hexamethonium has been researched along with Reperfusion Injury in 2 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pimonidazole binding, which reflects tissue hypoxia, was increased 2-fold by manipulation." | 3.70 | Graft survival is improved by hepatic denervation before organ harvesting. ( Bunzendahl, H; Raleigh, JA; Schemmer, P; Thurman, RG, 1999) |
| "This infarct-protective effect of remote IPC in LD muscle flaps was abolished by an intravenous bolus injection of the nonselective opioid receptor antagonist naloxone (3 mg/kg) 10 min before remote IPC and a continuous intravenous infusion (3 mg/kg) during remote IPC and by an intravenous bolus injection of the selective delta 1-opioid receptor antagonist 7-benzylidenealtrexone maleate (3 mg/kg)." | 1.32 | Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction. ( Addison, PD; Ashrafpour, H; Forrest, CR; Khan, A; Moses, M; Neligan, PC; Pang, CY; Zhong, A, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Addison, PD | 1 |
| Neligan, PC | 1 |
| Ashrafpour, H | 1 |
| Khan, A | 1 |
| Zhong, A | 1 |
| Moses, M | 1 |
| Forrest, CR | 1 |
| Pang, CY | 1 |
| Schemmer, P | 1 |
| Bunzendahl, H | 1 |
| Raleigh, JA | 1 |
| Thurman, RG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Triple-blind Placebo Controlled Trial of Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival and Neurological Outcome[NCT04009759] | Phase 1 | 240 participants (Anticipated) | Interventional | 2021-10-01 | Not yet recruiting | ||
| Remote Ischemic Preconditioning in Head and Neck Cancer Reconstruction - A Randomized Controlled Trial[NCT02548377] | 60 participants (Actual) | Interventional | 2015-09-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for hexamethonium and Reperfusion Injury
| Article | Year |
|---|---|
Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction.
Topics: Abdomen; Adenosine Triphosphate; Animals; Ganglionic Blockers; Hexamethonium; Hindlimb; Infarction; | 2003 |
Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction.
Topics: Abdomen; Adenosine Triphosphate; Animals; Ganglionic Blockers; Hexamethonium; Hindlimb; Infarction; | 2003 |
Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction.
Topics: Abdomen; Adenosine Triphosphate; Animals; Ganglionic Blockers; Hexamethonium; Hindlimb; Infarction; | 2003 |
Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction.
Topics: Abdomen; Adenosine Triphosphate; Animals; Ganglionic Blockers; Hexamethonium; Hindlimb; Infarction; | 2003 |
Graft survival is improved by hepatic denervation before organ harvesting.
Topics: Animals; Antihypertensive Agents; Denervation; Female; Graft Survival; Hepatic Artery; Hexamethonium | 1999 |