hexamethonium has been researched along with Hypersensitivity in 3 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The degree of protection against inhaled histamine achieved by inhalation of the ganglion blocker hexamethonium bromide plus placebo, hexamethonium plus atropine sulphate, and placebo plus placebo was examined in six atopic subjects, four of whom had current asthma." | 5.05 | The effect of inhaled hexamethonium bromide and atropine sulphate on airway responsiveness to histamine. ( Daniel, EE; Hargreave, FE; Latimer, KM; Morris, MM; O'Byrne, PM; Roberts, RS; Thomson, NC, 1985) |
| "Brown-Norway rats (n=113) sensitized and challenged with nDer f 1 allergen were used to examine the contribution of lung sensory nerves to ozone (O(3)) exacerbation of asthma." | 3.78 | Vagal afferents contribute to exacerbated airway responses following ozone and allergen challenge. ( Schelegle, ES; Walby, WF, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schelegle, ES | 1 |
| Walby, WF | 1 |
| Namimatsu, A | 1 |
| Go, K | 1 |
| Tanimoto, H | 1 |
| Okuda, M | 1 |
| O'Byrne, PM | 1 |
| Thomson, NC | 1 |
| Latimer, KM | 1 |
| Roberts, RS | 1 |
| Morris, MM | 1 |
| Daniel, EE | 1 |
| Hargreave, FE | 1 |
1 trial available for hexamethonium and Hypersensitivity
| Article | Year |
|---|---|
The effect of inhaled hexamethonium bromide and atropine sulphate on airway responsiveness to histamine.
Topics: Adult; Asthma; Atropine; Blood Pressure; Drug Interactions; Female; Forced Expiratory Volume; Heart | 1985 |
2 other studies available for hexamethonium and Hypersensitivity
| Article | Year |
|---|---|
Vagal afferents contribute to exacerbated airway responses following ozone and allergen challenge.
Topics: Air Pollutants; Airway Resistance; Allergens; Animals; Asthma; Bronchoconstriction; Capsaicin; Gangl | 2012 |
Mechanism of nasal secretion mediated via nerve reflex in guinea pigs and evaluation of antiallergic drugs.
Topics: Allergens; Aminopyridines; Animals; Atropine Derivatives; Bronchodilator Agents; Capsaicin; Ganglion | 1992 |