hispidulin and Asthma

hispidulin has been researched along with Asthma* in 1 studies

Other Studies

1 other study(ies) available for hispidulin and Asthma

Article	Year
Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites. Journal of ethnopharmacology, 2001, Volume: 78, Issue:1 The ethanolic extract of Clerodendrum petasites was tested to evaluate the spasmolytic activity on isolated guinea-pig tracheal smooth muscle. The crude extract (2.25-9.0 mg/ml) dose-dependently caused relaxation of tracheal smooth muscle which was contracted by exposure to histamine. A bioassay-guided fractionation of the crude extract was performed by means of partitioning and centrifugal partition chromatography. Finally the active principle was isolated and identified as the flavonoid hispidulin (EC(50): (3.0+/-0.8)x10(-5) M). These results suggest that hispidulin may be beneficial in the treatment of asthma. Topics: Animals; Asthma; Bronchodilator Agents; Flavones; Flavonoids; Guinea Pigs; In Vitro Techniques; Lamiaceae; Magnetic Resonance Spectroscopy; Mass Spectrometry; Muscle Contraction; Plant Extracts; Spectrophotometry, Ultraviolet; Thailand; Trachea	2001

Article

Year

Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites.

Journal of ethnopharmacology, 2001, Volume: 78, Issue:1

The ethanolic extract of Clerodendrum petasites was tested to evaluate the spasmolytic activity on isolated guinea-pig tracheal smooth muscle. The crude extract (2.25-9.0 mg/ml) dose-dependently caused relaxation of tracheal smooth muscle which was contracted by exposure to histamine. A bioassay-guided fractionation of the crude extract was performed by means of partitioning and centrifugal partition chromatography. Finally the active principle was isolated and identified as the flavonoid hispidulin (EC(50): (3.0+/-0.8)x10(-5) M). These results suggest that hispidulin may be beneficial in the treatment of asthma.

Topics: Animals; Asthma; Bronchodilator Agents; Flavones; Flavonoids; Guinea Pigs; In Vitro Techniques; Lamiaceae; Magnetic Resonance Spectroscopy; Mass Spectrometry; Muscle Contraction; Plant Extracts; Spectrophotometry, Ultraviolet; Thailand; Trachea

2001