hexamethylene bisacetamide has been researched along with Leukemia, Myeloid, Acute in 16 studies
N,N'-diacetyl-1,6-diaminohexane: chemical name obtained from Acta Biol Hung 1990;41(1-3):199-208
Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hexamethylene bisacetamide (HMBA) is a potent inducer of differentiation of a number of transformed cell lines in vitro." | 6.67 | Hexamethylene bisacetamide in myelodysplastic syndrome and acute myelogenous leukemia: a phase II clinical trial with a differentiation-inducing agent. ( Andreeff, M; Ervin, T; Kufe, D; Marks, PA; Michaeli, J; Rifkind, RA; Sogoloff, H; Stone, R; Tong, WP; Young, CW, 1992) |
| "Hexamethylene bisacetamide (HMBA) is a potent inducer of differentiation of a number of transformed cell lines in vitro." | 2.67 | Hexamethylene bisacetamide in myelodysplastic syndrome and acute myelogenous leukemia: a phase II clinical trial with a differentiation-inducing agent. ( Andreeff, M; Ervin, T; Kufe, D; Marks, PA; Michaeli, J; Rifkind, RA; Sogoloff, H; Stone, R; Tong, WP; Young, CW, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (62.50) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ren, X | 1 |
| Zhang, Y | 1 |
| Li, C | 1 |
| Wang, H | 1 |
| Jiang, Z | 1 |
| Zhang, Z | 1 |
| Guo, Q | 1 |
| Song, G | 1 |
| Bi, K | 1 |
| Jiang, G | 1 |
| Koeffler, HP | 1 |
| Sugiura, M | 1 |
| Shafman, T | 1 |
| Mitchell, T | 2 |
| Griffin, J | 1 |
| Kufe, D | 3 |
| Pantazis, P | 2 |
| Bonner, WM | 1 |
| Lazarou, SA | 1 |
| Papadopoulos, NM | 1 |
| Fibach, E | 1 |
| Treves, A | 1 |
| Peled, T | 1 |
| Rachmilewitz, EA | 1 |
| Herwig, S | 1 |
| Su, Q | 1 |
| Zhang, W | 1 |
| Ma, Y | 1 |
| Tempst, P | 1 |
| Andreeff, M | 1 |
| Stone, R | 1 |
| Michaeli, J | 1 |
| Young, CW | 1 |
| Tong, WP | 1 |
| Sogoloff, H | 1 |
| Ervin, T | 1 |
| Rifkind, RA | 1 |
| Marks, PA | 1 |
| Hassan, HT | 2 |
| Rees, JK | 1 |
| Veit, A | 1 |
| Maurer, HR | 1 |
| Tawhid, H | 1 |
| Rees, J | 1 |
| Egorin, MJ | 2 |
| Snyder, SW | 2 |
| Cohen, AS | 1 |
| Zuhowski, EG | 1 |
| Subramanyam, B | 1 |
| Callery, PS | 2 |
| Geelhaar, LA | 1 |
| Hamburger, AW | 1 |
| Sirotnak, FM | 1 |
| Jacobsen, DM | 1 |
| Yang, CH | 1 |
| Imaizumi, M | 1 |
| Uozumi, J | 1 |
| Breitman, TR | 1 |
| Watanabe, T | 1 |
| Sariban, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical and Ultramicroscopic Myocardial Randomized Study of On-Pump Beating Heart Mitral Valve Replacement[NCT01641614] | Phase 4 | 34 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for hexamethylene bisacetamide and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications.
Topics: 3-Deazauridine; Acetamides; Alkaloids; Animals; Calcitriol; Cell Differentiation; Cell Line; Cells, | 1983 |
1 trial available for hexamethylene bisacetamide and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
Hexamethylene bisacetamide in myelodysplastic syndrome and acute myelogenous leukemia: a phase II clinical trial with a differentiation-inducing agent.
Topics: Acetamides; Adolescent; Adult; Aged; Bone Marrow; Cell Differentiation; Hematopoietic Stem Cells; Hu | 1992 |
14 other studies available for hexamethylene bisacetamide and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
Enhancement of baicalin by hexamethylene bisacetamide on the induction of apoptosis contributes to simultaneous activation of the intrinsic and extrinsic apoptotic pathways in human leukemia cells.
Topics: Acetamides; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; C | 2013 |
Involvement of spermidine in proliferation and differentiation of human promyelocytic leukemia cells.
Topics: Acetamides; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; DNA; Eflornithine; Hu | 1984 |
Specific alterations in the pattern of histone-3 synthesis during conversion of human leukemic cells to terminally differentiated cells in culture.
Topics: Acetamides; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Histones; Humans; Interphase; Leuke | 1984 |
Isoenzymes of lactate dehydrogenase in human leukemic cells in culture treated with inducers of differentiation.
Topics: Acetamides; Butyrates; Cell Differentiation; Cell Line; Cell Survival; Diamines; Dimethyl Sulfoxide; | 1981 |
Changes in cell kinetics associated with differentiation of a human promyelocytic cell line (HL60).
Topics: Acetamides; Butyrates; Cell Differentiation; Cell Division; Cell Line; Diamines; Dimethyl Sulfoxide; | 1982 |
Distinct temporal patterns of defensin mRNA regulation during drug-induced differentiation of human myeloid leukemia cells.
Topics: Acetamides; Biomarkers; Blood Proteins; Cell Differentiation; Cycloheximide; Cytokines; Dactinomycin | 1996 |
Effect of AML serum on normal human myeloid differentiation and hexamethylene bisacetamide-induced granulocytic differentiation of the human HL-60 promyelocytic leukaemic cell line.
Topics: Acetamides; Age Factors; Cell Differentiation; Granulocytes; Hematopoiesis; Humans; In Vitro Techniq | 1990 |
Synergistic interactions between differentiation-inducing agents in inhibiting the proliferation of HL-60 human myeloid leukaemia cells in clonogenic micro assays.
Topics: Acetamides; Aged; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Differentiation; | 1991 |
Triple combination of retinoic acid + 6-thioguanine + hexamethylene bisacetamide induces differentiation of human AML blasts in primary culture.
Topics: Acetamides; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cell Differenti | 1990 |
Metabolism of hexamethylene bisacetamide and its metabolites in leukemic cells.
Topics: Acetamides; Animals; Humans; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Leukemia, Myeloi | 1988 |
Induction of differentiation of human promyelocytic leukemia cells (HL60) by metabolites of hexamethylene bisacetamide.
Topics: Acetamides; Cell Differentiation; Dose-Response Relationship, Drug; Leukemia, Myeloid, Acute; Struct | 1988 |
Alteration of folate analogue transport following induced maturation of HL-60 leukemia cells. Early decline in mediated influx, relationship to commitment, and functional dissociation of entry and exit routes.
Topics: Acetamides; Biological Transport, Active; Cell Differentiation; Cell Line; Cells, Cultured; Folic Ac | 1986 |
Retinoic acid-induced monocytic differentiation of HL60/MRI, a cell line derived from a transplantable HL60 tumor.
Topics: Acetamides; Animals; Antigens, Surface; Cell Differentiation; Cell Line; Chromosome Aberrations; Dim | 1987 |
Human c-myc and N-ras expression during induction of HL-60 cellular differentiation.
Topics: Acetamides; Calcitriol; Carcinogens; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Gene Expre | 1985 |