hippuric acid has been researched along with Crohn Disease in 3 studies
hippuric acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #4591
N-benzoylglycine : An N-acylglycine in which the acyl group is specified as benzoyl.
Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has previously been observed that Crohn's disease (CD) patients excrete significantly less hippurate than controls." | 1.36 | Differences in gut microbial metabolism are responsible for reduced hippurate synthesis in Crohn's disease. ( Cobbold, JF; Cox, IJ; Marshall, SE; Orchard, TR; Taylor-Robinson, SD; Walker, DG; Williams, HR, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takis, PG | 1 |
| Oraiopoulou, ME | 1 |
| Konidaris, C | 1 |
| Troganis, AN | 1 |
| Williams, HR | 2 |
| Cox, IJ | 2 |
| Walker, DG | 2 |
| North, BV | 1 |
| Patel, VM | 1 |
| Marshall, SE | 2 |
| Jewell, DP | 1 |
| Ghosh, S | 1 |
| Thomas, HJ | 1 |
| Teare, JP | 1 |
| Jakobovits, S | 1 |
| Zeki, S | 1 |
| Welsh, KI | 1 |
| Taylor-Robinson, SD | 2 |
| Orchard, TR | 2 |
| Cobbold, JF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Controlled Trial of a Duodenal Sleeve Bypass Device (EndoBarrier)Compared With Standard Medical Therapy for the Management of Obese Subjects With Type 2 Diabetes[NCT02459561] | 170 participants (Actual) | Interventional | 2015-03-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for hippuric acid and Crohn Disease
| Article | Year |
|---|---|
(1)H-NMR based metabolomics study for the detection of the human urine metabolic profile effects of Origanum dictamnus tea ingestion.
Topics: Adult; Biomarkers; Citric Acid; Creatinine; Crohn Disease; Ethanol; Female; Greece; Hippurates; Huma | 2016 |
Characterization of inflammatory bowel disease with urinary metabolic profiling.
Topics: Adolescent; Adult; Aged; Biomarkers; Colitis, Ulcerative; Cresols; Crohn Disease; Female; Formates; | 2009 |
Differences in gut microbial metabolism are responsible for reduced hippurate synthesis in Crohn's disease.
Topics: Administration, Oral; Adult; Aged; Bacteria; Crohn Disease; Female; Follow-Up Studies; Gastrointesti | 2010 |