hinokiflavone has been researched along with Leukemia--Myelogenous--Chronic--BCR-ABL-Positive* in 1 studies
1 other study(ies) available for hinokiflavone and Leukemia--Myelogenous--Chronic--BCR-ABL-Positive
Article | Year |
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Hinokiflavone induces apoptosis, cell cycle arrest and autophagy in chronic myeloid leukemia cells through MAPK/NF-κB signaling pathway.
Chronic myeloid leukemia (CML) is a myeloproliferative tumor originating from hematopoietic stem cells, and resistance to tyrosine kinase inhibitors (TKI) has become a major cause of treatment failure. Alternative drug therapy is one of the important ways to overcome TKI resistance. Hinokiflavone (HF) is a C-O-C type biflavonoid with low toxicity and antitumor activity. This study investigated the antitumor effect and possible mechanisms of HF in CML cells.. Cell viability was measured by CCK-8 assay. Cell apoptosis and cell cycle distribution were analyzed by flow cytometry. Western blotting was used to assess protein expression levels.. HF shows a good anti-leukemia effect and is expected to become a potential therapeutic drug for CML. Topics: Apoptosis; Autophagy; Biflavonoids; Cell Cycle Checkpoints; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; NF-kappa B; Signal Transduction | 2022 |