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hexobarbital and Palsy

hexobarbital has been researched along with Palsy in 40 studies

Hexobarbital: A barbiturate that is effective as a hypnotic and sedative.
hexobarbital : A member of the class of barbiturates taht is barbituric acid substituted at N-1 by methyl and at C-5 by methyl and cyclohex-1-enyl groups.

Research Excerpts

ExcerptRelevanceReference
"Effects of furazolidone (FZ) on the sleeping time induced with hexobarbital (HEX) and paralysis time induced by zoxazolamine (ZOX) were investigated by measuring the length of time required to recover from righting reflex loss in rats after oral administration of FZ at doses of 50, 100, 200 and 400 mg/kg/day for 4 successive days."3.69Effects of furazolidone on duration of righting reflex loss induced with hexobarbital and zoxazolamine in the rat. ( Sasaki, N, 1994)
"In male rats bearing carrageenan-induced paw edema twenty-four hours after treatment with carrageenan the duration of hexobarbital hypnosis was prolonged and the rate of hepatic hexobarbital metabolism was inhibited."3.68Modulation of zoxazolamine metabolism in carrageenan-induced inflammation in rats. ( Ishikawa, M; Sasaki, K; Yakayanagi, Y, 1990)
"Using hexobarbital sleeping and zoxazolamine paralysis time as indices of in vivo hepatic drug metabolism, the effects of endotoxin on drug action appear to be time- and dose-dependent and the lipid A moiety of endotoxin appears to be responsible for its inhibitory effects."3.67Effects of lipid A content, hydrocortisone and polymyxin B on endotoxin-induced decreases in in vivo drug metabolism. ( Abernathy, CO; Utili, R; Zimmerman, HJ, 1987)
" dose (5 mg/kg) of a light lanthanon, praseodymium, prolonged the duration of hexobarbital-induced sleep and zoxazolamine-induced paralysis, as well as it modified pharmacokinetic parameters of hexobarbital and zoxazolamine, in rats."3.67Effect of praseodymium chloride on liver microsomal enzymes of rats. ( Araujo Filho, AP; Galvão, JF; Oga, S; Yasaka, WJ, 1986)
" Pretreatment with piperine prolonged hexobarbital sleeping time and zoxazolamine paralysis time in mice at half the dose of SKF-525A."3.67Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism. ( Atal, CK; Dubey, RK; Singh, J, 1985)
" Both agents also prolonged hexobarbital sleeping time and zoxazolamine paralysis time in mice."3.66Protective effect of diethyldithiocarbamate and carbon disulfide against liver injury induced by various hepatotoxic agents. ( Masuda, Y; Nakayama, N, 1982)
"A single 8-h exposure to trans-1,2-dichloroethylene (t-DCE) or cis-1,2-dichloroethylene (c-DCE) at 200 ppm (hygienic standard in workplaces) resulted in a significant increase in the hexobarbital sleeping time, the zoxazolamine paralysis time, and the metabolic formation of 4-aminoantipyrine from aminopyrine in adult female Wistar rats."3.66Inhibition of mixed function oxidases in rat liver by trans- and cis-1,2-dichloroethylene. ( Freundt, KJ; Macholz, J, 1978)
"Zoxazolamine paralysis, hexobarbital anesthesia and digitoxin convulsions were diminished in rats by 3 days of pretreatment with pregnenolone-16alpha-carbonitrile (PCN)."3.65Studies on drug metabolism and liver ultrastructure after conjoint treatment with pregnenolone-16alpha-carbonitrile and dl-ethionine. ( Garg, BD; Kourounakis, P; Kovacs, K; Szabo, S; Tuchweber, B, 1977)
"Sixteen strains of mice were compared with respect to their hexobarbitone sleeping time and their zoxazolamine paralysis time."3.65A survey of the response of different strains of mice to substances metabolised by microsomal oxidation; hexobarbitone, zoxazolamine and warfarin. ( Lush, IE, 1976)
" A single oral 24-hr pretreatment with CVP (15 mg/kg) increased the oral LD50 of its next dosage to threefold."1.28Metabolic induction of the hepatic cytochrome P450 system by chlorfenvinphos in rats. ( Ikeda, T; Shirasu, Y; Tsuda, S, 1991)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199036 (90.00)18.7374
1990's3 (7.50)18.2507
2000's1 (2.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
PERRET, W1
VON REDWITZ, E1
Singh, B1
Chandan, BK1
Sharma, N1
Bhardwaj, V1
Satti, NK1
Gupta, VN1
Gupta, BD1
Suri, KA1
Suri, OP1
Calley, DJ1
Guess, WL1
Autian, J1
Cram, RL1
Fouts, JR1
Masuda, Y1
Nakayama, N1
Graham, JA1
Menzel, DB1
Miller, FJ1
Illing, JW1
Gardner, DE1
Abernathy, CO3
Zimmerman, HJ2
Utili, R2
Sasaki, N1
Freundt, KJ1
Macholz, J1
Yasaka, WJ2
Sasame, HA1
Saul, W1
Maling, HM1
Gillette, JR1
Unseld, A1
de Matteis, F1
Garg, BD2
Kourounakis, P1
Tuchweber, B3
Szabo, S2
Kovacs, K3
Mathur, PP1
Smyth, RD1
Witmer, CM1
Carr, GS1
Reavey-Cantwell, NH1
Wiebel, FJ1
Waters, HL1
Elliot, S1
Gelboin, HV1
Lush, IE1
Ikeda, T1
Tsuda, S1
Shirasu, Y1
Ishikawa, M1
Sasaki, K2
Yakayanagi, Y1
Oga, S1
Galvão, JF1
Araujo Filho, AP1
Atal, CK1
Dubey, RK1
Singh, J1
Buchel, L1
Absil, J1
Murawsky, M1
Kato, R3
Takanaka, A3
Coper, H1
von Herrath, D1
Veit, J1
Grosse, W1
Wade, AE1
Stonard, MD1
Nenov, PZ1
Lazar, G1
Murphy, JP1
Van Stee, EW1
Back, KC1
Radzialowski, FM1
Oppermann, JA1
Khandekar, JD1
Dardachti, D1
Brodeur, J1
Marchand, C1
Stull, RE1
Ferguson, NM1
Ferguson, GG1
Prabhu, VG1
Oester, YT1
Philpot, RM1
Guthrie, FE1
Hodgson, E1
Onoda, K1
Fujii, K1
Jaffe, H1
Bishop, Y1
Arnold, E1
Mackintosh, D1
Epstein, SS1
Lemberger, L1
Sernatinger, E1
Kuntzman, R1
Gerber, N1
Arnold, K1
Dewhurst, F1
Kitchen, DA1

Other Studies

40 other studies available for hexobarbital and Palsy

ArticleYear
[Evipan and curare paralysis as special form of narcosis paralysis].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1951, Volume: 22, Issue:5

    Topics: Barbital; Curare; Hexobarbital; Paralysis; Stupor

1951
[Evipan and curare paralysis as a special form of anesthetic paralysis].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1951, Volume: 22, Issue:11

    Topics: Anesthesia; Anesthetics; Brachial Plexus; Curare; Hexobarbital; Humans; Paralysis

1951
Isolation, structure elucidation and in vivo hepatoprotective potential of trans-tetracos-15-enoic acid from Indigofera tinctoria Linn.
    Phytotherapy research : PTR, 2006, Volume: 20, Issue:10

    Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fatty Acids, M

2006
Hepatotoxicity of a series of organotin esters.
    Journal of pharmaceutical sciences, 1967, Volume: 56, Issue:2

    Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Ataxia; Behavior, Animal; Blepharoptosis

1967
The influence of DDT and gamma-chlordane on the metabolism of hexobarbital and zoxazolamine in 2 mouse strains.
    Biochemical pharmacology, 1967, Volume: 16, Issue:6

    Topics: Animals; Chlordan; DDT; Hexobarbital; Male; Mice; Paralysis; Sleep; Zoxazolamine

1967
Protective effect of diethyldithiocarbamate and carbon disulfide against liver injury induced by various hepatotoxic agents.
    Biochemical pharmacology, 1982, Sep-01, Volume: 31, Issue:17

    Topics: Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Ditiocarb; Hexobarbital; Male; Mi

1982
Effect of ozone on drug-induced sleeping time in mice pretreated with mixed-function oxidase inducers and inhibitors.
    Toxicology and applied pharmacology, 1982, Mar-15, Volume: 62, Issue:3

    Topics: Animals; Drug Interactions; Enzyme Induction; Female; Hexobarbital; Mice; Mice, Inbred C57BL; Mice,

1982
Effects of endotoxin-tolerance on in vivo drug metabolism in mice.
    Research communications in chemical pathology and pharmacology, 1980, Volume: 29, Issue:1

    Topics: Animals; Drug Interactions; Drug Tolerance; Endotoxins; Hexobarbital; Male; Mice; Mice, Inbred BALB

1980
Effects of furazolidone on duration of righting reflex loss induced with hexobarbital and zoxazolamine in the rat.
    The Journal of veterinary medical science, 1994, Volume: 56, Issue:4

    Topics: Administration, Oral; Animals; Body Weight; Cytochrome P-450 Enzyme System; Dose-Response Relationsh

1994
Inhibition of mixed function oxidases in rat liver by trans- and cis-1,2-dichloroethylene.
    Toxicology, 1978, Volume: 10, Issue:2

    Topics: Animals; Dichloroethylenes; Female; Hexobarbital; Hydrocarbons, Chlorinated; In Vitro Techniques; Ki

1978
Mechanisms in the potentiation and inhibition of pharmacological actions of hexobarbital and zoxazolamine by glycofurol.
    Biochemical pharmacology, 1978, Volume: 27, Issue:24

    Topics: Animals; Behavior, Animal; Brain; Drug Interactions; Furans; Hexobarbital; In Vitro Techniques; Kine

1978
Destruction of endogenous and exogenous haem by 2-allyl-2-isopropylacetamide: role of the liver cytochrome P-450 which is inducible by phenobarbitone.
    The International journal of biochemistry, 1978, Volume: 9, Issue:12

    Topics: Acetamides; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; E

1978
Studies on drug metabolism and liver ultrastructure after conjoint treatment with pregnenolone-16alpha-carbonitrile and dl-ethionine.
    Archives internationales de pharmacodynamie et de therapie, 1977, Volume: 227, Issue:2

    Topics: Animals; Digitoxin; Drug Interactions; Ethionine; Female; Hexobarbital; In Vitro Techniques; Liver;

1977
Temporal pattern and reversal of impaired hepatic mono-oxygenases by phenobarbital in rats with developing and established adjuvant disease.
    The Journal of pharmacology and experimental therapeutics, 1977, Volume: 203, Issue:1

    Topics: Animals; Arthritis; Arthritis, Experimental; Cytochromes; Hexobarbital; Male; Microsomes, Liver; Oxy

1977
Effect of 7 8-benzoflavone on the duration of zoxazolamine paralysis and hexobarbital hypnosis in rats.
    Biochemical pharmacology, 1976, Jun-15, Volume: 25, Issue:12

    Topics: Animals; Depression, Chemical; Flavonoids; Hexobarbital; Male; Methylcholanthrene; Paralysis; Phenob

1976
A survey of the response of different strains of mice to substances metabolised by microsomal oxidation; hexobarbitone, zoxazolamine and warfarin.
    Chemico-biological interactions, 1976, Volume: 12, Issue:3-4

    Topics: Animals; Female; Hexobarbital; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Paralysis; Sex F

1976
Metabolic induction of the hepatic cytochrome P450 system by chlorfenvinphos in rats.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1991, Volume: 17, Issue:2

    Topics: Animals; Chlorfenvinphos; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; Hexobarb

1991
Modulation of zoxazolamine metabolism in carrageenan-induced inflammation in rats.
    Research communications in chemical pathology and pharmacology, 1990, Volume: 70, Issue:3

    Topics: Animals; Carrageenan; Edema; Female; Foot; Hexobarbital; Male; Paralysis; Rats; Rats, Inbred Strains

1990
Effects of lipid A content, hydrocortisone and polymyxin B on endotoxin-induced decreases in in vivo drug metabolism.
    Microbios, 1987, Volume: 49, Issue:199

    Topics: Animals; Endotoxins; Escherichia coli; Female; Hexobarbital; Hydrocortisone; Lipid A; Liver; Mice; M

1987
Effect of praseodymium chloride on liver microsomal enzymes of rats.
    Life sciences, 1986, Jun-02, Volume: 38, Issue:22

    Topics: Animals; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Drug Synergism; Half-Li

1986
Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:1

    Topics: Alkaloids; Animals; Aryl Hydrocarbon Hydroxylases; Benzodioxoles; Biological Availability; Dose-Resp

1985
[Half-life of hexobarbital and zoxazolamine in rodents. 2-In the rat].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1974, Volume: 168, Issue:2-3

    Topics: Animals; Brain Chemistry; Female; Half-Life; Hexobarbital; Injections, Intravenous; Male; Paralysis;

1974
Effect of starvation on the in vivo metabolism and effect of drugs in female and male rats.
    Japanese journal of pharmacology, 1967, Volume: 17, Issue:2

    Topics: Amides; Anesthesia; Animals; Barbiturates; Body Weight; Carisoprodol; Diphosphates; Female; Hexobarb

1967
On the mechanism of the sleep-prolonging effect of antimetabolites of nicotinamide.
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1968, Volume: 259, Issue:2

    Topics: Anesthesia; Animals; Antimetabolites; Brain; Central Nervous System; Glucosephosphate Dehydrogenase;

1968
The effect of thiamine consumption on liver microsomal drug-metabolizing pathways.
    The Journal of pharmacology and experimental therapeutics, 1971, Volume: 176, Issue:3

    Topics: Aminopyrine; Aniline Compounds; Animals; Body Weight; Cytochromes; Diet; Esterases; Female; Glucosep

1971
Effect of hexachlorobenzene on hepatic microsomal enzymes in the rat.
    Biochemical pharmacology, 1974, Volume: 23, Issue:15

    Topics: Aging; Alcohol Oxidoreductases; Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; Diet; Enzym

1974
Effect of hypophysectomy and cyproterone acetate on the liver ultrastructure as well as on hexobarbital anesthesia and zoxazolamine paralysis in rats.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1973, Volume: 5, Issue:2

    Topics: Androgen Antagonists; Animals; Body Weight; Cyproterone; Enzyme Induction; Female; Hexobarbital; Hyp

1973
Effect of dibromotetrafluoroethane inhalation on hepatic drug metabolism in mice.
    Biochemical pharmacology, 1973, Nov-15, Volume: 22, Issue:22

    Topics: Animals; Chlorofluorocarbons, Methane; Drug Interactions; Hexobarbital; Hydrocarbons, Halogenated; L

1973
Effect of phencyclidine on hepatic drug metabolism in the rat.
    Toxicology and applied pharmacology, 1974, Volume: 27, Issue:1

    Topics: Aminopyrine; Animals; Anisoles; Dealkylation; Hexobarbital; Hydroxylation; Liver; Male; Nitro Compou

1974
Hepatic fine structural changes and microsomal hypofunction in Walker tumor-bearing rats.
    Cancer, 1972, Volume: 29, Issue:3

    Topics: Adenocarcinoma; Animals; Benz(a)Anthracenes; Carcinoma 256, Walker; Endoplasmic Reticulum; Female; H

1972
Effect of splenectomy on the activity of drug-metabolizing enzymes in the liver of rats.
    Canadian journal of physiology and pharmacology, 1971, Volume: 49, Issue:3

    Topics: Animals; Anisoles; Biological Assay; Carbon Isotopes; Cytochromes; Enzyme Induction; Female; Hexobar

1971
Selected pharmacological studies of an alkaloidal extract of Banisteriopsis quitensis.
    Journal of pharmaceutical sciences, 1971, Volume: 60, Issue:8

    Topics: Alkaloids; Animals; Ataxia; Blood Pressure; Drug Interactions; Electrocardiography; Hallucinogens; H

1971
Neuromuscular functions of mature mice following neonatal monosodium glutamate.
    Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 189, Issue:1

    Topics: Animals; Animals, Newborn; Body Weight; Crowding; Dextroamphetamine; Female; Food Additives; Glutama

1971
Inductive effects of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane(DDT), phenobarbital, and benzpyrene on microsomal cytochrome B450, ethyl isocyanide spectra, and metabolism in vivo of zoxazolamine and hexobarbital in the mouse.
    Biochemical pharmacology, 1971, Volume: 20, Issue:9

    Topics: Animals; Benzopyrenes; Cyanides; Cytochrome P-450 Enzyme System; DDT; Enzyme Induction; Hexobarbital

1971
Metabolism of drugs in old rats. II. Metabolism in vivo and effect of drugs in old rats.
    Japanese journal of pharmacology, 1968, Volume: 18, Issue:4

    Topics: Aging; Anesthesia; Animals; Carisoprodol; Female; Hexobarbital; Injections, Intraperitoneal; Insecti

1968
Studies on age difference in mice for the activity of drug-metabolizing enzymes of liver microsomes.
    Japanese journal of pharmacology, 1970, Volume: 20, Issue:4

    Topics: Aging; Aminopyrine; Anesthesia; Aniline Compounds; Animals; Body Weight; Cytochromes; Electron Trans

1970
Structure-activity relations for methylenedioxyphenyl and related compounds on hepatic microsomal enzyme function, as measured by prolongation of hexobarbital narcosis and zoxazolamine paralysis in mice.
    Toxicology and applied pharmacology, 1970, Volume: 16, Issue:2

    Topics: Chemical Phenomena; Chemistry; Dioxoles; Drug Synergism; Hexobarbital; Insecticides; Microsomes, Liv

1970
Effect of desmethylimipramine, iprindole and DL-erythro-alpha-(3,4-dichlorophenyl)-beta-(t-butyl amino) propanol HC1 on the metabolism of amphetamine.
    Biochemical pharmacology, 1970, Volume: 19, Issue:12

    Topics: 1-Propanol; Amines; Amino Alcohols; Amphetamine; Animals; Antidepressive Agents; Brain; Butylamines;

1970
Studies on the metabolism of diphenylhydantoin in mice.
    The Journal of pharmacology and experimental therapeutics, 1969, Volume: 167, Issue:1

    Topics: Animals; Cycloheximide; Cytochromes; Hexobarbital; Hydroxyzine; Kinetics; Liver; Male; Mice; Microso

1969
The effect of benzo[a]pyrene derivatives upon drug metabolising enzyme activities.
    Biochemical pharmacology, 1969, Volume: 18, Issue:4

    Topics: Animals; Benzopyrenes; Chemical Phenomena; Chemistry; Enzyme Induction; Hexobarbital; Liver; Mice; P

1969