hexamethylene bisacetamide has been researched along with Cell Transformation, Neoplastic in 26 studies
N,N'-diacetyl-1,6-diaminohexane: chemical name obtained from Acta Biol Hung 1990;41(1-3):199-208
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hexamethylene bisacetamide (HMBA)-induced growth inhibition and differentiation of the rat C6 glioma cell line were found to be accompanied by down-regulation of the constitutively expressed fra-1 gene." | 3.72 | Overexpression of the immediate early gene fra-1 inhibits proliferation, induces apoptosis, and reduces tumourigenicity of c6 glioma cells. ( Shaikh, SA; Shirsat, NV, 2003) |
| "With virus-transformed murine erythroleukemia cells as a model, HMBA was shown to cause these cells to arrest in G1 phase and express globin genes." | 2.39 | Induced differentiation, the cell cycle, and the treatment of cancer. ( Marks, PA; Richon, VM; Rifkind, RA, 1996) |
| "Murine erythroleukemia cells developed for resistance to SAHA are cross-resistant to trichostatin A, a known deacetylase inhibitor and differentiation inducer, but are not cross-resistant to HMBA." | 1.30 | A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. ( Breslow, R; Emiliani, S; Marks, PA; Richon, VM; Rifkind, RA; Verdin, E; Webb, Y, 1998) |
| "Mucoepidermoid carcinoma is the most common malignant tumor of salivary glands." | 1.29 | [Human mucoepidermoid carcinoma MEC-1 cells induced differentiation by HMBA]. ( Chen, Y; SiTu, Z; Wu, J, 1996) |
| "Treatment with hexamethylene bisacetamide (HMBA), a differentiation inducing and poly (ADP-ribose)-synthesis modifying substance, influences expression of multilayered foci in a treatment schedule-dependent manner." | 1.28 | Modification of transformation of C3H/10T1/2 cells by a differentiation-inducing substance. ( Schneider, M, 1990) |
| "Vincristine-resistant murine erythroleukemia cells also are shown to have marked increased sensitivity to these hybrid polar/apolar compounds." | 1.28 | Polar/apolar chemical inducers of differentiation of transformed cells: strategies to improve therapeutic potential. ( Breslow, R; Marks, PA; Ngo, L; Rifkind, RA; Singh, R, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (34.62) | 18.7374 |
| 1990's | 15 (57.69) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, BY | 1 |
| Liang, YY | 1 |
| Wang, DS | 1 |
| Shirsat, NV | 1 |
| Shaikh, SA | 1 |
| Barel, M | 1 |
| Charriaut, C | 1 |
| Frade, R | 1 |
| Sugiura, M | 1 |
| Shafman, T | 1 |
| Mitchell, T | 1 |
| Griffin, J | 1 |
| Kufe, D | 1 |
| Suthanthiran, M | 1 |
| Rubin, AL | 1 |
| Novogrodsky, A | 1 |
| Stenzel, KH | 1 |
| Rajagopalan, S | 1 |
| Rodrigues, M | 1 |
| Polk, T | 1 |
| Wilson, D | 1 |
| Chader, GJ | 1 |
| Hayden, BJ | 1 |
| Rifkind, RA | 4 |
| Richon, VM | 2 |
| Marks, PA | 4 |
| Shayo, CC | 1 |
| Mladovan, AG | 1 |
| Baldi, A | 1 |
| Chen, Y | 1 |
| SiTu, Z | 1 |
| Wu, J | 1 |
| Emiliani, S | 1 |
| Verdin, E | 1 |
| Webb, Y | 1 |
| Breslow, R | 2 |
| Xie, D | 1 |
| Ren, L | 1 |
| Li, LS | 1 |
| Witte, MM | 1 |
| Parker, RF | 1 |
| Wang, H | 1 |
| Scott, RE | 1 |
| Mencherini, F | 1 |
| Khochbin, S | 1 |
| Chabanas, A | 1 |
| Lawrence, JJ | 1 |
| Wu, H | 1 |
| Scher, BM | 1 |
| Chu, CL | 1 |
| Leonard, M | 1 |
| Olmedo, R | 1 |
| Scher, GS | 1 |
| Stecker, S | 1 |
| Scher, W | 1 |
| Waxman, S | 1 |
| Orlow, SJ | 1 |
| Chakraborty, AK | 1 |
| Boissy, RE | 1 |
| Pawelek, JM | 1 |
| Yamazawa, K | 1 |
| Sekiya, S | 2 |
| Kimura, H | 2 |
| Shirasawa, H | 1 |
| Kawata, M | 2 |
| Takamizawa, H | 1 |
| Schneider, M | 1 |
| Hasegawa, T | 1 |
| Nakada, S | 1 |
| Nakajima, T | 1 |
| Oda, K | 1 |
| Rowinsky, EK | 1 |
| Donehower, RC | 1 |
| Spivak, JL | 1 |
| Burke, PJ | 1 |
| Griffin, CA | 1 |
| Jones, RJ | 1 |
| Andrews, PW | 1 |
| Nudelman, E | 1 |
| Hakomori, S | 1 |
| Fenderson, BA | 1 |
| Hammond, KD | 1 |
| Cloutman, LJ | 1 |
| Gilbert, DA | 1 |
| Ngo, L | 1 |
| Singh, R | 1 |
| Milo, GE | 1 |
| Kurian, P | 1 |
| Kirsten, E | 1 |
| Kun, E | 1 |
| Watanabe, T | 1 |
| Nomura, S | 1 |
| Kaneko, T | 1 |
| Yamagoe, S | 1 |
| Oishi, M | 1 |
| Sheffery, M | 1 |
| Ramsay, R | 1 |
| Ikeda, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| IGHID 11424 - A Pilot Trial of the Effect of Vorinostat and AGS-004 on Persistent HIV-1 Infection (The VOR VAX Study)[NCT02707900] | Phase 1 | 6 participants (Actual) | Interventional | 2016-03-31 | Terminated (stopped due to Manufacturing of the AGS-004 HIV vaccine by Argos could no longer be provided.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for hexamethylene bisacetamide and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Induced differentiation, the cell cycle, and the treatment of cancer.
Topics: Acetamides; Antineoplastic Agents; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cell Division; | 1996 |
Induction of transformed cells to terminal differentiation.
Topics: Acetamides; Animals; Cell Differentiation; Cell Transformation, Neoplastic; Cell Transformation, Vir | 1987 |
24 other studies available for hexamethylene bisacetamide and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
[Regulative effects of bailong and Hexamethylene bisacetamide on growth and phenotype of human gastric cancer cells in cell cycle].
Topics: Acetamides; Adenocarcinoma; Antineoplastic Agents; Cell Cycle; Cell Division; Cell Transformation, N | 2001 |
Overexpression of the immediate early gene fra-1 inhibits proliferation, induces apoptosis, and reduces tumourigenicity of c6 glioma cells.
Topics: Acetamides; Animals; Antineoplastic Agents; Apoptosis; Astrocytoma; Brain Neoplasms; Bucladesine; Ce | 2003 |
Use of cell differentiation effectors to select a human B lymphoblastoid cell line enriched in C3b receptors.
Topics: Acetamides; B-Lymphocytes; Bromodeoxyuridine; Bucladesine; Cell Line; Cell Separation; Cell Transfor | 1981 |
Involvement of spermidine in proliferation and differentiation of human promyelocytic leukemia cells.
Topics: Acetamides; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; DNA; Eflornithine; Hu | 1984 |
Immunosuppressive properties of polar organic compounds that induce cellular differentiation in Friend erythroleukemia cells.
Topics: 3-Hydroxybutyric Acid; Acetamides; Adult; Animals; Butyrates; Cell Transformation, Neoplastic; Cytot | 1982 |
Modulation of retinoblastoma cell characteristics by hexamethylene bis-acetamide and other differentiating agents in culture.
Topics: Acetamides; Antineoplastic Agents; Butyrates; Cell Adhesion Molecules, Neuronal; Cell Transformation | 1993 |
Differentiating agents modulate topoisomerase I activity in U-937 promonocytic cells.
Topics: Acetamides; Antineoplastic Agents; Blotting, Northern; Blotting, Western; Carcinogens; Cell Transfor | 1997 |
[Human mucoepidermoid carcinoma MEC-1 cells induced differentiation by HMBA].
Topics: Acetamides; Antineoplastic Agents; Carcinoma, Mucoepidermoid; Cell Transformation, Neoplastic; DNA, | 1996 |
A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.
Topics: Acetamides; Animals; Carcinoma; Cell Differentiation; Cell Line, Transformed; Cell Transformation, N | 1998 |
[Immobilization of N-acetyl-1,6-diaminohexane(NADAH) on diol-silica and study of mechanism of NADAH and hexamethylene bisacetamide(HMBA) inducing tumor cells differentiation].
Topics: Acetamides; Carcinoma, Transitional Cell; Cell Transformation, Neoplastic; Chromatography, High Pres | 1998 |
Repression of SV40 T oncoprotein expression by DMSO.
Topics: Acetamides; Animals; Antigens, Polyomavirus Transforming; Azacitidine; Blotting, Northern; Blotting, | 1992 |
Seric factors influence cell cycle modifications during commitment of murine erythroleukemia cells to differentiation.
Topics: Acetamides; Animals; Biomarkers, Tumor; Blood Proteins; Blotting, Northern; Butyrates; Cell Cycle; C | 1992 |
Reduction in lactate accumulation correlates with differentiation-induced terminal cell division of leukemia cells.
Topics: Acetamides; Animals; Carbon Dioxide; Cell Differentiation; Cell Division; Cell Transformation, Neopl | 1991 |
Inhibition of induced melanogenesis in Cloudman melanoma cells by four phenotypic modifiers.
Topics: 1-Methyl-3-isobutylxanthine; Acetamides; Animals; Butyrates; Butyric Acid; Cell Transformation, Neop | 1990 |
[Fundamental studies on differentiation inducers using a human embryonal carcinoma model].
Topics: Acetamides; Animals; Cell Transformation, Neoplastic; DNA, Neoplasm; Humans; Karyotyping; Mice; Mode | 1991 |
Modification of transformation of C3H/10T1/2 cells by a differentiation-inducing substance.
Topics: Acetamides; Animals; Cell Differentiation; Cell Transformation, Neoplastic; Clone Cells; Gene Expres | 1990 |
Expression of various viral and cellular enhancer-promoters during differentiation of human embryonal carcinoma cells.
Topics: Acetamides; Adenovirus Early Proteins; Cell Transformation, Neoplastic; Chloramphenicol O-Acetyltran | 1990 |
Effects of the differentiating agent hexamethylene bisacetamide on normal and myelodysplastic hematopoietic progenitors.
Topics: Acetamides; Adult; Aged; Bone Marrow; Cell Differentiation; Cell Transformation, Neoplastic; Colony- | 1990 |
Different patterns of glycolipid antigens are expressed following differentiation of TERA-2 human embryonal carcinoma cells induced by retinoic acid, hexamethylene bisacetamide (HMBA) or bromodeoxyuridine (BUdR).
Topics: Acetamides; Antibodies, Monoclonal; Antibody Specificity; Antigens, Neoplasm; Antigens, Surface; Bio | 1990 |
Cancer reversal: regulation of phosphotyrosine phosphatase.
Topics: Acetamides; Animals; Cell Differentiation; Cell Transformation, Neoplastic; Dexamethasone; Leukemia, | 1989 |
Suppression of tumorigenicity by polar compounds that induce terminal differentiation of transformed cells.
Topics: Acetamides; Animals; Cell Differentiation; Cell Transformation, Neoplastic; Dogs; Humans; Mice; Rats | 1989 |
Polar/apolar chemical inducers of differentiation of transformed cells: strategies to improve therapeutic potential.
Topics: Acetamides; Animals; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Leukemia, Ery | 1989 |
Inhibition of carcinogen-induced cellular transformation of human fibroblasts by drugs that interact with the poly(ADP-ribose) polymerase system. Initial evidence for the development of transformation resistance.
Topics: Acetamides; Anti-Bacterial Agents; Benzamides; Butylated Hydroxyanisole; Carcinogens; Cell Transform | 1985 |
Intracellular factors involved in erythroid differentiation of mouse erythroleukaemia cells.
Topics: Acetamides; Animals; Cell Fusion; Cell Transformation, Neoplastic; Dimethyl Sulfoxide; Erythrocytes; | 1988 |