hispidin has been researched along with Obesity* in 2 studies
2 other study(ies) available for hispidin and Obesity
Article | Year |
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Anti-obesity effects of hispidin and Alpinia zerumbet bioactives in 3T3-L1 adipocytes.
Obesity and its related disorders have become leading metabolic diseases. In the present study, we used 3T3-L1 adipocytes to investigate the anti-obesity activity of hispidin and two related compounds that were isolated from Alpinia zerumbet (alpinia) rhizomes. The results showed that hispidin, dihydro-5,6-dehydrokawain (DDK), and 5,6-dehydrokawain (DK) have promising anti-obesity properties. In particular, all three compounds significantly increased intracellular cyclic adenosine monophosphate (cAMP) concentrations by 81.2% ± 0.06%, 67.0% ± 1.62%, and 56.9% ± 0.19%, respectively. Hispidin also stimulated glycerol release by 276.4% ± 0.8% and inhibited lipid accumulation by 47.8% ± 0.16%. Hispidin and DDK decreased intracellular triglyceride content by 79.5% ± 1.37% and 70.2% ± 1.4%, respectively, and all three compounds inhibited glycerol-3-phosphate dehydrogenase (GPDH) and pancreatic lipase, with hispidin and DDK being the most potent inhibitors. Finally, none of the three compounds reduced 3T3-L1 adipocyte viability. These results highlight the potential for developing hispidin and its derivatives as anti-obesity compounds. Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Alpinia; Animals; Anti-Obesity Agents; Cell Survival; Cyclic AMP; Glycerol; Glycerolphosphate Dehydrogenase; Lipase; Lipids; Mice; Obesity; Plant Extracts; Pyrones; Triglycerides | 2014 |
PKC-β activation and pharmacologically induced weight gain during antipsychotic treatment.
Topics: Adipogenesis; Adipose Tissue; Antipsychotic Agents; Humans; Mesenchymal Stem Cells; Obesity; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Pyrones; Weight Gain | 2011 |