hexamethonium has been researched along with Hypoxia in 17 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was designed to evaluate the importance of sympathoadrenal activation in the acute cardiovascular response to apneas and the role of hypoxemia in this response." | 7.70 | Mechanisms of acute cardiovascular response to periodic apneas in sedated pigs. ( Chen, L; Scharf, SM; Sica, AL, 1999) |
| "This study was designed to evaluate the importance of sympathoadrenal activation in the acute cardiovascular response to apneas and the role of hypoxemia in this response." | 3.70 | Mechanisms of acute cardiovascular response to periodic apneas in sedated pigs. ( Chen, L; Scharf, SM; Sica, AL, 1999) |
| " Pimonidazole binding, which reflects tissue hypoxia, was increased 2-fold by manipulation." | 3.70 | Graft survival is improved by hepatic denervation before organ harvesting. ( Bunzendahl, H; Raleigh, JA; Schemmer, P; Thurman, RG, 1999) |
| "After saline pretreatment, response to 5-HT consisted of immediate and brief apnea, bradycardia, and hypotension, followed by sustained tachypnea, tachycardia, pulmonary hypertension, and hypocapnic hypoxemia." | 3.69 | Parasympathetic component of 5-hydroxytryptamine-induced pulmonary dysfunctions in healthy calves. ( Amory, H; Desmecht, DJ; Lekeux, PM; Linden, AS, 1996) |
| "To test the hypothesis that decreased acetylcholine (ACh) metabolism during hypoxia is behaviorally important, the effects of cholinergic drugs and 4-aminopyridine, an enhancer of ACh release, were examined in hypoxic mice." | 3.66 | Cholinergic drugs and 4-aminopyridine alter hypoxic-induced behavioral deficits. ( Gibson, GE; Pelmas, CJ; Peterson, C, 1983) |
| "In contrast to selective anoxia (Po2 < 5 mmHg) or glucose withdrawal, respectively, anoxia in combination with glucose withdrawal (5-40 min) markedly potentiated nicotine-induced NE release both in guinea-pig heart and human atrium." | 1.29 | Nicotine-induced exocytotic norepinephrine release in guinea-pig heart, human atrium and bovine adrenal chromaffin cells: modulation by single components of ischaemia. ( Gerber, S; Haass, M; Haunstetter, A; Kaufmann, A; Krüger, C; Kübler, W; Serf, C, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Perim, RR | 1 |
| Amorim, MR | 1 |
| Bonagamba, TLLGH | 1 |
| Machado, BH | 2 |
| Niane, L | 1 |
| Joseph, V | 1 |
| Bairam, A | 1 |
| Regan, KS | 1 |
| Jonz, MG | 1 |
| Wright, PA | 1 |
| MOORE, RE | 1 |
| UNDERWOOD, MC | 1 |
| Zoccal, DB | 1 |
| Bonagamba, LG | 1 |
| Oliveira, FR | 1 |
| Antunes-Rodrigues, J | 1 |
| Gibson, GE | 1 |
| Pelmas, CJ | 1 |
| Peterson, C | 1 |
| Krüger, C | 1 |
| Haunstetter, A | 1 |
| Gerber, S | 1 |
| Serf, C | 1 |
| Kaufmann, A | 1 |
| Kübler, W | 1 |
| Haass, M | 1 |
| Linden, AS | 1 |
| Desmecht, DJ | 1 |
| Amory, H | 1 |
| Lekeux, PM | 1 |
| Sun, MK | 1 |
| Reis, DJ | 1 |
| Chen, L | 1 |
| Sica, AL | 1 |
| Scharf, SM | 1 |
| Schemmer, P | 1 |
| Bunzendahl, H | 1 |
| Raleigh, JA | 1 |
| Thurman, RG | 1 |
| Schneider, H | 1 |
| Schaub, CD | 1 |
| Chen, CA | 1 |
| Andreoni, KA | 1 |
| Schwartz, AR | 1 |
| Smith, PL | 1 |
| Robotham, JL | 1 |
| O'Donnell, CP | 1 |
| Rozanov, C | 1 |
| Roy, A | 1 |
| Mokashi, A | 1 |
| Daudu, P | 1 |
| Lahiri, S | 1 |
| Mulder, AL | 1 |
| Miedema, A | 1 |
| De Mey, JG | 1 |
| Giussani, DA | 1 |
| Blanco, CE | 1 |
| Cheung, CY | 1 |
| Rohlicek, CV | 1 |
| Polosa, C | 1 |
| Lodato, RF | 1 |
| Michael, JR | 1 |
| Murray, PA | 1 |
17 other studies available for hexamethonium and Hypoxia
| Article | Year |
|---|---|
Previous exposure to chronic intermittent hypoxia blunts the development of one-kidney, one-clip hypertension in rats.
Topics: Animals; Arterial Pressure; Cardiovascular System; Carotid Body; Ganglionic Blockers; Hexamethonium; | 2018 |
Role of cholinergic-nicotinic receptors on hypoxic chemoreflex during postnatal development in rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocycli | 2009 |
Neuroepithelial cells and the hypoxia emersion response in the amphibious fish Kryptolebias marmoratus.
Topics: Animals; Chemoreceptor Cells; Cyprinodontiformes; Gills; Hexamethonium; Hypoxia; Immunohistochemistr | 2011 |
Hexamethonium, hypoxia and heat production in new-born and infant kittens and puppies.
Topics: Animals; Body Temperature; Cats; Dogs; Female; Hexamethonium; Hypoxia; Thermogenesis | 1962 |
Increased sympathetic activity in rats submitted to chronic intermittent hypoxia.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Chronic Disease; Disease Models, A | 2007 |
Cholinergic drugs and 4-aminopyridine alter hypoxic-induced behavioral deficits.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Arecoline; Atropine; Behavior, Animal; Cholinesterase Inhi | 1983 |
Nicotine-induced exocytotic norepinephrine release in guinea-pig heart, human atrium and bovine adrenal chromaffin cells: modulation by single components of ischaemia.
Topics: Adrenal Medulla; Animals; Calcium; Cattle; Cyanides; Dose-Response Relationship, Drug; Exocytosis; F | 1995 |
Parasympathetic component of 5-hydroxytryptamine-induced pulmonary dysfunctions in healthy calves.
Topics: Aging; Animals; Apnea; Atropine; Bradycardia; Cattle; Cattle Diseases; Cholinergic Agents; Ganglioni | 1996 |
Intracisternally applied angiotensin II does not excite reticulospinal vasomotor neurons in anesthetized rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antidiuretic Hormone Receptor Antagonists | 1996 |
Mechanisms of acute cardiovascular response to periodic apneas in sedated pigs.
Topics: Anesthesia; Animals; Apnea; Blood Pressure; Cardiac Output; Epinephrine; Female; Heart Rate; Hemodyn | 1999 |
Graft survival is improved by hepatic denervation before organ harvesting.
Topics: Animals; Antihypertensive Agents; Denervation; Female; Graft Survival; Hepatic Artery; Hexamethonium | 1999 |
Neural and local effects of hypoxia on cardiovascular responses to obstructive apnea.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Cardiovascular System; Disease Models, Animal; Do | 2000 |
Barium-stimulated chemosensory activity may not reflect inhibition of background voltage-insensitive K+ channels in the rat carotid body.
Topics: Animals; Barium; Cadmium; Calcium Channels; Carotid Body; Chelating Agents; Egtazic Acid; Electron T | 2001 |
Sympathetic control of the cardiovascular response to acute hypoxemia in the chick embryo.
Topics: Acute Disease; Animals; Cardiac Output; Chick Embryo; Epinephrine; Ganglionic Blockers; Hexamethoniu | 2002 |
Fetal adrenal medulla catecholamine response to hypoxia-direct and neural components.
Topics: Adrenal Medulla; Animals; Autonomic Nerve Block; Carbon Dioxide; Fetus; Ganglionic Blockers; Hexamet | 1990 |
Neural effects of systemic hypoxia and hypercapnia on hindlimb vascular resistance in acute spinal cats.
Topics: Animals; Blood Pressure; Cats; Decerebrate State; Female; Ganglia; Hexamethonium; Hexamethonium Comp | 1986 |
Absence of neural modulation of hypoxic pulmonary vasoconstriction in conscious dogs.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Body Weight; Cardiac Output; Constriction; Dogs; | 1988 |