hoe-777 and Erythema

Aloe vera is a natural product that is frequently used in soothing skin care products such as aftersun lotions. In the present study we aimed to explore the anti-inflammatory potential of a highly concentrated A. vera gel in the UV erythema test in vivo.. 40 volunteers with skin types II and III were included in the randomized, double-blind, placebo-controlled, phase III monocenter study. Test areas on the back were irradiated with the 1.5-fold minimal erythema dose of UVB. Subsequently, the test areas were treated occlusively on 2 subsequent days with A. vera gel (97.5%), the positive controls (0.25% prednicarbate, 1% hydrocortisone in placebo gel and 1% hydrocortisone cream) and a placebo gel. Erythema values were determined photometrically after 24 and 48 h.. A. vera gel (97.5%) significantly reduced UV-induced erythema after 48 h, being superior to 1% hydrocortisone in placebo gel. In contrast, 1% hydrocortisone in cream was more efficient than A. vera gel.. In this study after 48 h the A. vera gel (97.5%) displayed some anti-inflammatory effects superior to those of 1% hydrocortisone in placebo gel. The A. vera gel tested here might be useful in the topical treatment of inflammatory skin conditions such as UV-induced erythema.

Topics: Administration, Topical; Adult; Aloe; Anti-Inflammatory Agents; Back; Double-Blind Method; Drug Evaluation; Erythema; Female; Gels; Humans; Hydrocortisone; Male; Middle Aged; Phytotherapy; Plant Preparations; Prednisolone; Prospective Studies; Skin; Ultraviolet Rays

Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Blister; Dermatitis, Atopic; Double-Blind Method; Drug Tolerance; Erythema; Female; Fluocortolone; Follow-Up Studies; Glucocorticoids; Humans; Keratosis; Lichenoid Eruptions; Male; Middle Aged; Ointments; Prednisolone; Pruritus; Remission Induction

Topics: Administration, Cutaneous; Adult; Betamethasone Valerate; Double-Blind Method; Drug Evaluation; Erythema; Female; Humans; Hydrocortisone; Male; Prednisolone; Skin; Ultraviolet Rays; Vasoconstriction

Topics: Administration, Topical; Aged; Anti-Inflammatory Agents; Dermatitis, Allergic Contact; Edema; Erythema; Genitalia, Male; Glucocorticoids; Humans; Male; Patch Tests; Prednisolone