hirudin and Marfan-Syndrome

hirudin has been researched along with Marfan-Syndrome* in 1 studies

Other Studies

1 other study(ies) available for hirudin and Marfan-Syndrome

Article	Year
Early onset of heparin-induced thrombocytopenia with thrombosis after open heart surgery: importance of an early diagnosis and Lepirudin treatment. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2004, Volume: 15, Issue:2 Heparin-induced thrombocytopenia with thrombosis (HITT) is a rare complication of cardiac surgery with cardiopulmonary bypass. We report two cases of HITT treated with the direct thrombin inhibitor Lepirudin. Immediate diagnosis was essential to prompt heparin discontinuation and successful early Lepirudin administration in the first case. In the second, the presence of an intra-aortic balloon pump delayed HITT recognition, and Lepirudin infusion could not prevent limb amputation. In both cases HITT occurred earlier (< 5 days after heparin exposure) than its usual presentation. Topics: Adult; Aged; Amputation, Surgical; Anticoagulants; Aorta; Aortic Aneurysm; Aortic Dissection; Aortic Valve; Blood Vessel Prosthesis Implantation; Combined Modality Therapy; Coronary Artery Bypass; Early Diagnosis; Fibrinolytic Agents; Heart Valve Prosthesis Implantation; Heparin; Hirudins; Humans; Intra-Aortic Balloon Pumping; Ischemia; Leg; Male; Marfan Syndrome; Mitral Valve; Postoperative Complications; Recombinant Proteins; Thrombocytopenia; Thrombophlebitis	2004

Article

Year

Early onset of heparin-induced thrombocytopenia with thrombosis after open heart surgery: importance of an early diagnosis and Lepirudin treatment.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2004, Volume: 15, Issue:2

Heparin-induced thrombocytopenia with thrombosis (HITT) is a rare complication of cardiac surgery with cardiopulmonary bypass. We report two cases of HITT treated with the direct thrombin inhibitor Lepirudin. Immediate diagnosis was essential to prompt heparin discontinuation and successful early Lepirudin administration in the first case. In the second, the presence of an intra-aortic balloon pump delayed HITT recognition, and Lepirudin infusion could not prevent limb amputation. In both cases HITT occurred earlier (< 5 days after heparin exposure) than its usual presentation.

Topics: Adult; Aged; Amputation, Surgical; Anticoagulants; Aorta; Aortic Aneurysm; Aortic Dissection; Aortic Valve; Blood Vessel Prosthesis Implantation; Combined Modality Therapy; Coronary Artery Bypass; Early Diagnosis; Fibrinolytic Agents; Heart Valve Prosthesis Implantation; Heparin; Hirudins; Humans; Intra-Aortic Balloon Pumping; Ischemia; Leg; Male; Marfan Syndrome; Mitral Valve; Postoperative Complications; Recombinant Proteins; Thrombocytopenia; Thrombophlebitis

2004