hexamethonium has been researched along with Hypothermia in 7 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the mechanism of the antagonistic effect of Na-((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L-prolin amide monohydrate (CAS 131404-34-7, JTP-2942) on reserpine-induced hypothermia, the role of the autonomic nervous system, adrenal gland, and thyroid gland regarding the effects of JTP-2942 has been studied in mice." | 7.69 | Mechanism of the hyperthermic effect of the novel thyrotropin-releasing hormone analogue Na-((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L- prolinamide monohydrate in mice with reserpine-induced hypothermia. ( Iwata, K; Matsushita, M; Ohta, A; Yonemori, F, 1995) |
| "Acute doses of saline, nicotine, and varenicline were given to mice, and locomotor depression and hypothermia were measured." | 3.78 | Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo. ( Grady, SR; Marks, MJ; O'Neill, HC; Ortiz, NC, 2012) |
| "To investigate the mechanism of the antagonistic effect of Na-((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L-prolin amide monohydrate (CAS 131404-34-7, JTP-2942) on reserpine-induced hypothermia, the role of the autonomic nervous system, adrenal gland, and thyroid gland regarding the effects of JTP-2942 has been studied in mice." | 3.69 | Mechanism of the hyperthermic effect of the novel thyrotropin-releasing hormone analogue Na-((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L- prolinamide monohydrate in mice with reserpine-induced hypothermia. ( Iwata, K; Matsushita, M; Ohta, A; Yonemori, F, 1995) |
| "In addition, hypothermia has been reported as an adverse event." | 1.39 | Reduction in sympathetic nerve activity as a possible mechanism for the hypothermic effect of oseltamivir, an anti-influenza virus drug, in normal mice. ( Chazono, K; Iwajima, Y; Maeda, Y; Nagano, Y; Ohsawa, M; Ono, H; Yamamoto, S, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Shimaoka, H | 1 |
| Shiina, T | 1 |
| Suzuki, H | 1 |
| Horii, Y | 1 |
| Horii, K | 1 |
| Shimizu, Y | 1 |
| Ortiz, NC | 1 |
| O'Neill, HC | 1 |
| Marks, MJ | 1 |
| Grady, SR | 1 |
| Ono, H | 1 |
| Iwajima, Y | 1 |
| Nagano, Y | 1 |
| Chazono, K | 1 |
| Maeda, Y | 1 |
| Ohsawa, M | 1 |
| Yamamoto, S | 1 |
| BALDINI, L | 1 |
| Matsushita, M | 1 |
| Yonemori, F | 1 |
| Ohta, A | 1 |
| Iwata, K | 1 |
| Gho, BC | 1 |
| Schoemaker, RG | 1 |
| van den Doel, MA | 1 |
| Duncker, DJ | 1 |
| Verdouw, PD | 1 |
| Niida, H | 1 |
| Takeuchi, K | 1 |
| Ueshima, K | 1 |
| Okabe, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cardiopulmonary Protection of Modified Remote Ischaemic Preconditioning in Mitral Valve Replacement Surgery[NCT03010839] | 86 participants (Actual) | Interventional | 2016-11-05 | Completed | |||
| Effect of Remote Ischemic Preconditioning on Pulmonary Injury in Cardic Surgery[NCT03016182] | 60 participants (Anticipated) | Interventional | 2017-02-07 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for hexamethonium and Hypothermia
| Article | Year |
|---|---|
Successful induction of deep hypothermia by isoflurane anesthesia and cooling in a non-hibernator, the rat.
Topics: Anesthetics, Inhalation; Animals; Antihypertensive Agents; Cold Temperature; Gene Expression Regulat | 2021 |
Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.
Topics: Animals; Benzazepines; Dose-Response Relationship, Drug; Female; Genotype; Hexamethonium; Hypothermi | 2012 |
Reduction in sympathetic nerve activity as a possible mechanism for the hypothermic effect of oseltamivir, an anti-influenza virus drug, in normal mice.
Topics: Animals; Antiviral Agents; Body Temperature; Hexamethonium; Hypothermia; Injections, Intraperitoneal | 2013 |
[Action of chlorpromazine and hexamethonium on electrocardiogram of hypothermal rats].
Topics: Animals; Chlorpromazine; Electrocardiography; Hexamethonium; Hexamethonium Compounds; Hypothermia; R | 1956 |
Mechanism of the hyperthermic effect of the novel thyrotropin-releasing hormone analogue Na-((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L- prolinamide monohydrate in mice with reserpine-induced hypothermia.
Topics: Adrenal Medulla; Animals; Body Temperature; Hexamethonium; Hypothermia; Hypothyroidism; Male; Mice; | 1995 |
Myocardial protection by brief ischemia in noncardiac tissue.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Coronary Vessels; Ganglia, Autonomic; Heart; H | 1996 |
Myocardial protection by brief ischemia in noncardiac tissue.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Coronary Vessels; Ganglia, Autonomic; Heart; H | 1996 |
Myocardial protection by brief ischemia in noncardiac tissue.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Coronary Vessels; Ganglia, Autonomic; Heart; H | 1996 |
Myocardial protection by brief ischemia in noncardiac tissue.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Coronary Vessels; Ganglia, Autonomic; Heart; H | 1996 |
Vagally mediated acid hypersecretion and lesion formation in anesthetized rat under hypothermic conditions.
Topics: Animals; Atropine; Carbachol; Clonidine; Ganglionic Blockers; Gastric Acid; Gastric Mucosa; Gastroin | 1991 |