hexamethonium has been researched along with Substance Withdrawal Syndrome in 5 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The tremorogenic effect of nicotine was studied in control rats and in rats withdrawn for 16-48 h from six to nine days' ethanol administration." | 7.67 | Ethanol withdrawal tremor potentiates the tremorogenic action of nicotine. ( Gothóni, P; Ikola, W, 1985) |
| "The tremorogenic effect of nicotine was studied in control rats and in rats withdrawn for 16-48 h from six to nine days' ethanol administration." | 3.67 | Ethanol withdrawal tremor potentiates the tremorogenic action of nicotine. ( Gothóni, P; Ikola, W, 1985) |
| "hexamethonium (2 mg/kg) pretreatment did not abolish the increase in the heart rate, but it delayed the blood pressure increase." | 1.28 | Yohimbine-precipitated clonidine withdrawal: an experimental model of the antihypertensive drug withdrawal syndrome. ( Jhamandas, K; Penning, DH, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clarke, PB | 1 |
| Kumar, R | 1 |
| Zarrindast, MR | 1 |
| Farzin, D | 1 |
| Malin, DH | 1 |
| Lake, JR | 1 |
| Schopen, CK | 1 |
| Kirk, JW | 1 |
| Sailer, EE | 1 |
| Lawless, BA | 1 |
| Upchurch, TP | 1 |
| Shenoi, M | 1 |
| Rajan, N | 1 |
| Penning, DH | 1 |
| Jhamandas, K | 1 |
| Gothóni, P | 1 |
| Ikola, W | 1 |
5 other studies available for hexamethonium and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
The effects of nicotine on locomotor activity in non-tolerant and tolerant rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Hexamethonium; Hexamethonium Compounds; H | 1983 |
Nicotine attenuates naloxone-induced jumping behaviour in morphine-dependent mice.
Topics: Animals; Atropine; Behavior, Animal; Benzazepines; Hexamethonium; Male; Mecamylamine; Mice; Morphine | 1996 |
Nicotine abstinence syndrome precipitated by central but not peripheral hexamethonium.
Topics: Animals; Behavior, Animal; Central Nervous System; Dose-Response Relationship, Drug; Hexamethonium; | 1997 |
Yohimbine-precipitated clonidine withdrawal: an experimental model of the antihypertensive drug withdrawal syndrome.
Topics: Animals; Antihypertensive Agents; Atropine; Blood Pressure; Central Nervous System; Choline; Clonidi | 1992 |
Ethanol withdrawal tremor potentiates the tremorogenic action of nicotine.
Topics: Animals; Ethanol; Hexamethonium; Hexamethonium Compounds; Male; Nicotine; Propranolol; Rats; Rats, I | 1985 |