hexamethonium has been researched along with Hypotension in 53 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An increase in endogenous central histamine concentration after inhibition of histamine N-methyltransferase (HNMT) activity reverses critical hypotension and improves the survival of rats in haemorrhagic shock." | 7.72 | Involvement of the sympathetic nervous system in the reversal of critical haemorrhagic hypotension by endogenous central histamine in rats. ( Jochem, J, 2004) |
| "Pretreatment with mecamylamine (50 micrograms; i." | 5.29 | Central choline reverses hypotension caused by alpha-adrenoceptor or ganglion blockade in rats: the role of vasopressin. ( Savci, V; Ulus, IH, 1996) |
| "An increase in endogenous central histamine concentration after inhibition of histamine N-methyltransferase (HNMT) activity reverses critical hypotension and improves the survival of rats in haemorrhagic shock." | 3.72 | Involvement of the sympathetic nervous system in the reversal of critical haemorrhagic hypotension by endogenous central histamine in rats. ( Jochem, J, 2004) |
| "Concentrations of gamma-aminobutyric acid (GABA) and other amino acids were measured in microdissected areas of the rostral ventro-lateral medulla (RVL), nucleus tractus solitarii (NTS) and caudal ventrolateral medulla (CVL) of the rat, and effects on the amino acid levels, of hypotension induced by hexamethonium and nifedipine were examined." | 3.68 | Hypotension decreases GABA levels in brainstem regions of the rat. ( Kihara, M; Kubo, T; Misu, Y, 1990) |
| "Our objectives were 1) to investigate the extent to which the pulmonary vascular response to increasing cardiac index after a period of hypotension and hypoperfusion (defined as reperfusion) measured in conscious dogs is altered during pentobarbital sodium anesthesia, and 2) to determine whether pentobarbital anesthesia modifies autonomic nervous system (ANS) regulation of the pulmonary circulation during reperfusion." | 3.67 | Pentobarbital anesthesia modifies pulmonary vasoregulation after hypoperfusion. ( Chen, BB; Clougherty, PW; Fehr, DM; Goll, HM; Murray, PA; Nyhan, DP, 1988) |
| " To test this hypothesis, we have used a novel approach to effectively "clamp" the sympathetic nervous system at a fixed level through chronic administration of the ganglionic blocking agent hexamethonium (15 mg/kg/h) and the alpha agonist phenylephrine (2." | 1.33 | Role of a responsive sympathetic nervous system in the chronic hypotensive effects of losartan in normal rats. ( Collister, JP; Osborn, JW, 2005) |
| "In hexamethonium-treated rats, the blood-pressure-lowering effect of frII was almost abolished." | 1.32 | Medicinal plants in Suriname: hypotensive effect of Gossypium barbadense. ( Hasrat, JA; Pieters, L; Vlietinck, AJ, 2004) |
| "Pretreatment with mecamylamine (50 micrograms; i." | 1.29 | Central choline reverses hypotension caused by alpha-adrenoceptor or ganglion blockade in rats: the role of vasopressin. ( Savci, V; Ulus, IH, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (71.70) | 18.7374 |
| 1990's | 7 (13.21) | 18.2507 |
| 2000's | 7 (13.21) | 29.6817 |
| 2010's | 1 (1.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, G | 1 |
| Walsh, E | 1 |
| Shryock, JC | 1 |
| Messina, E | 1 |
| Wu, Y | 1 |
| Zeng, D | 1 |
| Xu, X | 1 |
| Ochoa, M | 1 |
| Baker, SP | 1 |
| Hintze, TH | 1 |
| Belardinelli, L | 1 |
| Lahlou, S | 1 |
| MASON, AA | 1 |
| PELMORE, JF | 1 |
| ASERMAN, D | 1 |
| PETIT-DUTAILLIS, D | 1 |
| GUIOT, G | 1 |
| DAMOISEAU, B | 1 |
| SHAPIRO, AP | 1 |
| GROLLMAN, A | 1 |
| BENKE, A | 1 |
| SCHWEIZER, O | 1 |
| PARISCENTI, P | 2 |
| SALA, G | 2 |
| MANDOW, GA | 1 |
| ARDEN, GP | 1 |
| STONEHAM, FJ | 1 |
| DE COTTEN, MV | 1 |
| BROWN, JM | 1 |
| KRONEN, PS | 1 |
| WALKER, G | 1 |
| LEVY, L | 1 |
| HYMAN, A | 1 |
| ROMNEY, R | 1 |
| VETTER, H | 1 |
| GRABNER, G | 1 |
| MLCZOCH, F | 1 |
| STEINBEREITHNER, K | 1 |
| POOLE, EW | 1 |
| MOYER, JH | 4 |
| MORRIS, G | 2 |
| GUIDETTI, B | 1 |
| ALVISI, C | 1 |
| SNYDER, HB | 1 |
| MORRIS, GC | 2 |
| HAYNES, BW | 1 |
| VAN BERGEN, FH | 2 |
| BUCKLEY, JJ | 1 |
| FRENCH, LA | 1 |
| DOBKIN, AB | 1 |
| BROWN, IA | 1 |
| SMIRK, FH | 1 |
| SEIBERT, RA | 1 |
| PIPBERGER, H | 1 |
| KALIN, R | 1 |
| ROSSIER, PH | 1 |
| HOLMES, F | 3 |
| COULTER, RL | 2 |
| ZAMBONI, P | 1 |
| AZZOLINI, G | 1 |
| KLEINER, GM | 1 |
| STONE, HH | 1 |
| MACKRELL, TN | 1 |
| WECHSLER, RL | 1 |
| McCONN, R | 1 |
| GRIFFITHS, JA | 1 |
| HUGHES, G | 1 |
| VILLINGER, R | 1 |
| WILFLINGSEDER, P | 1 |
| MIELE, E | 1 |
| MARMO, E | 1 |
| PREZIOSI, P | 1 |
| VOURC'H, G | 2 |
| Jochem, J | 1 |
| Hasrat, JA | 1 |
| Pieters, L | 1 |
| Vlietinck, AJ | 1 |
| CHATEAUREYNAUD, J | 1 |
| DU BOUCHET, N | 1 |
| LATSCHA, BI | 1 |
| PASSELECQ, J | 1 |
| D'AUBIAC, PB | 1 |
| Collister, JP | 1 |
| Osborn, JW | 1 |
| Kunz, TH | 1 |
| Scott, M | 1 |
| Ittner, LM | 1 |
| Fischer, JA | 1 |
| Born, W | 1 |
| Vogel, J | 1 |
| Lizardo, JH | 1 |
| Silveira, EA | 1 |
| Vassallo, DV | 1 |
| Oliveira, EM | 1 |
| Teranishi, Y | 2 |
| Iriuchijima, J | 1 |
| Savci, V | 1 |
| Ulus, IH | 1 |
| Dunbar, JC | 1 |
| O'Leary, DS | 1 |
| Wang, G | 1 |
| Wright-Richey, J | 1 |
| Ullman, J | 1 |
| Diéguez, G | 1 |
| Fernández, N | 1 |
| Sánchez, MA | 1 |
| Martínez, MA | 1 |
| García-Villalón, AL | 1 |
| Monge, L | 1 |
| Gómez, B | 1 |
| Iida, N | 1 |
| Ishioka, N | 1 |
| Sugino, H | 1 |
| Amano, T | 1 |
| Abdel-Rahman, AA | 1 |
| Carroll, RG | 1 |
| el-Mas, MM | 1 |
| Kubo, T | 1 |
| Kihara, M | 1 |
| Misu, Y | 1 |
| Chen, BB | 1 |
| Nyhan, DP | 1 |
| Goll, HM | 1 |
| Clougherty, PW | 1 |
| Fehr, DM | 1 |
| Murray, PA | 1 |
53 other studies available for hexamethonium and Hypotension
| Article | Year |
|---|---|
Antiadrenergic and hemodynamic effects of ranolazine in conscious dogs.
Topics: Acetanilides; Adrenergic Antagonists; Animals; Autonomic Agents; Coronary Circulation; Dogs; Dose-Re | 2011 |
Mechanisms underlying the cardiovascular responses to spinal dopamine receptor stimulation by apomorphine in anesthetized rats.
Topics: Adrenalectomy; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Apomorphine; Atenolol; | 2003 |
Combined use of hexamethonium bromide and procaine amide in controlled hypotension; a preliminary report.
Topics: Cardiovascular Agents; Hexamethonium; Hypotension; Hypotension, Controlled; Muscle Relaxants, Centra | 1953 |
Controlled hypotension in neurosurgery with hexamethonium and procaine amide.
Topics: Cardiovascular Agents; Hexamethonium; Hypotension; Hypotension, Controlled; Muscle Relaxants, Centra | 1953 |
[Utilization of certain ganglion blocking agents and results of their use in neurosurgery; hexamethonium, C-9295].
Topics: Ganglionic Blockers; Hexamethonium; Hypotension; Muscle Relaxants, Central; Neurosurgery; Neurosurgi | 1952 |
A critical evaluation of the hypotensive asction of hydrallazine, hexamethonium, tetraethylammonium and dibenzyline salts in human and experimental hypertension.
Topics: Cardiovascular Agents; Hexamethonium; Hydralazine; Hypertension; Hypotension; Muscle Relaxants, Cent | 1953 |
[Controlled hypotension with depressin and pendiomide].
Topics: Autonomic Agents; Cardiovascular Agents; Hexamethonium; Hypotension; Hypotension, Controlled; Muscle | 1953 |
Clinical and investigational experiences with hypotension induced by hexamethonium bromide.
Topics: Cardiovascular Agents; Hexamethonium; Humans; Hypotension; Muscle Relaxants, Central | 1953 |
[Influence of cortisone on hexamethonium hypotension].
Topics: Cardiovascular Agents; Cortisone; Hexamethonium; Hypotension; Muscle Relaxants, Central | 1953 |
[Effect of cortisone on hypotension caused by hexamethonium].
Topics: Cardiovascular Agents; Cortisone; Hexamethonium; Hypotension; Muscle Relaxants, Central; Rheumatic D | 1953 |
Hypotension induced with hexamethonium bromide during anaesthesia.
Topics: Anesthesia; Hexamethonium; Humans; Hypotension; Hypotension, Controlled; Muscle Relaxants, Central | 1954 |
Heart force responses to pressor amines during hypotension produced by hexamethonium.
Topics: Amines; Heart; Hexamethonium; Hypotension; Sympathomimetics; Vasoconstrictor Agents | 1954 |
Prolonged hypotensive reaction to hexamethonium.
Topics: Cardiovascular Agents; Hexamethonium; Hypotension; Muscle Relaxants, Central | 1954 |
[Cardiac catheterization studies in severe hexamethonium-induced hypotension].
Topics: Cardiac Catheterization; Heart; Hexamethonium; Humans; Hypotension; Muscle Relaxants, Central | 1954 |
Reactions of the cat pial circulation to hypotensive states induced by hexamethonium bromide.
Topics: Animals; Cats; Felis; Hexamethonium; Hypotension; Muscle Relaxants, Central; Pia Mater | 1954 |
Cerebral hemodynamics during controlled hypotension induced by the continuous infusion of ganglionic blocking agents (hexamethonium, pendiomide and arfonad).
Topics: Autonomic Agents; Brain; Ganglionic Blockers; Hemodynamics; Hexamethonium; Hypotension; Hypotension, | 1954 |
[Hexamethonium in neurosurgery and neurology].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Brain; Brain Neoplasms; Hexamethonium; Hypotension; | 1954 |
The effect of hexamethonium-induced hypotension on water and electrolyte excretion in man.
Topics: Body Fluids; Cardiovascular Agents; Electrolytes; Hexamethonium; Hypotension; Muscle Relaxants, Cent | 1953 |
Physiologic alterations associated with hexamethonium-induced hypotension.
Topics: Blood Circulation; Blood Pressure; Electrocardiography; Electroencephalography; Hexamethonium; Hypot | 1954 |
Blood pressure reduction in arterial hypertension by hexamethonium and pentapyrrolidinium salts.
Topics: Blood Pressure; Cardiovascular Agents; Hexamethonium; Hypertension; Hypotension; Muscle Relaxants, C | 1954 |
Renal function during controlled hypotension with hexamethonium and following norepinephrine.
Topics: Hexamethonium; Humans; Hypotension; Hypotension, Controlled; Kidney; Muscle Relaxants, Central; Nore | 1955 |
Hexamethonium-induced hypotension.
Topics: Hexamethonium; Hypotension; Minnesota; Muscle Relaxants, Central | 1955 |
[Vectorcardiographic studies in hypertensive patients with massive blood pressure reduction by hexamethonium; contribution to the theory of ventricular gradients].
Topics: Blood Pressure; Hexamethonium; Humans; Hypertension; Hypotension; Muscle Relaxants, Central; Vectorc | 1955 |
Induced hypotension in orthopaedic surgery; hexamethonium bromide (C6) in 407 orthopaedic operations.
Topics: Hexamethonium; Humans; Hypotension; Hypotension, Controlled; Orthopedic Procedures; Orthopedics | 1956 |
Induced hypotension in orthopaedic surgery; hexamethonium bromide (C6) in 407 orthopaedic operations.
Topics: Hexamethonium; Humans; Hypotension; Hypotension, Controlled; Orthopedic Procedures; Orthopedics | 1956 |
Induced hypotension in orthopaedic surgery; hexamethonium bromide (C6) in 407 orthopaedic operations.
Topics: Hexamethonium; Humans; Hypotension; Hypotension, Controlled; Orthopedic Procedures; Orthopedics | 1956 |
Induced hypotension in orthopaedic surgery; hexamethonium bromide (C6) in 407 orthopaedic operations.
Topics: Hexamethonium; Humans; Hypotension; Hypotension, Controlled; Orthopedic Procedures; Orthopedics | 1956 |
Controlled hypotension; the use of an adrenergic blocking agent to supplement hexamethonium.
Topics: Adrenergic Antagonists; Hexamethonium; Hexamethonium Compounds; Humans; Hypotension; Hypotension, Co | 1957 |
Controlled hypotension; the use of an adrenergic blocking agent to supplement hexamethonium.
Topics: Adrenergic Antagonists; Hexamethonium; Hexamethonium Compounds; Humans; Hypotension; Hypotension, Co | 1957 |
Controlled hypotension; the use of an adrenergic blocking agent to supplement hexamethonium.
Topics: Adrenergic Antagonists; Hexamethonium; Hexamethonium Compounds; Humans; Hypotension; Hypotension, Co | 1957 |
Controlled hypotension; the use of an adrenergic blocking agent to supplement hexamethonium.
Topics: Adrenergic Antagonists; Hexamethonium; Hexamethonium Compounds; Humans; Hypotension; Hypotension, Co | 1957 |
[Role of the carotid sinus in hypotension caused by the central action of hexamethonium].
Topics: Carotid Sinus; Hexamethonium; Hexamethonium Compounds; Humans; Hypotension | 1957 |
Bloodless operating field in middle-ear surgery. Review of 138 cases of induced hypotension with hexamethonium bromide (C6).
Topics: Ear, Middle; Hexamethonium; Hexamethonium Compounds; Humans; Hypotension; Hypotension, Controlled; O | 1961 |
[HEXONIUM THERAPY OF PATIENTS WITH PEPTIC ULCER].
Topics: Blood Pressure Determination; Hexamethonium; Hexamethonium Compounds; Humans; Hypotension; Peptic Ul | 1963 |
The effect on cerebral circulation and metabolism in man of acute reduction in blood pressure by means of intravenous hexamethonium bromide and head-up tilt.
Topics: Blood Pressure; Blood Pressure Determination; Brain; Cerebrovascular Circulation; Hexamethonium; Hum | 1955 |
Effect of controlled hypotension with pendiomid (as used in surgery) on renal hemodynamics and water and electrolyte excretion: a comparison with hexamethonium and arfonad and the effect of norepinephrine on these responses.
Topics: Autonomic Agents; Electrolytes; Hemodynamics; Hexamethonium; Humans; Hypotension; Hypotension, Contr | 1955 |
Some circulatory aspects of induced hypotension with hexamethonium.
Topics: Blood Circulation; Cardiovascular Agents; Hexamethonium; Hypotension; Muscle Relaxants, Central | 1955 |
The investigation of cerebral blood flow during anaesthesia with hypotension induced by the use of hexamethonium bromide and posture.
Topics: Anesthesia; Anesthesiology; Brain; Cerebrovascular Circulation; Hexamethonium; Hibernation; Humans; | 1955 |
[Ganglion blocking and artificial hypotension with hexamethonium in thyroid gland surgery].
Topics: Autonomic Agents; Hexamethonium; Hypotension; Muscle Relaxants, Central; Parathyroid Glands; Thyroid | 1955 |
[Diverse effect of hydrochlorothiazide in relation to the hypotensive activity of reserpine, rescinnamine, syrosingopine, 1, 4-dihydrazino-phthlazine (alone or associated with reserpine), hexamethonium and guanethidine].
Topics: Alkaloids; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Chlorothiazide; Gu | 1961 |
[Three cases of hypotension controlled by hexamethonium in neurosurgery].
Topics: Cardiovascular Agents; Hexamethonium; Hypotension; Muscle Relaxants, Central; Neurosurgery; Neurosur | 1952 |
Involvement of the sympathetic nervous system in the reversal of critical haemorrhagic hypotension by endogenous central histamine in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine Derivatives; Blood Pres | 2004 |
Medicinal plants in Suriname: hypotensive effect of Gossypium barbadense.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; Drug Synergism; Gossypium; Guinea Pigs; Hexamet | 2004 |
[Weight method of evaluation of surgical hemorrhage systematic utilization of hexamethonium salts in pulmonary surgery].
Topics: Blood Loss, Surgical; Body Weights and Measures; Hexamethonium; Hypotension; Lung; Muscle Relaxants, | 1952 |
[First results of the use of hexamethonium in heart surgery].
Topics: Cardiac Surgical Procedures; Hemorrhage; Hexamethonium; Hypotension; Muscle Relaxants, Central; Thor | 1952 |
[Hexamethonium in neurosurgery].
Topics: Hemorrhage; Hexamethonium; Hypotension; Muscle Relaxants, Central; Neurosurgery; Neurosurgical Proce | 1952 |
[Use of hexamethonium in digestive surgery with open thorax].
Topics: Gastrointestinal Tract; Hemorrhage; Hexamethonium; Hypotension; Muscle Relaxants, Central; Thorax | 1952 |
Role of a responsive sympathetic nervous system in the chronic hypotensive effects of losartan in normal rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Chronic Disease; Ganglionic Blocke | 2005 |
Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activity.
Topics: Adrenergic beta-Antagonists; Adrenomedullin; Animals; Blood Pressure; Calcitonin Gene-Related Peptid | 2007 |
Post-resistance exercise hypotension in spontaneously hypertensive rats is mediated by nitric oxide.
Topics: Animals; Blood Pressure; Hexamethonium; Hypertension; Hypotension; Male; NG-Nitroarginine Methyl Est | 2008 |
Hindquarter vascular resistance as compensator for hypotension in conscious rats.
Topics: Animals; Consciousness; Ganglia; Hexamethonium; Hindlimb; Hypotension; Male; Mesenteric Artery, Supe | 1994 |
Central choline reverses hypotension caused by alpha-adrenoceptor or ganglion blockade in rats: the role of vasopressin.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Blood Pres | 1996 |
Mechanisms mediating insulin-induced hypotension in rats. A role for nitric oxide and autonomic mediators.
Topics: Animals; Antihypertensive Agents; Atenolol; Atropine; Autonomic Nervous System; Blood Glucose; Blood | 1996 |
Vasopressin and angiotensin II in blood pressure control during isoflurane anesthesia in rats.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Angiotensin II; Angiotensin-Converting Enzyme Inhib | 1999 |
Role of nitric oxide in the cerebral circulation during hypotension after hemorrhage, ganglionic blockade and diazoxide in awake goats.
Topics: Animals; Blood Pressure; Cerebrovascular Circulation; Diazoxide; Enzyme Inhibitors; Female; Ganglion | 1999 |
Is compensatory vasoconstrictor tone in the hindquarter vascular region induced by hemorrhage in conscious spontaneously hypertensive rats?
Topics: Animals; Aorta, Abdominal; Blood Flow Velocity; Blood Pressure; Consciousness; Ganglionic Blockers; | 2001 |
Role of the sympathetic nervous system in the alcohol-guanabenz hemodynamic interaction.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Catecholamines; Dose-Response Relationship, Drug; | 1992 |
Hypotension decreases GABA levels in brainstem regions of the rat.
Topics: Alanine; Animals; Blood Pressure; Brain Stem; gamma-Aminobutyric Acid; Ganglionic Blockers; Glycine; | 1990 |
Pentobarbital anesthesia modifies pulmonary vasoregulation after hypoperfusion.
Topics: Acetylcholine; Anesthesia, General; Animals; Autonomic Nervous System; Blood Pressure; Cardiac Outpu | 1988 |