hispolon and Urinary-Bladder-Neoplasms

hispolon has been researched along with Urinary-Bladder-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for hispolon and Urinary-Bladder-Neoplasms

Article	Year
Hispolon Methyl Ether, a Hispolon Analog, Suppresses the SRC/STAT3/Survivin Signaling Axis to Induce Cytotoxicity in Human Urinary Bladder Transitional Carcinoma Cell Lines. International journal of molecular sciences, 2022, Dec-21, Volume: 24, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Cell Line, Tumor; Cell Proliferation; Humans; STAT3 Transcription Factor; Survivin; Urinary Bladder; Urinary Bladder Neoplasms	2022
Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2009, Volume: 47, Issue:8 The MDM2 proto-oncogene is overexpressed in many human tumors. Although MDM2 inhibits tumor-suppressor function of p53, there exists a p53-independent role for MDM2 in tumorigenesis. Therefore, downregulation of MDM2 has been considered an attractive therapeutic strategy. Hispolon extracted from Phellinus species was found to induce epidermoid and gastric cancer cell apoptosis. However, the mechanisms are not fully understood. Herein, we report our findings that hispolon inhibited breast and bladder cancer cell growth, regardless of p53 status. Furthermore, p21(WAF1), a cyclin-dependent kinase inhibitor, was elevated in hispolon-treated cells. MDM2, a negative regulator of p21(WAF1), was ubiquitinated and degraded after hispolon treatment. We also found that activated ERK1/2 (extracellular signal-regulated kinase1/2) was recruited to MDM2 and involved in mediating MDM2 ubiquitination. Based on this finding, we investigated whether the sensitivity of cells to hispolon was related to ERK1/2 activity. The results indicated that cells with higher ERK1/2 activity were more sensitive to hispolon. In addition, hispolon-induced caspase-7 cleavage was inhibited by the ERK1/2 inhibitor, U0126. In conclusion, hispolon ubiquitinates and downregulates MDM2 via MDM2-recruited activated ERK1/2. Therefore, hispolon may be a potential anti-tumor agent in breast and bladder cancers. Topics: Agaricales; Antibiotics, Antineoplastic; Apoptosis; Breast Neoplasms; Caspase 7; Catechols; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Enzyme Induction; Female; Flow Cytometry; Humans; Immunoprecipitation; Indicators and Reagents; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Poly(ADP-ribose) Polymerases; Proto-Oncogene Mas; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53; Urinary Bladder Neoplasms	2009

Article

Year

Hispolon Methyl Ether, a Hispolon Analog, Suppresses the SRC/STAT3/Survivin Signaling Axis to Induce Cytotoxicity in Human Urinary Bladder Transitional Carcinoma Cell Lines.

International journal of molecular sciences, 2022, Dec-21, Volume: 24, Issue:1

Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Cell Line, Tumor; Cell Proliferation; Humans; STAT3 Transcription Factor; Survivin; Urinary Bladder; Urinary Bladder Neoplasms

2022

Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2009, Volume: 47, Issue:8

The MDM2 proto-oncogene is overexpressed in many human tumors. Although MDM2 inhibits tumor-suppressor function of p53, there exists a p53-independent role for MDM2 in tumorigenesis. Therefore, downregulation of MDM2 has been considered an attractive therapeutic strategy. Hispolon extracted from Phellinus species was found to induce epidermoid and gastric cancer cell apoptosis. However, the mechanisms are not fully understood. Herein, we report our findings that hispolon inhibited breast and bladder cancer cell growth, regardless of p53 status. Furthermore, p21(WAF1), a cyclin-dependent kinase inhibitor, was elevated in hispolon-treated cells. MDM2, a negative regulator of p21(WAF1), was ubiquitinated and degraded after hispolon treatment. We also found that activated ERK1/2 (extracellular signal-regulated kinase1/2) was recruited to MDM2 and involved in mediating MDM2 ubiquitination. Based on this finding, we investigated whether the sensitivity of cells to hispolon was related to ERK1/2 activity. The results indicated that cells with higher ERK1/2 activity were more sensitive to hispolon. In addition, hispolon-induced caspase-7 cleavage was inhibited by the ERK1/2 inhibitor, U0126. In conclusion, hispolon ubiquitinates and downregulates MDM2 via MDM2-recruited activated ERK1/2. Therefore, hispolon may be a potential anti-tumor agent in breast and bladder cancers.

Topics: Agaricales; Antibiotics, Antineoplastic; Apoptosis; Breast Neoplasms; Caspase 7; Catechols; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Enzyme Induction; Female; Flow Cytometry; Humans; Immunoprecipitation; Indicators and Reagents; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Poly(ADP-ribose) Polymerases; Proto-Oncogene Mas; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53; Urinary Bladder Neoplasms

2009