hexobarbital has been researched along with Aging in 30 studies
Hexobarbital: A barbiturate that is effective as a hypnotic and sedative.
hexobarbital : A member of the class of barbiturates taht is barbituric acid substituted at N-1 by methyl and at C-5 by methyl and cyclohex-1-enyl groups.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The influence of aging on the metabolism of antipyrine (AP) and hexobarbital enantiomers (R-HB and S-HB) with and without phenobarbital (PB) induction was investigated in a longitudinal study in rats aged 6, 12, 24 and 30 months." | 7.69 | The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: a longitudinal study. ( Breimer, DD; Groen, K; Jansen, EJ; van Bezooijen, CF, 1994) |
| " For S-hexobarbital the half-life is somewhat shorter and the volume of distribution and plasma clearance is higher than for its antipode." | 1.28 | Influence of age on stereoselective pharmacokinetics and metabolism of hexobarbital in the rat. ( Belpaire, FM; Bogaert, MG; De Smet, F; Rosseel, MT; Vermeulen, AM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (83.33) | 18.7374 |
| 1990's | 5 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| STREICHER, E | 1 |
| GARBUS, J | 1 |
| KATO, R | 4 |
| VASSANELLI, P | 1 |
| FRONTINO, G | 1 |
| CHIESARA, E | 1 |
| ALBRECHT, E | 1 |
| KUNTZMAN, R | 1 |
| JACOBSON, M | 1 |
| SCHNEIDMAN, K | 1 |
| CONNEY, AH | 1 |
| Lee, NH | 1 |
| Hospado, MA | 1 |
| Manthei, RW | 2 |
| Shapiro, BH | 3 |
| Szczotka, SM | 1 |
| Bolander, HG | 1 |
| Halász, P | 1 |
| Baird, MB | 3 |
| Agrawal, AK | 1 |
| Pampori, NA | 1 |
| Groen, K | 1 |
| Breimer, DD | 1 |
| Jansen, EJ | 1 |
| van Bezooijen, CF | 1 |
| Korkmaz, S | 1 |
| Carlsson, S | 1 |
| Wahlström, G | 1 |
| Weiss, LR | 1 |
| Krop, S | 1 |
| James, RC | 1 |
| Franklin, MR | 1 |
| Nicolosi, RJ | 1 |
| Massie, HR | 2 |
| Samis, HV | 1 |
| Zimmerman, JA | 1 |
| Pacilio, LV | 1 |
| Vermeulen, AM | 1 |
| Belpaire, FM | 1 |
| De Smet, F | 1 |
| Rosseel, MT | 1 |
| Bogaert, MG | 1 |
| Smith, DA | 1 |
| Chandler, MH | 2 |
| Shedlofsky, SI | 1 |
| Wedlund, PJ | 1 |
| Blouin, RA | 2 |
| Niedermeyer, TM | 1 |
| Scott, SR | 1 |
| Klinger, W | 3 |
| Freytag, A | 1 |
| Schmitt, W | 1 |
| Wilson, JT | 1 |
| Takanaka, A | 3 |
| Hospador, MA | 1 |
| Grosso, LS | 1 |
| Stonard, MD | 1 |
| Nenov, PZ | 1 |
| Funcke, AB | 1 |
| Timmerman, H | 1 |
| Onoda, K | 1 |
| Ankermann, H | 1 |
| Möller, A | 1 |
| Kramer, B | 1 |
1 review available for hexobarbital and Aging
| Article | Year |
|---|---|
Developmental pharmacology: a review of its application to clinical and basic science.
Topics: Aging; Androgens; Aniline Compounds; Animals; Estrogens; Ethanol; Female; Fetus; Fluorosis, Dental; | 1972 |
29 other studies available for hexobarbital and Aging
| Article | Year |
|---|---|
The effect of age and sex on the duration of hexobarbital anesthesia in rats.
Topics: Aging; Analgesia; Anesthesia; Anesthesia and Analgesia; Animals; Barbiturates; Education, Medical; H | 1955 |
VARIATION IN THE ACTIVITY OF LIVER MICROSOMAL DRUG-METABOLIZING ENZYMES IN RATS IN RELATION TO THE AGE.
Topics: Aging; Animals, Newborn; Carisoprodol; Diphosphates; Hexobarbital; Insecticides; Liver; Meprobamate; | 1964 |
[EVALUATION OF POTENTIATED BARBITURATE ANESTHESIA IN GYNECOLOGICAL OPERATIONS].
Topics: Aging; Anesthesia; Anesthesia, Intravenous; Barbiturates; Female; Genital Diseases, Female; Hexobarb | 1964 |
SIMILARITIES BETWEEN OXIDATIVE DRUG-METABOLIZING ENZYMES AND STEROID HYDROXYLASES IN LIVER MICROSOMES.
Topics: Aging; Animals; Chlordan; Estradiol; Fatty Acids; Hexobarbital; Liver; Methylcholanthrene; Mice; Mic | 1964 |
Influence of age and dietary stress on hexobarbital activity in mice.
Topics: Aging; Animals; Body Weight; Diet; Dietary Carbohydrates; Dietary Proteins; Hexobarbital; In Vitro T | 1967 |
Androgenic repression of hexobarbitone metabolism and action in Crl:CD-1 (ICR)BR mice.
Topics: Aging; Androgens; Animals; Castration; Female; Hexobarbital; In Vitro Techniques; Kinetics; Male; Mi | 1984 |
Age-related changes in CNS-sensitivity to hexobarbital and thiopental in the rat.
Topics: Aging; Anesthesia; Animals; Body Weight; Brain; Brain Chemistry; Electroencephalography; Hexobarbita | 1984 |
Generalized epilepsy with spike-wave paroxysms as an epileptic disorder of the function of sleep promotion.
Topics: Adolescent; Adult; Aging; Brain; Circadian Rhythm; Consciousness; Electroencephalography; Epilepsies | 1981 |
A longitudinal study of the relationship between aging and the duration of hexobarbital hypnosis in male CFN rats.
Topics: Aging; Animals; Biotransformation; Hexobarbital; Hypnosis, Anesthetic; Longitudinal Studies; Male; M | 1983 |
Neonatal phenobarbital-induced defects in age- and sex-specific growth hormone profiles regulating monooxygenases.
Topics: Aging; Animals; Animals, Newborn; Female; Growth Hormone; Hexobarbital; Male; Microsomes, Liver; Mix | 1995 |
The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: a longitudinal study.
Topics: Aging; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Longitud | 1994 |
Maturation-related changes in tolerance development to hexobarbital after short term treatment with diazepam in the rat.
Topics: Aging; Animals; Diazepam; Drug Tolerance; Electroencephalography; Hexobarbital; Male; Rats; Rats, Sp | 1993 |
Advanced age as a factor in the response of rodents to drugs [proceedings].
Topics: Aging; Animals; Cricetinae; Female; Hexobarbital; Hydralazine; Isoproterenol; Male; Mesocricetus; Mi | 1978 |
The triphasic amphetamine lethal dose curve in mice and its possible relationship to drug metabolism.
Topics: Aging; Amphetamine; Animals; Anticonvulsants; Dextroamphetamine; Hexobarbital; In Vitro Techniques; | 1978 |
Microsomal mixed-function oxidase activity and senescence-I. Hexobarbital sleep time and induction of components of the hepatic microsomal enzyme system in rats of different ages.
Topics: Age Factors; Aging; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Liver; | 1975 |
Microsomal mixed-function oxidase activity and senescence--II. In vivo and in vitro hepatic drug metabolism in rats of different ages following partial hepatectomy.
Topics: Aging; Animals; Hepatectomy; Hexobarbital; Liver; Liver Regeneration; Male; Mixed Function Oxygenase | 1976 |
Influence of age on stereoselective pharmacokinetics and metabolism of hexobarbital in the rat.
Topics: Aging; Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Hematocrit; Hexobarbital; Liver; Ma | 1992 |
Age-dependent stereoselective increase in the oral clearance of hexobarbitone isomers caused by rifampicin.
Topics: Administration, Oral; Adult; Aged; Aging; Chromatography, High Pressure Liquid; Drug Interactions; H | 1991 |
Selective androgen insensitivity of hepatic drug-metabolizing enzymes in senescent mice.
Topics: Aging; Animals; Body Weight; Female; Hexobarbital; Liver; Male; Mice; Mice, Inbred ICR; Microsomes, | 1988 |
Age-associated stereoselective alterations in hexobarbital metabolism.
Topics: Administration, Oral; Adult; Aged; Aging; Hexobarbital; Humans; Male; Psychomotor Performance; Stere | 1988 |
Influence of age, hexobarbital, and aniline on NADPH/NADH dependent hydrogen peroxide production in rat hepatic microsomes.
Topics: Aging; Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Hexobarbital; Hydrogen Peroxide; | 1986 |
Metabolism of drugs in old rats. I. Activities of NADPH-linked electron transport and drug-metabolizing enzyme systems in liver microsomes of old rats.
Topics: Aging; Aminobenzoates; Aminopyrine; Aniline Compounds; Animals; Azo Compounds; Benzoates; Body Weigh | 1968 |
Influence of age and diet on the induction of microsomal enzymes in the mouse.
Topics: Aging; Animals; Antipyrine; Benzopyrenes; Biotransformation; Caseins; Cytochromes; Dietary Proteins; | 1971 |
Effect of hexachlorobenzene on hepatic microsomal enzymes in the rat.
Topics: Aging; Alcohol Oxidoreductases; Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; Diet; Enzym | 1974 |
Comparison of phenobarbital with orphenadrine hydrochloride and tofenacine hydrochloride for enzyme-inducing activity in young and adult rats.
Topics: Aging; Animals; Benzene Derivatives; Body Weight; Drug Tolerance; Enzyme Induction; Ethers; Ethylami | 1973 |
Metabolism of drugs in old rats. II. Metabolism in vivo and effect of drugs in old rats.
Topics: Aging; Anesthesia; Animals; Carisoprodol; Female; Hexobarbital; Injections, Intraperitoneal; Insecti | 1968 |
Studies on age difference in mice for the activity of drug-metabolizing enzymes of liver microsomes.
Topics: Aging; Aminopyrine; Anesthesia; Aniline Compounds; Animals; Body Weight; Cytochromes; Electron Trans | 1970 |
[Hexobarbital narcosis and age].
Topics: Aging; Anesthesia, General; Animals; Basal Metabolism; Hexobarbital; Oxygen Consumption; Rats | 1965 |
[Investigations on the mechanism of enzyme induction in rats and mice. IV. Influence of age on 1-ascorbic acid excretion and its increase as well as on hexobarbital sleep duration and its reduction by barbital].
Topics: Aging; Animals; Ascorbic Acid; Barbiturates; Female; Hexobarbital; Male; Mice; Rats; Sleep | 1965 |