histidinohydroxylysinonorleucine and Amyotrophic-Lateral-Sclerosis

histidinohydroxylysinonorleucine has been researched along with Amyotrophic-Lateral-Sclerosis* in 2 studies

Other Studies

2 other study(ies) available for histidinohydroxylysinonorleucine and Amyotrophic-Lateral-Sclerosis

Article	Year
Collagen fibril diameter and its relation to cross-linking of collagen in the skin of patients with amyotrophic lateral sclerosis. Journal of the neurological sciences, 1993, Volume: 119, Issue:1 The diameter of collagen fibrils and the age-related, stable cross-link, histidinohydroxylysinonorleucine (HHL), of skin tissue (left biceps) were measured and compared in 11 patients with amyotrophic lateral sclerosis (ALS) and 7 controls. In ALS patients, it was found that (1) the diameter of collagen fibrils and the content of HHL were negatively and significantly associated with the duration of illness (r = -0.74, P < 0.01 and r = -0.72, P < 0.02, respectively), and (2) there was an appreciable positive correlation between the diameter of collagen fibrils and the content of HHL (r = 0.73, P < 0.02). These findings were not observed in controls. These suggest there is a close relationship between the decreased amount of HHL and the small diameter of collagen fibrils in ALS. Topics: Aged; Amyotrophic Lateral Sclerosis; Collagen; Cross-Linking Reagents; Dipeptides; Female; Histidine; Humans; Male; Microscopy, Electron; Middle Aged; Skin	1993
Collagen cross-linking of skin in patients with amyotrophic lateral sclerosis. Annals of neurology, 1992, Volume: 31, Issue:3 Collagen cross-links of skin tissue (left upper arm) from 11 patients with amyotrophic lateral sclerosis (ALS) and 9 age-matched control subjects were quantified. It was found that patients with ALS had a significant reduction in the content of an age-related, stable cross-link, histidinohydroxylysinonorleucine, that was negatively correlated with the duration of illness. The contents of sodium borohydride-reducible labile cross-links, dehydro-hydroxylysinonorleucine and dehydro-histidinohydroxymerodesmosine, were significantly increased and were positively associated with the duration of illness (r = 0.703, p less than 0.05 and r = 0.684, p less than 0.05, respectively). The results clearly indicate that during the course of ALS, the cross-linking pathway of skin collagen runs counter to its normal aging, resulting in a "rejuvenation" phenomenon of skin collagen. Thus, cross-linking of skin collagen is affected in ALS. Topics: Aged; Aging; Amyotrophic Lateral Sclerosis; Arm; Borohydrides; Collagen; Desmosine; Dipeptides; Female; Histidine; Humans; Male; Middle Aged; Muscular Diseases; Nervous System Diseases; Oxidation-Reduction; Skin	1992

Article

Year

Collagen fibril diameter and its relation to cross-linking of collagen in the skin of patients with amyotrophic lateral sclerosis.

Journal of the neurological sciences, 1993, Volume: 119, Issue:1

The diameter of collagen fibrils and the age-related, stable cross-link, histidinohydroxylysinonorleucine (HHL), of skin tissue (left biceps) were measured and compared in 11 patients with amyotrophic lateral sclerosis (ALS) and 7 controls. In ALS patients, it was found that (1) the diameter of collagen fibrils and the content of HHL were negatively and significantly associated with the duration of illness (r = -0.74, P < 0.01 and r = -0.72, P < 0.02, respectively), and (2) there was an appreciable positive correlation between the diameter of collagen fibrils and the content of HHL (r = 0.73, P < 0.02). These findings were not observed in controls. These suggest there is a close relationship between the decreased amount of HHL and the small diameter of collagen fibrils in ALS.

Topics: Aged; Amyotrophic Lateral Sclerosis; Collagen; Cross-Linking Reagents; Dipeptides; Female; Histidine; Humans; Male; Microscopy, Electron; Middle Aged; Skin

1993

Collagen cross-linking of skin in patients with amyotrophic lateral sclerosis.

Annals of neurology, 1992, Volume: 31, Issue:3

Collagen cross-links of skin tissue (left upper arm) from 11 patients with amyotrophic lateral sclerosis (ALS) and 9 age-matched control subjects were quantified. It was found that patients with ALS had a significant reduction in the content of an age-related, stable cross-link, histidinohydroxylysinonorleucine, that was negatively correlated with the duration of illness. The contents of sodium borohydride-reducible labile cross-links, dehydro-hydroxylysinonorleucine and dehydro-histidinohydroxymerodesmosine, were significantly increased and were positively associated with the duration of illness (r = 0.703, p less than 0.05 and r = 0.684, p less than 0.05, respectively). The results clearly indicate that during the course of ALS, the cross-linking pathway of skin collagen runs counter to its normal aging, resulting in a "rejuvenation" phenomenon of skin collagen. Thus, cross-linking of skin collagen is affected in ALS.

Topics: Aged; Aging; Amyotrophic Lateral Sclerosis; Arm; Borohydrides; Collagen; Desmosine; Dipeptides; Female; Histidine; Humans; Male; Middle Aged; Muscular Diseases; Nervous System Diseases; Oxidation-Reduction; Skin

1992