hirudin has been researched along with Drug-Overdose* in 3 studies
3 other study(ies) available for hirudin and Drug-Overdose
| Article | Year |
|---|---|
Impact of smart infusion technology on administration of anticoagulants (unfractionated Heparin, Argatroban, Lepirudin, and Bivalirudin).
This study reviewed 863 alerts generated from the infusion of anticoagulants in 355 patients from October 2003 to January 2005. Alerts were generated by smart infusion technology pumps and recorded in the devices' memory. The most common alerts were underdose alerts (59.8%), followed by overdose alerts (31.3%) and duplicate drug therapy alerts (8.9%). In response to the alerts, users' most frequent action was to cancel (46.5%) or reprogram (43.1%) the infusions. The highest percentage of alerts occurred from 2 to 4 p.m. During the study, there were 4 infusion rate errors, compared with 15 in the immediately preceding 16-month period. In conclusion, smart infusion technology intercepted keypad entry errors, thereby reducing the likelihood of intravenous anticoagulant overdose or underdose. Dose or infusion rate programming during intravenous anticoagulation is an important targets for medication safety interventions. Topics: Anticoagulants; Arginine; Boston; Drug Overdose; Drug Therapy, Computer-Assisted; Heparin; Hirudins; Humans; Infusion Pumps; Infusions, Intravenous; Medication Errors; Medication Systems, Hospital; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Research Design; Sulfonamides | 2007 |
Treatment of hirudin overdosage in a dialysis patient with heparin-induced thrombocytopenia with mixed hemodialysis and hemofiltration treatment.
We report a patient who developed type II heparin-induced thrombocytopenia (HIT) and accidentally received a recombinant hirudin (r-hirudin) overdosage. Treatment with hemodialysis (HD) using high-flux polysulfone dialyzer and hemofiltration was performed. Length of treatment was adjusted, monitoring activated partial thromboplastin time (aPTT) to 1.5-2.5 times the mean of the normal range. She developed deep venous thrombosis and occlusion of vascular access. Only after cessation of heparin lock catheter, platelet count began to increase. After one year of treatment with acenocoumarol and additional low-dose r-hirudin, neither bleeding nor thrombotic episodes have been reported. Topics: Aged; Drug Overdose; Female; Hemofiltration; Heparin; Hirudin Therapy; Hirudins; Humans; Recombinant Proteins; Renal Dialysis; Renal Insufficiency; Thrombocytopenia | 2006 |
Treatment of hirudin overdosage in a patient with chronic renal failure.
Topics: Anticoagulants; Drug Overdose; Heart Failure; Hemodiafiltration; Hemorrhage; Hirudins; Humans; Kidney Failure, Chronic; Male; Middle Aged; Partial Thromboplastin Time; Recombinant Proteins; Renal Dialysis | 1999 |