Compounds > hexobarbital
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hexobarbital and Acute Liver Injury, Drug-Induced

hexobarbital has been researched along with Acute Liver Injury, Drug-Induced in 47 studies

Hexobarbital: A barbiturate that is effective as a hypnotic and sedative.
hexobarbital : A member of the class of barbiturates taht is barbituric acid substituted at N-1 by methyl and at C-5 by methyl and cyclohex-1-enyl groups.

Research Excerpts

ExcerptRelevanceReference
" Both agents also prolonged hexobarbital sleeping time and zoxazolamine paralysis time in mice."3.66Protective effect of diethyldithiocarbamate and carbon disulfide against liver injury induced by various hepatotoxic agents. ( Masuda, Y; Nakayama, N, 1982)
"The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase."1.28Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis? ( Ben-Zvi, Z; Danon, A; Katz, S; Weissman-Teitellman, B, 1990)
" In rat LD50 was estimated at about 500 mg/100 g b."1.27Testing of dioxolan-methyl-metaacrylate (DMA) for hepatotoxicity and nephrotoxicity. ( Bräunlich, H; Kersten, L; Klinger, W, 1988)
"When thioacetamide was given for a prolonged period, the ascorbic acid content in the urine increased at the beginning; later one, at the end of three weeks, it was slightly inferior to the control value."1.26[The excretion of hippuric acid and ascorbic acid in the urine of liver-damaged rats (author's transl]. ( Bien, E; Kündiger, R; Müller, R; Skorka, G, 1979)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-199036 (76.60)18.7374
1990's4 (8.51)18.2507
2000's4 (8.51)29.6817
2010's3 (6.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Vorne, M2
Arvela, P1
Alavaikko, M2
Sreedevi, CD1
Latha, PG3
Ancy, P1
Suja, SR2
Shyamal, S2
Shine, VJ2
Sini, S1
Anuja, GI1
Rajasekharan, S2
Sharma, N2
Shukla, S1
Banu, S1
Bhaskar, B1
Balasekar, P1
Pushpangadan, P1
Sadasivan, S1
Sasikumar, JM1
Rajashekaran, S1
Singh, B2
Chandan, BK2
Bhardwaj, V2
Satti, NK1
Gupta, VN2
Gupta, BD1
Suri, KA1
Suri, OP1
Calley, DJ1
Guess, WL1
Autian, J1
Chang, IM1
Ryu, JC1
Park, YC1
Yun, HS1
Yang, KH1
Masuda, Y1
Nakayama, N1
Cebula, TA1
El-Hage, AN1
Ferrans, VJ1
Kündiger, R3
Müller, R3
Bien, E5
Gohlke, R1
Skorka, G3
Buntrock, P1
Barkova, EN1
Gurov, OV1
Shedlofsky, SI1
Israel, BC1
McClain, CJ1
Hill, DB1
Blouin, RA1
Anand, KK1
Saxena, AK1
Chiba, T1
Horiuchi, M1
Akashi, Y1
Gopinath, C1
Ford, JH1
Suriyachan, D1
Thithapandha, A1
Braun, R1
Greeff, U1
Netter, KJ1
Kulcsár, A4
Kulcsár-Gergely, J4
Udvardy, M1
Cagen, SZ1
Gibson, JE1
Schröder, S1
Kuhlmey, B1
Kiss, A1
Torrielli, MV2
Ugazio, G2
Carlson, GP1
Tardiff, RG1
Ben-Zvi, Z1
Weissman-Teitellman, B1
Katz, S1
Danon, A1
Kersten, L1
Bräunlich, H1
Klinger, W2
Poland, A1
Goldstein, J1
Hickman, P1
Burse, VW1
Ruckebusch, Y1
Grivel, ML1
Brenner, G1
Trautmann, H1
Tuchweber, B1
Werringloer, J1
Kourounakis, P1
Brown, BR1
Sipes, IG1
Sagalyn, AM1
Gabriel, L1
Burdino, E1
Freundt, KJ1
Liebaldt, GP1
Sieber, KH1
Mancini, RE1
Kocsis, JJ1
Wei, E1
Wong, LC1
Hine, CH1
Varga, F1
Fischer, E1
Franken, FH1
Hagelskamp, W1
Stenger, RJ1
Johnson, EA1

Other Studies

47 other studies available for hexobarbital and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Effect of phenobarbital on hepatic injury induced by chronic carbon tetrachloride treatment.
    Pathology, research and practice, 1981, Volume: 172, Issue:4

    Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Synergism; Excitatory Am

1981
Hepatoprotective studies on Sida acuta Burm. f.
    Journal of ethnopharmacology, 2009, Jul-15, Volume: 124, Issue:2

    Topics: Acetaminophen; Alkaline Phosphatase; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Cou

2009
Hepatoprotective potential of aqueous extract of Butea monosperma against CCl(4) induced damage in rats.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2011, Volume: 63, Issue:7-8

    Topics: Adenosine Triphosphatases; Animals; Blood Chemical Analysis; Butea; Carbon Tetrachloride; Carbon Tet

2011
Hepatoprotective and antioxidant activity of Leucas aspera against D-galactosamine induced liver damage in rats.
    Pharmaceutical biology, 2012, Volume: 50, Issue:12

    Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease M

2012
Evaluation of hepatoprotective effects of Helminthostachys zeylanica (L.) Hook against carbon tetrachloride-induced liver damage in Wistar rats.
    Journal of ethnopharmacology, 2004, Volume: 92, Issue:1

    Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ferns; Hexobarbital; Lipid Pe

2004
Hepatoprotective studies on Hedyotis corymbosa (L.) Lam.
    Journal of ethnopharmacology, 2006, Jun-30, Volume: 106, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dose-Respo

2006
Isolation, structure elucidation and in vivo hepatoprotective potential of trans-tetracos-15-enoic acid from Indigofera tinctoria Linn.
    Phytotherapy research : PTR, 2006, Volume: 20, Issue:10

    Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fatty Acids, M

2006
Hepatotoxicity of a series of organotin esters.
    Journal of pharmaceutical sciences, 1967, Volume: 56, Issue:2

    Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Ataxia; Behavior, Animal; Blepharoptosis

1967
Protective activities of aucubin against carbon tetrachloride-induced liver damage in mice.
    Drug and chemical toxicology, 1983, Volume: 6, Issue:5

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical

1983
Protective effect of diethyldithiocarbamate and carbon disulfide against liver injury induced by various hepatotoxic agents.
    Biochemical pharmacology, 1982, Sep-01, Volume: 31, Issue:17

    Topics: Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Ditiocarb; Hexobarbital; Male; Mi

1982
Toxic interactions of benzyl alcohol with bacterial endotoxin.
    Infection and immunity, 1984, Volume: 44, Issue:1

    Topics: Animals; Benzyl Alcohol; Benzyl Alcohols; Benzyl Compounds; Blood Chemical Analysis; Chemical and Dr

1984
[Enzyme activities in the blood serum from rats with chronic liver damage. part 3: Effect of thioacetamide].
    Die Pharmazie, 1983, Volume: 38, Issue:4

    Topics: Acetamides; Animals; Chemical and Drug Induced Liver Injury; Hexobarbital; Liver; Liver Diseases; Ma

1983
The excretion of ascorbic acid and hippuric acid in the urine of rats with liver injury.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1980, Volume: 4

    Topics: Aminopyrine; Animals; Ascorbic Acid; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver

1980
[Hepatotoxicological studies of pyrazolone derivatives on rats. Part 2: The study of propyphenazone and phenazone (author's transl)].
    Die Pharmazie, 1981, Volume: 36, Issue:8

    Topics: Aminopyrine N-Demethylase; Animals; Antipyrine; Body Weight; Chemical and Drug Induced Liver Injury;

1981
[Daily dynamics of the duration of hexenal narcosis in experimental hepatosis].
    Biulleten' eksperimental'noi biologii i meditsiny, 1995, Volume: 119, Issue:5

    Topics: Animals; Chemical and Drug Induced Liver Injury; Circadian Rhythm; Hexobarbital; Hypnotics and Sedat

1995
Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism.
    The Journal of clinical investigation, 1994, Volume: 94, Issue:6

    Topics: Administration, Oral; Adult; Antipyrine; C-Reactive Protein; Chemical and Drug Induced Liver Injury;

1994
3,4,5-Trihydroxy benzoic acid (gallic acid), the hepatoprotective principle in the fruits of Terminalia belerica-bioassay guided activity.
    Pharmacological research, 1997, Volume: 36, Issue:4

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Female; Gallic Acid

1997
[Effect of thiol compounds on experimental liver damage (III). Effect of tiopronin (2-mercaptopropionylglycine) and glutathione on drug metabolizing activity (author's transl)].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1979, Volume: 75, Issue:6

    Topics: Amino Acids, Sulfur; Aminopyrine; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Chemical

1979
The role of microsomal hydroxylases in the modification of chloroform hepatotoxicity in rats.
    British journal of experimental pathology, 1975, Volume: 56, Issue:5

    Topics: Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chloroform; Chlorpromazine; DDT;

1975
Modification of carbon tetrachloride hepatotoxicity by chemicals.
    Toxicology and applied pharmacology, 1977, Volume: 41, Issue:2

    Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur

1977
Liver injury by the false morel poison gyromitrin.
    Toxicology, 1979, Volume: 12, Issue:2

    Topics: Acetaldehyde; Aminopyrine; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme

1979
[The excretion of hippuric acid and ascorbic acid in the urine of liver-damaged rats (author's transl].
    Die Pharmazie, 1979, Volume: 34, Issue:11

    Topics: Aminopyrine; Animals; Ascorbic Acid; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver

1979
Sex differences and sex hormones in experimental liver injury.
    Arzneimittel-Forschung, 1979, Volume: 29, Issue:6

    Topics: Animals; Biotransformation; Carbon Tetrachloride Poisoning; Castration; Chemical and Drug Induced Li

1979
Liver damage following paraquat in selenium-deficient and diethyl maleate-pretreated mice.
    Toxicology and applied pharmacology, 1977, Volume: 40, Issue:2

    Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Diet; Drug Interactions; Fema

1977
[Enzyme activities in the blood serum of rats with chronic liver damage. 1. Effect of carbon tetrachloride].
    Die Pharmazie, 1976, Volume: 31, Issue:10

    Topics: Animals; Body Weight; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chroni

1976
The role of sex differences in the effect of anabolics on the liver.
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:3

    Topics: Anabolic Agents; Anesthesia; Animals; Body Weight; Carbon Tetrachloride Poisoning; Chemical and Drug

1975
Biochemical aspects of the protective action of propyl gallate on liver injury in rats poisoned with carbon tetrachloride.
    Toxicology and applied pharmacology, 1975, Volume: 34, Issue:1

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Body Temperature;

1975
Effect of chlorinated benzenes on the metabolism of foreign organic compounds.
    Toxicology and applied pharmacology, 1976, Volume: 36, Issue:2

    Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Chlorobenzenes; Hexachlorobenzene; Hex

1976
Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis?
    Archives of toxicology, 1990, Volume: 64, Issue:4

    Topics: Acetaminophen; Animals; Aspirin; Chemical and Drug Induced Liver Injury; Glutathione; Hexobarbital;

1990
Testing of dioxolan-methyl-metaacrylate (DMA) for hepatotoxicity and nephrotoxicity.
    Die Pharmazie, 1988, Volume: 43, Issue:10

    Topics: Animals; Anticonvulsants; Biotransformation; Chemical and Drug Induced Liver Injury; Female; Hexobar

1988
A reciprocal relationship between the induction of -aminolevulinic acid synthetase and drug metabolism produced by m-dichlorobenzene.
    Biochemical pharmacology, 1971, Volume: 20, Issue:6

    Topics: Acyltransferases; Animals; Benzene Derivatives; Body Weight; Chemical and Drug Induced Liver Injury;

1971
The influence of a ganglion-blocking agent on experimental liver injury.
    Toxicology, 1973, Volume: 1, Issue:2

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Enzyme Induction; F

1973
Sympathetic receptor functions in liver damage.
    Arzneimittel-Forschung, 1974, Volume: 24, Issue:11

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Depression, Chemica

1974
[Hepatic insufficiency and neurotropic medicinal activity].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1966, Volume: 160, Issue:4

    Topics: Animals; Chemical and Drug Induced Liver Injury; Dogs; Drug Synergism; Female; Hexobarbital; Ipronia

1966
[Effect of xanthinol-nicotinate on detoxification processes in liver. Experimental studies on the model of hexobarbital-narcosis in rat].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:12

    Topics: Anesthesia, General; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Dru

1969
Effect of phenobarbital or pregnenolone-16alpha-carbonitrile (PCN) pretreatment on acute carbon tetrachloride hepatotoxicity in rats.
    Biochemical pharmacology, 1974, Feb-01, Volume: 23, Issue:3

    Topics: Animals; Carbon Tetrachloride Poisoning; Cattle; Chemical and Drug Induced Liver Injury; Cytochrome

1974
Mechanisms of acute hepatic toxicity: chloroform, halothane, and glutathione.
    Anesthesiology, 1974, Volume: 41, Issue:6

    Topics: Acute Disease; Anesthesia, Inhalation; Aniline Compounds; Animals; Biotransformation; Chemical and D

1974
Time course of protection by N'N--diphenyl-p-phenylendiamine (DPPD) against carbon tetrachloride hepatotoxicy.
    Agents and actions, 1974, Volume: 4, Issue:5

    Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical

1974
Effect of barbiturates on the liver of rats exposed to carbon disulphide vapour.
    Internationales Archiv fur Arbeitsmedizin, 1974, Jan-31, Volume: 32, Issue:4

    Topics: Animals; Barbiturates; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Environmental Expos

1974
Dimethylsulfoxide increases the lethality of CCl4 in rats but decreases its hepatotoxicity.
    Toxicology and applied pharmacology, 1974, Volume: 27, Issue:1

    Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur

1974
Selective potentiation of carbon tetrachloride hepatotoxicity by ethanol.
    Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 189, Issue:1

    Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Dr

1971
Effect of carbon tetrachloride induced progressive liver damage on the metabolism of hexobarbital and bilirubin in vivo.
    Acta pharmacologica et toxicologica, 1971, Volume: 29, Issue:5

    Topics: Animals; Bilirubin; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hexob

1971
Hexobarbital sleeping time in male rats with hepatic injury.
    Acta physiologica Academiae Scientiarum Hungaricae, 1969, Volume: 36, Issue:4

    Topics: Acetates; Alcohols; Amides; Animals; Aspartate Aminotransferases; Benzene Derivatives; Biotransforma

1969
[Barbiturates and liver].
    Deutsche medizinische Wochenschrift (1946), 1970, Jul-31, Volume: 95, Issue:31

    Topics: Amobarbital; Animals; Barbiturates; Chemical and Drug Induced Liver Injury; Enzyme Activation; Fatty

1970
Further observations upon the effects of phenobarbital pretreatment on the hepatotoxicity of carbon tetrachloride.
    Experimental and molecular pathology, 1971, Volume: 14, Issue:2

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Endoplasmic Reticul

1971
[Studies on the mechanism of enzyme induction. XII. Effect of liver damage by CCl-4].
    Acta biologica et medica Germanica, 1968, Volume: 20, Issue:1

    Topics: Animals; Ascorbic Acid; Barbiturates; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Live

1968