hexarelin and Amyotrophic-Lateral-Sclerosis

Amyotrophic lateral sclerosis (ALS) is an incurable motor neuron disease whose etiology remains unresolved; nonetheless, mutations of superoxide dismutase 1 (SOD1) have been associated with several variants of ALS. Currently available pharmacologic interventions are only symptomatic and palliative in effect; therefore, there is a pressing demand for more effective drugs. This study examined potential therapeutic effects of growth hormone secretagogues (GHSs), a large family of synthetic compounds, as possible candidates for the treatment of ALS. Human neuroblastoma cells expressing the SOD1-G93A mutated protein (SH-SY5Y SOD1

Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Line; Disease Models, Animal; Humans; Hydrogen Peroxide; Mice; Mice, Transgenic; Neuroblastoma; Superoxide Dismutase; Superoxide Dismutase-1