hexamethonium has been researched along with Myocardial Ischemia in 7 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In acute experiments in anesthetized rabbits the changes of the pulmonary hemodynamics following myocardial ischemia in the region of the descendent left coronary artery were studied in control animals and after the blockade of alpha-adrenoreceptors by phentolamine or N-cholinoreceptors of autonomic ganglia by hexamethonium." | 3.78 | [The adrenergic mechanisms are involved in the pulmonary hemodynamics changes following experimental myocardial ischemia in rabbits]. ( Evlakhov, VI; Poiasov, IZ, 2012) |
| "Pretreatment with hexamethonium could abolish this protection (IA/AR, 67 +/- 4%)." | 1.31 | Bradykinin mediates cardiac preconditioning at a distance. ( Schoemaker, RG; van Heijningen, CL, 2000) |
| "In many species arrhythmias induced by myocardial ischaemia appear to be in part dependent upon cardiac sympathetic nerves." | 1.30 | Cardiac transplantation does not effect ischaemia-induced arrhythmias in rats. ( Guo, P; Pugsley, MK; Walker, MJ; Yong, SL, 1999) |
| "In contrast to selective anoxia (Po2 < 5 mmHg) or glucose withdrawal, respectively, anoxia in combination with glucose withdrawal (5-40 min) markedly potentiated nicotine-induced NE release both in guinea-pig heart and human atrium." | 1.29 | Nicotine-induced exocytotic norepinephrine release in guinea-pig heart, human atrium and bovine adrenal chromaffin cells: modulation by single components of ischaemia. ( Gerber, S; Haass, M; Haunstetter, A; Kaufmann, A; Krüger, C; Kübler, W; Serf, C, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Evlakhov, VI | 2 |
| Poiasov, IZ | 2 |
| Krüger, C | 1 |
| Haunstetter, A | 1 |
| Gerber, S | 1 |
| Serf, C | 1 |
| Kaufmann, A | 1 |
| Kübler, W | 1 |
| Haass, M | 1 |
| Koley, J | 1 |
| Basak, AK | 1 |
| Das, M | 1 |
| Sinha, S | 1 |
| Koley, B | 1 |
| Guo, P | 1 |
| Pugsley, MK | 1 |
| Yong, SL | 1 |
| Walker, MJ | 1 |
| Schoemaker, RG | 1 |
| van Heijningen, CL | 1 |
| Liem, DA | 1 |
| Verdouw, PD | 1 |
| Ploeg, H | 1 |
| Kazim, S | 1 |
| Duncker, DJ | 1 |
7 other studies available for hexamethonium and Myocardial Ischemia
| Article | Year |
|---|---|
[The role of the adreno-cholinergic interaction in the pulmonary hemodynamics changes following myocardial ischemia].
Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Atropine; Blood Pressure; Cardiac Output; Coronary V | 2014 |
[The adrenergic mechanisms are involved in the pulmonary hemodynamics changes following experimental myocardial ischemia in rabbits].
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cardiac Output; Coronary Vessels; Disease Mod | 2012 |
Nicotine-induced exocytotic norepinephrine release in guinea-pig heart, human atrium and bovine adrenal chromaffin cells: modulation by single components of ischaemia.
Topics: Adrenal Medulla; Animals; Calcium; Cattle; Cyanides; Dose-Response Relationship, Drug; Exocytosis; F | 1995 |
Rectal response of cardiac origin in the cat: involvement of nitric oxide and acetylcholine.
Topics: Acetylcholine; Afferent Pathways; Animals; Arginine; Atropine; Blood Pressure; Cats; Coronary Vessel | 1997 |
Cardiac transplantation does not effect ischaemia-induced arrhythmias in rats.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac | 1999 |
Bradykinin mediates cardiac preconditioning at a distance.
Topics: Adrenergic beta-Antagonists; Animals; Bradykinin; Bradykinin Receptor Antagonists; Coronary Vessels; | 2000 |
Sites of action of adenosine in interorgan preconditioning of the heart.
Topics: Adenosine; Animals; Blood Pressure; Coronary Vessels; Ganglionic Blockers; Heart Rate; Hexamethonium | 2002 |