hexamethonium has been researched along with Muscle Relaxation in 40 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nicotine has been shown to reduce both tone and muscular activity in the human colon by releasing nitric oxide (NO) from nerves." | 1.35 | Nicotine-induced neurogenic relaxation in the mouse colon: changes with dextran sodium sulfate-induced colitis. ( Fujino, H; Hamada, Y; Horie, S; Murakami, I; Murayama, T; Yamane, S, 2009) |
| "Pretreatment with hexamethonium, as well as truncal vagotomy, abolished the gastric motor responses to hyperglycemia (250 mg/dl), and perivagal and gastroduodenal applications of capsaicin significantly reduced the gastric responses to hyperglycemia." | 1.35 | Gastric relaxation induced by hyperglycemia is mediated by vagal afferent pathways in the rat. ( Lu, YX; Owyang, C; Zhou, SY, 2008) |
| "Histamine 1 microM was used to increase baseline tone." | 1.30 | Investigation of endogenous neurotransmitters of guinea pig gallbladder using nicotinic agonist stimulation. ( Pagano, AP; Parkman, HP; Ryan, JP, 1998) |
| "Treatment with trimethaphan (10(-4)-10(-3)M) protected alpha-adrenergic receptors from persistent blockade by phenoxybenzamine." | 1.27 | Trimethaphan is a direct arterial vasodilator and an alpha-adrenoceptor antagonist. ( Harioka, T; Hatano, Y; Mori, K; Toda, N, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (20.00) | 18.7374 |
| 1990's | 26 (65.00) | 18.2507 |
| 2000's | 4 (10.00) | 29.6817 |
| 2010's | 2 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kiver, EN | 1 |
| Kirilina, VM | 1 |
| Fedin, AN | 1 |
| Kirvchenko, AI | 1 |
| Murakami, I | 1 |
| Hamada, Y | 1 |
| Yamane, S | 1 |
| Fujino, H | 1 |
| Horie, S | 1 |
| Murayama, T | 1 |
| Jiang, Y | 1 |
| Bhargava, V | 1 |
| Lal, HA | 1 |
| Mittal, RK | 1 |
| Ayajiki, K | 1 |
| Okamura, T | 4 |
| Noda, K | 1 |
| Toda, N | 5 |
| Zhou, SY | 1 |
| Lu, YX | 1 |
| Owyang, C | 2 |
| Downes, H | 1 |
| Taylor, SM | 1 |
| Harioka, T | 1 |
| Hatano, Y | 1 |
| Mori, K | 1 |
| von Heyden, B | 1 |
| Riemer, RK | 1 |
| Nunes, L | 1 |
| Brock, GB | 1 |
| Lue, TF | 1 |
| Tanagho, EA | 1 |
| Yoshida, K | 2 |
| Takahashi, T | 1 |
| Meulemans, AL | 1 |
| Eelen, JG | 1 |
| Schuurkes, JA | 1 |
| Tsukimi, Y | 1 |
| Okabe, S | 1 |
| Canning, BJ | 1 |
| Undem, BJ | 1 |
| Kishimoto, S | 1 |
| Machino, H | 1 |
| Kobayashi, H | 1 |
| Haruma, K | 1 |
| Kajiyama, G | 1 |
| Miyoshi, A | 1 |
| Fujii, K | 1 |
| Kortezova, N | 1 |
| Mizhorkova, Z | 1 |
| Milusheva, E | 1 |
| Varga, G | 1 |
| Vizi, ES | 1 |
| Papasova, M | 1 |
| Hayashida, H | 1 |
| Fujimoto, H | 1 |
| Tomoyoshi, T | 1 |
| Koley, J | 1 |
| Basak, AK | 1 |
| Das, M | 1 |
| Sinha, S | 1 |
| Koley, B | 1 |
| Uno, H | 1 |
| Arakawa, T | 1 |
| Fukuda, T | 1 |
| Higuchi, K | 1 |
| Kobayashi, K | 1 |
| Gross, J | 1 |
| Mutschler, E | 2 |
| Lambrecht, G | 2 |
| Börjesson, L | 2 |
| Nordgren, S | 2 |
| Delbro, DS | 2 |
| Smith, TK | 1 |
| Robertson, WJ | 1 |
| Parkman, HP | 1 |
| Pagano, AP | 1 |
| Ryan, JP | 1 |
| Blommaart, PJ | 1 |
| Ferwerda, G | 1 |
| Kodde, A | 1 |
| Tytgat, GN | 1 |
| Boeckxstaens, GE | 1 |
| Krowicki, ZK | 1 |
| Sivarao, DV | 1 |
| Abrahams, TP | 1 |
| Hornby, PJ | 1 |
| Paterson, CA | 1 |
| Anvari, M | 1 |
| Tougas, G | 1 |
| Huizinga, JD | 1 |
| Greenwood, B | 1 |
| Blank, E | 1 |
| Dodds, WJ | 2 |
| Glick, MR | 1 |
| Gehman, JD | 1 |
| Gascho, JA | 1 |
| Lefebvre, RA | 1 |
| De Beurme, FA | 1 |
| Sas, S | 1 |
| Desai, KM | 1 |
| Zembowicz, A | 1 |
| Sessa, WC | 1 |
| Vane, JR | 1 |
| Chakder, S | 1 |
| Rattan, S | 1 |
| Jaiswal, N | 1 |
| Tacke, R | 1 |
| Malik, KU | 1 |
| Grous, M | 1 |
| Ormsbee, H | 1 |
| Barnette, M | 1 |
| Schulze-Delrieu, K | 1 |
| Percy, WH | 1 |
| Ren, J | 1 |
| Shirazi, SS | 1 |
| Von Derau, K | 1 |
| Takaki, M | 1 |
| Jin, JG | 1 |
| Nakayama, S | 1 |
| Lüscher, TF | 1 |
| Vanhoutte, PM | 1 |
| Takanashi, H | 1 |
| Terawaki, T | 1 |
| Takahashi, I | 1 |
| Itoh, Z | 1 |
| Gilbert, RJ | 1 |
| Bouchoucha, M | 1 |
| Arhan, P | 1 |
| Devroede, G | 1 |
| Bortolussi, M | 1 |
| Faverdin, C | 1 |
| Héro, M | 1 |
| Barbier, JP | 1 |
| Pellerin, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Adding Yoga Respiratory Training to Osteopathic Manipulative Treatment on Exhaled Nitric Oxide Level and Cardiopulmonary Function in Patients With Pulmonary Arterial Hypertension[NCT04076241] | 48 participants (Actual) | Interventional | 2019-09-07 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
40 other studies available for hexamethonium and Muscle Relaxation
| Article | Year |
|---|---|
[THE INFLUENCE OF HISTAMINE ON THE EFFECTOR NEURONS OF INTRAMURAL GANGLIA OF THE TRACHEA AND BRONCHI].
Topics: Animals; Bronchi; Enzyme Inhibitors; Female; Ganglionic Blockers; Hexamethonium; Histamine; Histamin | 2016 |
Nicotine-induced neurogenic relaxation in the mouse colon: changes with dextran sodium sulfate-induced colitis.
Topics: Animals; Atropine; Bethanechol; Colitis, Ulcerative; Colon; Colon, Descending; Colon, Transverse; De | 2009 |
Variability in the muscle composition of rat esophagus and neural pathway of lower esophageal sphincter relaxation.
Topics: Animals; Esophageal Sphincter, Lower; Ganglionic Blockers; Hexamethonium; Male; Mechanoreceptors; Mo | 2011 |
Functional study on nitroxidergic nerve in isolated dog pulmonary arteries and veins.
Topics: Animals; Dogs; Hexamethonium; In Vitro Techniques; Methylene Blue; Muscle Relaxation; Nicotine; Nitr | 2002 |
Gastric relaxation induced by hyperglycemia is mediated by vagal afferent pathways in the rat.
Topics: Afferent Pathways; Animals; Blood Glucose; Capsaicin; Carbachol; Electric Stimulation; Fenclonine; G | 2008 |
Distinctive pharmacological profile of a nonadrenergic inhibitory system in bullfrog lung.
Topics: Adenosine; Adenosine Triphosphate; Animals; Atropine; Catecholamines; Dipyridamole; Hexamethonium; H | 1983 |
Trimethaphan is a direct arterial vasodilator and an alpha-adrenoceptor antagonist.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Arteries; Dinoprost; Dogs; Dose-Response Relationshi | 1984 |
Response of guinea pig smooth and striated urethral sphincter to cromakalim, prazosin, nifedipine, nitroprusside, and electrical stimulation.
Topics: Amino Acid Oxidoreductases; Animals; Antihypertensive Agents; Benzopyrans; Calcium; Calmodulin-Bindi | 1995 |
Involvement of nitroxidergic and noradrenergic nerves in the relaxation of dog and monkey temporal veins.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amino Acid Oxidoreductases; Animals; Argi | 1995 |
Vagal control of nitric oxide and vasoactive intestinal polypeptide release in the regulation of gastric relaxation in rat.
Topics: Animals; Atropine; Calcium; Electric Stimulation; Gastric Mucosa; Hexamethonium; Male; Motor Activit | 1995 |
NO mediates gastric relaxation after brief vagal stimulation in anesthetized dogs.
Topics: Animals; Arginine; Dogs; Electric Stimulation; Female; Hexamethonium; Muscle Relaxation; Nitric Oxid | 1995 |
Mechanism underlying nicotine-induced relaxation in dog saphenous arteries.
Topics: Animals; Arginine; Calcitonin Gene-Related Peptide; Dogs; Drug Interactions; Female; Hexamethonium; | 1994 |
Effect of anterior unilateral vagotomy on healing of kissing gastric ulcers induced in rats.
Topics: Animals; Cell Division; Deoxyglucose; Diet; Food; Gastric Acid; Gastric Emptying; Gastric Mucosa; Ga | 1994 |
Evidence that distinct neural pathways mediate parasympathetic contractions and relaxations of guinea-pig trachealis.
Topics: Action Potentials; Animals; Atropine; Dinoprost; Electric Stimulation; Esophagus; Ganglia, Parasympa | 1993 |
Inhibitory action of CCK-OP on rat proximal colon.
Topics: Acetylcholine; Animals; Atropine; Colon; Fasting; Hexamethonium; Hexamethonium Compounds; Muscle Con | 1994 |
Non-adrenergic non-cholinergic neuron stimulation in the cat lower esophageal sphincter.
Topics: Animals; Cats; Chymotrypsin; Electric Stimulation; Esophagogastric Junction; Guanethidine; Hexametho | 1996 |
Comparison of neurogenic contraction and relaxation in canine corpus cavernosum and penile artery and vein.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Arteries; Dogs; Dose-Response Relations | 1996 |
Rectal response of cardiac origin in the cat: involvement of nitric oxide and acetylcholine.
Topics: Acetylcholine; Afferent Pathways; Animals; Arginine; Atropine; Blood Pressure; Cats; Coronary Vessel | 1997 |
Involvement of capsaicin-sensitive sensory nerves in gastric adaptive relaxation in isolated guinea-pig stomachs.
Topics: Adaptation, Physiological; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation | 1997 |
Evidence for muscarinic M4 receptors mediating nonadrenergic noncholinergic relaxations in rabbit anococcygeus muscle.
Topics: Animals; Atropine Derivatives; Electric Stimulation; Hexamethonium; In Vitro Techniques; Male; Musca | 1997 |
DMPP causes relaxation of rat distal colon by a purinergic and a nitrergic mechanism.
Topics: Adenosine Triphosphate; Anesthetics, Local; Animals; Carbachol; Colon; Dimethylphenylpiperazinium Io | 1997 |
Synchronous movements of the longitudinal and circular muscle during peristalsis in the isolated guinea-pig distal colon.
Topics: Anal Canal; Animals; Apamin; Atropine; Colon; Digestive System; Digestive System Physiological Pheno | 1998 |
Investigation of endogenous neurotransmitters of guinea pig gallbladder using nicotinic agonist stimulation.
Topics: Animals; Atropine; Dimethylphenylpiperazinium Iodide; Gallbladder; Guinea Pigs; Hexamethonium; Hista | 1998 |
K(+)-induced neurogenic relaxation of rat distal colon.
Topics: Animals; Apamin; Carbachol; Colon; Drug Interactions; Enzyme Inhibitors; Hexamethonium; In Vitro Tec | 1999 |
Nicotinic acetylcholine receptor blocking effect of guanethidine in the rat gastric fundus.
Topics: Animals; Electric Stimulation; Gastric Fundus; Guanethidine; Hexamethonium; In Vitro Techniques; Iso | 1999 |
Excitation of dorsal motor vagal neurons evokes non-nicotinic receptor-mediated gastric relaxation.
Topics: Animals; Area Under Curve; Atropine; Dose-Response Relationship, Drug; Gastrointestinal Motility; Gl | 1999 |
Nitrergic and cholinergic vagal pathways involved in the regulation of canine proximal gastric tone: an in vivo study.
Topics: Animals; Dilatation, Pathologic; Dogs; Enzyme Inhibitors; Gastric Fundus; Hexamethonium; Muscle Rela | 2000 |
Nicotine stimulates esophageal peristaltic contractions in cats by a central mechanism.
Topics: Animals; Cats; Deglutition; Electromyography; Esophagus; Female; Hexamethonium; Hexamethonium Compou | 1992 |
Adenosine increases total venous capacitance in awake instrumented rats.
Topics: Acetylcholine; Adenosine; Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Arrest; H | 1992 |
Relaxant effect of capsaicin in the rat gastric fundus.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Female; Gastric Fundus; Hexamethonium; Hexameth | 1991 |
Nitroxergic nerves mediate vagally induced relaxation in the isolated stomach of the guinea pig.
Topics: Animals; Arginine; Atropine; Guanethidine; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; In V | 1991 |
Effects of galanin on the opossum internal anal sphincter: structure-activity relationship.
Topics: Anal Canal; Animals; Atropine; Esophagogastric Junction; Galanin; Ganglionic Blockers; Hexamethonium | 1991 |
Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Antihy | 1991 |
Dimethylphenylpiperazinium (DMPP)-induced relaxation and elevation of cyclic GMP content in canine lower esophageal sphincter (LES).
Topics: Animals; Cyclic GMP; Dimethylphenylpiperazinium Iodide; Dogs; Electromagnetic Fields; Esophagogastri | 1990 |
Evidence for inhibition of opossum LES through intrinsic gastric nerves.
Topics: Animals; Electric Stimulation; Esophagogastric Junction; Esophagus; Hexamethonium; Hexamethonium Com | 1989 |
Possible involvement of calcitonin gene-related peptide (CGRP) in non-cholinergic non-adrenergic relaxation induced by mesenteric nerve stimulation in guinea pig ileum.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Guanethidine; Gui | 1989 |
Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Pressure; Body Weight; Cytochrome P-450 Enzyme System | 1986 |
[Receptive relaxation of the canine stomach].
Topics: Afferent Pathways; Animals; Atropine; Dogs; Eating; Gastrointestinal Motility; Hexamethonium; Hexame | 1986 |
Subtypes of muscarinic receptors in vagal inhibitory pathway to the lower esophageal sphincter of the opossum.
Topics: Animals; Esophagogastric Junction; Female; Ganglia, Parasympathetic; Hexamethonium; Hexamethonium Co | 1987 |
[Action of trimethyl 3,3-N-hexene-5-lactam on the mechanical properties of the longitudinal fibers of the rat colon. An in vitro study].
Topics: Animals; Atropine; Carbachol; Colon; Electric Stimulation; Hexamethonium; Hexamethonium Compounds; I | 1987 |