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hexobarbital and Aging

hexobarbital has been researched along with Aging in 30 studies

Hexobarbital: A barbiturate that is effective as a hypnotic and sedative.
hexobarbital : A member of the class of barbiturates taht is barbituric acid substituted at N-1 by methyl and at C-5 by methyl and cyclohex-1-enyl groups.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The influence of aging on the metabolism of antipyrine (AP) and hexobarbital enantiomers (R-HB and S-HB) with and without phenobarbital (PB) induction was investigated in a longitudinal study in rats aged 6, 12, 24 and 30 months."7.69The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: a longitudinal study. ( Breimer, DD; Groen, K; Jansen, EJ; van Bezooijen, CF, 1994)
" For S-hexobarbital the half-life is somewhat shorter and the volume of distribution and plasma clearance is higher than for its antipode."1.28Influence of age on stereoselective pharmacokinetics and metabolism of hexobarbital in the rat. ( Belpaire, FM; Bogaert, MG; De Smet, F; Rosseel, MT; Vermeulen, AM, 1992)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199025 (83.33)18.7374
1990's5 (16.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
STREICHER, E1
GARBUS, J1
KATO, R4
VASSANELLI, P1
FRONTINO, G1
CHIESARA, E1
ALBRECHT, E1
KUNTZMAN, R1
JACOBSON, M1
SCHNEIDMAN, K1
CONNEY, AH1
Lee, NH1
Hospado, MA1
Manthei, RW2
Shapiro, BH3
Szczotka, SM1
Bolander, HG1
Halász, P1
Baird, MB3
Agrawal, AK1
Pampori, NA1
Groen, K1
Breimer, DD1
Jansen, EJ1
van Bezooijen, CF1
Korkmaz, S1
Carlsson, S1
Wahlström, G1
Weiss, LR1
Krop, S1
James, RC1
Franklin, MR1
Nicolosi, RJ1
Massie, HR2
Samis, HV1
Zimmerman, JA1
Pacilio, LV1
Vermeulen, AM1
Belpaire, FM1
De Smet, F1
Rosseel, MT1
Bogaert, MG1
Smith, DA1
Chandler, MH2
Shedlofsky, SI1
Wedlund, PJ1
Blouin, RA2
Niedermeyer, TM1
Scott, SR1
Klinger, W3
Freytag, A1
Schmitt, W1
Wilson, JT1
Takanaka, A3
Hospador, MA1
Grosso, LS1
Stonard, MD1
Nenov, PZ1
Funcke, AB1
Timmerman, H1
Onoda, K1
Ankermann, H1
Möller, A1
Kramer, B1

Reviews

1 review available for hexobarbital and Aging

ArticleYear
Developmental pharmacology: a review of its application to clinical and basic science.
    Annual review of pharmacology, 1972, Volume: 12

    Topics: Aging; Androgens; Aniline Compounds; Animals; Estrogens; Ethanol; Female; Fetus; Fluorosis, Dental;

1972

Other Studies

29 other studies available for hexobarbital and Aging

ArticleYear
The effect of age and sex on the duration of hexobarbital anesthesia in rats.
    Journal of gerontology, 1955, Volume: 10, Issue:4

    Topics: Aging; Analgesia; Anesthesia; Anesthesia and Analgesia; Animals; Barbiturates; Education, Medical; H

1955
VARIATION IN THE ACTIVITY OF LIVER MICROSOMAL DRUG-METABOLIZING ENZYMES IN RATS IN RELATION TO THE AGE.
    Biochemical pharmacology, 1964, Volume: 13

    Topics: Aging; Animals, Newborn; Carisoprodol; Diphosphates; Hexobarbital; Insecticides; Liver; Meprobamate;

1964
[EVALUATION OF POTENTIATED BARBITURATE ANESTHESIA IN GYNECOLOGICAL OPERATIONS].
    Zeitschrift fur arztliche Fortbildung, 1964, May-01, Volume: 58

    Topics: Aging; Anesthesia; Anesthesia, Intravenous; Barbiturates; Female; Genital Diseases, Female; Hexobarb

1964
SIMILARITIES BETWEEN OXIDATIVE DRUG-METABOLIZING ENZYMES AND STEROID HYDROXYLASES IN LIVER MICROSOMES.
    The Journal of pharmacology and experimental therapeutics, 1964, Volume: 146

    Topics: Aging; Animals; Chlordan; Estradiol; Fatty Acids; Hexobarbital; Liver; Methylcholanthrene; Mice; Mic

1964
Influence of age and dietary stress on hexobarbital activity in mice.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1967, Volume: 125, Issue:1

    Topics: Aging; Animals; Body Weight; Diet; Dietary Carbohydrates; Dietary Proteins; Hexobarbital; In Vitro T

1967
Androgenic repression of hexobarbitone metabolism and action in Crl:CD-1 (ICR)BR mice.
    British journal of pharmacology, 1984, Volume: 81, Issue:1

    Topics: Aging; Androgens; Animals; Castration; Female; Hexobarbital; In Vitro Techniques; Kinetics; Male; Mi

1984
Age-related changes in CNS-sensitivity to hexobarbital and thiopental in the rat.
    Archives internationales de pharmacodynamie et de therapie, 1984, Volume: 267, Issue:2

    Topics: Aging; Anesthesia; Animals; Body Weight; Brain; Brain Chemistry; Electroencephalography; Hexobarbita

1984
Generalized epilepsy with spike-wave paroxysms as an epileptic disorder of the function of sleep promotion.
    Acta physiologica Academiae Scientiarum Hungaricae, 1981, Volume: 57, Issue:1

    Topics: Adolescent; Adult; Aging; Brain; Circadian Rhythm; Consciousness; Electroencephalography; Epilepsies

1981
A longitudinal study of the relationship between aging and the duration of hexobarbital hypnosis in male CFN rats.
    Experimental gerontology, 1983, Volume: 18, Issue:1

    Topics: Aging; Animals; Biotransformation; Hexobarbital; Hypnosis, Anesthetic; Longitudinal Studies; Male; M

1983
Neonatal phenobarbital-induced defects in age- and sex-specific growth hormone profiles regulating monooxygenases.
    The American journal of physiology, 1995, Volume: 268, Issue:3 Pt 1

    Topics: Aging; Animals; Animals, Newborn; Female; Growth Hormone; Hexobarbital; Male; Microsomes, Liver; Mix

1995
The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: a longitudinal study.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:2

    Topics: Aging; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Longitud

1994
Maturation-related changes in tolerance development to hexobarbital after short term treatment with diazepam in the rat.
    Brain research, 1993, Jan-15, Volume: 600, Issue:2

    Topics: Aging; Animals; Diazepam; Drug Tolerance; Electroencephalography; Hexobarbital; Male; Rats; Rats, Sp

1993
Advanced age as a factor in the response of rodents to drugs [proceedings].
    Advances in experimental medicine and biology, 1978, Volume: 97

    Topics: Aging; Animals; Cricetinae; Female; Hexobarbital; Hydralazine; Isoproterenol; Male; Mesocricetus; Mi

1978
The triphasic amphetamine lethal dose curve in mice and its possible relationship to drug metabolism.
    Toxicology and applied pharmacology, 1978, Volume: 44, Issue:1

    Topics: Aging; Amphetamine; Animals; Anticonvulsants; Dextroamphetamine; Hexobarbital; In Vitro Techniques;

1978
Microsomal mixed-function oxidase activity and senescence-I. Hexobarbital sleep time and induction of components of the hepatic microsomal enzyme system in rats of different ages.
    Experimental gerontology, 1975, Volume: 10, Issue:2

    Topics: Age Factors; Aging; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Liver;

1975
Microsomal mixed-function oxidase activity and senescence--II. In vivo and in vitro hepatic drug metabolism in rats of different ages following partial hepatectomy.
    Experimental gerontology, 1976, Volume: 11, Issue:5-6

    Topics: Aging; Animals; Hepatectomy; Hexobarbital; Liver; Liver Regeneration; Male; Mixed Function Oxygenase

1976
Influence of age on stereoselective pharmacokinetics and metabolism of hexobarbital in the rat.
    Mechanisms of ageing and development, 1992, Volume: 65, Issue:2-3

    Topics: Aging; Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Hematocrit; Hexobarbital; Liver; Ma

1992
Age-dependent stereoselective increase in the oral clearance of hexobarbitone isomers caused by rifampicin.
    British journal of clinical pharmacology, 1991, Volume: 32, Issue:6

    Topics: Administration, Oral; Adult; Aged; Aging; Chromatography, High Pressure Liquid; Drug Interactions; H

1991
Selective androgen insensitivity of hepatic drug-metabolizing enzymes in senescent mice.
    Biochemical pharmacology, 1988, Jan-15, Volume: 37, Issue:2

    Topics: Aging; Animals; Body Weight; Female; Hexobarbital; Liver; Male; Mice; Mice, Inbred ICR; Microsomes,

1988
Age-associated stereoselective alterations in hexobarbital metabolism.
    Clinical pharmacology and therapeutics, 1988, Volume: 43, Issue:4

    Topics: Administration, Oral; Adult; Aged; Aging; Hexobarbital; Humans; Male; Psychomotor Performance; Stere

1988
Influence of age, hexobarbital, and aniline on NADPH/NADH dependent hydrogen peroxide production in rat hepatic microsomes.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1986, Volume: 9

    Topics: Aging; Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Hexobarbital; Hydrogen Peroxide;

1986
Metabolism of drugs in old rats. I. Activities of NADPH-linked electron transport and drug-metabolizing enzyme systems in liver microsomes of old rats.
    Japanese journal of pharmacology, 1968, Volume: 18, Issue:4

    Topics: Aging; Aminobenzoates; Aminopyrine; Aniline Compounds; Animals; Azo Compounds; Benzoates; Body Weigh

1968
Influence of age and diet on the induction of microsomal enzymes in the mouse.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1971, Volume: 136, Issue:3

    Topics: Aging; Animals; Antipyrine; Benzopyrenes; Biotransformation; Caseins; Cytochromes; Dietary Proteins;

1971
Effect of hexachlorobenzene on hepatic microsomal enzymes in the rat.
    Biochemical pharmacology, 1974, Volume: 23, Issue:15

    Topics: Aging; Alcohol Oxidoreductases; Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; Diet; Enzym

1974
Comparison of phenobarbital with orphenadrine hydrochloride and tofenacine hydrochloride for enzyme-inducing activity in young and adult rats.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 205, Issue:2

    Topics: Aging; Animals; Benzene Derivatives; Body Weight; Drug Tolerance; Enzyme Induction; Ethers; Ethylami

1973
Metabolism of drugs in old rats. II. Metabolism in vivo and effect of drugs in old rats.
    Japanese journal of pharmacology, 1968, Volume: 18, Issue:4

    Topics: Aging; Anesthesia; Animals; Carisoprodol; Female; Hexobarbital; Injections, Intraperitoneal; Insecti

1968
Studies on age difference in mice for the activity of drug-metabolizing enzymes of liver microsomes.
    Japanese journal of pharmacology, 1970, Volume: 20, Issue:4

    Topics: Aging; Aminopyrine; Anesthesia; Aniline Compounds; Animals; Body Weight; Cytochromes; Electron Trans

1970
[Hexobarbital narcosis and age].
    Acta biologica et medica Germanica, 1965, Volume: 14, Issue:5

    Topics: Aging; Anesthesia, General; Animals; Basal Metabolism; Hexobarbital; Oxygen Consumption; Rats

1965
[Investigations on the mechanism of enzyme induction in rats and mice. IV. Influence of age on 1-ascorbic acid excretion and its increase as well as on hexobarbital sleep duration and its reduction by barbital].
    Acta biologica et medica Germanica, 1965, Volume: 15, Issue:6

    Topics: Aging; Animals; Ascorbic Acid; Barbiturates; Female; Hexobarbital; Male; Mice; Rats; Sleep

1965