Page last updated: 2024-10-28

hexobarbital and Pregnancy

hexobarbital has been researched along with Pregnancy in 53 studies

Hexobarbital: A barbiturate that is effective as a hypnotic and sedative.
hexobarbital : A member of the class of barbiturates taht is barbituric acid substituted at N-1 by methyl and at C-5 by methyl and cyclohex-1-enyl groups.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

Excerpt	Relevance	Reference
"In Dutch-belted rabbits, pregnancy caused several-fold decrease of in vitro hepatic microsomal aminopyrine, benzphetamine, and hexobarbital biotransformations."	3.65	Effect of pregnancy on hepatic microsomal drug metabolism in rabbits and rats. ( Becker, BA; Gut, I; Gutová, M, 1976)
"Chlordiazepoxide HCl, a widely used tranquilizer, was evaluated for pre- and postnatal effects in rats by dosing orally on days 1--21 of gestation."	1.26	Effects of chlordiazepoxide on the pre- and postnatal development of rats. ( Buttar, HS, 1980)

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	50 (94.34)	18.7374
1990's	2 (3.77)	18.2507
2000's	1 (1.89)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
KISS, J	1
DOHMANN, HJ	2
PFAU, P	1
BACH, HG	1
Cherala, G	1
Shapiro, BH	1
D'mello, AP	1
Fabro, S	1
Smith, RL	1
Williams, RT	1
Catz, C	1
Yaffe, SJ	1
Sunouchi, M	2
Takanaka, A	2
Mizokami, K	2
Inoue, K	2
Fujimori, K	1
Kasuya, Y	2
Omori, Y	2
Tabacova, S	2
Nikiforov, B	2
Balabaeva, L	1
Hinkova, L	1
Dvorchik, BH	1
Hartman, RD	1
Buttar, HS	1
Jänicke, B	1
Coper, H	1
Klinger, W	2
Muller, D	1
Guenthner, TM	1
Mannering, GJ	1
Laube, R	4
Niedner, W	4
Hofmann, KD	1
Schmidt, D	1
Varga, J	2
Kiszel, J	2
Csömör, S	2
Balázs-Varga, M	1
Patkós, P	1
Vorontsov, AA	1
Porokhniak, OIa	1
Balázs, M	1
Somos, P	1
Gut, I	1
Becker, BA	1
Gutová, M	1
Ugazio, G	1
Bosio, A	1
Nebbia, C	1
Soffietti, MG	1
Su, MQ	1
Okita, GT	1
McClain, RM	1
Rohrs, JM	1
Weisbach, W	3
Menzel, K	3
Wagner, F	3
Jäger, KH	3
Siegismund, K	1
Beutner, M	1
Kyegombe, D	1
Franklin, C	1
Bergheim, P	1
Bergstrom, H	1
Bernstein, K	1
Wilson, JT	3
Schlede, E	1
Borowski, R	1
Frohman, LA	1
Soyka, LF	1
Deckert, FW	1
Lübke, F	1
Zielske, F	1
Milagin, SP	1
Kazantsev, FN	1
Vesell, ES	1
Neale, MG	1
Parke, DV	1
Kjellmer, I	1
Magno, R	1
Karlsson, K	1
Remmer, H	1
Abgarian, MT	1
Horn, E	1
Grote, W	1
Kabarity, A	1
Schade, H	1
Short, CR	1
Davis, LE	1
Mitoma, C	1
LeValley, SE	1
Elger, J	1
Franke, H	1
Reinicke, C	1
Traeger, A	1
Volkmann, H	1
Wahrenberg, I	1
Ankermann, H	1
Adamicova, M	1
Cunderlik, V	1
Hennig, H	1
Gáti, I	2
Bognár, J	2
Thán, E	2
Tóth, K	1
Balogh, S	2
Panka, J	2
Ratkóci, I	2
Hasitz, S	2
Kóbor, J	1
Mutschler, F	1
Csaba, I	1
Saáry, Z	1
Lajos, L	1
Dixon, RL	1
Willson, VJ	1
Ordy, JM	1
Samorajski, T	1
Collins, RL	1
Rolsten, C	1
Wuest, HM	1
Fratta, I	1
Sigg, EB	1

Reviews

2 reviews available for hexobarbital and Pregnancy

Article	Year
Developmental pharmacology: a review of its application to clinical and basic science. Annual review of pharmacology, 1972, Volume: 12 Topics: Aging; Androgens; Aniline Compounds; Animals; Estrogens; Ethanol; Female; Fetus; Fluorosis, Dental;	1972
Factors causing interindividual variations of drug concentrations in blood. Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:1 Topics: Absorption; Animals; Drug Antagonism; Drug Interactions; Drug Therapy; Environment; Enzyme Induction	1974

Trials

1 trial available for hexobarbital and Pregnancy

Article	Year
Psychic reactions after analgesia with nitrous oxide for caesarean section. Lancet (London, England), 1968, Sep-07, Volume: 2, Issue:7567 Topics: Adult; Analgesia; Cesarean Section; Dreams; Fear; Female; Hexobarbital; Humans; Nitrous Oxide; Oxyge	1968

Other Studies

50 other studies available for hexobarbital and Pregnancy

Article	Year
[Distension of the uterine orifice in evipan narcosis during labor]. Magyar noorvosok lapja, 1954, Volume: 17, Issue:1 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Barbiturates; Cervix Uteri; Female; Hexobarbital; H	1954
[Multiple births in evipan-orasthin anesthesia]. Geburtshilfe und Frauenheilkunde, 1956, Volume: 16, Issue:12 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Barbiturates; Female; Hexobarbital; Humans; Labor,	1956
[Multiple births in evipan-orasthin anesthesia]. Geburtshilfe und Frauenheilkunde, 1956, Volume: 16, Issue:12 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Barbiturates; Female; Hexobarbital; Humans; Labor,	1956
[Multiple births in evipan-orasthin anesthesia]. Geburtshilfe und Frauenheilkunde, 1956, Volume: 16, Issue:12 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Barbiturates; Female; Hexobarbital; Humans; Labor,	1956
[Multiple births in evipan-orasthin anesthesia]. Geburtshilfe und Frauenheilkunde, 1956, Volume: 16, Issue:12 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Barbiturates; Female; Hexobarbital; Humans; Labor,	1956
[Obstetrical narcosis with evipan-orasthin]. Geburtshilfe und Frauenheilkunde, 1958, Volume: 18, Issue:6 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Barbiturates; Female; Hexobarbital; Humans; Labor,	1958
Effect of perinatal low protein diets on the ontogeny of select hepatic cytochrome p450 enzymes and cytochrome p450 reductase in the rat. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:7 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome	2007
Toxicity and teratogenicity of optical isomers of thalidomide. Nature, 1967, Jul-15, Volume: 215, Issue:5098 Topics: Abnormalities, Drug-Induced; Animals; Chemical Phenomena; Chemistry, Physical; Female; Fetus; Hexoba	1967
Strain and age variations in hexobarbital response. The Journal of pharmacology and experimental therapeutics, 1967, Volume: 155, Issue:1 Topics: Animals; Behavior, Animal; Estrus; Female; Hexobarbital; Liver; Male; Mice; Pregnancy; Sleep	1967
Comparison of hepatic drug-metabolizing enzymes induced by 3-methylcholanthrene and phenobarbital between pre- and postnatal rats. Toxicology and applied pharmacology, 1984, Volume: 73, Issue:3 Topics: Aminopyrine; Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Cytochrome P-450 Enzyme System	1984
Toxicological implications of chronic noise exposure during gestation. Developments in toxicology and environmental science, 1983, Volume: 11 Topics: Animals; Female; Fetus; Hexobarbital; Motor Activity; Noise; Pregnancy; Rats; Sleep	1983
[Development of hexobarbital radiometry and its application (author's transl)]. Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences, 1980, Volume: 98 Topics: Animals; Enzyme Induction; Female; Fetus; Hexobarbital; Liver; Male; Oxygenases; Polychlorinated Bip	1980
Activity of some mixed function oxidases in prenatally carbon disulphide (CS2) treated rats. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1980, Volume: 4 Topics: Animals; Body Weight; Carbon Disulfide; Female; Hexobarbital; Liver; Mixed Function Oxygenases; Orga	1980
Hydroxylation of hexobarbital and benzo[a]pyrene by hepatic microsomes isolated from the fetal stumptailed monkey (Macaca arctoides). A developmental study. Biochemical pharmacology, 1982, Mar-15, Volume: 31, Issue:6 Topics: Animals; Benzopyrenes; Female; Fetus; Hexobarbital; Hydroxylation; In Vitro Techniques; Kinetics; Ma	1982
Effects of chlordiazepoxide on the pre- and postnatal development of rats. Toxicology, 1980, Volume: 17, Issue:3 Topics: Animals; Animals, Newborn; Body Weight; Chlordiazepoxide; Female; Fetus; Hexobarbital; Male; Pregnan	1980
The effects of prenatal alcohol exposure on the behavior of rats during their life span. Journal of gerontology, 1993, Volume: 48, Issue:4 Topics: Adaptation, Physiological; Animals; Behavior, Animal; Ethanol; Female; Hexobarbital; Male; Motor Act	1993
Developmental aspects of xenobiotic transformation. Environmental health perspectives, 1976, Volume: 18 Topics: Aminopyrine; Aniline Compounds; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Cytochro	1976
Induction of hepatic mono-oxygenase systems of pregnant rats with phenobarbital and 3-methylcholanthrene. Biochemical pharmacology, 1977, Apr-01, Volume: 26, Issue:7 Topics: Aniline Compounds; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Binding Sites; C	1977
[Animal experiments to study placental passage of Sombrevin and Hexobarbital and their concentrations in various foetal organ systems (author's transl)]. Zentralblatt fur Gynakologie, 1979, Volume: 101, Issue:14 Topics: Animals; Brain Chemistry; Female; Fetus; Hexobarbital; Liver; Maternal-Fetal Exchange; Myocardium; P	1979
[Comparative studies of placentar diffusion of propanidid (Sombrevin) and barbiturate in premature pregnancies and cesarean sections]. Zentralblatt fur Gynakologie, 1977, Volume: 99, Issue:6 Topics: Cesarean Section; Female; Fetal Blood; Hexobarbital; Humans; In Vitro Techniques; Infant, Newborn; I	1977
[Complications in peridural anesthesia]. Vestnik khirurgii imeni I. I. Grekova, 1978, Volume: 121, Issue:8 Topics: Adolescent; Adult; Aged; Anesthesia, Epidural; Child; Female; Genital Diseases, Female; Heart Arrest	1978
[Barbiturate determination in maternal as well as fetal serum during anesthesia of diabetic and non-diabetic pregnancies]. Zentralblatt fur Gynakologie, 1977, Volume: 99, Issue:6 Topics: Anesthesia, Obstetrical; Cesarean Section; Female; Fetal Blood; Hexobarbital; Humans; Maternal-Fetal	1977
Effect of pregnancy on hepatic microsomal drug metabolism in rabbits and rats. Archives of toxicology, 1976, Jan-30, Volume: 35, Issue:1 Topics: Aminopyrine; Aniline Compounds; Animals; Benzphetamine; Cytochrome P-450 Enzyme System; Female; Hexo	1976
Age- and sex-related effects on hepatic drug metabolism in rats chronically exposed to dietary atrazine. Research communications in chemical pathology and pharmacology, 1991, Volume: 73, Issue:2 Topics: Age Factors; Aminopyrine; Aniline Compounds; Animals; Atrazine; Body Weight; Enzyme Induction; Femal	1991
Effects of methylmercury on hypnotic action of hexobarbital, liver hydroxylase and cytochrome P-450 in mice. Toxicology, 1986, Volume: 39, Issue:3 Topics: Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Female	1986
Potentiation of the teratogenic effects and altered disposition of diphenylhydantoin in mice fed a purified diet. Toxicology and applied pharmacology, 1985, Volume: 77, Issue:1 Topics: Analysis of Variance; Animals; Cleft Palate; Congenital Abnormalities; Diet; Female; Fetus; Hexobarb	1985
[Effects of various anesthesia procedures used in forceps delivery on the cardiopulmonary adaptation of the newborn infant. 1. Modification of cardiac adaptation]. Zentralblatt fur Gynakologie, 1985, Volume: 107, Issue:9 Topics: Anesthesia, Obstetrical; Electrocardiography; Female; Heart Rate; Hexobarbital; Humans; Infant, Newb	1985
[Effects of various anesthesia procedures used in forceps delivery on the cardiopulmonary adaptation of the newborn infant. 2. Modification of pulmonary adaptation]. Zentralblatt fur Gynakologie, 1985, Volume: 107, Issue:9 Topics: Anesthesia, Obstetrical; Female; Hexobarbital; Humans; Infant, Newborn; Obstetrical Forceps; Pregnan	1985
[Anesthesia in cesarean section]. Zentralblatt fur Gynakologie, 1985, Volume: 107, Issue:9 Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Apgar Score; Bupivacaine; Cesarean Section; Etomidate	1985
[Modification of the cardiopulmonary adaptation of newborn infants following cesarean section depending on the maternal anesthesia procedure. 2. Pulmonary adaptation]. Anaesthesiologie und Reanimation, 1985, Volume: 10, Issue:3 Topics: Adaptation, Physiological; Anesthetics; Cesarean Section; Female; Hexobarbital; Humans; Infant, Newb	1985
Drug-metabolising enzymes in the human placenta, their induction and repression. Lancet (London, England), 1973, Feb-24, Volume: 1, Issue:7800 Topics: Alcohol Oxidoreductases; Barbiturates; Biotransformation; Cell Membrane; Endoplasmic Reticulum; Enzy	1973
Proceedings: The influence of steroids on microsomal NADH oxidation in rat liver and human placenta. Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 282, Issue:Suppl Topics: Androstenols; Animals; Female; Hexobarbital; Humans; In Vitro Techniques; Kinetics; Microsomes; Micr	1974
Decreased effect of phenobarbital treatment on microsomal drug metabolizing enzyme activity during gestation. Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 281, Issue:4 Topics: Animals; Benzopyrenes; Body Weight; Cytochrome P-450 Enzyme System; Dealkylation; Depression, Chemic	1974
Concomitant association between high plasma levels of growth hormone and low hepatic mixed-function oxidase activity in the young rat. The Journal of pharmacology and experimental therapeutics, 1974, Volume: 189, Issue:1 Topics: Age Factors; Aminopyrine; Aniline Compounds; Animals; Animals, Newborn; Body Weight; Cytochrome c Gr	1974
Further studies on the inhibition of drug metabolism by pregnanolone and related steroids. Biochemical pharmacology, 1974, May-01, Volume: 23, Issue:11 Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Hormones; Animals; Animals, Newborn; Anisoles; Cholesterol	1974
[On the difficulties of the evaluation of various anesthetic procedures in cesarean section]. Geburtshilfe und Frauenheilkunde, 1965, Volume: 25, Issue:7 Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Obstetrical; Cesarean Section; Female; Hexobarbital; Human	1965
[Effect of barbiturate derivatives on the state of the newborn infants after cesarean section]. Akusherstvo i ginekologiia, 1974, Issue:3 Topics: Adult; Anesthesia, Endotracheal; Anesthesia, Obstetrical; Apgar Score; Cesarean Section; Female; Hex	1974
Effects of pregnancy on the metabolism of drugs in the rat and rabbit. Biochemical pharmacology, 1973, Jun-15, Volume: 22, Issue:12 Topics: Animals; Cytochrome P-450 Enzyme System; Female; Germ-Free Life; Glucuronates; Hexobarbital; Hydroxy	1973
Anesthesia for Cesarean section. I. Effects on the respiratory adaptation of the newborn in elective Cesarean section. Acta anaesthesiologica Scandinavica, 1974, Volume: 18, Issue:1 Topics: Acidosis; Adult; Anesthesia, General; Anesthesia, Obstetrical; Apgar Score; Blood; Carbon Dioxide; C	1974
[Changes of drug effects caused by their metabolism in the liver]. Monatsschrift fur Kinderheilkunde, 1971, Volume: 119, Issue:7 Topics: Aminopyrine; Animals; Cytochromes; Dogs; Drug Stability; Endoplasmic Reticulum; Female; Fetus; Hexob	1971
[Use of different anesthetics for induction anesthesia for cesarean section]. Zhurnal eksperimental'noi i klinicheskoi meditsiny, 1971, Volume: 11, Issue:5 Topics: Adolescent; Adult; Anesthesia, General; Anesthesia, Obstetrical; Asphyxia Neonatorum; Cesarean Secti	1971
[Experience on insufflation anesthesia in cesarean section]. Zentralblatt fur Gynakologie, 1969, Oct-18, Volume: 91, Issue:42 Topics: Anesthesia, Obstetrical; Cesarean Section; Female; Fetal Diseases; Hexobarbital; Humans; Infant, New	1969
[Effects of a barbituric acid derivative upon the embryogenesis of rabbits by means of mitotic disturbances]. Humangenetik, 1970, Volume: 8, Issue:4 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Culture Techniques; Embryo, Mammalian;	1970
Perinatal development of drug-metabolizing enzyme activity in swine. The Journal of pharmacology and experimental therapeutics, 1970, Volume: 174, Issue:2 Topics: Age Factors; Amphetamine; Animals; Animals, Newborn; Biotransformation; Cytochromes; Female; Fetus;	1970
Effect on newborn rats of perinatal exposure to phenobarbital. Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 187, Issue:1 Topics: Acetaminophen; Animals; Animals, Newborn; Antipyrine; Brain; Female; Hexobarbital; Microsomes, Liver	1970
[Studies on the mechanism of enzyme induction. XV. Induction pattern and submicroscopic changes in the liver following application of phenylbutazone in rats of different ages]. Acta biologica et medica Germanica, 1970, Volume: 24, Issue:4 Topics: Age Factors; Aminopyrine; Animals; Animals, Newborn; Ascorbic Acid; Cholestasis; Endoplasmic Reticul	1970
[Anesthesia in obstetrics and gynecology (clinical experiences in 2,344 cases)]. Zentralblatt fur Gynakologie, 1970, May-30, Volume: 92, Issue:22 Topics: Aged; Anesthesia, Endotracheal; Anesthesia, Intravenous; Anesthesia, Obstetrical; Barbiturates; Cesa	1970
[On the value of various methods of anesthesia for gynecologic surgery]. Acta chirurgica Academiae Scientiarum Hungaricae, 1967, Volume: 8, Issue:1 Topics: Anesthesia, Endotracheal; Anesthesia, Inhalation; Ethyl Ethers; Female; Genital Diseases, Female; Ge	1967
[On the role of anesthesia in the formulation of surgical results]. Acta chirurgica Academiae Scientiarum Hungaricae, 1967, Volume: 8, Issue:2 Topics: Adult; Age Factors; Aged; Anesthesia, Endotracheal; Anesthesia, Inhalation; Anesthesia, Intravenous;	1967
Metabolism of hexobarbital and zoxazolamine by placentae and fetal liver supernatant fraction and response to phenobarbital and chlordane treatment. Archives internationales de pharmacodynamie et de therapie, 1968, Volume: 172, Issue:2 Topics: Age Factors; Animals; Chlordan; Female; Fetus; Hexobarbital; Liver; Phenobarbital; Placenta; Pregnan	1968
The effect of a pituitary mammotropic tumor on hepatic microsomal drug metabolism in the rat. Biochemical pharmacology, 1968, Volume: 17, Issue:7 Topics: Adenocarcinoma; Adrenal Glands; Aminopyrine; Aniline Compounds; Animals; Benzoates; Benzopyrenes; Bo	1968
Prenatal chlorpromazine effects on liver, survival and behavior of mice offspring. The Journal of pharmacology and experimental therapeutics, 1966, Volume: 151, Issue:1 Topics: Animals; Animals, Newborn; Behavior, Animal; Birth Weight; Chlorpromazine; Female; Fetus; Hexobarbit	1966
Teratological studies in the thalidomide field. Life sciences, 1966, Volume: 5, Issue:5 Topics: Abnormalities, Drug-Induced; Animals; Drug Synergism; Female; Fetal Death; Hexobarbital; Mice; Pregn	1966