hexobarbital has been researched along with Bile Duct Obstruction in 13 studies
Hexobarbital: A barbiturate that is effective as a hypnotic and sedative.
hexobarbital : A member of the class of barbiturates taht is barbituric acid substituted at N-1 by methyl and at C-5 by methyl and cyclohex-1-enyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pharmacokinetics of hexobarbital in rats is not influenced by ligature of the common bile duct or by ANIT-cholestasis." | 7.65 | [Hexobarbital-oxidation in vivo and in vitro in rats with bile duct ligation or ANIT-cholestasis (author's transl)]. ( Brachtel, D; Gallenkamp, H; Richter, E, 1977) |
| "Phenobarbital treatment leads to a decrease of the total biliary excretion of metabolites to about 200 microgram/100 g bw/h, the metabolite pattern remaining unchanged." | 5.26 | Alternative transport pathways of cholephilic 14C-hexobarbital metabolites in rats with experimental hepatitis and cholestasis. ( Buschmann, J; Joeres, R; Richter, E; Zilly, W, 1979) |
| " The average elimination half-life of hexobarbital had decreased from 624 to 262 min and that of tolbutamide from 292 to 160 min following rifampicin treatment." | 5.26 | Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance. ( Breimer, DD; Richter, E; Zilly, W, 1977) |
| "Patients with acute hepatitis and patients with compensated or decompensated cirrhosis of the liver have a decreased plasma clearance of hexobarbital." | 3.66 | [Drug metabolism in patients with liver disease (author's transl)]. ( Epping, J; Fuchshofen-Röckel, M; Heusler, H; Richter, E; Zilly, W, 1980) |
| "Pharmacokinetics of hexobarbital in rats is not influenced by ligature of the common bile duct or by ANIT-cholestasis." | 3.65 | [Hexobarbital-oxidation in vivo and in vitro in rats with bile duct ligation or ANIT-cholestasis (author's transl)]. ( Brachtel, D; Gallenkamp, H; Richter, E, 1977) |
| "Phenobarbital treatment leads to a decrease of the total biliary excretion of metabolites to about 200 microgram/100 g bw/h, the metabolite pattern remaining unchanged." | 1.26 | Alternative transport pathways of cholephilic 14C-hexobarbital metabolites in rats with experimental hepatitis and cholestasis. ( Buschmann, J; Joeres, R; Richter, E; Zilly, W, 1979) |
| " The average elimination half-life of hexobarbital had decreased from 624 to 262 min and that of tolbutamide from 292 to 160 min following rifampicin treatment." | 1.26 | Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance. ( Breimer, DD; Richter, E; Zilly, W, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Richter, E | 6 |
| Epping, J | 1 |
| Fuchshofen-Röckel, M | 1 |
| Heusler, H | 1 |
| Zilly, W | 5 |
| Joeres, R | 1 |
| Buschmann, J | 1 |
| Brachtel, D | 3 |
| Gallenkamp, H | 2 |
| Breimer, DD | 1 |
| Drew, R | 2 |
| Priestly, BG | 2 |
| O'Reilly, WJ | 1 |
| Ahonen, J | 1 |
| Aronsen, KF | 1 |
| Auranen, A | 1 |
| Grün, M | 1 |
| Kühn, HA | 1 |
| Klinger, W | 1 |
| Elger, J | 1 |
| Franke, H | 1 |
| Reinicke, C | 1 |
| Traeger, A | 1 |
| Volkmann, H | 1 |
| Wahrenberg, I | 1 |
| Ankermann, H | 1 |
| Kaltiala, EH | 1 |
| Roberts, RJ | 1 |
| Plaa, GL | 1 |
13 other studies available for hexobarbital and Bile Duct Obstruction
| Article | Year |
|---|---|
[Drug metabolism in patients with liver disease (author's transl)].
Topics: Acute Disease; Adult; Antipyrine; Biological Availability; Biotransformation; Cholestasis; Female; H | 1980 |
Alternative transport pathways of cholephilic 14C-hexobarbital metabolites in rats with experimental hepatitis and cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Cholestasis; Chromatography, Thin Layer; Galactosamine; Hep | 1979 |
[Symposion B: Experimental cholestasis--in vitro metabolism and in vivo metabolic clearance of hexobarbital in rats with ANIT-cholestasis].
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Cytochrome P-450 Enzyme System; Hexobarbital; Male; | 1976 |
Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance.
Topics: Adult; Aged; Cholestasis; Female; Hexobarbital; Humans; Kinetics; Liver Cirrhosis; Male; Metabolic C | 1977 |
Hexobarbital pharmacokinetics in rats after ligation of the common bile duct.
Topics: Animals; Cholestasis; Common Bile Duct; Hexobarbital; Injections, Intraperitoneal; Injections, Intra | 1977 |
[Hexobarbital-oxidation in vivo and in vitro in rats with bile duct ligation or ANIT-cholestasis (author's transl)].
Topics: 1-Naphthylisothiocyanate; Animals; Biotransformation; Cholestasis; Common Bile Duct; Disease Models, | 1977 |
Microsomal hexobarbital metabolizing enzymes in regenerating cholestatic rat liver.
Topics: Alkaline Phosphatase; Animals; Bilirubin; Cholestasis; Hexobarbital; Liver Regeneration; Male; Micro | 1977 |
Microsomal drug metabolism during alpha-naphthylisothiocyanate-induced cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Cholestasis; Hexobarbital; Liver; Male; Microsomes, Liver; | 1976 |
Liver involvement in cholecystitis and in obstructive icterus. A study with special reference to hexobarbital metabolism and glucose-6-phosphatase activity of human liver microsomes.
Topics: Adolescent; Adult; Aged; Animals; Biopsy; Carbohydrate Metabolism; Cholecystitis; Cholelithiasis; Ch | 1972 |
[Drug metabolism in experimental cholestasis].
Topics: Animals; Cholestasis; Hexobarbital; Phenobarbital; Rats | 1972 |
[Studies on the mechanism of enzyme induction. XV. Induction pattern and submicroscopic changes in the liver following application of phenylbutazone in rats of different ages].
Topics: Age Factors; Aminopyrine; Animals; Animals, Newborn; Ascorbic Acid; Cholestasis; Endoplasmic Reticul | 1970 |
The experimental obstructive jaundice and liver microsomal enzymes in rats.
Topics: Animals; Chlorpromazine; Cholestasis; Hexobarbital; Isonipecotic Acids; Male; Microsomes, Liver; Rat | 1971 |
Effect of norethandrolone, acetohexamide, and Enovid on alpha-naphthylisothiocyanate-induced hyperbilirubinemia and cholestasis.
Topics: Acetohexamide; Alanine Transaminase; Animals; Cholestasis; Drug Synergism; Hexobarbital; Hyperbiliru | 1966 |