hispidin and Alzheimer-Disease

hispidin has been researched along with Alzheimer-Disease* in 1 studies

Other Studies

1 other study(ies) available for hispidin and Alzheimer-Disease

Article	Year
A beta-secretase (BACE1) inhibitor hispidin from the mycelial cultures of Phellinus linteus. Planta medica, 2004, Volume: 70, Issue:2 In the course of screening for anti-dementia agents from natural products, a beta-secretase (BACE1) inhibitor was isolated from the culture broth of Phellinus linteus and identified as hispidin. It showed an IC (50) value of 4.9 x 10 (-6) M and a Ki value of 8.4 x 10 (-6) M. The compound was a non-competitive inhibitor. Hispidin also inhibited a prolyl endopeptidase (IC (50) = 1.6 x 10 (-5) M, Ki = 2.4 x 10 (-5) M), but it was less inhibitory to alpha-secretase (TACE) and other serine proteases such as chymotrypsin, trypsin, and elastase. Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cells, Cultured; Endopeptidases; Enzyme Inhibitors; Fungi; Humans; Inhibitory Concentration 50; Phytotherapy; Plant Extracts; Pyrones	2004

Article

Year

A beta-secretase (BACE1) inhibitor hispidin from the mycelial cultures of Phellinus linteus.

Planta medica, 2004, Volume: 70, Issue:2

In the course of screening for anti-dementia agents from natural products, a beta-secretase (BACE1) inhibitor was isolated from the culture broth of Phellinus linteus and identified as hispidin. It showed an IC (50) value of 4.9 x 10 (-6) M and a Ki value of 8.4 x 10 (-6) M. The compound was a non-competitive inhibitor. Hispidin also inhibited a prolyl endopeptidase (IC (50) = 1.6 x 10 (-5) M, Ki = 2.4 x 10 (-5) M), but it was less inhibitory to alpha-secretase (TACE) and other serine proteases such as chymotrypsin, trypsin, and elastase.

Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cells, Cultured; Endopeptidases; Enzyme Inhibitors; Fungi; Humans; Inhibitory Concentration 50; Phytotherapy; Plant Extracts; Pyrones

2004