hispidin and Facial-Neoplasms

hispidin has been researched along with Facial-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for hispidin and Facial-Neoplasms

Article	Year
Synthetic hispidin, a PKC inhibitor, is more cytotoxic toward cancer cells than normal cells in vitro. Cell biology and toxicology, 1997, Volume: 13, Issue:3 The trypanocidal activity of naturally occurring 6-(3,4-dihydroxystyryl)-4-hydroxy-2-pyrone (hispidin) prompted us to examine its cytotoxic activity toward normal and cancerous cells in culture. Hispidin synthesized in our laboratory to a high degree of purity (checked by 1H and 13C NMR spectroscopy) was shown to be cytotoxic (between 10(-3) mol/L and 10(-7) mol/L) toward normal human MRC-5 fibroblasts, human cancerous keratinocytes (SCL-1 cell line), and human cancerous pancreatic duct cells (Capan-1 cell line). Interestingly, addition of hispidin in three successive doses (between 10(-5) mol/L and 10(-7) mol/L) led to a 100-fold increase in activity with an enhanced activity on cancer cells compared to normal cells (50%). Synthetic hispidin was found to inhibit isoform beta of protein kinase C (IC50 of 2 x 10(-6) mol/L), but not E. coli and placental type XV alkaline phosphatases. The enhanced activity of hispidin toward the cancerous cell lines is discussed. Topics: Adenocarcinoma; Adult; Alkaline Phosphatase; Antineoplastic Agents; Basidiomycota; Carcinoma, Squamous Cell; Cell Line; Drug Screening Assays, Antitumor; Facial Neoplasms; Fibroblasts; Growth Inhibitors; Humans; Keratinocytes; Lung; Male; Pancreatic Neoplasms; Protein Kinase C; Pyrones; Tumor Cells, Cultured	1997

Article

Year

Synthetic hispidin, a PKC inhibitor, is more cytotoxic toward cancer cells than normal cells in vitro.

Cell biology and toxicology, 1997, Volume: 13, Issue:3

The trypanocidal activity of naturally occurring 6-(3,4-dihydroxystyryl)-4-hydroxy-2-pyrone (hispidin) prompted us to examine its cytotoxic activity toward normal and cancerous cells in culture. Hispidin synthesized in our laboratory to a high degree of purity (checked by 1H and 13C NMR spectroscopy) was shown to be cytotoxic (between 10(-3) mol/L and 10(-7) mol/L) toward normal human MRC-5 fibroblasts, human cancerous keratinocytes (SCL-1 cell line), and human cancerous pancreatic duct cells (Capan-1 cell line). Interestingly, addition of hispidin in three successive doses (between 10(-5) mol/L and 10(-7) mol/L) led to a 100-fold increase in activity with an enhanced activity on cancer cells compared to normal cells (50%). Synthetic hispidin was found to inhibit isoform beta of protein kinase C (IC50 of 2 x 10(-6) mol/L), but not E. coli and placental type XV alkaline phosphatases. The enhanced activity of hispidin toward the cancerous cell lines is discussed.

Topics: Adenocarcinoma; Adult; Alkaline Phosphatase; Antineoplastic Agents; Basidiomycota; Carcinoma, Squamous Cell; Cell Line; Drug Screening Assays, Antitumor; Facial Neoplasms; Fibroblasts; Growth Inhibitors; Humans; Keratinocytes; Lung; Male; Pancreatic Neoplasms; Protein Kinase C; Pyrones; Tumor Cells, Cultured

1997