hoe-777 and Scleroderma--Localized

The patient suffered from a 20-year course of generalized circumscribed scleroderma and presented with blisters in circumscribed areas of the affected skin. The development of subepidermal blisters has been described in all clinical forms of circumscribed scleroderma. Aetiology and pathogenesis of blister formation have not yet been clarified. An obstruction of the lymphatic vessels due to the present sclerosis is favoured. Treatment of bullous circumscribed scleroderma is considered to be difficult. Oral steroids, methotrexate, hydroxychloroquine and PUVA methods have been used with varying success.

Topics: Administration, Oral; Administration, Topical; Biopsy; Blister; Combined Modality Therapy; Disease Progression; Female; Follow-Up Studies; Humans; Methotrexate; Middle Aged; Penicillins; Prednisolone; Recurrence; Scleroderma, Localized; Skin; Ultraviolet Therapy