Li, MH; Li, X; Tang, XQ; Wei, HJ; Zhang, P; Zou, W | 1 |
| Boehm-Sturm, P; Caudill, MA; Dam, K; Dirnagl, U; Farr, TD; Foddis, M; Füchtemeier, M; Jadavji, NM; Malysheva, O | 1 |
| Balan, B; Beri, D; Chaubey, S; Subramaniam, S; Surendra, B; Tatu, U | 1 |
| Atucha, NM; García-Estañ, J; Iyú, D; Navarro, EG; Ortiz, MC; Romecín, P; Rosado, JA | 1 |
| Abais-Battad, JM; Boini, KM; Conley, SM; Li, PL; Yuan, X; Zhang, Q | 1 |
| Bigler, L; Bleul, C; Blom, H; Frisch, C; Linnebank, M; Prost, JC; Semmler, A; Smith, D | 1 |
| Karasu, E; Sadan, G; Tasatargil, A | 1 |
| Kumar, M; Lominadze, D; Moshal, KS; Pushpakumar, SB; Sen, U; Tyagi, N; Tyagi, SC; Vacek, T | 1 |
| Dayal, S; Lentz, SR | 2 |
| Arning, E; Bottiglieri, T; Cooke, JP; Dayal, S; Faraci, FM; Kimoto, M; Lentz, SR; Murry, DJ; Rodionov, RN | 1 |
| Delabar, JM; Hamelet, J; Janel, N; Matulewicz, E; Noll, C; Paul, JL | 1 |
| Chen, J; Hughes, WM; Kang, YJ; Moshal, KS; Rodriguez, WE; Rosenberger, D; Sen, U; Tyagi, N; Tyagi, SC; Vacek, T | 1 |
| Carrasco, M; Castro, C; Estrada, C; López-Toledano, MA; Murillo-Carretero, M; Rabaneda, LG; Ruiz, FA | 1 |
| Blom, H; Linnebank, M; Moskau, S; Semmler, A; Smith, D; Smulders, Y; Struys, E | 1 |
| Li, N; Li, PL; Tang, L; Xia, M; Yi, F; Zhang, C | 1 |
| Garcia, P; Herrmann, M; Herrmann, W; Hübner, U; Ross, S; Schorr, H; Taban-Shomal, O; Umanskaya, N; Wagner, A; Wildemann, B; Wolny, M | 1 |
| Levasseur, R | 1 |
| Dun, Y; Duplantier, J; Farley, MJ; Ganapathy, PS; Liu, K; Moister, B; Moister, TK; Mysona, BA; Prasad, PD; Roon, P; Smith, SB | 1 |
| Carru, C; Hare, DL; Jin, X; Lau, E; Learmont, J; Schwartz, GD; Sutarga, K; Wijaya, BP; Wookey, PJ; Zinellu, A; Zulli, A | 1 |
| Hwang, SY; O, K; Prathapasinghe, G; Siow, YL; Wu, N; Xu, Z | 1 |
| Abe, OA; Basu, P; Givvimani, S; Metreveli, N; Passmore, JC; Sen, U; Shah, KS; Tyagi, N; Tyagi, SC | 1 |
| Brosnan, JT; Francis, GA; Jacobs, RL; Kennedy, B; Su, B; Vance, DE; Vance, JE; Waddington, E; Zhao, Y | 1 |
| O, K; Siow, YL; Wu, N | 1 |
| Huang, X; Jia, Z; Li, L; Wu, Y; Zheng, Q | 1 |
| Elias, MS; Green, RM; Henkel, AS | 1 |
| Stover, PJ | 1 |
| Folbergrová, J; Haugvicová, R; Houstek, J; Jesina, P; Lisý, V | 1 |
| Gould, TJ; Kruger, WD; Portugal, GS; Pratico, D; Wang, H; Zhuo, JM | 1 |
| Guo, H; Liu, L; Shi, Y; Sun, A; Xu, F | 1 |
| Agnati, LF; Andreoli, N; Baldelli, E; Biagini, G; Fuxe, K; Leo, G | 1 |
| Alonso-Aperte, E; Partearroyo, T; Ubeda, N; Varela-Moreiras, G | 1 |
| Al-Melhim, WN; Al-Sultan, AI; Fouad, AA; Qureshi, HA; Yacoubi, MT | 1 |
| Gargoum, R; Maldonado, C; Metreveli, N; Rosenberger, D; Sen, U; Tyagi, N; Tyagi, S | 1 |
| Cole, PD; Gulinello, M; Li, Y; Vijayanathan, V | 1 |
| Chen, S; Le, W; Li, L; Wang, Q; Zhang, X | 2 |
| Kaur, T; Pal Singh, A; Singh Bedi, PM; Singh, N; SinghDahiya, R | 1 |
| Chi, J; Guo, H; Huang, D; Liu, L; Shi, Y; Sun, A; Xu, F | 1 |
| da Cunha, AA; Ferreira, AG; Wyse, AT | 1 |
| Miguel, TL; Pobbe, RL; Spiacci Junior, A; Zangrossi Junior, H | 1 |
| Arnal, C; Barranquero, C; Bregante, MA; García-Gimeno, MA; Gascón, S; Godino, J; Guillén, N; Guzmán, MA; Hernandez, E; Lou-Bonafonte, JM; Navarro, MA; Nuño-Ayala, M; Osada, J; Royo-Cañas, M; Sarría, AJ | 1 |
| Ataee, R; Ataie, A; Haghparast, A; Moghaddam, AH; Moghaddam, SN; Sabetkasaei, M | 1 |
| Basu, S; Chakrabarti, S; Pal, K; Saha, A; Sinha, M | 1 |
| Li, L; Li, Q; Sun, J; Tan, HM; Wu, WK; Yan, TT; Zhang, Q; Zhang, XH | 1 |
| Beard, RS; Bearden, SE | 1 |
| Falcone, JC; Givvimani, S; Munjal, C; Qipshidze, N; Tyagi, N; Tyagi, SC | 1 |
| da Cunha, AA; da Cunha, MJ; Kolling, J; Scherer, EB; Wyse, AT | 1 |
| Agam, G; Belmaker, R; Bromberg, A; Levine, J | 1 |
| O, K; Sarna, LK; Siow, YL; Wu, N | 1 |
| Ahmed, HH | 1 |
| Akahoshi, N; Hishiki, T; Ikeda, K; Ishii, I; Kubo, A; Matsuura, T; Miura, N; Nagahata, Y; Suematsu, M; Taguchi, R; Yamada, H | 1 |
| Fleming, JT; Tyagi, N; Tyagi, SC; Vacek, JC; Vacek, TP | 1 |
| Bailbe, D; Coulaud, J; Ehses, J; Homo-Delarche, F; Janel, N; Lacraz, G; Noll, C; Paul, JL; Portha, B | 1 |
| Deng, Y; Duan, Y; Guo, J; Kuang, D; Wan, J; Wang, G; Xiao, G; Zhu, Y | 1 |
| Bozard, BR; Ganapathy, PS; Ha, Y; Perry, E; Perry, RL; Roon, P; Smith, RM; Smith, SB; Tawfik, A | 1 |
| da Cunha, AA; da Cunha, MJ; Delwing, D; Kolling, J; Lima, DD; Scherer, EB; Schmitz, F; Sitta, A; Vargas, CR; Wyse, AT | 1 |
| Ali, N; Cole, PD; Gulinello, M; Vijayanathan, V | 1 |
| Atilla, P; Bitik, O; Çalş, M; Ersoy, US; Kamburoğlu, HO; Öcal, E; Pnar, A; Şafak, T; Sönmez, E; Uzun, H | 1 |
| Chen, Z; Guo, ZY; Hu, J; Liu, D; Tan, L; Wang, JZ; Wang, Q; Zhao, N; Zhou, P; Zhu, LQ | 1 |
| Druga, R; Folbergrová, J; Otáhal, J | 1 |
| Ge, J; Li, J; Wang, J; Xue, D; Yang, LN | 1 |
| Allen, RH; Greiner, LS; Jiang, H; Maclean, KN; Stabler, SP | 1 |
| Ganapathy, P; Peachey, NS; Smith, SB; Sturgill-Short, G; Tawfik, A; Yu, M | 1 |
| Cui, L; Handy, DE; Jiang, B; Joseph, J; Liao, R; Loscalzo, J; Pimental, D; Wang, X | 1 |
| Abrams, JA; Fox, JG; Gamble, MV; Gonda, TA; Kim, YI; Muthupalani, S; Salas, MC; Shibata, W; Sohn, KJ; Tycko, B; Wang, TC | 1 |
| Brown, AT; Deng, H; Luo, S; Moursi, MM; Nyalala, JO | 1 |
| Allen, RH; Beaudin, AE; Perry, CA; Stabler, SP; Stover, PJ | 1 |
| Ataie, A; Mansouri, Z; Masoudnia, F; Moradi, F; Sabetkasaei, M | 1 |
| Humpel, C; Pirchl, M; Sperner-Unterweger, B; Ullrich, C | 1 |
| Assis, PA; Baggio, MS; Bassi, SC; Benício, MT; Falcão, RP; Figueiredo-Pontes, LL; Garcia, AB; Jácomo, RH; Lange, AP; Lima, AS; Oliveira, LO; Rego, EM; Santana-Lemos, BA | 1 |
| da Cunha, AA; da Cunha, MJ; Ferreira, AG; Grudzinski, PB; Hoppe, JB; Horn, AP; Loureiro, SO; Salbego, CG; Schmitz, F; Wyse, AT | 1 |
| Faraji, A; Fraidouni, N; Haghdoost-Yazdi, H; Jahanihashemi, H; Sarookhani, M | 1 |
| Allen, RH; Jiang, H; Maclean, KN; Stabler, SP | 1 |
| Choi, SH; Jung, KJ; Kim, HY; Kim, JI; Lee, E; Park, KM | 1 |
| Chłopicki, S; Franczyk-Żarów, M; Gajda, M; Jackson, CL; Kostogrys, RB; Maślak, E; Mateuszuk, L | 1 |
| Ehrlich, D; Humpel, C | 1 |
| Chen, R; Liu, Y; Qin, L; Tang, Y; Zhang, R | 1 |
| Chai, GS; Cheng, XS; Jiang, X; Liu, GP; Ma, ZW; Ni, ZF; Wang, JZ; Wang, Q; Xie, AJ | 1 |
| Abarinov, EV; Allen, RH; Ash, JA; Caudill, MA; Field, MS; Malysheva, OV; Shields, KS; Stabler, SP; Stover, PJ; Strupp, BJ | 1 |
| Al-Shabrawey, M; Atherton, SS; Covar, JA; El-Remessy, A; Ganapathy, PS; Ganapathy, V; Matragoon, S; Roon, P; Smith, SB; Sonne, S; Tawfik, A | 1 |
| Farzaneh, M; Mobarraei, N; Nazifi, S; Rakhshandehroo, E; Razavi, SM | 1 |
| Angelini, GD; Jeremy, JY; Shukla, N | 1 |
| Bagley, P; Bottiglieri, T; Frosst, P; Hiou-Tim, F; Lussier-Cacan, S; Rozen, R; Selhub, J; Tran, P | 1 |
| O, K; Siow, YL; Sung, FL; Wang, G; Woo, CW | 1 |
| Boskey, AL; Cole, DE; Donovan, SM; Hauschka, P; Howell, DS; Massé, PG; Ziv, I | 1 |
| Mattson, MP | 1 |
| Folbergrová, J; Haugvicová, R; Mares, P | 2 |
| Calcagnotto, T; Matté, C; Streck, EL; Vieira, PS; Wajner, M; Wannmacher, CM; Wyse, AT | 1 |
| Chan, SL; Mattson, MP; Pak, KJ | 1 |
| Ji, C; Kaplowitz, N | 1 |
| Ferrante, RJ; Kubilis, J; Lee, J; Neve, R; Ratan, RR; Ross, BD; Ryu, H; Zaman, K | 1 |
| Delwing, D; Matté, C; Streck, EL; Tagliari, B; Wajner, M; Wannmacher, CM; Wyse, AT | 1 |
| Gilfix, BM | 1 |
| Brown, AT; Cruz, CP; Eidt, JF; Moursi, MM; Poirier, LA; Simmons, D; Smith, TP; Wang, Y; Williams, DK | 1 |
| Akita, T; Duan, J; Egami, K; Ikeda, H; Imaizumi, T; Murohara, T; Sasaki, K; Shimada, T; Shintani, S | 1 |
| Akdemir, I; Gursu, F; Kaplan, M; Kilic, N; Ozveren, F; Tiftikci, M; Topsakal, C | 1 |
| Berry, CL; Campbell, JH; Tailford, KA; Thomas, AC | 1 |
| Afman, LA; Blom, HJ; Van der Put, NM; Van Straaten, HW | 1 |
| Andersen, CB; Bentzon, JF; Bro, S; Falk, E; Nielsen, LB; Olgaard, K | 1 |
| Bohle, RM; Braun-Dullaeus, RC; Dreyer, T; Fink, L; Haberbosch, W; Jeide, I; Langheinrich, AC; Schilling, R; Tammoscheit, K; Walker, G | 1 |
| Allen, JC; Boyd, LC; Hoffman, M; Sauls, DL | 1 |
| Aupetit, J; Chassé, JF; Janel, N; Kamoun, P; London, J; Paly, E; Robert, K; Santiard-Baron, D | 1 |
| Ashline, D; Milhalik, S; Ortiz, D; Rogers, E; Shea, TB | 1 |
| Amiri, F; Endemann, D; Neves, MF; Pu, Q; Rozen, R; Schiffrin, EL; Virdis, A | 1 |
| Chen, Z; Garrow, T; James, SJ; Laryea, MD; Melnyk, S; Pogribny, I; Rozen, R; Schwahn, BC | 1 |
| Bavaresco, CS; Calcagnotto, T; Matté, C; Monteiro, SC; Netto, CA; Wyse, AT | 1 |
| Enokido, Y; Harada, T; Ishii, I; Kimura, H; Nagai, Y; Namekata, K | 1 |
| Nakata, R; Okawa, N; Shigematsu, N; Yagisawa, M | 1 |
| Janel, N; Maurin, N; Robert, K; Siauve, N; Vayssettes, C | 1 |
| Bohle, RM; Langheinrich, AC | 1 |
| Chang, N; Kim, HJ; Kim, JM; Lee, H; Lee, I | 1 |
| Andersen, ML; Benedito-Silva, AA; D'Almeida, V; Galdieri, LC; Martins, PJ; Souza, FG; Tufik, S | 1 |
| Bourdon, E; Delabar, JM; Delcayre, C; Friguet, B; Janel, N; Nehmé, J; Pivert, G; Robert, K | 1 |
| Joseph, T; Muntzel, MS; Onwumere, O | 1 |
| Franzon, R; Stefanello, FM; Tagliari, B; Wajner, M; Wannmacher, C; Wyse, AT | 1 |
| Lentz, SR; Wilson, KM | 1 |
| Seftel, AD | 1 |
| Lentz, SR | 1 |
| Belmaker, RH; Levine, J; Osher, Y; Sela, BA | 1 |
| Acin, S; Arbones-Mainar, JM; Arnal, C; Carnicer, R; Guillen, N; Martinez-Gracia, MV; Navarro, MA; Osada, J; Sarria, AJ; Surra, JC | 1 |
| Aupetit, J; Janel, N; Santiard-Baron, D | 1 |
| Mirelman, D; Miron, T; Oron-Herman, M; Rabinkov, A; Rosenthal, T; Sela, BA; Wilchek, M | 1 |
| Yeh, SM; Yeh, YY | 1 |
| Cruz-Sanchez, F; DeRosa, S; Howard, A; Pacheco-Quinto, J; Pappolla, MA; Petanceska, S; Refolo, L; Rodriguez de Turco, EB; Sambamurti, K | 1 |
| Hernández Ortega, E; Hernández Trujillo, Y; Macías Reyes, A; Medina, A; Rodríguez Esparragón, F; Rodríguez Pérez, JC | 1 |
| Netto, CA; Salbego, CG; Tagliari, B; Wyse, AT; Zamin, LL | 1 |
| Benedict, S; Nagelkerke, N; Padmanabhan, R; Shafiullah, M | 1 |
| Allen, JC; Arnold, EK; Bell, CW; Hoffman, M; Sauls, DL | 1 |
| Chai, H; Chen, C; Courson, A; Lin, PH; Lumsden, AB; Yao, Q; Zhou, W | 1 |
| Delabar, JM; Demuth, K; Hamelet, J; Janel, N; Paul, JL | 1 |
| Clarke, ZL; Lang, D; Lewis, MJ; Miller, AL; Moat, SJ; Randall, MD | 1 |
| Diaz, ML; Fariña, SL; Lago, NR; Monserrat, AJ; Ossani, GP; Pelayes, D; Zarate, JO | 1 |
| Chambers, S; Fraser, R; George, P; Lever, M; McEntyre, C; Slow, S; Vasudevamurthy, M | 1 |
| Brandsch, C; Dinger, C; Eder, K; Hirche, F; Stangl, GI; Weisse, K | 1 |
| Jung, SC; Kruger, WD; Lee, JS; Oh, HJ; Park, ES | 1 |
| Fu, M; Haugen, E; Kondziella, D; Zetterberg, H | 1 |
| Croft, KD; Earl, J; Hu, L; Kanjanapan, Y; Lee, SY; Lim, PS; McKenzie, KU; Miao, Y; Mori, TA; Whitworth, JA; Zhang, Y | 1 |
| Bottiglieri, T; Cross, JC; Elmore, CL; Gravel, RA; Krupenko, NI; Krupenko, SA; Leclerc, D; Matthews, RG; Rozen, R; Watson, ED; Wu, X | 1 |
| Pofelski, J; Roblin, X; Zarski, JP | 1 |
| Delabar, JM; Fulchiron, R; Hamelet, J; Janel, N; Maurin, N | 1 |
| Alberto, JM; Blaise, S; Bronowicki, JP; Delabar, JM; Guéant, JL; Hamelet, J; Janel, N; Noll, C | 1 |
| Chan, A; Chen, S; Rogers, EJ | 1 |
| Chen, H; Dong, YZ; Ge, J; Li, J; Wang, J; Zhang, LJ | 1 |
| Cohn, J; Jiang, H; Maclean, KN; Mikael, LG; Rozen, R; Schwahn, BC; Wang, XL; Wu, Q | 1 |
| Bea, F; Blessing, E; Isermann, B; Katus, HA; Kreuzer, J; Pedal, I; Preusch, MR; Rosenfeld, ME; Yang, SH | 1 |
| Huang, GW; Liu, H; Ren, DL; Wang, YM | 1 |
| Cao, J; Jiang, Y; Li, G; Sun, T; Wang, S; Xiong, J | 1 |
| Chen, YJ; Chen, YM; Chiang, EP; Hsiao, M; Huang, SF; Hwang, SF; Lee, YH; Li, AF; Li, YS; Liu, SP; Tsai, TF | 1 |
| Hennings, LJ; Joseph, L; Melnyk, SB; Nagarajan, S; Stewart, BW; Thampi, P | 1 |
| Aït-Yahya-Graison, E; Badel-Chagnon, A; Camproux, AC; Delabar, JM; Demuth, K; Hamelet, J; Janel, N; Matulewicz, E; Noll, C; Paul, JL | 1 |
| Antelava, NA; Gogoluari, LI; Gogoluari, MI; Okudzhava, MV; Pirtskhalaĭshvili, NN | 1 |
| Barraud, H; Bronowicki, JP; Guéant, JL; Lalonde, R; Ravey, J; Strazielle, C | 1 |
| Chang, L; Du, J; Geng, B; Jiang, H; Tang, C; Yu, F; Zhao, J | 1 |
| Distrutti, E; Donini, A; Fiorucci, S; Mencarelli, A; Orlandi, S; Renga, B; Santucci, L; Shah, V | 1 |
| Chen, T; Deaciuc, I; McClain, CJ; Song, Z; Zhou, Z | 1 |
| Austin, RC; DiBello, PM; Dickhout, J; Jacobsen, DW; Lhoták, S; Majors, AK; Shi, YY; Tedesco, V; Trigatti, B; Werstuck, GH; Zhou, J | 1 |
| James, SJ; Karp, N; Li, D; Melnyk, S; Rozen, R; Wang, XL; Wu, Q | 1 |
| Corrêa, FM; de Andrade, CR; de Oliveira, AM; Eberlin, MN; Haddad, R; Resstel, LB | 1 |
| Lentz, SR; Rodionov, RN | 1 |
| Benevenga, NJ; Smolin, LA | 1 |
| Reddy, GS; Wilcken, DE | 1 |
| Garcon, D; Jourdheuil-Rahmani, D; Masset, D; Rahmani, R; Rolland, PH | 1 |
| Curtis, CG; Elias, PR; Hann, AC; Rose, FA; Tudball, N | 1 |
| Aratani, Y; Kluckman, K; Maeda, N; Malinow, MR; Osada, J; Reddick, R; Watanabe, M | 1 |
| Okada, S; Okumura, H; Takeda, A | 1 |
| Kennedy, DG; Kennedy, S; Molloy, AM; Scott, JM; Weir, DG; Young, PB | 1 |
| Allen, RH; Buccellato, FR; Lindenbaum, J; Lorenzini, EC; Morabito, A; Scalabrino, G; Tredici, G | 1 |
| Fowler, B | 1 |
| Barfuss, DW; Zalups, RK | 1 |
| Austin, RC; Hirsh, J; Liaw, PC; Maeda, N; Outinen, PA; Podor, TJ; Ribau, J; Sarge, KD; Sood, SK; Weitz, JI | 1 |
| Jakobs, C; Stehouwer, CD | 1 |
| Brosnan, JT; Brosnan, ME; House, JD; Jacobs, RL | 1 |
| Jennings, R; Madsen, JR; Manning, SM | 1 |
| Dayal, S; Erger, RA; Faraci, FM; Heistad, DD; Lentz, SR; Maeda, N; Malinow, MR | 1 |
| Le Leu, RK; McIntosh, GH; Young, GP | 1 |
| Kirchgessner, M; Roth-Maier, DA; Stangl, GI | 1 |
| Akita, T; Duan, J; Ikeda, H; Imaizumi, T; Murohara, T; Sasaki, K; Shimada, T; Shintani, S | 1 |
| Auer, J; Berent, R; Eber, B; Lassnig, E; Weber, T | 1 |
| Arning, E; Bottiglieri, T; Dayal, S; Faraci, FM; Heistad, DD; Lentz, SR; Maeda, N; Malinow, MR; Sigmund, CD | 1 |
| Jansen, G; Peters, GJ | 1 |
| Brown, AT; Cruz, CP; Eidt, JF; Moursi, MM; Smith, TP | 1 |
| Hajjar, KA; Hiraoka, M; Ishii, H; Numano, F; Tanaka, A; Yasukochi, Y; Yoshida, M | 1 |
| Chen, C; Ma, M; Morsy, AH; Surowiec, SM | 1 |
| Cook, JW; Malinow, MR; Moneta, GL; Orloff, SL; Taylor, LM | 1 |
| Cutler, RG; Evans, M; Haughey, N; Kruman, II; Kruman, Y; Kumaravel, TS; Lee, J; Lohani, A; Mattson, MP; Pedersen, WA | 1 |
| Chen, YF; Li, N; Zou, AP | 1 |
| Adalbert, R; Engelhardt, JI; Siklós, L | 1 |
| Burgoon, JM; Nadeau, M; Sadler, TW; Selhub, J | 1 |
| Delabar, U; Kloor, D; Luippold, G; Mühlbauer, B; Osswald, H | 1 |
| Bale, A; Balling, R; Christensen, B; Colmenares, C; Ernest, S; Gilfix, BM; Hosack, A; Mamer, OA; McGrath, J; Nadeau, JH; Rodier, M; Rosenblatt, DS; Sankoff, D | 1 |
| Fischer, J; Mares, P; Payne, J | 1 |
| Lapin, IP; Ryzhov, IV | 1 |
| Donahue, S; Gaull, G; Struman, JA | 1 |
25 review(s) available for homocysteine and Disease Models, Animal
| Article | Year |
|---|---|
Activation of arginase II by asymmetric dimethylarginine and homocysteine in hypertensive rats induced by hypoxia: a new model of nitric oxide synthesis regulation in hypertensive processes?
Topics: Animals; Arginase; Arginine; Disease Models, Animal; Homocysteine; Hypertension; Hypoxia; Nitric Oxide; Rats; Rats, Wistar | 2021 |
Cystathionine β-synthase deficiency: Of mice and men.
Topics: Animals; Animals, Newborn; Cystathionine beta-Synthase; Disease Models, Animal; Genotype; Homocysteine; Homocystinuria; Humans; Male; Metabolism, Inborn Errors; Methionine; Mice; Mutation; Phenotype; Pyridoxine | 2017 |
Hyperhomocysteinemia and cardiovascular disease in animal model.
Topics: Animals; Cardiovascular Diseases; Disease Models, Animal; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Risk Factors | 2018 |
Nutritional modulation of cognitive function and mental health.
Topics: Animals; Antioxidants; Brain; Chronic Disease; Cognition; Diet, Mediterranean; Disease Models, Animal; Fatty Acids, Omega-3; Folic Acid; Homocysteine; Humans; Life Style; Mental Health; Nutritional Physiological Phenomena; Risk Factors; Vitamin B Complex | 2013 |
The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Dietary Supplements; Disease Models, Animal; DNA Methylation; Fasting; Fatty Liver; Folic Acid; Homocysteine; Humans; Liver; Metabolic Networks and Pathways; Methionine; Muscular Diseases; S-Adenosylmethionine | 2013 |
Vitamin B(12) metabolism during pregnancy and in embryonic mouse models.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Acyl Coenzyme A; Animals; Disease Models, Animal; Embryonic Development; Female; Homocysteine; Humans; Methionine; Methylmalonyl-CoA Mutase; Mice; Pregnancy; Vitamin B 12; Vitamin B 12 Deficiency | 2013 |
[Reconsideration of homocysteinemia].
Topics: Animals; Disease Models, Animal; Genetic Predisposition to Disease; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Sulfhydryl Compounds | 2013 |
Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID).
Topics: Animals; Cognitive Dysfunction; Dementia, Vascular; Disease Models, Animal; Homocysteine; Humans; Hyperhomocysteinemia | 2016 |
Murine models of hyperhomocysteinemia and their vascular phenotypes.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Diet; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Genetic Predisposition to Disease; Homocysteine; Hyperhomocysteinemia; Mice; Phenotype; Thrombosis | 2008 |
Bone tissue and hyperhomocysteinemia.
Topics: Animals; Bone and Bones; Bone Density; Bone Remodeling; Disease Models, Animal; Homocysteine; Humans; Hyperhomocysteinemia; Mice; Osteoporosis | 2009 |
Vascular complications of cystathionine β-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research.
Topics: Animals; Disease Models, Animal; Homocysteine; Homocystinuria; Humans; Hydrogen Sulfide; Mice; Vascular Diseases | 2011 |
Hyperhomocysteinemia: genetic determinants and selected mouse models.
Topics: Adenosine Deaminase; Animals; Disease Models, Animal; Homocysteine; Humans; Hyperhomocysteinemia; Mice; Models, Biological; Polymorphism, Genetic; Time Factors | 2003 |
Atherosclerosis: humoral and cellular factors of inflammation.
Topics: Animals; Arteriosclerosis; Diagnostic Imaging; Disease Models, Animal; Endothelial Cells; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infections; Inflammation; Leukocytes; Mice; Nitric Oxide | 2005 |
Mechanisms of the atherogenic effects of elevated homocysteine in experimental models.
Topics: Animals; Arteriosclerosis; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Hyperhomocysteinemia; Methionine; Mice; Nitric Oxide; Oxidative Stress; Risk Factors | 2005 |
Mechanisms of homocysteine-induced atherothrombosis.
Topics: Animals; Apolipoproteins E; Apoptosis; Arginine; Atherosclerosis; Coronary Thrombosis; Cysteine; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Methionine; Mice; Models, Biological; Nitric Oxide; Oxidative Stress; Oxygen; Phenotype; Signal Transduction | 2005 |
High homocysteine serum levels in young male schizophrenia and bipolar patients and in an animal model.
Topics: Adolescent; Adult; Age Factors; Aging; Animals; Behavior, Animal; Bipolar Disorder; Disease Models, Animal; Homocysteine; Humans; Male; Mice; Middle Aged; Schizophrenia; Sex Factors | 2005 |
Understanding the role of dietary components on atherosclerosis using genetic engineered mouse models.
Topics: Alcohol Drinking; Allergy and Immunology; Animals; Antioxidants; Apolipoproteins E; Arginine; Arteriosclerosis; Ascorbic Acid; Atherosclerosis; Cell Proliferation; Dietary Fats; Disease Models, Animal; Energy Metabolism; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Genetic Engineering; Genetic Variation; Genomics; Homocysteine; Insulin Resistance; Iron; Magnesium; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Models, Genetic; Phytosterols; Receptors, LDL; Sex Factors; Sodium; Taurine; Vitamin E | 2006 |
ADMA and hyperhomocysteinemia.
Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Homocysteine; Humans; Hyperhomocysteinemia; Nitric Oxide; Nitric Oxide Synthase Type III; Risk Factors; Superoxides; Vasodilation | 2005 |
[Concerning the significance of paraoxonase-1 and SR-B1 genes in atherosclerosis].
Topics: Animals; Anticholesteremic Agents; Aryldialkylphosphatase; Atherosclerosis; Cardiovascular Diseases; Cholesterol; Cholesterol Esters; Disease Models, Animal; Genetic Predisposition to Disease; Homocysteine; Humans; Lipid Metabolism; Lipoproteins, HDL; Lipoproteins, LDL; Male; Mice; Mice, Transgenic; Oxidative Stress; Phenotype; Polymorphism, Genetic; Receptors, Lipoprotein; Scavenger Receptors, Class B | 2006 |
[Steatosis, chronic hepatitis virus C infection and homocysteine].
Topics: Adult; Animals; Antiviral Agents; Child; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Resistance, Viral; Fatty Liver; Fatty Liver, Alcoholic; Female; Hepacivirus; Hepatitis C, Chronic; Homocysteine; Humans; Hyperhomocysteinemia; In Vitro Techniques; Insulin Resistance; Interferons; Liver; Liver Cirrhosis; Male; Mice; Mice, Transgenic; Multivariate Analysis; Mutation; Risk Factors | 2007 |
Disorders of homocysteine metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Amino Acid Metabolism, Inborn Errors; Animals; Cystathionine beta-Synthase; Disease Models, Animal; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases | 1997 |
Abnormalities of vascular function in hyperhomocysteinaemia: relationship to atherothrombotic disease.
Topics: Animals; Arteriosclerosis; Biological Availability; Disease Models, Animal; Endothelium, Vascular; Fibrinolysis; Homocysteine; Humans; Nitric Acid; Platelet Activation; Risk Factors; Thrombosis; Vasodilation | 1998 |
Pathophysiology, prevention, and potential treatment of neural tube defects.
Topics: Animals; Disease Models, Animal; Embryonic and Fetal Development; Folic Acid; Homocysteine; Humans; Incidence; Nervous System; Neural Tube Defects; Preventive Medicine | 2000 |
[Homocysteine and cardiovascular risk].
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Arteriosclerosis; Clinical Trials as Topic; Coronary Artery Disease; Disease Models, Animal; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Models, Biological; Vitamin B 12 | 2001 |
[Endogenous convulsants (review)].
Topics: Amino Acids; Animals; Carbolines; Cats; Cerebral Cortex; Convulsants; Cysteic Acid; Cysteine; Disease Models, Animal; Dogs; Estrogens; Folic Acid; Homocysteine; Kynurenine; Methionine; Mice; Neurotransmitter Agents; Prostaglandins; Pyridoxal Phosphate; Quinolinic Acid; Quinolinic Acids; Rats; Seizures; Spinal Cord | 1986 |
2 trial(s) available for homocysteine and Disease Models, Animal
| Article | Year |
|---|---|
Nitration-mediated deficiency of cystathionine β-synthase activity accelerates the progression of hyperhomocysteinemia.
Topics: Adult; Aged; Aged, 80 and over; Animals; Cystathionine beta-Synthase; Disease Models, Animal; Disease Progression; Female; Free Radical Scavengers; Homocysteine; Humans; Hyperhomocysteinemia; Male; Metalloporphyrins; Middle Aged; Mutation; Nitro Compounds; Nitrosative Stress; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Rats, Wistar; Tyrosine | 2017 |
Pro-thrombotic and pro-oxidant effects of diet-induced hyperhomocysteinemia.
Topics: Animals; Antioxidants; Ascorbic Acid; Caspase 3; Choline Deficiency; Diet; Disease Models, Animal; Female; Fibrinolysis; Folic Acid Deficiency; Homocysteine; Hyperhomocysteinemia; Mitochondria; Oxidative Stress; Rabbits; Risk Factors; Thrombosis; Vitamin E | 2007 |
286 other study(ies) available for homocysteine and Disease Models, Animal
| Article | Year |
|---|---|
Implication of
Topics: Aged; Aged, 80 and over; Animals; Cell Line; Choroidal Neovascularization; Cystathionine beta-Synthase; Disease Models, Animal; Endothelial Cells; Female; Homocysteine; Humans; Hyperhomocysteinemia; Hypoxia-Inducible Factor 1, alpha Subunit; Macular Degeneration; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Neovascularization, Pathologic; Primary Cell Culture; Receptors, N-Methyl-D-Aspartate; Retinal Pigment Epithelium; Vascular Endothelial Growth Factor A | 2021 |
Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation.
Topics: Adipose Tissue; Animals; Antigens, CD; CHO Cells; Cricetulus; Diabetes Mellitus, Type 2; Disease Models, Animal; Furin; HEK293 Cells; Hep G2 Cells; Homocysteine; Humans; Hyperhomocysteinemia; Insulin Resistance; Liver; Male; Mice, Inbred C57BL; Muscle, Skeletal; Protein Processing, Post-Translational; Rats; Receptor, Insulin | 2021 |
FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cytokines; Disease Models, Animal; Fatty Acid-Binding Proteins; Gene Expression Profiling; Homocysteine; Humans; Inflammation Mediators; Janus Kinase 2; Macrophages; Male; Mice, Inbred C57BL; Mice, Knockout; Proteins; rap1 GTP-Binding Proteins; Signal Transduction; STAT2 Transcription Factor; THP-1 Cells | 2022 |
Dendritic and behavioral changes in rats neonatally treated with homocysteine; A proposal as an animal model to study the attention deficit hyperactivity disorder.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Dendritic Spines; Disease Models, Animal; Homocysteine; Male; Neurons; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 2022 |
A High-Methionine Diet for One-Week Induces a High Accumulation of Methionine in the Cerebrospinal Fluid and Confers Bipolar Disorder-like Behavior in Mice.
Topics: Amino Acids; Animals; Bipolar Disorder; Disease Models, Animal; Drug Administration Schedule; Homocysteine; Male; Methionine; Mice; Open Field Test; Up-Regulation | 2022 |
Effect of hyperhomocysteinemia on a murine model of smoke-induced pulmonary emphysema.
Topics: Animals; Apoptosis; Disease Models, Animal; Emphysema; Homocysteine; Humans; Hyperhomocysteinemia; Male; Mice; Mice, Inbred C57BL; Nicotiana; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema | 2022 |
Melatonin Treatment Ameliorates Hyperhomocysteinemia-Induced Impairment of Erectile Function in a Rat Model.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Caspase 3; Disease Models, Animal; Erectile Dysfunction; Homocysteine; Humans; Hyperhomocysteinemia; Male; Malondialdehyde; Melatonin; NADPH Oxidases; Oxidative Stress; Penile Erection; Penis; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase | 2019 |
Dysbiotic 1-carbon metabolism in cardiac muscle remodeling.
Topics: Animals; Carbon; Cystathionine beta-Synthase; Disease Models, Animal; Dysbiosis; Epigenesis, Genetic; Gastrointestinal Microbiome; Homocysteine; Humans; Lactobacillus; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Myocardium; Myocytes, Cardiac; Probiotics | 2020 |
Blockade of the trans-sulfuration pathway in acute pancreatitis due to nitration of cystathionine β-synthase.
Topics: Animals; Ceruletide; Cystathionine; Cystathionine beta-Synthase; Cysteine; Disease Models, Animal; Glutathione; Homocysteine; Male; Mice; Nitric Oxide Synthase Type II; Pancreatitis; S-Adenosylmethionine; Up-Regulation | 2020 |
Intermedin
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Cells, Cultured; Diet, High-Fat; Disease Models, Animal; Endoplasmic Reticulum Stress; Homocysteine; Macrophages, Peritoneal; Male; Mice, Knockout, ApoE; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteoblasts; Peptide Hormones; Rats, Sprague-Dawley; Vascular Calcification | 2020 |
Folic acid ameliorates depression-like behaviour in a rat model of chronic unpredictable mild stress.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Behavior, Animal; Biogenic Monoamines; Brain; Citalopram; Depression; Disease Models, Animal; Folic Acid; Homocysteine; Male; Rats, Sprague-Dawley; Stress, Psychological | 2020 |
Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; HEK293 Cells; Homocysteine; Humans; Male; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Sulfonamides | 2020 |
Hyperhomocysteinemia: an instigating factor for periodontal disease.
Topics: Animals; Cystathionine beta-Synthase; Disease Models, Animal; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Mice; Mice, Transgenic; Oxidative Stress; Periodontitis; Periodontium | 2021 |
Cystathionine β-synthase Deficiency Impairs Vision in the Fruit Fly,
Topics: Animals; Blotting, Western; Cystathionine beta-Synthase; Disease Models, Animal; Drosophila melanogaster; Gene Expression Regulation, Enzymologic; Homocysteine; Homocystinuria; Phototaxis; Vision Disorders | 2021 |
Neocortical injury-induced status epilepticus.
Topics: Animals; Cobalt; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Female; Homocysteine; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Neocortex; Neuroimaging; Status Epilepticus; Video Recording | 2020 |
N-Methyl-D-aspartate receptor activation, novel mechanism of homocysteine-induced blood-retinal barrier dysfunction.
Topics: Animals; Blood-Retinal Barrier; Disease Models, Animal; Endothelial Cells; Homocysteine; Humans; Hyperhomocysteinemia; Mice, Inbred C57BL; Mice, Transgenic; Receptors, N-Methyl-D-Aspartate; Retina | 2021 |
Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis.
Topics: Adenosylhomocysteinase; Animals; Betaine; Cystathionine beta-Synthase; Disease Models, Animal; Folic Acid; Gene Expression Regulation, Enzymologic; Glycine Hydroxymethyltransferase; Homocysteine; Homocystinuria; Humans; Liver; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Polyamines | 2021 |
Hydrogen sulphide reduces hyperhomocysteinaemia-induced endothelial ER stress by sulfhydrating protein disulphide isomerase to attenuate atherosclerosis.
Topics: Animals; Atherosclerosis; Cell Line; Disease Models, Animal; Endoplasmic Reticulum Stress; Endothelial Cells; HEK293 Cells; Homocysteine; Humans; Hydrogen Sulfide; Hyperhomocysteinemia; Male; Mice; Mice, Knockout, ApoE; Protein Disulfide-Isomerases; Up-Regulation | 2021 |
Fetal Programming by Methyl Donor Deficiency Produces Pathological Remodeling of the Ascending Aorta.
Topics: Animal Nutritional Physiological Phenomena; Animals; Aorta; Aortic Diseases; Disease Models, Animal; Extracellular Matrix Proteins; Female; Fetal Development; Folic Acid Deficiency; Gene Expression Regulation, Developmental; Gestational Age; Homocysteine; Maternal Nutritional Physiological Phenomena; Peptide Hydrolases; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Wistar; Vascular Remodeling; Vitamin B 12 Deficiency | 2021 |
Transcriptomic Analysis Reveals an Altered Hcy Metabolism in the Stria Vascularis of the Pendred Syndrome Mouse Model.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Cell Adhesion; Disease Models, Animal; Gene Expression Regulation; Goiter, Nodular; Hearing Loss, Sensorineural; Homocysteine; Mice; Mice, Knockout; RNA; Signal Transduction; Stria Vascularis; Sulfate Transporters; Transcriptome | 2021 |
Homocysteine fibrillar assemblies display cross-talk with Alzheimer's disease β-amyloid polypeptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Cell Death; Cell Line, Tumor; Disease Models, Animal; Homocysteine; Humans; Ion Mobility Spectrometry; Kinetics; Mice, Transgenic; Models, Biological; Polyphenols; Saccharomyces cerevisiae | 2021 |
Simvastatin increases circulating endothelial progenitor cells and inhibits the formation of intracranial aneurysms in rats with diet-induced hyperhomocysteinemia.
Topics: Animals; Biomarkers; Disease Models, Animal; Endothelial Progenitor Cells; Endothelium, Vascular; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperhomocysteinemia; Intracranial Aneurysm; Male; Rats; Rats, Sprague-Dawley; Simvastatin; Vascular Remodeling | 2021 |
Genetic absence of ALOX5 protects from homocysteine-induced memory impairment, tau phosphorylation and synaptic pathology.
Topics: Animals; Arachidonate 5-Lipoxygenase; Brain; Disease Models, Animal; Female; Homocysteine; Humans; Male; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurodegenerative Diseases; Phosphorylation; Synapses | 2017 |
Engineering and Characterization of an Enzyme Replacement Therapy for Classical Homocystinuria.
Topics: Amino Acid Sequence; Animals; Cross-Linking Reagents; Cystathionine beta-Synthase; Cysteine; Delayed-Action Preparations; Disease Models, Animal; Enzyme Replacement Therapy; Homocysteine; Homocystinuria; Humans; Maleimides; Mice; Polyethylene Glycols; Succinimides | 2017 |
Evaluation of plasma sphingosine 1-phosphate, hepcidin and cardiovascular damage biomarkers (cardiac troponin I and homocysteine) in rats infected with brucellosis and vaccinated (Rev-1, RB-51).
Topics: Animals; Biomarkers; Blood Chemical Analysis; Brucella abortus; Brucella melitensis; Brucella Vaccine; Brucellosis; Copper; Disease Models, Animal; Hepcidins; Homocysteine; Iron; Lysophospholipids; Male; Malondialdehyde; Plasma; Rats; Sphingosine; Troponin I; Vaccination; Zinc | 2017 |
Folic acid attenuates homocysteine and enhances antioxidative capacity in atherosclerotic rats.
Topics: Animals; Antioxidants; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Cholesterol, HDL; Diet, High-Fat; Disease Models, Animal; Folic Acid; Homocysteine; Lipid Peroxidation; Male; Oxidative Stress; Plaque, Atherosclerotic; Rats, Wistar; Time Factors | 2017 |
CYLD Deubiquitinates Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Contributing to Adventitial Remodeling.
Topics: Adventitia; Animals; Aortic Aneurysm, Abdominal; Calcium Phosphates; Cell Movement; Cell Transdifferentiation; Chemokine CCL2; Chlorocebus aethiops; COS Cells; Cysteine Endopeptidases; Deubiquitinating Enzyme CYLD; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Stability; Extracellular Matrix; Genotype; Half-Life; HEK293 Cells; Homocysteine; Humans; Hyperhomocysteinemia; Interleukin-6; Male; Mice, Inbred C57BL; Mice, Knockout; Myofibroblasts; NADPH Oxidase 4; NADPH Oxidases; Phenotype; Proteolysis; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA Interference; Signal Transduction; Time Factors; Transfection; Transforming Growth Factor beta1; Ubiquitin Thiolesterase; Ubiquitination; Vascular Remodeling | 2017 |
Edoxaban improves venous thrombosis via increasing hydrogen sulfide and homocysteine in rat model.
Topics: Animals; Anticoagulants; Chlorides; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Endothelial Cells; Ferric Compounds; Gene Expression Regulation; Homocysteine; Hydrogen Sulfide; Male; Matrix Metalloproteinase 9; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiazoles; Venous Thrombosis | 2017 |
Chronic Mild Hyperhomocysteinemia Alters Inflammatory and Oxidative/Nitrative Status and Causes Protein/DNA Damage, as well as Ultrastructural Changes in Cerebral Cortex: Is Acetylsalicylic Acid Neuroprotective?
Topics: Acetylcholinesterase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Catalase; Cerebral Cortex; Comet Assay; Cytokines; Dendritic Spines; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Homocysteine; Hyperhomocysteinemia; Male; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2018 |
Homocysteine Increases Tau Phosphorylation, Truncation and Oligomerization.
Topics: Alzheimer Disease; Animals; Brain; Cell Line, Tumor; Cyclin-Dependent Kinase 5; Disease Models, Animal; Glycogen Synthase Kinase 3; Homocysteine; Humans; Hyperhomocysteinemia; Mice; Mice, Transgenic; Neurofibrillary Tangles; Phosphorylation; Protein Aggregation, Pathological; Protein Phosphatase 2; tau Proteins; Tauopathies | 2018 |
Moringa Oleifera Alleviates Homocysteine-Induced Alzheimer's Disease-Like Pathology and Cognitive Impairments.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Cognition Disorders; Disease Models, Animal; Homocysteine; Male; Maze Learning; Moringa oleifera; Nerve Tissue Proteins; Neurons; Oxidative Stress; Peptide Fragments; Phosphorylation; Plant Extracts; Rats; Rats, Sprague-Dawley; Silver Staining; tau Proteins | 2018 |
Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Arachidonate 5-Lipoxygenase; Brain; Disease Models, Animal; Female; Homocysteine; Male; Mice; Mice, Transgenic; Phenotype; Phosphorylation; Synapses; tau Proteins; Tauopathies | 2019 |
Hyperhomocysteinemia in polycystic ovary syndrome: decreased betaine-homocysteine methyltransferase and cystathionine β-synthase-mediated homocysteine metabolism.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Disease Models, Animal; Female; Homocysteine; Hyperhomocysteinemia; Liver; Polycystic Ovary Syndrome; Rats | 2018 |
Methylenetetrahydrofolate Reductase Deficiency Deregulates Regional Brain Amyloid-β Protein Precursor Expression and Phosphorylation Levels.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Female; Folic Acid; Glycogen Synthase Kinase 3 beta; Homocysteine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Transgenic; Mutation; Phosphorylation | 2018 |
Effect of Homocysteine on the Differentiation of CD4
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Colon; Cyclooxygenase 2; Disease Models, Animal; Folic Acid; Group IV Phospholipases A2; Homocysteine; Hyperhomocysteinemia; Inflammatory Bowel Diseases; Mucous Membrane; Nuclear Receptor Subfamily 1, Group F, Member 3; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Th17 Cells; Treatment Outcome; Vitamin B Complex | 2018 |
Time-response studies on development of cognitive deficits in an experimental model of insulin resistance.
Topics: Animals; Biomarkers; Blood Glucose; Cognitive Dysfunction; Cytokines; Disease Models, Animal; Fructose; Homocysteine; Insulin; Insulin Resistance; Male; Oxidative Stress; Rats; Rats, Wistar; Time Factors | 2019 |
A genetic deficiency in folic acid metabolism impairs recovery after ischemic stroke.
Topics: Animals; Apoptosis; Astrocytes; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Embryo, Mammalian; Female; Folic Acid; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Homocysteine; Male; Metabolic Diseases; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Neurons; Psychomotor Performance; Recovery of Function; Stroke | 2018 |
Nuclear factor erythroid 2-related factor 2 activation mediates hyperhomocysteinemia-associated lipolysis suppression in adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cytoplasm; Disease Models, Animal; Fatty Acids; Gene Knockdown Techniques; Glycerol; Homocysteine; Hyperhomocysteinemia; Lipolysis; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Triglycerides | 2018 |
ADMA, homocysteine and redox status improvement affected by 7-nitroindazole in spontaneously hypertensive rats.
Topics: Animals; Aorta; Arginine; Biomarkers; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; Homocysteine; Hypertension; Indazoles; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidation-Reduction; Rats, Inbred SHR | 2018 |
Metoprolol and Nebivolol Prevent the Decline of the Redox Status of Low-Molecular-Weight Aminothiols in Blood Plasma of Rats During Acute Cerebral Ischemia.
Topics: Acute Disease; Adrenergic beta-1 Receptor Antagonists; Animals; Brain Ischemia; Cerebrovascular Circulation; Cysteine; Disease Models, Animal; Glutathione; Hippocampus; Homocysteine; Male; Metoprolol; Molecular Weight; Nebivolol; Neuroprotective Agents; Oxidation-Reduction; Rats | 2018 |
Folate/Vitamin B Alleviates Hyperhomocysteinemia-Induced Alzheimer-Like Pathologies in Rat Retina.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Dietary Supplements; Disease Models, Animal; Folic Acid; Homocysteine; Hyperhomocysteinemia; Male; Rats, Sprague-Dawley; Retina; Retinal Vessels; tau Proteins; Vitamin B 12 | 2019 |
Astragaloside IV reversed the autophagy and oxidative stress induced by the intestinal microbiota of AIS in mice.
Topics: Animals; Antioxidants; Autophagy; Autophagy-Related Protein 12; Bacteria; Beclin-1; Brain; Disease Models, Animal; Fatty Acids; Feces; Gastrointestinal Microbiome; Genetic Vectors; Glutathione; Homocysteine; Ischemic Attack, Transient; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; NADPH Oxidase 2; NADPH Oxidase 4; Oxidative Stress; Reactive Oxygen Species; Saponins; Stroke; Superoxide Dismutase; Triterpenes | 2018 |
Hyperhomocysteinemia Causes Chorioretinal Angiogenesis with Placental Growth Factor Upregulation.
Topics: Animals; Capillaries; Choroid; Disease Models, Animal; Fluorescein Angiography; Fundus Oculi; Homocysteine; Hyperhomocysteinemia; Male; Placenta Growth Factor; Rats, Sprague-Dawley; Retina; Tomography, Optical Coherence; Up-Regulation | 2018 |
Ultra-high performance hydrophilic interaction liquid chromatography - Triple quadrupole tandem mass spectrometry method for determination of cysteine, homocysteine, cysteinyl-glycine and glutathione in rat plasma.
Topics: Animals; Chemical Fractionation; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; Disease Models, Animal; Glutathione; Homocysteine; Humans; Hydrophobic and Hydrophilic Interactions; Maleimides; Rats; Rats, Inbred SHR; Rats, Transgenic; Sensitivity and Specificity; Tandem Mass Spectrometry; tau Proteins; Tauopathies | 2019 |
Maternal choline supplementation ameliorates Alzheimer's disease pathology by reducing brain homocysteine levels across multiple generations.
Topics: Alzheimer Disease; Animals; Brain; Choline; Dietary Supplements; Disease Models, Animal; Female; Homocysteine; Male; Mice; Mice, Transgenic | 2020 |
Supplementation with dairy matrices impacts on homocysteine levels and gut microbiota composition of hyperhomocysteinemic mice.
Topics: Animals; Diet; Disease Models, Animal; Fermented Foods; Folic Acid; Gastrointestinal Microbiome; Homocysteine; Hyperhomocysteinemia; Male; Mice; Mice, Inbred C57BL; Milk | 2020 |
NRP1 regulates HMGB1 in vascular endothelial cells under high homocysteine condition.
Topics: Adult; Animals; Biomarkers; Case-Control Studies; Coculture Techniques; Disease Models, Animal; Female; HMGB1 Protein; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Hyperhomocysteinemia; Inflammation; Inflammation Mediators; Male; Middle Aged; Neuropilin-1; p38 Mitogen-Activated Protein Kinases; Rats, Sprague-Dawley; Signal Transduction; THP-1 Cells; Up-Regulation | 2019 |
Metabolomic study of altered energy metabolism during global forebrain ischemia and ischemic precoditioning in blood plasma in homocysteine treated rats.
Topics: Animals; Biomarkers; Brain Ischemia; Disease Models, Animal; Energy Metabolism; Homocysteine; Hyperhomocysteinemia; Ischemic Preconditioning; Magnetic Resonance Spectroscopy; Male; Metabolomics; Prosencephalon; Rats; Rats, Wistar | 2018 |
Developmental Impairments in a Rat Model of Methyl Donor Deficiency: Effects of a Late Maternal Supplementation with Folic Acid.
Topics: Animals; Behavior, Animal; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Growth and Development; Homocysteine; Methylation; MicroRNAs; Nervous System; Pregnancy; Rats, Wistar; Vitamin B 12 | 2019 |
Betaine ameliorates prenatal valproic-acid-induced autism-like behavioral abnormalities in mice by promoting homocysteine metabolism.
Topics: Animals; Antimanic Agents; Autism Spectrum Disorder; Behavior, Animal; Betaine; Disease Models, Animal; Female; Homocysteine; Mice; Mice, Inbred ICR; Pregnancy; Prenatal Exposure Delayed Effects; Protective Agents; Social Behavior; Valproic Acid | 2019 |
Betaine-rich sugar beet molasses protects from homocysteine-induced reduction of survival in Caenorhabditis elegans.
Topics: Animals; Betaine; Caenorhabditis elegans; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Homocysteine; Hot Temperature; Molasses; Stress, Physiological; Survival Analysis | 2020 |
Hyperhomocysteinemia leads to exacerbation of ischemic brain damage: Role of GluN2A NMDA receptors.
Topics: Animals; Behavior, Animal; Brain; Brain Ischemia; Disease Models, Animal; Disease Progression; Homocysteine; Hyperhomocysteinemia; Magnetic Resonance Imaging; Male; Mice; Mice, Knockout; Motor Activity; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Rotarod Performance Test; Severity of Illness Index; Signal Transduction | 2019 |
Maternal vitamin D deficiency increases the thromboxane/prostacyclin ratio through alterations in the one-carbon cycle in Wistar rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Calcium; Cyclooxygenase 2; Cystathionine beta-Synthase; Disease Models, Animal; Female; Folic Acid; Gene Expression Regulation; Group II Phospholipases A2; Homocysteine; Humans; Malondialdehyde; Parathyroid Hormone; Phosphates; Placenta; Pregnancy; Rats; Rats, Wistar; Signal Transduction; Thromboxane B2; Vitamin B 12; Vitamin D Deficiency | 2019 |
Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; Homocysteine; Male; MAP Kinase Signaling System; Neural Stem Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Stroke; TOR Serine-Threonine Kinases | 2019 |
A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy.
Topics: Animals; Calcium; Calcium Channels, T-Type; Cell Membrane; Disease Models, Animal; Ganglia, Spinal; Homocysteine; Hyperalgesia; Hyperhomocysteinemia; Nociception; Peripheral Nervous System Diseases; Rats; Rats, Wistar | 2019 |
Quercetin reduces serum homocysteine level in rats fed a methionine-enriched diet.
Topics: Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; Glutathione; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methionine; Organ Size; Oxidative Stress; Protein Carbonylation; Quercetin; Random Allocation; Rats; Rats, Wistar; Weight Gain | 2013 |
Paradoxical sleep deprivation potentiates epilepsy induced by homocysteine thiolactone in adult rats.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy; Homocysteine; Male; Rats; Rats, Wistar; Sleep Deprivation; Sleep, REM | 2013 |
The heart-placenta axis in the first month of pregnancy: induction and prevention of cardiovascular birth defects.
Topics: Animals; Birds; Cell Differentiation; Dietary Supplements; Disease Models, Animal; Ethanol; Female; Folic Acid; Folic Acid Deficiency; Gestational Age; Heart; Heart Defects, Congenital; Homocysteine; Humans; Lithium Compounds; Maternal Exposure; Mice; Myocytes, Cardiac; Placenta; Pregnancy; Prenatal Exposure Delayed Effects; Signal Transduction; Wnt Proteins | 2013 |
Exercise prevents hyperhomocysteinemia in a dietary folate-restricted mouse model.
Topics: Absorption; Animals; Betaine-Homocysteine S-Methyltransferase; Diet; Disease Models, Animal; Female; Folic Acid; Homocysteine; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Physical Conditioning, Animal | 2013 |
Methionine-induced hyperhomocysteinemia impairs the antioxidant ability of high-density lipoproteins without reducing in vivo macrophage-specific reverse cholesterol transport.
Topics: Animals; Antioxidants; Apolipoprotein A-I; Aryldialkylphosphatase; Atherosclerosis; Biological Transport; Cell Line; Cholesterol, HDL; Disease Models, Animal; Female; Homocysteine; Hyperhomocysteinemia; Lipid Metabolism; Liver; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2013 |
Anti-genotoxic potential of bilirubin in vivo: damage to DNA in hyperbilirubinemic human and animal models.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antimutagenic Agents; Antioxidants; Bilirubin; Body Mass Index; Case-Control Studies; Comet Assay; Creatinine; Disease Models, Animal; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Female; Gilbert Disease; Hepatocytes; Homocysteine; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Mutagens; Mutation; Oxygen; Rats; Rats, Gunn; Rats, Wistar; Young Adult | 2013 |
Effects of taurine supplementation on hepatic markers of inflammation and lipid metabolism in mothers and offspring in the setting of maternal obesity.
Topics: Animals; Animals, Newborn; Biomarkers; Body Weight; Dietary Supplements; Disease Models, Animal; Female; Gene Expression; Glucose; Glutamic Acid; Homocysteine; Inflammation; Lipid Metabolism; Liver; Male; Maternal Nutritional Physiological Phenomena; Obesity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Taurine | 2013 |
Exercise decreases susceptibility to homocysteine seizures: the role of oxidative stress.
Topics: Animals; Catalase; Disease Models, Animal; Electroencephalography; Hippocampus; Homocysteine; Male; Malondialdehyde; Oxidative Stress; Physical Conditioning, Animal; Rats, Wistar; Seizures; Superoxide Dismutase; Thiobarbiturates | 2014 |
Development of an animal model for gestational hypermethioninemia in rat and its effect on brain Na⁺,K⁺-ATPase/Mg²⁺-ATPase activity and oxidative status of the offspring.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Animals, Newborn; Brain; Brain Chemistry; Ca(2+) Mg(2+)-ATPase; Catalase; Disease Models, Animal; Female; Glycine N-Methyltransferase; Homocysteine; Maternal-Fetal Exchange; Methionine; Nerve Tissue Proteins; Oxidation-Reduction; Oxidative Stress; Pregnancy; Pregnancy Complications; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Sulfhydryl Compounds; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2014 |
Behavioral and neurochemical effects of dietary methyl donor deficiency combined with unpredictable chronic mild stress in rats.
Topics: Analysis of Variance; Animals; Biogenic Amines; Brain; Choline Deficiency; Chronic Disease; Corticosterone; Diet; Disease Models, Animal; Exploratory Behavior; Folic Acid Deficiency; Homocysteine; Maze Learning; Rats; Rats, Wistar; Spinal Cord; Stress, Psychological; Swimming | 2014 |
Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration.
Topics: Analysis of Variance; Animals; Brain; Cysteine Endopeptidases; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation; Genotype; Homocysteine; Hyperhomocysteinemia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Protein arginine hypomethylation in a mouse model of cystathionine β-synthase deficiency.
Topics: Animals; Arginine; Brain; Cystathionine beta-Synthase; Disease Models, Animal; DNA Methylation; Histones; Homocysteine; Homocystinuria; Liver; Methylation; Mice; S-Adenosylhomocysteine | 2014 |
Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cell Line, Tumor; Cognition Disorders; Diet; Disease Models, Animal; Homocysteine; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neuroblastoma; Neurofibrillary Tangles; Plaque, Amyloid; Presenilin-1; Signal Transduction; tau Proteins | 2014 |
Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism.
Topics: Acetylcholinesterase; Animals; Apoptosis; Betaine; Cerebellum; Choline; Choline O-Acetyltransferase; Disease Models, Animal; DNA Methylation; Ferredoxin-NADP Reductase; Gene Expression; Hippocampus; Homocysteine; Homocystinuria; Hyperhomocysteinemia; Male; Memory, Short-Term; Methionine; Mice; Mice, Knockout; Synaptic Transmission | 2014 |
Evaluation of the association between blood homocysteine concentration and the degree of behavioral symptoms in the 6-hydroxydopamine-induced Parkinsonism in rat.
Topics: Animals; Behavior, Animal; Cell Transplantation; Disease Models, Animal; Homocysteine; Male; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar | 2014 |
Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats.
Topics: Animals; Brain Diseases; Calcium Channel Blockers; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Therapy, Combination; Hippocampus; Homocysteine; Hyperhomocysteinemia; Indans; Male; Maze Learning; Memory Disorders; Nerve Tissue Proteins; Nifedipine; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Silver Staining; Tacrine | 2014 |
High levels of homocysteine results in cerebral amyloid angiopathy in mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animal Feed; Animals; Brain; Cerebral Amyloid Angiopathy; Diet; Disease Models, Animal; Female; Homocysteine; Hyperhomocysteinemia; Male; Mice, Transgenic; Random Allocation | 2015 |
Vitamin E supplementation in chemical colorectal carcinogenesis: a two-edged knife.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Biomarkers; Carcinogenesis; Carcinogens; Cell Proliferation; Colorectal Neoplasms; Cyclooxygenase 2; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Glutathione; Homocysteine; Immunohistochemistry; Male; Multivariate Analysis; Oxidative Stress; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Recommended Dietary Allowances; Vitamin E; Weight Gain | 2014 |
Homocysteine-mediated intestinal epithelial barrier dysfunction in the rat model of irritable bowel syndrome caused by maternal separation.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Homocysteine; Intestinal Mucosa; Irritable Bowel Syndrome; Rats | 2014 |
Protective vascular and cardiac effects of inducible nitric oxide synthase in mice with hyperhomocysteinemia.
Topics: Animals; Cerebral Arteries; Diet; Disease Models, Animal; Endothelium, Vascular; Female; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Mice; Mice, Knockout; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase Type II; Phenotype; Reactive Oxygen Species; Thrombosis; Vasodilator Agents | 2014 |
[Protective effect of tanshinol on the hepatopulmonary syndrome in rat].
Topics: Alanine Transaminase; Animals; Caffeic Acids; Disease Models, Animal; Endotoxins; Hepatopulmonary Syndrome; Homocysteine; Liver; Lung; Macrophages; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2014 |
Hyperhomocysteinemia is a result, rather than a cause, of depression under chronic stress.
Topics: Animals; Behavior, Animal; Betaine-Homocysteine S-Methyltransferase; Chronic Disease; Depression; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rats, Wistar; Recombinant Proteins; Sertraline; Stress, Psychological | 2014 |
Fatty acids rehabilitated long-term neurodegenerative: like symptoms in olfactory bulbectomized rats.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Body Temperature Regulation; Brain; Cholesterol; Cytokines; Disease Models, Animal; Eating; Fatty Acids; Homocysteine; Iron; Male; Maze Learning; Motor Activity; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Olfactory Bulb; Rats, Long-Evans; Synaptosomes | 2015 |
Homocysteine promotes intestinal fibrosis in rats with trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Colitis; Collagen Type I; Collagen Type III; Colon; Cytokines; Disease Models, Animal; Ethanol; Fibrosis; Homocysteine; Hyperhomocysteinemia; Inflammation Mediators; Intestinal Mucosa; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2015 |
Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase.
Topics: Angiotensin II; Animals; Binding Sites; CCCTC-Binding Factor; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; DNA Methylation; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Hyperhomocysteinemia; Male; Mice, Inbred C57BL; Promoter Regions, Genetic; Repressor Proteins; RNA Interference; S-Adenosylmethionine; Sp1 Transcription Factor; Telomerase; Telomere; Telomere Shortening; Time Factors; Transfection; Tumor Suppressor Protein p53 | 2015 |
Homocysteine-induced attenuation of vascular endothelium-dependent hyperalgesia in the rat.
Topics: Analgesics, Non-Narcotic; Animals; Cardiovascular Agents; Disease Models, Animal; Endothelin-1; Endothelium, Vascular; Homocysteine; Hyperalgesia; Hypoxia-Ischemia, Brain; Male; Methionine; Movement; Muscle, Skeletal; Myalgia; Rats, Sprague-Dawley; Reflex Sympathetic Dystrophy; Touch; Vibration | 2015 |
Resveratrol attenuated homocysteine-induced apoptosis of rat ventricular myocytes.
Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Apoptosis; Disease Models, Animal; Heart Ventricles; Homocysteine; Myocytes, Cardiac; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes | 2014 |
Oral exposure to the anti-pyridoxine compound 1-amino D-proline further perturbs homocysteine metabolism through the transsulfuration pathway in moderately vitamin B₆ deficient rats.
Topics: Animals; Asymptomatic Diseases; Biomarkers; Cystathionine; Cystathionine gamma-Lyase; Diet; Disease Models, Animal; Disease Progression; Flax; Homocysteine; Hyperhomocysteinemia; Liver; Male; Non-alcoholic Fatty Liver Disease; Proline; Pyridoxal Phosphate; Pyridoxine; Random Allocation; Rats, Sprague-Dawley; Seeds; Vitamin B 6; Vitamin B 6 Deficiency | 2015 |
Mechanisms of hyperhomocysteinemia induced skeletal muscle myopathy after ischemia in the CBS-/+ mouse model.
Topics: Animals; Antioxidants; Blotting, Western; Cystathionine beta-Synthase; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Ischemia; Mice, Inbred C57BL; Models, Biological; Muscle, Skeletal; Muscular Diseases; Nitric Oxide Donors; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR gamma; Protein Binding; Transcription Factors; Tyrosine | 2015 |
The application of a chemical determination of N-homocysteinylation levels in developing mouse embryos: implication for folate responsive birth defects.
Topics: Animals; Congenital Abnormalities; Disease Models, Animal; Embryo, Mammalian; Embryonic Development; Female; Folic Acid; Folic Acid Deficiency; Genotyping Techniques; Homocysteine; Mice; Neural Tube; Neural Tube Defects | 2015 |
Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil-DNA glycosylase impair learning in a mouse model of vascular cognitive impairment.
Topics: Animals; Basilar Artery; Brain; Carotid Artery Diseases; Cerebrovascular Disorders; Chronic Disease; Cognition Disorders; Diet; Disease Models, Animal; Female; Folic Acid Deficiency; Glial Fibrillary Acidic Protein; Gliosis; Homocysteine; Learning Disabilities; Male; Matrix Metalloproteinase 9; Maze Learning; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Random Allocation; Uracil-DNA Glycosidase | 2015 |
Plasma thiols levels in Alzheimer's disease mice under diet-induced hyperhomocysteinemia: effect of S-adenosylmethionine and superoxide-dismutase supplementation.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Chromatography; Chromatography, High Pressure Liquid; Disease Models, Animal; Glutathione; Homocysteine; Humans; Hyperhomocysteinemia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; S-Adenosylmethionine; Sulfhydryl Compounds; Superoxide Dismutase | 2015 |
Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Blood Glucose; Cholestyramine Resin; Cholic Acid; Circadian Rhythm; Cystathionine gamma-Lyase; Diet, High-Fat; Disease Models, Animal; Ethanol; Gene Expression Regulation, Enzymologic; Glucose Intolerance; Hepatocyte Nuclear Factor 3-alpha; Homeostasis; Homocysteine; Hyperhomocysteinemia; Liver; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Time Factors; Transcriptional Activation | 2015 |
Nitrous oxide related behavioral and histopathological changes may be related to oxidative stress.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Demyelinating Diseases; Disease Models, Animal; Glutathione; Homocysteine; Hyperhomocysteinemia; Male; Motor Activity; Muscle Strength; Nitrous Oxide; Oxidative Stress; Rats, Wistar; Spinal Cord; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2015 |
Dysfunction of blood pressure regulation in hyperhomocyteinemia model in rats.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cardiovascular Diseases; Disease Models, Animal; Elastic Tissue; Epinephrine; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Oxidation-Reduction; Rats, Sprague-Dawley; Risk Factors; Thiobarbiturates | 2015 |
Fitting homocysteine to disease models, as well as adjusting the models to the disease.
Topics: Animals; Cardiovascular Diseases; Disease Models, Animal; Folic Acid; Homocysteine; Humans; Hypercholesterolemia; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Oxidative Stress; Risk Factors; Signal Transduction; Vitamin B 12 | 2015 |
MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring.
Topics: Animals; Apoptosis; Body Weight; Choline Deficiency; Choline O-Acetyltransferase; Disease Models, Animal; Female; Folic Acid Deficiency; Hippocampus; Homocysteine; Homocystinuria; Male; Maternal Nutritional Physiological Phenomena; Maze Learning; Memory Disorders; Memory, Short-Term; Methylenetetrahydrofolate Reductase (NADPH2); Mice, Transgenic; Muscle Spasticity; Neurogenesis; Organ Size; Pregnancy; Pregnancy Complications; Psychotic Disorders; Recognition, Psychology | 2015 |
The effect of subchronic supplementation with folic acid on homocysteine induced seizures.
Topics: Animals; Behavior, Animal; Brain; Brain Waves; Dietary Supplements; Disease Models, Animal; Electroencephalography; Folic Acid; Homocysteine; Male; Rats, Wistar; Seizures; Sodium-Potassium-Exchanging ATPase; Time Factors; Up-Regulation | 2015 |
High homocysteine induces betaine depletion.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Carrier Proteins; Disease Models, Animal; Female; GABA Plasma Membrane Transport Proteins; Homocysteine; Homocystinuria; Humans; Male; Mice; Mice, Transgenic; Rats; Rats, Wistar | 2015 |
Sulfur amino acids and atherosclerosis: a role for excess dietary methionine.
Topics: Amino Acids, Sulfur; Animals; Apolipoproteins E; Atherosclerosis; Biomarkers; Blood Chemical Analysis; Diet; Disease Models, Animal; Homocysteine; Metabolic Networks and Pathways; Methionine; Mice; Mice, Knockout; Plaque, Atherosclerotic; Time Factors | 2016 |
Placental NRP1 and VEGF expression in pre-eclamptic women and in a homocysteine-treated mouse model of pre-eclampsia.
Topics: Adult; Animals; Disease Models, Animal; Female; Homocysteine; Humans; Hyperhomocysteinemia; Mice; Neuropilin-1; Placenta; Pre-Eclampsia; Pregnancy; Vascular Endothelial Growth Factor A | 2016 |
Combination of hyperhomocysteinemia and ischemic tolerance in experimental model of global ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Ischemic Preconditioning; Male; Mitogen-Activated Protein Kinases; Rats, Wistar | 2015 |
Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects.
Topics: Animals; Autoantibodies; Blood Proteins; Diet; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Gestational Age; Homocysteine; Humans; Mice; Mice, Inbred C57BL; Neural Tube Defects; Pregnancy; Protein Processing, Post-Translational | 2016 |
Selenium Inhibits Homocysteine-Induced Endothelial Dysfunction and Apoptosis via Activation of AKT.
Topics: Animals; Apoptosis; Cell Movement; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Gene Expression Regulation; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Male; Methionine; Proto-Oncogene Proteins c-akt; Rats; Selenium | 2016 |
Ratio of S-adenosylmethionine to S-adenosylhomocysteine as a sensitive indicator of atherosclerosis.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Biomarkers; Chemokine CCL2; Disease Models, Animal; DNA Methylation; Fatty Acid-Binding Proteins; Homocysteine; Interspersed Repetitive Sequences; Male; Mice; Mice, Knockout; Plaque, Atherosclerotic; S-Adenosylhomocysteine; S-Adenosylmethionine; Superoxide Dismutase | 2016 |
Folic Acid Supplementation Adversely Affects Chemosensitivity of Colon Cancer Cells to 5-fluorouracil.
Topics: Animals; Cell Proliferation; Colonic Neoplasms; Dietary Supplements; Disease Models, Animal; Drug Interactions; Epithelial Cells; Fluorouracil; Folic Acid; Gene Expression Regulation, Neoplastic; HCT116 Cells; Homocysteine; Humans; Male; Mice; Mice, Nude; Multidrug Resistance-Associated Proteins; Xenograft Model Antitumor Assays | 2016 |
Berberine activates peroxisome proliferator-activated receptor gamma to increase atherosclerotic plaque stability in Apoe
Topics: Animals; Apolipoproteins E; Berberine; Carotid Arteries; Cell Survival; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Homocysteine; Hyperhomocysteinemia; Male; Mice; Mice, Knockout; Oxidative Stress; Plaque, Atherosclerotic; PPAR gamma | 2016 |
Impact of Dyrk1A level on alcohol metabolism.
Topics: Alanine Transaminase; Animals; Aryldialkylphosphatase; Cystathionine beta-Synthase; Disease Models, Animal; Dyrk Kinases; Ethanol; Female; Homocysteine; Humans; Hyperhomocysteinemia; Liver; Liver Diseases, Alcoholic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; NAD(P)H Dehydrogenase (Quinone); Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Triglycerides; Up-Regulation | 2016 |
L-DOPA treatment in MPTP-mouse model of Parkinson's disease potentiates homocysteine accumulation in substantia nigra.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Homocysteine; Levodopa; Male; Mice; Motor Activity; Parkinsonian Disorders; Substantia Nigra; Tyrosine 3-Monooxygenase | 2016 |
Lack of global epigenetic methylation defects in CBS deficient mice.
Topics: Animals; Cystathionine beta-Synthase; Disease Models, Animal; DNA; DNA Methylation; Epigenesis, Genetic; Epigenomics; Homocysteine; Homocystinuria; Kidney; Liver; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine | 2017 |
Multi-Vitamin B Supplementation Reverses Hypoxia-Induced Tau Hyperphosphorylation and Improves Memory Function in Adult Mice.
Topics: Animals; Avoidance Learning; Cerebral Cortex; Choline; Dietary Supplements; Disease Models, Animal; Folic Acid; Glycogen Synthase Kinase 3 beta; Hippocampus; Homocysteine; Hypoxia; Male; Maze Learning; Memory; Memory Disorders; Mice; Phosphorylation; tau Proteins; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2016 |
Targeting therapy for homocysteic acid in the blood represents a potential recovery treatment for cognition in Alzheimer's disease patients.
Topics: Alzheimer Disease; Animals; Antibodies; Cognition Disorders; Disease Models, Animal; Homocysteine; Mice | 2016 |
Oxidative stress and mitochondrial dysfunction are the underlying events of dopaminergic neurodegeneration in homocysteine rat model of Parkinson's disease.
Topics: Animals; Antioxidants; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Electron Transport Complex I; Homocysteine; Male; Mitochondria; Oxidative Stress; Parkinson Disease; Rats, Sprague-Dawley | 2016 |
Therapeutic Potential of Progranulin in Hyperhomocysteinemia-Induced Cardiorenal Dysfunction.
Topics: Animals; Cardio-Renal Syndrome; Disease Models, Animal; Echocardiography; Granulins; Homocysteine; Hyperhomocysteinemia; Intercellular Signaling Peptides and Proteins; Kidney Glomerulus; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Progranulins; Recombinant Proteins | 2017 |
Hydrogen Sulfide Ameliorates Homocysteine-Induced Cognitive Dysfunction by Inhibition of Reactive Aldehydes Involving Upregulation of ALDH2.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Aldehydes; Animals; Cognition Disorders; Disease Models, Animal; Gasotransmitters; Glutathione; Hippocampus; Homocysteine; Hydrogen Sulfide; Injections, Intraventricular; Male; Maze Learning; Quinolines; Rats; Rats, Sprague-Dawley; Recognition, Psychology; Spatial Navigation; Thiazolidinediones; Up-Regulation | 2017 |
Increased homocysteine levels impair reference memory and reduce cortical levels of acetylcholine in a mouse model of vascular cognitive impairment.
Topics: Acetylcholine; Animals; Cerebral Cortex; Dementia, Vascular; Disease Models, Animal; Female; Folic Acid Deficiency; Homocysteine; Male; Memory; Methylenetetrahydrofolate Reductase (NADPH2); Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neovascularization, Pathologic; Random Allocation | 2017 |
A disrupted transsulphuration pathway results in accumulation of redox metabolites and induction of gametocytogenesis in malaria.
Topics: Animals; Culture Media; Cystathionine; Cysteine; Disease Models, Animal; Erythrocytes; Glutathione; Homocysteine; Humans; Malaria; Mass Spectrometry; Metabolic Networks and Pathways; Mice; Oxidation-Reduction; Plasmodium falciparum; Protozoan Proteins; Sulfur; Transcription Factors; Transcriptional Activation | 2017 |
Role of homocysteine and folic acid on the altered calcium homeostasis of platelets from rats with biliary cirrhosis.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Bile Ducts; Blood Platelets; Calcium; Calcium Signaling; Cholestasis; Disease Models, Animal; Folic Acid; Homocysteine; Ligation; Liver Cirrhosis, Biliary; Male; Platelet Aggregation; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Thrombin | 2017 |
Contribution of guanine nucleotide exchange factor Vav2 to NLRP3 inflammasome activation in mouse podocytes during hyperhomocysteinemia.
Topics: Animals; CARD Signaling Adaptor Proteins; Disease Models, Animal; Homocysteine; Humans; Hyperhomocysteinemia; Inflammasomes; Kidney Glomerulus; Mice; Neuropeptides; NLR Family, Pyrin Domain-Containing 3 Protein; Podocytes; Proto-Oncogene Proteins c-vav; rac1 GTP-Binding Protein; Reactive Oxygen Species; RNA, Small Interfering | 2017 |
Intrauterine valproate exposure is associated with alterations in hippocampal cell numbers and folate metabolism in a rat model of valproate teratogenicity.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Astrocytes; Cell Count; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Female; Folic Acid; Hippocampus; Homocysteine; Liver; Male; Neurogenesis; Neurons; Organ Size; Rats, Wistar; Valproic Acid | 2017 |
Effects of hyperhomocysteinemia on non-adrenergic non-cholinergic relaxation in isolated rat duodenum.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Disease Models, Animal; Duodenum; Electric Stimulation; Enteric Nervous System; Enzyme Inhibitors; Epinephrine; gamma-Aminobutyric Acid; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Sulfathiazoles | 2008 |
GABAA receptor agonist mitigates homocysteine-induced cerebrovascular remodeling in knockout mice.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Cerebral Arteries; Cerebrovascular Circulation; Coloring Agents; Dementia, Vascular; Disease Models, Animal; Down-Regulation; Evans Blue; Extracellular Matrix Proteins; Female; GABA Agonists; GABA-A Receptor Agonists; Homocysteine; Homocystinuria; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscimol; Receptors, GABA-A; Up-Regulation | 2008 |
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.
Topics: Amidohydrolases; Animals; Arginine; Carotid Arteries; Cell Line; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; RNA, Messenger; Vasodilation; Vasodilator Agents | 2008 |
Effects of red wine polyphenolic compounds on paraoxonase-1 and lectin-like oxidized low-density lipoprotein receptor-1 in hyperhomocysteinemic mice.
Topics: Animals; Antioxidants; Aorta; Aryldialkylphosphatase; Biomarkers; Caffeic Acids; Cystathionine beta-Synthase; Disease Models, Animal; Female; Flavonoids; Gene Expression Regulation, Enzymologic; Heterozygote; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Phenols; Polyphenols; Receptors, Oxidized LDL; Wine | 2009 |
Role of copper and homocysteine in pressure overload heart failure.
Topics: Animals; Aorta; Blood Pressure; Blotting, Western; Cardiomyopathy, Dilated; Constriction; Copper; Dietary Supplements; Disease Models, Animal; Echocardiography; Electrocardiography; Endothelium, Vascular; Female; Fibrosis; Heart Failure; Hemodynamics; Homocysteine; Hypertrophy, Left Ventricular; Male; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Myocardium; Protein-Lysine 6-Oxidase; Tissue Inhibitor of Metalloproteinases; Ventricular Remodeling | 2008 |
Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2-dependent cyclin E expression.
Topics: Adult Stem Cells; Aged; Aged, 80 and over; Animals; Cell Proliferation; Cells, Cultured; Cognition Disorders; Cyclin E; Dementia; Dentate Gyrus; Disease Models, Animal; Fibroblast Growth Factor 2; Folic Acid; Gene Expression Regulation; Homocysteine; Humans; Hyperhomocysteinemia; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurodegenerative Diseases; Neurons; Trigeminal Caudal Nucleus | 2008 |
Methionine metabolism in an animal model of sepsis.
Topics: Animals; Cysteine; Disease Models, Animal; Glutathione; Homocysteine; Lipopolysaccharides; Male; Methionine; Oxidation-Reduction; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Sepsis | 2008 |
Contribution of guanine nucleotide exchange factor Vav2 to hyperhomocysteinemic glomerulosclerosis in rats.
Topics: Animals; Disease Models, Animal; Extracellular Matrix; Folic Acid; Homocysteine; Hyperhomocysteinemia; Kidney Failure, Chronic; Kidney Glomerulus; Matrix Metalloproteinases; NADPH Oxidases; Oxidative Stress; Proto-Oncogene Proteins c-vav; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; RNA; Sclerosis; Superoxides; Tissue Inhibitor of Metalloproteinase-1; Transfection | 2009 |
Experimental folate and vitamin B12 deficiency does not alter bone quality in rats.
Topics: Animals; Biomarkers; Biomechanical Phenomena; Body Weight; Bone and Bones; Bone Remodeling; Disease Models, Animal; Female; Folic Acid Deficiency; Homocysteine; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12 Deficiency | 2009 |
Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-beta-synthase mutant mouse.
Topics: Animals; Apoptosis; Chromatography, High Pressure Liquid; Cystathionine beta-Synthase; Disease Models, Animal; Female; Fluorescent Antibody Technique, Indirect; Gene Expression; Glutathione; Homocysteine; Hyperhomocysteinemia; Male; Mice; Mice, Knockout; Microarray Analysis; Mutation; Retinal Diseases; Retinal Ganglion Cells | 2009 |
High dietary taurine reduces apoptosis and atherosclerosis in the left main coronary artery: association with reduced CCAAT/enhancer binding protein homologous protein and total plasma homocysteine but not lipidemia.
Topics: Analysis of Variance; Animals; Apoptosis; CCAAT-Binding Factor; Coronary Artery Disease; Diet, Atherogenic; Dietary Supplements; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Hyperlipidemias; Male; Methionine; Nitric Oxide; Oxidative Stress; Probability; Rabbits; Random Allocation; Reference Values; Sensitivity and Specificity; Taurine | 2009 |
Ischemia-reperfusion reduces cystathionine-beta-synthase-mediated hydrogen sulfide generation in the kidney.
Topics: Animals; Apoptosis; Cyclic N-Oxides; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Models, Animal; Free Radical Scavengers; Homeostasis; Homocysteine; Hydrogen Sulfide; Imidazoles; Kidney; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2009 |
Hydrogen sulfide ameliorates hyperhomocysteinemia-associated chronic renal failure.
Topics: Animals; Antioxidants; Apoptosis; Cystathionine beta-Synthase; Desmin; Disease Models, Animal; Glutathione; Glutathione Disulfide; Homocysteine; Hydrogen Sulfide; Hyperhomocysteinemia; Kidney; Kidney Failure, Chronic; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nephrectomy; Oxidative Stress; Proteinuria; Sulfides; Superoxides | 2009 |
Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice.
Topics: Animals; Apolipoproteins B; Atherosclerosis; Cholesterol; Cholesterol Esters; Disease Models, Animal; Female; Homocysteine; Kinetics; Lipoproteins, IDL; Lipoproteins, LDL; Lipoproteins, VLDL; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Receptors, LDL; Triglycerides | 2009 |
Induction of hepatic cyclooxygenase-2 by hyperhomocysteinemia via nuclear factor-kappaB activation.
Topics: Animals; Antioxidants; Cell Nucleus; Cyclic N-Oxides; Cyclooxygenase 2; Disease Models, Animal; Enzyme Induction; Hepatitis; Homocysteine; Hyperhomocysteinemia; I-kappa B Proteins; Liver; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidative Stress; Phosphorylation; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spin Labels; Superoxides; Thiocarbamates; Time Factors | 2009 |
Evaluation of the impacts of homocysteine and hypoxia on vascular endothelial function based on the profiling of neuro-endocrine-immunity network in rats.
Topics: Animals; Disease Models, Animal; Endocrine System; Endothelium, Vascular; Homocysteine; Humans; Hypoxia; Immune System; Male; Neurotransmitter Agents; Rats; Rats, Wistar | 2009 |
Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitis.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cells, Cultured; Choline Deficiency; Dietary Supplements; Disease Models, Animal; Fatty Liver; Female; Homocysteine; Liver; Liver Neoplasms; Methionine; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylmethionine; Unfolded Protein Response | 2009 |
One-carbon metabolism-genome interactions in folate-associated pathologies.
Topics: Animals; Carbon; Child; Developmental Disabilities; Disease Models, Animal; Environment; Folic Acid; Gastrointestinal Neoplasms; Genetic Phenomena; Genome, Human; Homocysteine; Humans; Methionine; Mice; Neural Tube Defects; Purines; Risk Factors; Thymidine Monophosphate | 2009 |
Sustained deficiency of mitochondrial complex I activity during long periods of survival after seizures induced in immature rats by homocysteic acid.
Topics: Aldehydes; Animals; Animals, Newborn; Cerebral Cortex; Convulsants; Disease Models, Animal; Down-Regulation; Electron Transport Complex I; Energy Metabolism; Epilepsy; Excitatory Amino Acid Agonists; Free Radical Scavengers; Homocysteine; Male; Metabolic Networks and Pathways; Mitochondria; Mitochondrial Diseases; Oxidative Stress; Rats; Rats, Wistar; Seizures; Survival Rate; Time Factors; Tyrosine | 2010 |
Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Brain; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Down-Regulation; Female; Food, Formulated; Glycogen Synthase Kinase 3; Homocysteine; Hyperhomocysteinemia; Mice; Mice, Transgenic; Plaque, Amyloid; Serine | 2010 |
Heparin inhibits the production of matrix metalloproteinase-2 and improves atherosclerosis in LDL receptor-deficient mice.
Topics: Animals; Aorta; Atherosclerosis; Biomarkers; Body Weight; Cardiovascular Agents; Cholesterol; Cholesterol, HDL; Disease Models, Animal; Eating; Heparin; Homocysteine; Immunohistochemistry; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, LDL; Triglycerides | 2010 |
Homocysteine potentiates seizures and cell loss induced by pilocarpine treatment.
Topics: Amyloid beta-Peptides; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lobe; Fluoresceins; Hippocampus; Homocysteine; Humans; Male; Nerve Degeneration; Organic Chemicals; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2010 |
Moderate or supranormal folic acid supplementation does not exert a protective effect for homocysteinemia and methylation markers in growing rats.
Topics: Analysis of Variance; Animals; Biomarkers; Chromatography, High Pressure Liquid; Diet; Dietary Supplements; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Glutathione; Homocysteine; Male; Methionine; Rats; Rats, Sprague-Dawley; Vitamin B Complex | 2010 |
Nephroprotective effect of telmisartan in rats with ischemia/reperfusion renal injury.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Benzimidazoles; Benzoates; Blood Pressure; Blood Urea Nitrogen; Caspase 3; Catalase; Creatinine; Disease Models, Animal; Glutathione; Homocysteine; Kidney; Kidney Diseases; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Telmisartan; Tumor Necrosis Factor-alpha | 2010 |
Homocysteine enriched diet leads to prolonged QT interval and reduced left ventricular performance in telemetric monitored mice.
Topics: Animals; Arrhythmias, Cardiac; Cardiovascular Diseases; Connexins; Diet; Disease Models, Animal; Echocardiography; Heart Ventricles; Homocysteine; Hyperhomocysteinemia; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Neural Conduction; Random Allocation; Telemetry; Ventricular Dysfunction, Left; Ventricular Remodeling | 2011 |
Intrathecal methotrexate induces focal cognitive deficits and increases cerebrospinal fluid homocysteine.
Topics: Animals; Antimetabolites, Antineoplastic; Behavior, Animal; Cisterna Magna; Cognition Disorders; Disease Models, Animal; Folic Acid; Folic Acid Antagonists; Homocysteine; Inflammation Mediators; Injections, Spinal; Male; Memory Disorders; Methotrexate; Motor Activity; Neuropsychological Tests; Psychomotor Performance; Rats; Rats, Long-Evans; Recognition, Psychology; Time Factors | 2010 |
Decreased level of 5-methyltetrahydrofolate: a potential biomarker for pre-symptomatic amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Chromatography, Liquid; Disease Models, Animal; Folic Acid; Gene Expression Regulation; Homocysteine; Humans; Mice; Mice, Transgenic; Severity of Illness Index; Statistics as Topic; Superoxide Dismutase; Tandem Mass Spectrometry; Tetrahydrofolates; Time Factors | 2010 |
Ameliorative role of rosiglitazone in hyperhomocysteinemia-induced experimental cardiac hypertrophy.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Homocysteine; Hyperhomocysteinemia; Hypertrophy, Left Ventricular; Male; Methionine; Oxidative Stress; PPAR gamma; Rats; Rats, Wistar; Rosiglitazone; Thiazolidinediones | 2010 |
Chinese yellow wine and red wine inhibit matrix metalloproteinase-2 and improve atherosclerotic plaque in LDL receptor knockout mice.
Topics: Alanine Transaminase; Animals; Aortic Diseases; Aspartate Aminotransferases; Atherosclerosis; Biomarkers; China; Disease Models, Animal; Enzyme Activation; Homocysteine; Lipids; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Protease Inhibitors; Receptors, LDL; Wine | 2010 |
Increased inflammatory markers in brain and blood of rats subjected to acute homocysteine administration.
Topics: Animals; Biomarkers; Blood Proteins; Brain; C-Reactive Protein; Cerebral Cortex; Chemokines; Cytokines; Disease Models, Animal; Drug Administration Schedule; Glycoproteins; Hippocampus; Homocysteine; Hyperhomocysteinemia; Inflammation Mediators; Leukocyte Count; Orosomucoid; Rats; Rats, Wistar | 2010 |
Dorsal raphe nucleus regulation of a panic-like defensive behavior evoked by chemical stimulation of the rat dorsal periaqueductal gray matter.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Disease Models, Animal; Escape Reaction; Homocysteine; Kainic Acid; Male; Molsidomine; Panic Disorder; Periaqueductal Gray; Piperazines; Pyridines; Raphe Nuclei; Rats; Rats, Wistar; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists | 2010 |
Cysteinemia, rather than homocysteinemia, is associated with plasma apolipoprotein A-I levels in hyperhomocysteinemia: lipid metabolism in cystathionine beta-synthase deficiency.
Topics: Administration, Oral; Animals; Apolipoprotein A-I; Beverages; Biomarkers; Blood Glucose; Cholesterol, HDL; Cysteine; Disease Models, Animal; Glycine; Homocysteine; Homocystinuria; Hyperhomocysteinemia; Lipid Metabolism; Liver; Male; Mice; Mice, Knockout; RNA, Messenger; Spain; Triglycerides | 2010 |
Curcumin exerts neuroprotective effects against homocysteine intracerebroventricular injection-induced cognitive impairment and oxidative stress in rat brain.
Topics: Animals; Brain; Cognition Disorders; Curcumin; Disease Models, Animal; Homocysteine; Humans; Infusions, Intraventricular; Learning; Male; Memory; Motor Activity; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar | 2010 |
Aging and antioxidants modulate rat brain levels of homocysteine and dehydroepiandrosterone sulphate (DHEA-S): implications in the pathogenesis of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Brain; Dehydroepiandrosterone Sulfate; Disease Models, Animal; Homocysteine; Rats; Rats, Wistar | 2010 |
Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/Akt/endothelial nitric oxide synthase signalling.
Topics: Animals; Aorta, Thoracic; Blotting, Western; Cell Culture Techniques; Cell Line; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Nitric Oxide; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Vasodilation | 2010 |
Mesenteric vascular remodeling in hyperhomocysteinemia.
Topics: Abdominal Pain; Amidohydrolases; Animals; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blotting, Western; Connexins; Cystathionine beta-Synthase; Disease Models, Animal; Elasticity; Elastin; Extracellular Matrix Proteins; Fluorescent Antibody Technique; Gap Junction alpha-5 Protein; Homocysteine; Hyperhomocysteinemia; Hypertension; Male; Matrix Metalloproteinase 9; Mesenteric Artery, Superior; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Microscopy, Video; Nitric Oxide Synthase Type III; Nitrites; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Splanchnic Circulation; Telemetry; Vascular Resistance | 2011 |
Homocysteine induces oxidative-nitrative stress in heart of rats: prevention by folic acid.
Topics: Animals; Antioxidants; Catalase; Disease Models, Animal; Female; Fluoresceins; Folic Acid; Heart Diseases; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Male; Myocardium; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Reactive Nitrogen Species; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2011 |
Hyperhomocysteinemia does not affect global DNA methylation and nicotinamide N-methyltransferase expression in mice.
Topics: Animals; Brain; Disease Models, Animal; DNA Methylation; Gene Expression Regulation, Enzymologic; Homocysteine; Hyperhomocysteinemia; Leukocytes; Mice; Mice, Inbred ICR; Nicotinamide N-Methyltransferase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2011 |
Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia.
Topics: Alanine Transaminase; AMP-Activated Protein Kinases; Animals; Aspartate Aminotransferases; Berberine; Cholesterol; Disease Models, Animal; Enzyme Activation; Hep G2 Cells; Homocysteine; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperhomocysteinemia; Liver; Male; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, LDL; Time Factors; Up-Regulation | 2011 |
Modulatory effects of vitamin E, acetyl-L-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.
Topics: Alzheimer Disease; Animals; Antioxidants; Biomarkers; Brain; Carnitine; Cholinesterase Inhibitors; Dietary Supplements; Disease Models, Animal; Donepezil; Enzyme-Linked Immunosorbent Assay; Homocysteine; Indans; Insulin-Like Growth Factor I; Interleukin-1beta; Male; Piperidines; Rats; Rats, Sprague-Dawley; Thioctic Acid; Tumor Necrosis Factor-alpha; Vitamin E | 2012 |
Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria.
Topics: Animals; Blotting, Western; Case-Control Studies; Disease Models, Animal; Fatty Liver; Homocysteine; Homocystinuria; Liver Regeneration; Mice; Phospholipids; Spectrometry, Mass, Electrospray Ionization; Triglycerides | 2011 |
Hyperhomocysteinemia decreases bone blood flow.
Topics: Animals; Biomarkers; Biomechanical Phenomena; Blood Pressure; Bone Density; Bone Remodeling; Disease Models, Animal; Folic Acid; Homocysteine; Hyperhomocysteinemia; Laser-Doppler Flowmetry; Male; Osteoporosis; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Tibia; Time Factors; Up-Regulation; Vitamin B 12 | 2011 |
Early reduction of circulating homocysteine levels in Goto-Kakizaki rat, a spontaneous nonobese model of type 2 diabetes.
Topics: Age Factors; Animals; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Glutathione; Homocysteine; Insulin Resistance; Male; Rats; Rats, Wistar | 2011 |
Hyperhomocysteinemia inhibited cardiac stem cell homing into the peri-infarcted area post myocardial infarction in rats.
Topics: Animals; Animals, Newborn; Blotting, Western; Cell Movement; Cells, Cultured; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Homocysteine; Hyperhomocysteinemia; Immunohistochemistry; Male; Methionine; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Stem Cell Factor; Stem Cells | 2011 |
Homocysteine-mediated modulation of mitochondrial dynamics in retinal ganglion cells.
Topics: Animals; Animals, Newborn; Axons; Caspase 3; Cells, Cultured; Disease Models, Animal; DNA Primers; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique, Indirect; GTP Phosphohydrolases; Homocysteine; Hyperhomocysteinemia; Immunoenzyme Techniques; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial Proteins; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
Development of an animal model for chronic mild hyperhomocysteinemia and its response to oxidative damage.
Topics: Animals; Antioxidants; Catalase; Cerebral Cortex; Disease Models, Animal; Glutathione Peroxidase; Homocysteine; Humans; Hyperhomocysteinemia; Nitrites; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2011 |
Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist.
Topics: Animals; Cognition Disorders; Dextromethorphan; Disease Models, Animal; Excitatory Amino Acid Antagonists; Folic Acid; Glutamic Acid; Homocysteine; Humans; Injections, Spinal; Male; Memory Disorders; Methotrexate; Rats; Rats, Long-Evans; Recognition, Psychology | 2011 |
The effects of hyperhomocysteinemia on the microcirculation of skin flaps.
Topics: Animals; Disease Models, Animal; Graft Survival; Homocysteine; Hyperhomocysteinemia; Male; Microcirculation; Microvessels; Necrosis; Rats; Rats, Sprague-Dawley; Surgical Flaps | 2011 |
Acetyl-L-carnitine attenuates homocysteine-induced Alzheimer-like histopathological and behavioral abnormalities.
Topics: Acetylcarnitine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Brain; Disease Models, Animal; Hippocampus; Homocysteine; Male; Maze Learning; Phosphorylation; Rats; Rats, Sprague-Dawley; Silver Staining; tau Proteins | 2011 |
Brain superoxide anion formation in immature rats during seizures: protection by selected compounds.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Homocysteine; Infusions, Intraventricular; Male; Metalloporphyrins; Proline; Rats; Rats, Wistar; Seizures; Statistics, Nonparametric; Superoxides; Time Factors | 2012 |
[Protective effects and its mechanism on neural cells after folic acid intervention in preeclampsia rat model].
Topics: Animals; Apoptosis; Disease Models, Animal; Female; Folic Acid; Homocysteine; Male; Neurons; Neuroprotective Agents; NF-kappa B; Pre-Eclampsia; Pregnancy; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Sodium Glutamate | 2011 |
Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Blood Coagulation; Cystathionine beta-Synthase; Diet; Dietary Supplements; Disease Models, Animal; Homocysteine; Homocystinuria; Interleukin-1beta; Male; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Thrombosis; Tumor Necrosis Factor-alpha | 2012 |
Age-related changes in visual function in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia.
Topics: Aging; Animals; Cystathionine beta-Synthase; Dark Adaptation; Disease Models, Animal; Electroretinography; Evoked Potentials, Visual; Homocysteine; Hyperhomocysteinemia; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Retina; Retinal Pigment Epithelium; Visual Acuity; Visual Cortex | 2012 |
Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress.
Topics: Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Gene Expression Regulation; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Male; MAP Kinase Signaling System; Mice; Myocardial Contraction; Myocytes, Cardiac; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Reactive Oxygen Species; Thioredoxins | 2012 |
Folic acid increases global DNA methylation and reduces inflammation to prevent Helicobacter-associated gastric cancer in mice.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Disease Models, Animal; DNA Methylation; Folic Acid; Gastric Mucosa; Gastrins; Gastritis; Gene Expression Profiling; Gene Expression Regulation; Helicobacter felis; Helicobacter Infections; Homocysteine; Immunohistochemistry; Lymphocytes; Male; Mice; Mice, Transgenic; Myofibroblasts; Stomach; Stomach Neoplasms; Stromal Cells; Up-Regulation | 2012 |
Estrogen replacement attenuates exaggerated neointimal hyperplasia following carotid endarterectomy in rats.
Topics: Angioplasty; Animals; Biomarkers; Carotid Artery Injuries; Carotid Artery, Common; Carotid Stenosis; Disease Models, Animal; Endarterectomy, Carotid; Estradiol; Estrogen Replacement Therapy; Female; Homocysteine; Hyperhomocysteinemia; Hyperplasia; Infusion Pumps, Implantable; Jugular Veins; Ovariectomy; Rats; Rats, Sprague-Dawley; Time Factors; Tunica Intima | 2011 |
Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice.
Topics: Aminohydrolases; Animals; Choline; Choline Deficiency; Crosses, Genetic; Disease Models, Animal; Embryo Loss; Female; Fetal Growth Retardation; Folic Acid; Folic Acid Deficiency; Formate-Tetrahydrofolate Ligase; Genes, Lethal; Heterozygote; Homocysteine; Hypoxanthine; Maternal Nutritional Physiological Phenomena; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Mutant Strains; Multienzyme Complexes; Mutagenesis, Insertional; Neural Tube Defects; Pregnancy | 2012 |
Curcumin has neuroprotection effect on homocysteine rat model of Parkinson.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Brain; Curcumin; Disease Models, Animal; Drug Interactions; Homocysteine; Male; Neuroprotective Agents; Parkinsonian Disorders; Rats; Rats, Wistar | 2012 |
Homocysteine has anti-inflammatory properties in a hypercholesterolemic rat model in vivo.
Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Disease Models, Animal; Homocysteine; Hypercholesterolemia; Immunohistochemistry; Inflammation; Learning; Male; Memory Disorders; Rats; Rats, Sprague-Dawley | 2012 |
Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia.
Topics: Animals; Annexin A2; Blood Coagulation; Bone Marrow Transplantation; Disease Models, Animal; Fibrinolysin; Fibrinolysis; Homocysteine; Hyperhomocysteinemia; Leukemia, Promyelocytic, Acute; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Recombinant Proteins; Tissue Plasminogen Activator | 2012 |
Evidence that AKT and GSK-3β pathway are involved in acute hyperhomocysteinemia.
Topics: Animals; Cell Nucleus; Cytosol; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Homocysteine; Hyperhomocysteinemia; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; tau Proteins; Time Factors | 2012 |
High intake of folic acid or complex of B vitamins provides anti-Parkinsonism effect: no role for serum level of homocysteine.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Area Under Curve; Disease Models, Animal; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Folic Acid; Homocysteine; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Statistics, Nonparametric; Stereotyped Behavior; Vitamin B Complex | 2012 |
Altered expression of apoA-I, apoA-IV and PON-1 activity in CBS deficient homocystinuria in the presence and absence of treatment: possible implications for cardiovascular outcomes.
Topics: Adolescent; Adult; Animals; Apolipoprotein A-I; Apolipoproteins A; Aryldialkylphosphatase; Betaine; Brain; Carboxylic Ester Hydrolases; Child; Child, Preschool; Dietary Supplements; Disease Models, Animal; Homocysteine; Homocystinuria; Humans; Lipotropic Agents; Liver; Male; Mice; Mice, Knockout; Young Adult | 2012 |
Protective role of methionine sulfoxide reductase A against ischemia/reperfusion injury in mouse kidney and its involvement in the regulation of trans-sulfuration pathway.
Topics: Animals; Antigens, Ly; Disease Models, Animal; Enzyme Activation; Gene Deletion; Gene Expression Regulation; Homocysteine; Hydrogen Sulfide; Inflammation; Kidney; Male; Methionine Sulfoxide Reductases; Mice; Mice, Knockout; Oxidative Stress; Reperfusion Injury | 2013 |
Low carbohydrate, high protein diet promotes atherosclerosis in apolipoprotein E/low-density lipoprotein receptor double knockout mice (apoE/LDLR(-/-)).
Topics: Adiponectin; Animals; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Biomarkers; Brachiocephalic Trunk; Cholesterol, Dietary; Diet, Atherogenic; Diet, Carbohydrate-Restricted; Diet, High-Fat; Dietary Proteins; Disease Models, Animal; Disease Progression; Female; Homocysteine; Mice; Mice, Knockout; Plaque, Atherosclerotic; Receptors, LDL; Risk Factors; Rupture, Spontaneous; Triglycerides | 2012 |
Chronic vascular risk factors (cholesterol, homocysteine, ethanol) impair spatial memory, decline cholinergic neurons and induce blood-brain barrier leakage in rats in vivo.
Topics: Animals; Blood-Brain Barrier; Cholesterol; Cholinergic Neurons; Dietary Supplements; Disease Models, Animal; Ethanol; Homocysteine; Hypercholesterolemia; Hyperhomocysteinemia; Inflammation; Male; Maze Learning; Memory Disorders; Rats; Rats, Sprague-Dawley; Risk Factors; Space Perception; Time Factors | 2012 |
[Concentration increase in Hcy and anti-CCP antibody in the serum of depression rat model induced by chronic unpredictable mild stress].
Topics: Animals; Autoantibodies; Depression; Disease Models, Animal; Fluoxetine; Homocysteine; Male; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Stress, Physiological | 2012 |
Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine.
Topics: Alzheimer Disease; Animals; Betaine; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Lipotropic Agents; Male; Memory Disorders; Rats; Rats, Sprague-Dawley | 2013 |
Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.
Topics: Animals; Biomarkers; Choline; Cysteine; Disease Models, Animal; Folic Acid Deficiency; Heterozygote; Homocysteine; Isoenzymes; Liver; Male; Methionine; Methylation; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mutagenesis, Insertional; Mutant Proteins; Random Allocation | 2013 |
Alterations of retinal vasculature in cystathionine-Beta-synthase mutant mice, a model of hyperhomocysteinemia.
Topics: Animals; Blood-Retinal Barrier; Capillary Permeability; Cystathionine beta-Synthase; Disease Models, Animal; Fluorescein Angiography; Fundus Oculi; Gene Expression Regulation; Homocysteine; Hyperhomocysteinemia; Immunohistochemistry; Mice; Mice, Mutant Strains; Microscopy, Fluorescence; Retina; Retinal Diseases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factor A | 2013 |
Dynamics of the enzymatic antioxidants during experimental caprine coccidiosis.
Topics: Animals; Antioxidants; Coccidiosis; Disease Models, Animal; Eimeria; Enzymes; Goat Diseases; Goats; Homocysteine; Malondialdehyde; Serum; Time Factors | 2013 |
Homocysteine and cardiovascular disease in diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Disease Models, Animal; Female; Homocysteine; Hyperhomocysteinemia; Male; Nitric Oxide; Rabbits; Rats; Rats, Inbred Strains; Risk Factors; Sensitivity and Specificity; Severity of Illness Index | 2002 |
The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr.
Topics: 5' Flanking Region; Animals; Cholates; Disease Models, Animal; Folic Acid; Homocysteine; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors | 2002 |
Increased monocyte adhesion to aortic endothelium in rats with hyperhomocysteinemia: role of chemokine and adhesion molecules.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Cell Adhesion Molecules; Chemokine CCL2; Chemokines; Diet; Disease Models, Animal; E-Selectin; Endothelium, Vascular; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Macrophages; Male; Monocytes; Rats; Rats, Sprague-Dawley; Tissue Adhesions; Vascular Cell Adhesion Molecule-1 | 2002 |
Chemical and biomechanical characterization of hyperhomocysteinemic bone disease in an animal model.
Topics: Animals; Blood Chemical Analysis; Bone and Bones; Bone Density; Bone Development; Bone Diseases; Bone Matrix; Chickens; Diet; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Radiography; Tibia | 2003 |
Will caloric restriction and folate protect against AD and PD?
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Animals; Brain; Brain-Derived Neurotrophic Factor; Caloric Restriction; Disease Models, Animal; Energy Intake; Folic Acid; Homocysteine; Humans; Middle Aged; Neurons; Oxidative Stress; Parkinson Disease; Rats; Risk Factors | 2003 |
Seizures induced by homocysteic acid in immature rats are prevented by group III metabotropic glutamate receptoragonist (R,S)-4-phosphonophenylglycine.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroencephalography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Frontal Lobe; Glucose; Glycine; Hippocampus; Homocysteine; Injections, Intraventricular; Male; Phosphoserine; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures | 2003 |
Impairment of energy metabolism in hippocampus of rats subjected to chemically-induced hyperhomocysteinemia.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Disease Models, Animal; Electron Transport Complex IV; Energy Metabolism; Glucose; Hippocampus; Homocysteine; Hyperhomocysteinemia; Rats; Rats, Wistar; Succinate Dehydrogenase | 2003 |
Homocysteine and folate deficiency sensitize oligodendrocytes to the cell death-promoting effects of a presenilin-1 mutation and amyloid beta-peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cell Death; Cells, Cultured; Disease Models, Animal; DNA Damage; Enzyme Inhibitors; Folic Acid Deficiency; Homocysteine; Membrane Proteins; Mice; Mice, Mutant Strains; Mutation; Nerve Fibers, Myelinated; Oligodendroglia; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Presenilin-1; Tumor Suppressor Protein p53; Up-Regulation | 2003 |
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice.
Topics: Animals; Betaine; Central Nervous System Depressants; Disease Models, Animal; Endoplasmic Reticulum; Ethanol; Fatty Liver, Alcoholic; Gastrointestinal Agents; Gene Expression; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Methylation; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis | 2003 |
Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons.
Topics: Animals; Apoptosis; Cell Nucleus; Cell Survival; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; DNA; DNA Damage; DNA-Binding Proteins; Glutathione; Homocysteine; Huntington Disease; Male; Mice; Mice, Transgenic; Neurons; Nitro Compounds; Oxidants; Oxidative Stress; Propionates; Rats; Rats, Sprague-Dawley; Response Elements; Sp1 Transcription Factor; Sp3 Transcription Factor; Transcription Factors; Transfection; Zinc Fingers | 2003 |
Brain energy metabolism is compromised by the metabolites accumulating in homocystinuria.
Topics: Animals; Brain; Carbon Dioxide; Disease Models, Animal; Electron Transport Complex IV; Energy Metabolism; Glucose; Hippocampus; Homocysteine; Homocystinuria; Methionine; Rats; Rats, Wistar | 2003 |
Intimal hyperplasia following carotid endarterectomy in an insulin-resistant rat model.
Topics: Animals; Cystathionine gamma-Lyase; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Sucrose; Disease Models, Animal; Endarterectomy, Carotid; Folic Acid; Homocysteine; Hyperplasia; Insulin; Insulin Resistance; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Sprague-Dawley; Tunica Intima | 2003 |
Rescue of hypercholesterolemia-related impairment of angiogenesis by oral folate supplementation.
Topics: Administration, Oral; Animals; Cholesterol; Cholesterol, HDL; Cyclic GMP; Dietary Supplements; Disease Models, Animal; Drug Evaluation, Preclinical; Folic Acid; Hindlimb; Homocysteine; Hypercholesterolemia; Ischemia; Male; Neovascularization, Pathologic; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peripheral Vascular Diseases; Rats; Rats, Sprague-Dawley; Risk Factors; Severity of Illness Index | 2003 |
Effects of prostaglandin E1, melatonin, and oxytetracycline on lipid peroxidation, antioxidant defense system, paraoxonase (PON1) activities, and homocysteine levels in an animal model of spinal cord injury.
Topics: Acute Disease; Alprostadil; Animals; Antioxidants; Aryldialkylphosphatase; Biomarkers; Disease Models, Animal; Double-Blind Method; Free Radical Scavengers; Homocysteine; Lipid Peroxidation; Male; Malondialdehyde; Melatonin; Oxidative Stress; Oxytetracycline; Prospective Studies; Random Allocation; Rats; Rats, Wistar; Spinal Cord; Spinal Cord Injuries; Treatment Outcome | 2003 |
A casein variant in cow's milk is atherogenic.
Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Biomarkers; Carotid Artery Diseases; Carotid Artery, Internal; Caseins; Chelating Agents; Cholesterol, Dietary; Cholesterol, HDL; Cholesterol, LDL; Diet, Atherogenic; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Genetic Variation; Homocysteine; Male; Milk; Models, Cardiovascular; Pilot Projects; Rabbits; Time Factors; Triglycerides; Tunica Intima; Weight Loss | 2003 |
Homocysteine interference in neurulation: a chick embryo model.
Topics: Abnormalities, Multiple; Animals; Chick Embryo; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Homocysteine; Neural Tube Defects; Organ Culture Techniques; Teratogens | 2003 |
Chronic renal failure accelerates atherogenesis in apolipoprotein E-deficient mice.
Topics: Animals; Aortic Diseases; Apolipoproteins E; Arteriosclerosis; Blood Pressure; Blood Proteins; Disease Models, Animal; Homocysteine; Kidney Failure, Chronic; Lipids; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nephrectomy; Uremia | 2003 |
Effects of 3-deazaadenosine on homocysteine and atherosclerosis in apolipoprotein E-deficient mice.
Topics: Analysis of Variance; Animals; Apolipoproteins E; Arteriosclerosis; Base Sequence; Biopsy, Needle; Cholesterol; Diet, Atherogenic; Disease Models, Animal; DNA, Complementary; Flow Cytometry; Homocysteine; Immunohistochemistry; Male; Mice; Mice, Knockout; Molecular Sequence Data; Polymerase Chain Reaction; Probability; Reference Values; RNA, Messenger; Sinus of Valsalva; Transaminases; Tubercidin; Tunica Intima | 2003 |
Differences in the metabolic response to exogenous homocysteine in juvenile and adult rabbits.
Topics: Aging; Animals; Disease Models, Animal; Fatty Acids; Folic Acid; Glutathione; Homocysteine; Lipid Peroxidation; Liver; Metabolic Clearance Rate; Rabbits; Thiobarbituric Acid Reactive Substances | 2004 |
The neuronal SAPK/JNK pathway is altered in a murine model of hyperhomocysteinemia.
Topics: Activating Transcription Factor 2; Animals; Brain; Brain Chemistry; Cyclic AMP Response Element-Binding Protein; Cystathionine beta-Synthase; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Hippocampus; Homocysteine; Hyperhomocysteinemia; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neurons; Oligonucleotide Array Sequence Analysis; Signal Transduction; Transcription Factors | 2004 |
The S-adenosyl homocysteine hydrolase inhibitor 3-deaza-adenosine prevents oxidative damage and cognitive impairment following folate and vitamin E deprivation in a murine model of age-related, oxidative stress-induced neurodegeneration.
Topics: Adenosylhomocysteinase; Animals; Apolipoproteins E; Brain; Brain Chemistry; Cognition Disorders; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Female; Folic Acid Deficiency; Homocysteine; Male; Methionine; Mice; Mice, Knockout; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Tubercidin; Vitamin E Deficiency | 2004 |
Small artery mechanics in hyperhomocysteinemic mice: effects of angiotensin II.
Topics: Angiotensin II; Animals; Blood Pressure; Collagen; Disease Models, Animal; Elastin; Female; Homocysteine; Hyperhomocysteinemia; Male; Mesenteric Arteries; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Mice, Knockout; Vasoconstrictor Agents | 2004 |
Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency.
Topics: Animals; Animals, Suckling; Betaine; Body Weight; Brain; Disease Models, Animal; Female; Genotype; Homocysteine; Homocystinuria; Lactation; Liver; Male; Maternal-Fetal Exchange; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Knockout; Organ Size; Pregnancy | 2004 |
In vivo and in vitro effects of homocysteine on Na+, K+-ATPase activity in parietal, prefrontal and cingulate cortex of young rats.
Topics: Amidines; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Gyrus Cinguli; Homocysteine; Homocystinuria; In Vitro Techniques; Prefrontal Cortex; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Synaptic Membranes; Thiobarbituric Acid Reactive Substances; Time Factors | 2004 |
Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia.
Topics: Animals; Apolipoprotein B-100; Apolipoproteins B; Blotting, Northern; Cholesterol; Chromatography, High Pressure Liquid; Cystathionine beta-Synthase; Disease Models, Animal; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Gene Expression Regulation; Genotype; Heterozygote; Homocysteine; Homozygote; Hyperhomocysteinemia; Lipid Metabolism; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Liver; Mice; Mice, Transgenic; Oxygen; Phosphatidylcholine-Sterol O-Acyltransferase; Risk Factors; RNA, Messenger; Sulfhydryl Compounds; Time Factors; Tissue Distribution; Triglycerides | 2004 |
Effects of intravenous betaine on methionine-loading-induced plasma homocysteine elevation in rats.
Topics: Animals; Betaine; Disease Models, Animal; Glycine; Homocysteine; Hyperhomocysteinemia; Injections, Intravenous; Male; Methionine; Rats; Sarcosine | 2004 |
Cystathionine beta synthase deficiency affects mouse endochondral ossification.
Topics: Animals; Bone and Bones; Breeding; Cystathionine beta-Synthase; Disease Models, Animal; DNA; Female; Genotype; Homocysteine; Hyperhomocysteinemia; Male; Marfan Syndrome; Mice; Mice, Inbred Strains; Mice, Knockout; Osteogenesis; Radiography; Scoliosis | 2005 |
Folic acid supplementation can reduce the endothelial damage in rat brain microvasculature due to hyperhomocysteinemia.
Topics: Animals; Cerebrovascular Circulation; Dietary Supplements; Disease Models, Animal; Endothelium, Vascular; Energy Intake; Folic Acid; Homocysteine; Hyperhomocysteinemia; Male; Microcirculation; Rats; Rats, Sprague-Dawley; Reference Values; Thiobarbituric Acid Reactive Substances; Vitamin B 12; Weight Gain | 2005 |
Physiological variation in plasma total homocysteine concentrations in rats.
Topics: Aging; Animals; Biomarkers; Circadian Rhythm; Disease Models, Animal; Estrous Cycle; Female; Genital Diseases, Female; Homocysteine; Hyperhomocysteinemia; Male; Rats; Rats, Wistar | 2005 |
Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver.
Topics: Animals; Apoptosis; Collagen Type I; Cystathionine beta-Synthase; Disease Models, Animal; Fatty Liver; Homocysteine; Homocystinuria; Hyperhomocysteinemia; Liver; Liver Cirrhosis; Mice; Mice, Mutant Strains; Oxidative Stress; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
Acute homocysteine administration does not elevate sympathetic nerve activity in rats.
Topics: Animals; Blood Pressure; Disease Models, Animal; Heart Rate; Homocysteine; Hyperhomocysteinemia; Infusions, Intravenous; Lumbosacral Plexus; Male; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System | 2006 |
Reduction of butyrylcholinesterase activity in rat serum subjected to hyperhomocysteinemia.
Topics: Animals; Antioxidants; Arteriosclerosis; Ascorbic Acid; Butyrylcholinesterase; Disease Models, Animal; Down-Regulation; Enzyme Activation; Free Radicals; Homocysteine; Homocystinuria; Hyperhomocysteinemia; Lipid Metabolism; Oxidative Stress; Rats; Rats, Wistar; Vitamin E | 2005 |
Cavernosal dysfunction in a rabbit model of hyperhomocysteinaemia.
Topics: Animals; Cyclic GMP; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Impotence, Vasculogenic; Male; Muscle, Smooth, Vascular; Nitric Oxide; Organ Culture Techniques; Penis; Rabbits; Risk Factors; Superoxides; Veins | 2005 |
Plasma homocysteine levels are not increased in murine models of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Biomarkers; Disease Models, Animal; Homocysteine; Humans; Mice; Mice, Transgenic; Risk Factors | 2005 |
The effects of S-allylmercaptocaptopril, the synthetic product of allicin and captopril, on cardiovascular risk factors associated with the metabolic syndrome.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Cyclopropanes; Disease Models, Animal; Disulfides; Homocysteine; Hypertension; Hypoglycemic Agents; Insulin; Male; Metabolic Syndrome; Rats; Rats, Sprague-Dawley; Risk Factors; Sulfinic Acids; Treatment Outcome; Triglycerides | 2005 |
Homocysteine-lowering action is another potential cardiovascular protective factor of aged garlic extract.
Topics: Animals; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Garlic; Homocysteine; Hyperhomocysteinemia; Male; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley | 2006 |
Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Animals; Blotting, Western; Brain; Brain Chemistry; Cell Count; Cystathionine beta-Synthase; Disease Models, Animal; Female; Homocysteine; Immunohistochemistry; Male; Mice; Mice, Transgenic; Mutation; Neurons; Polymerase Chain Reaction; Sex Factors | 2006 |
Hyperhomocysteinemia increases damage on brain slices exposed to in vitro model of oxygen and glucose deprivation: prevention by folic acid.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Folic Acid; Glucose; Homocysteine; Hyperhomocysteinemia; Hypoxia; Hypoxia-Ischemia, Brain; In Vitro Techniques; Lactate Dehydrogenases; Male; Rats; Rats, Wistar; Vitamin A; Vitamin B Complex | 2006 |
Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Female; Fetal Growth Retardation; Folic Acid; Gestational Age; Homocysteine; Homocystine; Mice; Neural Tube Defects; Pregnancy; Random Allocation; Teratogens; Valproic Acid; Vitamin B 12 | 2006 |
Ginkgolide A attenuates homocysteine-induced endothelial dysfunction in porcine coronary arteries.
Topics: Animals; Coronary Artery Disease; Coronary Vessels; Disease Models, Animal; Down-Regulation; Endothelium, Vascular; Ginkgo biloba; Homocysteine; In Vitro Techniques; Nitric Oxide Synthase Type III; Phytotherapy; Plant Preparations; Polymerase Chain Reaction; Risk Factors; RNA; Swine; Treatment Outcome; Vasodilation | 2006 |
Hyperhomocysteinemia due to cystathionine beta synthase deficiency induces dysregulation of genes involved in hepatic lipid homeostasis in mice.
Topics: Animals; Base Sequence; Cholesterol; Cystathionine beta-Synthase; Disease Models, Animal; DNA Primers; Endoplasmic Reticulum; Homocysteine; Homocystinuria; Hyperhomocysteinemia; Lipid Metabolism; Liver; Male; Mice; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; RNA, Messenger | 2007 |
Differential effects of low and high dose folic acid on endothelial dysfunction in a murine model of mild hyperhomocysteinaemia.
Topics: Animals; Clotrimazole; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Folic Acid; Homocysteine; Hyperhomocysteinemia; Mesenteric Arteries; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Vasodilation; Vasodilator Agents | 2006 |
Ocular lesions and experimental choline deficiency.
Topics: Analysis of Variance; Animals; Choline Deficiency; Creatinine; Diet; Disease Models, Animal; Eye; Eye Injuries; Homocysteine; Kidney Cortex Necrosis; Kidney Tubular Necrosis, Acute; Male; Rats; Rats, Wistar; Retinal Hemorrhage; Severity of Illness Index; Urea | 2006 |
Dimethylthetin treatment causes diffuse alveolar lung damage: a pilot study in a sheep model of Continuous Ambulatory Peritoneal Dialysis (CAPD).
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Dialysis Solutions; Disease Models, Animal; Glycine; Homocysteine; Hyperhomocysteinemia; Nephrectomy; Peritoneal Dialysis, Continuous Ambulatory; Pilot Projects; Pulmonary Alveoli; Renal Insufficiency; Sheep; Substrate Specificity | 2007 |
Homocysteine thiolactone-induced hyperhomocysteinemia does not alter concentrations of cholesterol and SREBP-2 target gene mRNAS in rats.
Topics: Animals; Cholesterol; Diet; Disease Models, Animal; Gene Expression; Homocysteine; Hydroxymethylglutaryl CoA Reductases; Hyperhomocysteinemia; Intestine, Small; Lipoproteins; Liver; Rats; Rats, Sprague-Dawley; Receptors, LDL; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sterol Regulatory Element Binding Protein 2 | 2007 |
Recombinant adeno-associated virus mediated gene transfer in a mouse model for homocystinuria.
Topics: Animals; Cell Line; Cystathionine beta-Synthase; Dependovirus; Disease Models, Animal; DNA, Recombinant; Gene Transfer Techniques; Genetic Therapy; Homocysteine; Homocystinuria; Humans; Immunohistochemistry; Mice; Survival Rate | 2006 |
Hypertension in spontaneously hypertensive rats occurs despite low plasma levels of homocysteine.
Topics: Amino Acids; Animals; Chromatography, Ion Exchange; Disease Models, Animal; Down-Regulation; Homocysteine; Hyperhomocysteinemia; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2008 |
Folic acid prevents and partially reverses glucocorticoid-induced hypertension in the rat.
Topics: Adrenocorticotropic Hormone; Animals; Antihypertensive Agents; Biopterins; Blood Pressure; Body Weight; Dexamethasone; Disease Models, Animal; F2-Isoprostanes; Folic Acid; Glucocorticoids; Homocysteine; Hypertension; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Thymus Gland; Time Factors | 2007 |
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.
Topics: Animals; Brain; Disease Models, Animal; Embryo, Mammalian; Female; Ferredoxin-NADP Reductase; Folic Acid; Heart; Homocysteine; Hyperhomocysteinemia; Kidney; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Mice lacking cystathionine beta synthase have lung fibrosis and air space enlargement.
Topics: Animals; Cell Differentiation; Cystathionine beta-Synthase; Disease Models, Animal; Fibroblasts; Homocysteine; Hyperhomocysteinemia; Mice; Mice, Knockout; Polymerase Chain Reaction; Pulmonary Disease, Chronic Obstructive; Pulmonary Fibrosis | 2007 |
Mice deficient in cystathionine beta synthase display altered homocysteine remethylation pathway.
Topics: Animals; Cystathionine beta-Synthase; Disease Models, Animal; Homocysteine; Homocystinuria; Methylation; Mice; MicroRNAs | 2007 |
Folate deficiency and plasma homocysteine during increased oxidative stress.
Topics: Alzheimer Disease; Animals; Apolipoproteins E; Cardiovascular Diseases; Disease Models, Animal; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Mice; Mice, Transgenic; Oxidative Stress; Risk Factors | 2007 |
[Study of animal model of hypertensive disorder complicating pregnancy in pregnant rats stimulated by homocysteine and monosodium glutamate].
Topics: Animals; Animals, Newborn; Blood Pressure; Cerebral Cortex; Disease Models, Animal; Female; Homocysteine; Hypertension, Pregnancy-Induced; Kidney; Liver Function Tests; Male; Pregnancy; Random Allocation; Rats; Rats, Wistar; Sodium Glutamate | 2007 |
Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia.
Topics: Animals; Animals, Genetically Modified; Aorta; Apolipoprotein A-I; Betaine; Cholesterol; Disease Models, Animal; Fatty Liver; Homocysteine; Hyperhomocysteinemia; Immunohistochemistry; Lipotropic Agents; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Time; Triglycerides; Tyrosine | 2007 |
Long-term administration of 3-deazaadenosine does not alter progression of advanced atherosclerotic lesions in apolipoprotein E-deficient mice.
Topics: Actins; Adenosine; Animals; Aorta, Thoracic; Apolipoproteins E; Atherosclerosis; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Female; Homocysteine; Intercellular Adhesion Molecule-1; Interleukin-10; Interleukin-1beta; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Transcription Factor AP-1; Tubercidin; Vascular Cell Adhesion Molecule-1 | 2007 |
[Effects of folic acid, vitamin B(6) and vitamin B(12) on learning and memory function in cerebral ischemia rats].
Topics: Animals; Brain Ischemia; Disease Models, Animal; Female; Folic Acid; Homocysteine; Infarction, Middle Cerebral Artery; Learning; Male; Memory; Rats; Rats, Sprague-Dawley; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2007 |
Hyperhomocysteinemia-mediated DNA hypomethylation and its potential epigenetic role in rats.
Topics: Animals; Atherosclerosis; Base Sequence; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Homocysteine; Hyperhomocysteinemia; Male; Mice; Molecular Sequence Data; Rabbits; Rats; Rats, Sprague-Dawley | 2007 |
Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.
Topics: Alanine Transaminase; Animals; ATPases Associated with Diverse Cellular Activities; Chromosome Mapping; Disease Models, Animal; Down-Regulation; Embryo, Mammalian; Female; Gene Expression; Gene Expression Profiling; Glycine N-Methyltransferase; Glycogen; Glycogen Storage Disease; Hepatitis, Chronic; Homocysteine; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Polymerase Chain Reaction; Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Dietary homocysteine promotes atherosclerosis in apoE-deficient mice by inducing scavenger receptors expression.
Topics: Animals; Apolipoproteins E; Atherosclerosis; CD36 Antigens; Cells, Cultured; Diet, Atherogenic; Disease Models, Animal; Endothelial Cells; Female; Foam Cells; Homocysteine; Humans; Lipoproteins, LDL; Mice; Mice, Knockout; Scavenger Receptors, Class E; Umbilical Veins | 2008 |
Homocysteine threshold value based on cystathionine beta synthase and paraoxonase 1 activities in mice.
Topics: Animals; Aryldialkylphosphatase; Cystathionine beta-Synthase; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Liver; Mice | 2007 |
[Efficacy and safety of heptral, vitamin B6 and folic acid during toxic hepatitis induced by CCL4].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Cytochromes b5; Disease Models, Animal; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Hepatocytes; Homocysteine; Male; Rats; S-Adenosylmethionine; Treatment Outcome; Vitamin B 6; Vitamin B Complex | 2007 |
Effects of a B-vitamin-deficient diet on exploratory activity, motor coordination, and spatial learning in young adult Balb/c mice.
Topics: Age Factors; Aging; Animals; Body Weight; Brain; Disease Models, Animal; Drinking; Eating; Exploratory Behavior; Female; Folic Acid Deficiency; Homocysteine; Hyperhomocysteinemia; Hyperkinesis; Learning Disabilities; Male; Memory Disorders; Mice; Motor Skills Disorders; Movement; Movement Disorders; Space Perception; Vitamin B 12 Deficiency; Vitamin B Deficiency | 2008 |
Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats.
Topics: Animals; Cystathionine gamma-Lyase; Disease Models, Animal; Electron Transport Complex IV; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme Activation; Heart Diseases; Heat-Shock Proteins; Homocysteine; Hydrogen Peroxide; Hydrogen Sulfide; Lipid Peroxidation; Male; Mitochondria, Heart; Molecular Chaperones; Myocardium; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Succinate Dehydrogenase; Superoxide Dismutase; Superoxides; Time Factors | 2008 |
The methionine connection: homocysteine and hydrogen sulfide exert opposite effects on hepatic microcirculation in rats.
Topics: Acetylcholine; Animals; Disease Models, Animal; Homocysteine; Hydrogen Sulfide; Hyperhomocysteinemia; Liver; Liver Circulation; Liver Cirrhosis; Male; Methionine; Microcirculation; Rats; Rats, Wistar | 2008 |
Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease.
Topics: Adiponectin; Adipose Tissue; Animals; Betaine; Cystathionine beta-Synthase; Disease Models, Animal; Endoplasmic Reticulum; Ethanol; Homocysteine; Hyperhomocysteinemia; Liver Diseases, Alcoholic; Male; Methionine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Rats; Rats, Sprague-Dawley | 2008 |
Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice.
Topics: Animals; Atherosclerosis; Diet, Atherogenic; Dietary Supplements; Disease Models, Animal; Female; Homocysteine; Hyaluronic Acid; Hyperhomocysteinemia; Immunohistochemistry; Lipids; Methionine; Mice; Mice, Inbred C57BL | 2008 |
Mefolinate (5-methyltetrahydrofolate), but not folic acid, decreases mortality in an animal model of severe methylenetetrahydrofolate reductase deficiency.
Topics: Animals; Brain; Disease Models, Animal; Female; Folic Acid; Genotype; Homocysteine; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Survival Rate; Tetrahydrofolates | 2008 |
Hyperhomocysteinaemia-induced cardiovascular changes in rats.
Topics: Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Cardiotonic Agents; Cardiovascular System; Disease Models, Animal; Heart Rate; Homocysteine; Hyperhomocysteinemia; Hypertension; Male; Nitroprusside; Phenylephrine; Rats, Wistar; Sympathetic Nervous System; Tachycardia; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents | 2008 |
Folic acid protects motor neurons against the increased homocysteine, inflammation and apoptosis in SOD1 G93A transgenic mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Folic Acid; Gas Chromatography-Mass Spectrometry; Homocysteine; Inflammation; Mice; Mice, Transgenic; Motor Neurons; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rotarod Performance Test; Spinal Cord; Superoxide Dismutase; Vitamin B 12; Vitamin B Complex | 2008 |
The homocysteine paradox.
Topics: Animals; Arginine; Cardiovascular Diseases; Cystatin C; Cystatins; Disease Models, Animal; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Diseases; Risk Factors; Vitamin B 12; Vitamin B 6 | 2008 |
Accumulation of homocyst(e)ine in vitamin B-6 deficiency: a model for the study of cystathionine beta-synthase deficiency.
Topics: Animals; Blood Proteins; Cystathionine beta-Synthase; Cysteine; Dietary Proteins; Disease Models, Animal; Homocysteine; Homocystine; Homocystinuria; Humans; Hydro-Lyases; Male; Protein Binding; Rats; Vitamin B 6 Deficiency | 1982 |
Experimental homocysteinemia in pigs: comparison with studies in sixteen homocystinuric patients.
Topics: Adolescent; Adult; Amino Acids; Aminobutyrates; Animals; Child; Child, Preschool; Dipeptides; Disease Models, Animal; Homocysteine; Homocystine; Homocystinuria; Humans; Kinetics; Methionine; Middle Aged; Swine; Taurine | 1982 |
Alterations of methionine fluxes and incorporation in intestines of miniature pigs fed a diet high in caseinate are restricted by angiotensin-converting enzyme inhibitor.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Caseins; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Epithelium; Homocysteine; Hydrochlorothiazide; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Methionine; Random Allocation; Sodium Chloride Symporter Inhibitors; Swine; Swine, Miniature; Tritium | 1995 |
A rat vein perfusion model for studying homocysteine induced toxicity.
Topics: Animals; Arteriosclerosis; Ascorbic Acid; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Homocystinuria; Humans; Male; Microscopy, Electron, Scanning; Perfusion; Rats; Rats, Sprague-Dawley | 1994 |
Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Base Sequence; Cloning, Molecular; Cystathionine beta-Synthase; Disease Models, Animal; Gene Expression; Heterozygote; Homocysteine; Homocystine; Homozygote; Liver; Mice; Mice, Knockout; Molecular Sequence Data; Oligodeoxyribonucleotides; Restriction Mapping; RNA, Messenger | 1995 |
Liver distribution of 99mTc-DL-homocysteine in experimental hepatitis rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Drug Interactions; Hepatitis, Viral, Animal; Homocysteine; Liver; Male; Organotechnetium Compounds; Radionuclide Imaging; Rats; Rats, Wistar; Subcellular Fractions | 1993 |
Lipid peroxidation induced in vivo by hyperhomocysteinaemia in pigs.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Disease Models, Animal; Fatty Acids, Unsaturated; Heart; Homocysteine; Hypercholesterolemia; Iron; Lipid Peroxidation; Lipoproteins, LDL; Malondialdehyde; Myocardium; Nitrous Oxide; Random Allocation; Risk Factors; Swine | 1997 |
Enhanced levels of biochemical markers for cobalamin deficiency in totally gastrectomized rats: uncoupling of the enhancement from the severity of spongy vacuolation in spinal cord.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Pernicious; Animals; Bacteria, Anaerobic; Citrates; Cystathionine; Disease Models, Animal; Erythromycin; Gastrectomy; Homocysteine; Humans; Intestines; Lincomycin; Male; Methylmalonic Acid; Methylmalonyl-CoA Mutase; Postgastrectomy Syndromes; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Diseases; Vacuoles; Vitamin B 12; Vitamin B 12 Deficiency | 1997 |
Participation of mercuric conjugates of cysteine, homocysteine, and N-acetylcysteine in mechanisms involved in the renal tubular uptake of inorganic mercury.
Topics: Acetylcysteine; Analysis of Variance; Animals; Biological Transport; Cysteine; Disease Models, Animal; Drug Interactions; Feces; Homocysteine; Kidney; Kidney Tubules, Proximal; Ligation; Liver; Male; Mercury; Normal Distribution; Rats; Rats, Sprague-Dawley; Reference Values; Ureter; Urine | 1998 |
Characterization of the stress-inducing effects of homocysteine.
Topics: Animals; Carrier Proteins; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Cystathionine beta-Synthase; Disease Models, Animal; DNA-Binding Proteins; Endoplasmic Reticulum Chaperone BiP; Endothelium, Vascular; Gene Expression Regulation; Heat-Shock Proteins; Homocysteine; HSP70 Heat-Shock Proteins; Humans; Hydrogen Peroxide; Immunohistochemistry; Mice; Molecular Chaperones; Muscle, Smooth; RNA, Messenger; Stress, Physiological; Transcription Factor CHOP; Transcription Factors | 1998 |
Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine-Homocysteine S-Methyltransferase; Blood Glucose; Body Weight; Creatinine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Eating; Homocysteine; Hypoglycemic Agents; Insulin; Kidney; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Methyltransferases; Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Sprague-Dawley | 1998 |
Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Energy Metabolism; Epilepsy; Excitatory Amino Acid Antagonists; Glucose; Homocysteine; Injections, Intraventricular; Male; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2000 |
Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice.
Topics: Animals; Aorta; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Folic Acid; Food, Formulated; Heterozygote; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Thrombomodulin; Vasodilator Agents | 2000 |
Folate deficiency diminishes the occurrence of aberrant crypt foci in the rat colon but does not alter global DNA methylation status.
Topics: Animals; Azoxymethane; Carcinogens; Chromatography, High Pressure Liquid; Colon; Colonic Neoplasms; Data Interpretation, Statistical; Disease Models, Animal; DNA Methylation; Folic Acid; Folic Acid Deficiency; Homocysteine; Injections, Subcutaneous; Intestinal Mucosa; Liver; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Risk Factors; Time Factors | 2000 |
Vitamin B-12 deficiency and hyperhomocysteinemia are partly ameliorated by cobalt and nickel supplementation in pigs.
Topics: Animal Feed; Animals; Cobalt; Copper; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Homocysteine; Hyperhomocysteinemia; Iron; Liver; Male; Nickel; Swine; Trace Elements; Vitamin B 12; Vitamin B 12 Deficiency | 2000 |
Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia.
Topics: Angiography; Animals; Arginine; Blood Pressure; Body Weight; Collateral Circulation; Cyclic GMP; Disease Models, Animal; Heart Rate; Hindlimb; Homocysteine; Hyperhomocysteinemia; Immunohistochemistry; Ischemia; Laser-Doppler Flowmetry; Muscle, Skeletal; Neovascularization, Physiologic; Nitrates; Nitrites; Rats; Regional Blood Flow; Time Factors | 2000 |
Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice.
Topics: Animals; Aorta; Brain; Chronic Disease; Cystathionine beta-Synthase; Disease Models, Animal; Endothelium, Vascular; Folic Acid; Food, Fortified; Heterozygote; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; S-Adenosylhomocysteine; S-Adenosylmethionine; Thrombomodulin; Vasoconstrictor Agents; Vasodilator Agents; Vasomotor System | 2001 |
Folate homeostasis and antiproliferative activity of folates and antifolates.
Topics: Animals; Caco-2 Cells; Cell Division; Colonic Neoplasms; Disease Models, Animal; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Homeostasis; Homocysteine; Humans; Kinetics; Mice; Risk Factors | 2001 |
Folate supplementation inhibits intimal hyperplasia induced by a high-homocysteine diet in a rat carotid endarterectomy model.
Topics: Animals; Dietary Supplements; Disease Models, Animal; Endarterectomy, Carotid; Folic Acid; Homocysteine; Hyperplasia; Rats; Rats, Sprague-Dawley; Tunica Intima | 2001 |
Recombinant annexin II modulates impaired fibrinolytic activity in vitro and in rat carotid artery.
Topics: Animals; Annexin A2; Bleeding Time; Blood Coagulation; Blotting, Western; Carotid Arteries; Carotid Artery Thrombosis; Cells, Cultured; Disease Models, Animal; Endothelium, Vascular; Fibrinolysin; Fibrinolysis; Homocysteine; Humans; Immunohistochemistry; In Vitro Techniques; Male; Plasminogen Activator Inhibitor 1; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 2001 |
Intraperitoneal infusion of homocysteine increases intimal hyperplasia in balloon-injured rat carotid arteries.
Topics: Animals; Carotid Artery Injuries; Catheterization; Disease Models, Animal; Dose-Response Relationship, Drug; Homocysteine; Hyperplasia; Infusions, Parenteral; Male; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Tunica Intima | 2002 |
Neointimal hyperplasia in balloon-injured rat carotid arteries: the influence of hyperhomocysteinemia.
Topics: Animals; Carotid Artery Injuries; Carotid Artery, Common; Catheterization; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Hyperplasia; Image Processing, Computer-Assisted; Male; Rats; Rats, Inbred Lew; Time Factors; Tunica Intima | 2002 |
Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Cell Survival; Cells, Cultured; Diet; Disease Models, Animal; DNA Damage; DNA Repair; Folic Acid Deficiency; Hippocampus; Homocysteine; Hyperhomocysteinemia; Mice; Mice, Transgenic; Neurons; Rats; Uracil | 2002 |
Implications of hyperhomocysteinemia in glomerular sclerosis in hypertension.
Topics: Animals; Chromatography, High Pressure Liquid; Diet; Disease Models, Animal; Glomerular Mesangium; Homocysteine; Hyperhomocysteinemia; Hypertension; Methionine; Rats; Rats, Sprague-Dawley; Salts; Sclerosis | 2002 |
DL-Homocysteic acid application disrupts calcium homeostasis and induces degeneration of spinal motor neurons in vivo.
Topics: Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Calcium; Calcium Signaling; Cell Death; Disease Models, Animal; Glutamic Acid; Homeostasis; Homocysteine; Male; Microscopy, Electron; Rats; Rats, Inbred Strains | 2002 |
Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model.
Topics: Animals; Body Weight; Cleft Palate; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Homocysteine; Male; Mice; Mice, Inbred ICR; Neural Tube Defects; Pregnancy | 2002 |
Tissue levels of S-adenosylhomocysteine in the rat kidney: effects of ischemia and homocysteine.
Topics: Adenosine; Animals; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Ischemia; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 2002 |
Genetic and molecular control of folate-homocysteine metabolism in mutant mice.
Topics: Animals; Blotting, Northern; Disease Models, Animal; Female; Folic Acid; Gene Expression Regulation; Homocysteine; Hyperhomocysteinemia; Liver; Methylmalonic Acid; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Oligonucleotide Array Sequence Analysis; Signal Transduction | 2002 |
The electrographic pattern of homocysteine-induced seizures in the rat.
Topics: Animals; Bioelectric Energy Sources; Cerebral Cortex; Disease Models, Animal; Electrophysiology; Homocysteine; Injections, Intraperitoneal; Male; Rats; Seizures | 1976 |
Arteriosclerosis due to homocyst (e) inemia. Failure to reproduce the model in weanling rabbits.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Arteries; Arteriosclerosis; Brain; Disease Models, Animal; Homocysteine; Injections, Intraperitoneal; Injections, Subcutaneous; Kidney; Lung; Myocardium; Rabbits | 1974 |