hirudin has been researched along with Flushing* in 1 studies
1 other study(ies) available for hirudin and Flushing
| Article | Year |
|---|---|
Treatment of an acute flush reaction caused by subcutaneous r-hirudin with pegylated hirudin.
We report a patient who was treated with recombinant (r)-hirudin for heparin-induced thrombocytopenia and developed a flush reaction twice upon re-exposure to 25 mg of subcutaneous r-hirudin. Antihirudin IgG antibodies developed. The patient received 50 mg of PEG-hirudin subcutaneously over 2 days. No side-effects occurred. The level of IgG antihirudin antibodies increased. Ecarin clotting time and thrombin inhibition S2238 assay were not influenced by the patient's IgG antihirudin antibody. PEG-hirudin may be used in patients with intolerance to r-hirudin because of a dissociation of the allergenic and immunogenic properties of the pegylated drug. Topics: Acute Disease; Anticoagulants; Antithrombins; Drug Administration Schedule; Flushing; Heparin; Hirudin Therapy; Hirudins; Humans; Injections, Subcutaneous; Male; Middle Aged; Recombinant Proteins; Thrombocytopenia | 2000 |