holomycin and Atherosclerosis

Clonal hematopoiesis (CH) has emerged as an independent risk factor for atherosclerotic cardiovascular disease, with activation of macrophage inflammasomes as a potential underlying mechanism. The NLRP3 (NLR family pyrin domain containing 3) inflammasome has a key role in promoting atherosclerosis in mouse models of. We used cholesterol-loaded TET2-deficient murine and embryonic stem cell-derived isogenic human macrophages to evaluate mechanisms of NLRP3 inflammasome activation in vitro and hypercholesterolemic. Hypercholesterolemia and TET2 deficiency converge on a common pathway of NLRP3 inflammasome activation mediated by JNK1 activation and BRCC3-mediated NLRP3 deubiquitylation, with potential therapeutic implications for the prevention of cardiovascular disease in

Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Cholesterol; Clonal Hematopoiesis; Deubiquitinating Enzymes; Dioxygenases; DNA-Binding Proteins; Humans; Hypercholesterolemia; Inflammasomes; Mice; NLR Family, Pyrin Domain-Containing 3 Protein