hippuric acid has been researched along with Kidney Diseases in 9 studies
hippuric acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #4591
N-benzoylglycine : An N-acylglycine in which the acyl group is specified as benzoyl.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We examined nine patients with testicular cancer on 2 consecutive days for acute nephrotoxicity while they were undergoing treatment with cis-platinum." | 1.27 | Acute and long-term nephrotoxicity of cis-platinum in man. ( Christensen, AB; Groth, S; Nielsen, H; Pedersen, AG; Rørth, M; Sørensen, JB, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prokopienko, AJ | 1 |
| West, RE | 1 |
| Stubbs, JR | 1 |
| Nolin, TD | 1 |
| Sirich, TL | 1 |
| Aronov, PA | 1 |
| Plummer, NS | 2 |
| Hostetter, TH | 2 |
| Meyer, TW | 2 |
| Marquez, IO | 1 |
| Tambra, S | 1 |
| Luo, FY | 1 |
| Li, Y | 1 |
| Klingensmith, WC | 1 |
| Fritzberg, AR | 1 |
| Spitzer, VM | 1 |
| Johnson, DL | 1 |
| Kuni, CC | 1 |
| Williamson, MR | 1 |
| Washer, G | 1 |
| Weil, R | 1 |
| van Guldener, C | 1 |
| Gans, RO | 1 |
| ter Wee, PM | 1 |
| Clorius, JH | 1 |
| Mandelbaum, A | 1 |
| Hupp, T | 1 |
| Reinbold, F | 1 |
| Zuna, I | 1 |
| Denk, S | 1 |
| Fellhauer, C | 1 |
| van Kaick, G | 1 |
| Stĕtinová, V | 1 |
| Trejtnar, F | 1 |
| Kopecký, J | 1 |
| Grossmann, V | 1 |
| Kvètina, J | 1 |
| Kopecká, L | 1 |
| Semecký, V | 1 |
| Groth, S | 1 |
| Nielsen, H | 1 |
| Sørensen, JB | 1 |
| Christensen, AB | 1 |
| Pedersen, AG | 1 |
| Rørth, M | 1 |
| Taylor, A | 1 |
| Lallone, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Pilot Study of Hemodialysis Initiation Comparing Twice-Weekly Hemodialysis Plus Dialysis-Sparing Therapy Versus Thrice-Weekly Hemodialysis (The TWOPLUS-HD Trial)[NCT03740048] | Phase 3 | 51 participants (Actual) | Interventional | 2019-06-19 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Residual renal clearance was calculated based on 24-hour urine collection performed at baseline at enrollment; and interdialytic urine collection performed at baseline, 6 Weeks, 12 Weeks and 24 Weeks (NCT03740048)
Timeframe: Baseline, 6 Weeks, 12 Weeks, 24 Weeks
| Intervention | mL/day (Least Squares Mean) | |||
|---|---|---|---|---|
| Urine volume at Baseline | Urine volume at Week 6 | Urine volume at 12 weeks | Urine volume at 24 Weeks | |
| Conventional Hemodialysis Regimen | 1424 | 553 | 484 | 876 |
| Hemodialysis and Pharmacologic Therapy | 914 | 504 | 479 | 862 |
Residual renal clearance was calculated based on 24-hour urine collection performed at baseline at enrollment; and interdialytic urine collection performed during weeks 6, 12, and 24. (NCT03740048)
Timeframe: Baseline, 6 Weeks, 12 Weeks, 24 Weeks
| Intervention | mL/min/1.73m^2 (Least Squares Mean) | |||
|---|---|---|---|---|
| Baseline Renal Creatinine Clearance | Week 6 Renal Creatinine Clearance | Week 12 Renal Creatinine Clearance | Week 24 Renal Creatinine Clearance | |
| Conventional Hemodialysis Regimen | 10.8 | 6.8 | 5.8 | 5.4 |
| Hemodialysis and Pharmacologic Therapy | 8.4 | 5.5 | 5.3 | 5.6 |
Residual renal clearance was calculated based on 24-hour urine collection performed at baseline at enrollment; and interdialytic urine collection performed during weeks 6, 12, and 24. (NCT03740048)
Timeframe: Baseline, 6 Weeks, 12 Weeks, 24 Weeks
| Intervention | mL/min/1.73m^2 (Least Squares Mean) | |||
|---|---|---|---|---|
| Baseline Renal Urea Clearance | Week 6 Renal Urea Clearance | Week 12 Renal Urea Clearance | Week 24 Renal Urea Clearance | |
| Conventional Hemodialysis Regimen | 4.1 | 2.3 | 2.0 | 2.2 |
| Hemodialysis and Pharmacologic Therapy | 3.3 | 2.3 | 2.1 | 1.6 |
≥95% of participants randomized in the intervention group will adhere to the HD regimen. All participants who completed 6 and 12 months of follow-up completed interdialytic timed urine collections - Patient adherence to the study protocol was assessed by the number of participants randomized to each intervention who adhered to the study protocol and at 6 months and at 12 months (NCT03740048)
Timeframe: 6 months, 12 months, 24 months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Patients adherence to study protocol | interdialytic timed urine collections at 6 month followup | interdialytic timed urine collections at 12 month followup | |
| Conventional Hemodialysis Regimen | 24 | 19 | 10 |
| Hemodialysis and Pharmacologic Therapy | 22 | 19 | 10 |
1 trial available for hippuric acid and Kidney Diseases
| Article | Year |
|---|---|
Exercise activates renal dysfunction in hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Exercise; Female; Gamma Cameras; Heart Rate; Hippurates; Hu | 1996 |
8 other studies available for hippuric acid and Kidney Diseases
| Article | Year |
|---|---|
Development and validation of a UHPLC-MS/MS method for measurement of a gut-derived uremic toxin panel in human serum: An application in patients with kidney disease.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Cresols; Hippurates; Humans; Hydrogen | 2019 |
Numerous protein-bound solutes are cleared by the kidney with high efficiency.
Topics: Adult; Aged; Aged, 80 and over; Chromatography, Liquid; Cresols; Female; Hippurates; Humans; Indican | 2013 |
Contribution of residual function to removal of protein-bound solutes in hemodialysis.
Topics: Adult; Aged; Cresols; Female; Glomerular Filtration Rate; Hippurates; Humans; Indican; Kidney; Kidne | 2011 |
Clinical evaluation of Tc-99m N,N'-bis(mercaptoacetyl)-2,3-diaminopropanoate as a replacement for I-131 hippurate: concise communication.
Topics: Alanine; beta-Alanine; Computers; Computers, Analog; Hippurates; Humans; Iodine Radioisotopes; Kidne | 1984 |
Constant infusion clearance is an inappropriate method for accurate assessment of an impaired glomerular filtration rate.
Topics: Glomerular Filtration Rate; Hippurates; Humans; Infusions, Intravenous; Iodine Radioisotopes; Iothal | 1995 |
Possible use of excretion of tubular epithelial cells for the study of the nephrotoxic effect of xenobiotics.
Topics: Acetylglucosaminidase; Amphotericin B; Animals; Anti-Bacterial Agents; CD13 Antigens; Cyclosporine; | 1996 |
Acute and long-term nephrotoxicity of cis-platinum in man.
Topics: Acute Disease; Adult; Bleomycin; Chronic Disease; Cisplatin; Extracellular Space; Glomerular Filtrat | 1986 |
Differential renal function in unilateral renal injury: possible effects of radiopharmaceutical choice.
Topics: Animals; Glomerular Filtration Rate; Hippurates; Iodine Radioisotopes; Iothalamic Acid; Ischemia; Ki | 1985 |