hexobarbital has been researched along with Liver Cirrhosis in 9 studies
Hexobarbital: A barbiturate that is effective as a hypnotic and sedative.
hexobarbital : A member of the class of barbiturates taht is barbituric acid substituted at N-1 by methyl and at C-5 by methyl and cyclohex-1-enyl groups.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The average elimination half-life of hexobarbital had decreased from 624 to 262 min and that of tolbutamide from 292 to 160 min following rifampicin treatment." | 5.26 | Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance. ( Breimer, DD; Richter, E; Zilly, W, 1977) |
| "Hexobarbital was determined gaschromatographically in serial blood samples and the hexobarbital-clearance was calculated from the plasma concentration curve versus time." | 5.26 | [Metabolism of hexobarbital in patients with acute hepatitis and cirrhosis (author's transl)]. ( Brachtel, D; Breimer, DD; Gallenkamp, H; Keller, B; Richter, E; Zilly, W, 1977) |
| "Patients with acute hepatitis and patients with compensated or decompensated cirrhosis of the liver have a decreased plasma clearance of hexobarbital." | 3.66 | [Drug metabolism in patients with liver disease (author's transl)]. ( Epping, J; Fuchshofen-Röckel, M; Heusler, H; Richter, E; Zilly, W, 1980) |
| "Hexobarbital was determined by gas chromatography with N-selective detection, and a single point clearance was calculated." | 1.28 | [Drug clearance as a decision aid for further invasive liver diagnosis--studies with hexobarbital as a model substrate]. ( Richter, E; Zilly, W, 1992) |
| " The average elimination half-life of hexobarbital had decreased from 624 to 262 min and that of tolbutamide from 292 to 160 min following rifampicin treatment." | 1.26 | Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance. ( Breimer, DD; Richter, E; Zilly, W, 1977) |
| "Hexobarbital was determined gaschromatographically in serial blood samples and the hexobarbital-clearance was calculated from the plasma concentration curve versus time." | 1.26 | [Metabolism of hexobarbital in patients with acute hepatitis and cirrhosis (author's transl)]. ( Brachtel, D; Breimer, DD; Gallenkamp, H; Keller, B; Richter, E; Zilly, W, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Richter, E | 5 |
| Epping, J | 1 |
| Fuchshofen-Röckel, M | 1 |
| Heusler, H | 1 |
| Zilly, W | 5 |
| Breimer, DD | 3 |
| Gallenkamp, H | 1 |
| Keller, B | 1 |
| Brachtel, D | 1 |
| Vorne, M | 3 |
| Arvela, P | 1 |
| Alavaikko, M | 1 |
| Srinivasan, S | 1 |
| Balwani, JH | 1 |
9 other studies available for hexobarbital and Liver Cirrhosis
| Article | Year |
|---|---|
[Drug metabolism in patients with liver disease (author's transl)].
Topics: Acute Disease; Adult; Antipyrine; Biological Availability; Biotransformation; Cholestasis; Female; H | 1980 |
Hexobarbital disposition in compensated and decompensated cirrhosis of the liver.
Topics: Adult; Aged; Ascites; Blood Proteins; Female; Half-Life; Hexobarbital; Humans; Kinetics; Liver Cirrh | 1978 |
Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance.
Topics: Adult; Aged; Cholestasis; Female; Hexobarbital; Humans; Kinetics; Liver Cirrhosis; Male; Metabolic C | 1977 |
[Metabolism of hexobarbital in patients with acute hepatitis and cirrhosis (author's transl)].
Topics: Acute Disease; Adolescent; Adult; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Female | 1977 |
[Drug clearance as a decision aid for further invasive liver diagnosis--studies with hexobarbital as a model substrate].
Topics: Cytochrome P-450 CYP11B2; Cytochrome P-450 Enzyme System; Diagnosis, Differential; Hepatitis, Chroni | 1992 |
Effect of carbon tetrachloride induced progressive liver damage on drug-metabolizing enzymes and cytochrome P-450 in rat liver.
Topics: Aniline Compounds; Animals; Body Weight; Carbon Tetrachloride; Cytochromes; Glucosephosphate Dehydro | 1971 |
Effect of carbon tetrachloride induced progressive liver damage on the metabolism of hexobarbital and bilirubin in vivo.
Topics: Animals; Bilirubin; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hexob | 1971 |
Effect of partial liver resection and phenobarbital on the restoration of impaired drug metabolism in carbon tetrachloride induced liver damage.
Topics: Animals; Benzoates; Carbon Tetrachloride Poisoning; Cytochromes; Enzyme Induction; Hepatectomy; Hexo | 1971 |
Effect of zinc sulphate on carbon tetrachloride hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Hexobarbital; Injections, Intraperito | 1969 |