hexamethonium has been researched along with Pregnancy in 27 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nicotine may link cigarette smoking during pregnancy with sudden infant death syndrome (SIDS)." | 3.75 | Alterations in cholinergic sensitivity of respiratory neurons induced by pre-natal nicotine: a mechanism for respiratory dysfunction in neonatal mice. ( Bravo, E; Coddou, C; Eugenín, J, 2009) |
| " Nefiracetam potentiated alpha4beta2-like ACh- and NMDA-induced currents at nanomolar concentrations forming bell-shaped dose-response curves with the maximum potentiation occurring at 1 and 10 nM, respectively." | 1.32 | Unique mechanism of action of Alzheimer's drugs on brain nicotinic acetylcholine receptors and NMDA receptors. ( Marszalec, W; Moriguchi, S; Narahashi, T; Yeh, JZ; Zhao, X, 2003) |
| " Cumulative dose-response curves to noradrenaline and methoxamine on the circular contraction of isolated iliac arteries showed a significant shift to the right, together with a reduction in the maximal contraction." | 1.27 | Vascular reactivity in perinatally undernourished rats. ( Del Basso, P; Keller, EA; Orsingher, OA; Salica, C, 1983) |
| "Oxytocinergic neurones were identified by their antidromic response to the stimulation of the neurohypophysis and by their characteristic high frequency discharge of action potentials approximately 15-20s before reflex milk ejection." | 1.27 | Effect of microelectrophoretically applied acetylcholine, noradrenaline, dopamine and serotonin on the discharge of paraventricular oxytocinergic neurones in the rat. ( Fukuoka, T; Higuchi, T; Honda, K; Negoro, H; Uchide, K, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (70.37) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 5 (18.52) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moritz, KM | 1 |
| Dodic, M | 1 |
| Jefferies, AJ | 1 |
| Wintour, EM | 1 |
| DeMatteo, R | 1 |
| Singh, RR | 1 |
| Evans, RG | 1 |
| Coddou, C | 1 |
| Bravo, E | 1 |
| Eugenín, J | 1 |
| Niane, L | 1 |
| Joseph, V | 1 |
| Bairam, A | 1 |
| Nakamori, C | 1 |
| Shiina, T | 1 |
| Shimizu, Y | 1 |
| DIGONNET, L | 1 |
| BERGES, L | 1 |
| LEPOTIER, I | 1 |
| CAHN, J | 1 |
| ROY, J | 1 |
| YOUNG, IM | 2 |
| CENTONZE, M | 1 |
| FIGOUREUX, JJ | 1 |
| HALLUM, JL | 1 |
| HATCHUEL, WL | 1 |
| BOSCARO, M | 1 |
| RUSSO, A | 1 |
| VAN BOUWDIJK BASTIAANSE, MA | 1 |
| ZHUPANENKO, TI | 1 |
| ASHE, JR | 1 |
| THOMAS, WL | 1 |
| Narahashi, T | 1 |
| Marszalec, W | 1 |
| Moriguchi, S | 1 |
| Yeh, JZ | 1 |
| Zhao, X | 1 |
| PENNY, CJ | 1 |
| SHACKLETON, RP | 1 |
| MULCAHY, R | 1 |
| Casais, M | 1 |
| Delgado, SM | 1 |
| Sosa, Z | 1 |
| Rastrilla, AM | 1 |
| Del Basso, P | 1 |
| Keller, EA | 1 |
| Salica, C | 1 |
| Orsingher, OA | 1 |
| Butler, TG | 1 |
| Simonetta, G | 1 |
| Roberts, ML | 1 |
| McMillen, IC | 1 |
| Fiol, G | 1 |
| Machado, F | 1 |
| Hernandez, I | 1 |
| Inglés, AC | 1 |
| Abad, L | 1 |
| Parrilla, JJ | 1 |
| Meseguer, J | 1 |
| Quesada, T | 1 |
| Carbonell, LF | 1 |
| Davis, LE | 1 |
| Hohimer, AR | 1 |
| Giraud, GD | 1 |
| Paul, MS | 1 |
| Morton, MJ | 1 |
| Honda, K | 1 |
| Negoro, H | 1 |
| Fukuoka, T | 1 |
| Higuchi, T | 1 |
| Uchide, K | 1 |
| Moriya, K | 1 |
| Yahata, T | 1 |
| Kuroshima, A | 1 |
| Brace, RA | 1 |
| Brittingham, DS | 1 |
| Lewis, AB | 1 |
| Ferry, DA | 1 |
| Sadeghi, M | 1 |
| Bicknell, RJ | 1 |
| Leng, G | 1 |
| Lincoln, DW | 1 |
| Russell, JA | 1 |
27 other studies available for hexamethonium and Pregnancy
| Article | Year |
|---|---|
Haemodynamic characteristics of hypertension induced by prenatal cortisol exposure in sheep.
Topics: Animals; Antihypertensive Agents; Female; Hemodynamics; Hexamethonium; Hydrocortisone; Hypertension; | 2009 |
Alterations in cholinergic sensitivity of respiratory neurons induced by pre-natal nicotine: a mechanism for respiratory dysfunction in neonatal mice.
Topics: Analysis of Variance; Animals; Atropine; Brain Stem; Electrophysiology; Female; Hexamethonium; Hydro | 2009 |
Role of cholinergic-nicotinic receptors on hypoxic chemoreflex during postnatal development in rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocycli | 2009 |
Postnatal changes in vagal control of esophageal muscle contractions in rats.
Topics: Acetylcholine; Animals; Animals, Newborn; Atropine; Electric Stimulation; Esophagus; Female; Ganglio | 2012 |
[Eclampsia in a six and a half month pregnant woman, treated with hexamethonium].
Topics: Cardiovascular Agents; Eclampsia; Female; Hexamethonium; Muscle Relaxants, Central; Pregnancy | 1952 |
The placental transfer of hexamethonium bromide and the origin of amniotic fluid in the rabbit.
Topics: Amniotic Fluid; Animals; Cardiovascular Agents; Female; Hexamethonium; Muscle Relaxants, Central; Pl | 1953 |
[Hexamethonium-veratrum viride combination in treatment of diseases of pregnancy].
Topics: Female; Hexamethonium; Humans; Muscle Relaxants, Central; Pre-Eclampsia; Pregnancy; Veratrum; Veratr | 1953 |
[Treatment of pregnancy toxemia with hexamethonium iodine].
Topics: Cardiovascular Agents; Female; Hexamethonium; Iodides; Iodine; Muscle Relaxants, Central; Pre-Eclamp | 1954 |
Congenital paralytic ielus in a premature baby as a complication of hexamethonium bromide therapy for toxaemia of pregnancy.
Topics: Child; Female; Hexamethonium; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, | 1954 |
[Effect of a substance with ganglioplegic action (hexamethonium bitartrate) on the course of labor].
Topics: Female; Hexamethonium; Humans; Labor, Obstetric; Muscle Relaxants, Central; Pregnancy | 1955 |
[A patient with eclampsia treated with hexamethonium chloride].
Topics: Cardiovascular Agents; Eclampsia; Female; Hexamethonium; Muscle Relaxants, Central; Pregnancy | 1956 |
[Treatment of late toxemias of pregnancy with hexonium combined with reserpine].
Topics: Female; Hexamethonium; Hexamethonium Compounds; Humans; Pre-Eclampsia; Pregnancy; Reserpine; Toxemia | 1963 |
Hexamethonium chloride and apresoline in toxemia of pregnancy; a preliminary report.
Topics: Female; Hexamethonium; Hydralazine; Muscle Relaxants, Central; Pre-Eclampsia; Pregnancy; Sympatholyt | 1955 |
Unique mechanism of action of Alzheimer's drugs on brain nicotinic acetylcholine receptors and NMDA receptors.
Topics: Acetylcholine; Aconitine; Alzheimer Disease; Animals; Brain Chemistry; Bungarotoxins; Dihydro-beta-E | 2003 |
A case of eclampsia treated with hexamethonium bromide.
Topics: Cardiovascular Agents; Eclampsia; Female; Hexamethonium; Muscle Relaxants, Central; Pregnancy | 1951 |
The placental transfer of hexamethonium bromide in the rabbit and its appearance in the amniotic fluid.
Topics: Amniotic Fluid; Animals; Cardiovascular Agents; Female; Hexamethonium; Muscle Relaxants, Central; Pl | 1952 |
The treatment of toxaemia of pregnancy with hexamethonium bitartrate.
Topics: Female; Hexamethonium; Muscle Relaxants, Central; Pre-Eclampsia; Pregnancy; Sepsis; Toxemia | 1952 |
Pregnancy in rats is modulated by ganglionic cholinergic action.
Topics: Acetylcholine; Androstenedione; Animals; Atropine; Cholinergic Agonists; Cholinergic Antagonists; Fe | 2006 |
Vascular reactivity in perinatally undernourished rats.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Hexamethonium; Hexamethonium Comp | 1983 |
Impact of gestational age on the catecholamine responses of the fetal sheep adrenal to cholinergic stimulation in vitro.
Topics: Acetylcholine; Adrenal Glands; Animals; Catecholamines; Dose-Response Relationship, Drug; Female; Ge | 1995 |
Role of nitric oxide on the central hemodynamic response to acute volume expansion in the pregnant rat.
Topics: Animals; Blood Pressure; Blood Volume; Cardiac Output; Enzyme Inhibitors; Female; Ganglionic Blocker | 1998 |
Vascular pressure-volume relationships in pregnant and estrogen-treated guinea pigs.
Topics: Animals; Blood Circulation; Blood Pressure; Blood Volume; Dextrans; Estradiol; Female; Ganglionic Bl | 1989 |
Effect of microelectrophoretically applied acetylcholine, noradrenaline, dopamine and serotonin on the discharge of paraventricular oxytocinergic neurones in the rat.
Topics: Acetylcholine; Action Potentials; Animals; Atropine; Dopamine; Female; Hexamethonium; Hexamethonium | 1985 |
Lasting consistency of cold adaptability in rats reared in cold for many generations.
Topics: Adaptation, Physiological; Adipose Tissue, Brown; Animals; Body Temperature Regulation; Cold Tempera | 1985 |
Fetal vascular pressure and heart rate responses to nonlabor uterine contractions.
Topics: Amniotic Fluid; Animals; Autonomic Nervous System; Blood Pressure; Cardiovascular Physiological Phen | 1986 |
Fetal cardiovascular and breathing movement responses to endogenous opiates.
Topics: Animals; Atropine; beta-Endorphin; Cardiovascular System; Endorphins; Enkephalin, Methionine; Female | 1986 |
Naloxone excites oxytocin neurones in the supraoptic nucleus of lactating rats after chronic morphine treatment.
Topics: Action Potentials; Animals; Atropine; Female; Hexamethonium; Hexamethonium Compounds; Lactation; Mor | 1988 |