hexobarbital has been researched along with Liver Diseases in 21 studies
Hexobarbital: A barbiturate that is effective as a hypnotic and sedative.
hexobarbital : A member of the class of barbiturates taht is barbituric acid substituted at N-1 by methyl and at C-5 by methyl and cyclohex-1-enyl groups.
Liver Diseases: Pathological processes of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with acute hepatitis and patients with compensated or decompensated cirrhosis of the liver have a decreased plasma clearance of hexobarbital." | 3.66 | [Drug metabolism in patients with liver disease (author's transl)]. ( Epping, J; Fuchshofen-Röckel, M; Heusler, H; Richter, E; Zilly, W, 1980) |
| "Hexobarbital was determined by gas chromatography with N-selective detection, and a single point clearance was calculated." | 1.28 | [Drug clearance as a decision aid for further invasive liver diagnosis--studies with hexobarbital as a model substrate]. ( Richter, E; Zilly, W, 1992) |
| "The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase." | 1.28 | Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis? ( Ben-Zvi, Z; Danon, A; Katz, S; Weissman-Teitellman, B, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (71.43) | 18.7374 |
| 1990's | 4 (19.05) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vorne, M | 2 |
| Arvela, P | 1 |
| Alavaikko, M | 2 |
| BUSANNY-CASPARI, W | 1 |
| ROCHOLL, G | 1 |
| GREWE, HE | 1 |
| KREMER, K | 1 |
| Sadasivan, S | 1 |
| Latha, PG | 1 |
| Sasikumar, JM | 1 |
| Rajashekaran, S | 1 |
| Shyamal, S | 1 |
| Shine, VJ | 1 |
| Singh, B | 2 |
| Chandan, BK | 2 |
| Sharma, N | 1 |
| Bhardwaj, V | 2 |
| Satti, NK | 1 |
| Gupta, VN | 2 |
| Gupta, BD | 1 |
| Suri, KA | 1 |
| Suri, OP | 1 |
| Cebula, TA | 1 |
| El-Hage, AN | 1 |
| Ferrans, VJ | 1 |
| Kündiger, R | 1 |
| Müller, R | 1 |
| Bien, E | 1 |
| Gohlke, R | 1 |
| Rietbrock, I | 1 |
| Richter, E | 2 |
| Epping, J | 1 |
| Fuchshofen-Röckel, M | 1 |
| Heusler, H | 1 |
| Zilly, W | 2 |
| Barkova, EN | 1 |
| Gurov, OV | 1 |
| Anand, KK | 1 |
| Saxena, AK | 1 |
| Chiba, T | 1 |
| Horiuchi, M | 1 |
| Akashi, Y | 1 |
| Suriyachan, D | 1 |
| Thithapandha, A | 1 |
| Ben-Zvi, Z | 1 |
| Weissman-Teitellman, B | 1 |
| Katz, S | 1 |
| Danon, A | 1 |
| Schellens, JH | 1 |
| Janssens, AR | 1 |
| van der Wart, JH | 1 |
| van der Velde, EA | 1 |
| Breimer, DD | 1 |
| McEwen, J | 1 |
| Stevenson, IH | 1 |
| Wei, E | 1 |
| Wong, LC | 1 |
| Hine, CH | 1 |
| Varga, F | 1 |
| Fischer, E | 1 |
| Stenger, RJ | 1 |
| Johnson, EA | 1 |
2 reviews available for hexobarbital and Liver Diseases
| Article | Year |
|---|---|
[Altered pharmacokinetics of anaesthetic agents in liver disease during anaesthesia and surgery and intensive-care treatment (author's transl)].
Topics: Anesthetics; Critical Care; Dose-Response Relationship, Drug; Drug Tolerance; Fentanyl; Hexobarbital | 1980 |
Drug metabolism.
Topics: Adult; Aged; Alcohol Oxidoreductases; Animals; Antipyrine; Dogs; Enzyme Induction; Enzyme Inhibitors | 1972 |
19 other studies available for hexobarbital and Liver Diseases
| Article | Year |
|---|---|
Effect of phenobarbital on hepatic injury induced by chronic carbon tetrachloride treatment.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Synergism; Excitatory Am | 1981 |
[The problem of evipan narcosis in liver disease].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthesia, Intravenous; Barbiturates; Hexobarbital | 1954 |
[Investigations on the effect of methionine on the course of evipal narcosis in experimental liver disease].
Topics: Anesthesia; Barbital; Hexobarbital; Liver Diseases; Methionine; Stupor | 1951 |
Hepatoprotective studies on Hedyotis corymbosa (L.) Lam.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dose-Respo | 2006 |
Isolation, structure elucidation and in vivo hepatoprotective potential of trans-tetracos-15-enoic acid from Indigofera tinctoria Linn.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fatty Acids, M | 2006 |
Toxic interactions of benzyl alcohol with bacterial endotoxin.
Topics: Animals; Benzyl Alcohol; Benzyl Alcohols; Benzyl Compounds; Blood Chemical Analysis; Chemical and Dr | 1984 |
[Enzyme activities in the blood serum from rats with chronic liver damage. part 3: Effect of thioacetamide].
Topics: Acetamides; Animals; Chemical and Drug Induced Liver Injury; Hexobarbital; Liver; Liver Diseases; Ma | 1983 |
[Drug metabolism in patients with liver disease (author's transl)].
Topics: Acute Disease; Adult; Antipyrine; Biological Availability; Biotransformation; Cholestasis; Female; H | 1980 |
[Daily dynamics of the duration of hexenal narcosis in experimental hepatosis].
Topics: Animals; Chemical and Drug Induced Liver Injury; Circadian Rhythm; Hexobarbital; Hypnotics and Sedat | 1995 |
3,4,5-Trihydroxy benzoic acid (gallic acid), the hepatoprotective principle in the fruits of Terminalia belerica-bioassay guided activity.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Female; Gallic Acid | 1997 |
[Effect of thiol compounds on experimental liver damage (III). Effect of tiopronin (2-mercaptopropionylglycine) and glutathione on drug metabolizing activity (author's transl)].
Topics: Amino Acids, Sulfur; Aminopyrine; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Chemical | 1979 |
Modification of carbon tetrachloride hepatotoxicity by chemicals.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1977 |
[Drug clearance as a decision aid for further invasive liver diagnosis--studies with hexobarbital as a model substrate].
Topics: Cytochrome P-450 CYP11B2; Cytochrome P-450 Enzyme System; Diagnosis, Differential; Hepatitis, Chroni | 1992 |
Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis?
Topics: Acetaminophen; Animals; Aspirin; Chemical and Drug Induced Liver Injury; Glutathione; Hexobarbital; | 1990 |
Relationship between the metabolism of antipyrine, hexobarbital and theophylline in patients with liver disease as assessed by a 'cocktail' approach.
Topics: Adult; Aged; Antipyrine; Female; Hexobarbital; Humans; Liver Diseases; Male; Metabolic Clearance Rat | 1989 |
Selective potentiation of carbon tetrachloride hepatotoxicity by ethanol.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Dr | 1971 |
Effect of carbon tetrachloride induced progressive liver damage on the metabolism of hexobarbital and bilirubin in vivo.
Topics: Animals; Bilirubin; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hexob | 1971 |
Hexobarbital sleeping time in male rats with hepatic injury.
Topics: Acetates; Alcohols; Amides; Animals; Aspartate Aminotransferases; Benzene Derivatives; Biotransforma | 1969 |
Further observations upon the effects of phenobarbital pretreatment on the hepatotoxicity of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Endoplasmic Reticul | 1971 |