hexamethonium has been researched along with Heart Failure in 12 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two signatures of heart failure are activation of the sympathetic nervous system and catecholamine desensitization." | 1.30 | Effects of cardiac denervation on development of heart failure and catecholamine desensitization. ( Asai, K; Ghaleh-Marzban, B; Kudej, RK; Mirsky, I; Patrick, TA; Sato, N; Shannon, RP; Shen, YT; Uechi, M; Vatner, DE; Vatner, SF, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (75.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| KELLEY, RT | 1 |
| FREIS, ED | 3 |
| HIGGINS, TF | 1 |
| WILSON, AG | 1 |
| WILSON, VH | 1 |
| KEELEY, KJ | 1 |
| BURCH, RR | 1 |
| PHILLIPS, JH | 1 |
| ULLMANN, TD | 1 |
| MENCZEL, J | 1 |
| Burch, GE | 1 |
| Brändle, M | 1 |
| Patel, KP | 1 |
| Wang, W | 1 |
| Zucker, IH | 1 |
| Sato, N | 1 |
| Vatner, SF | 1 |
| Shen, YT | 1 |
| Kudej, RK | 1 |
| Ghaleh-Marzban, B | 1 |
| Uechi, M | 1 |
| Asai, K | 1 |
| Mirsky, I | 1 |
| Patrick, TA | 1 |
| Shannon, RP | 1 |
| Vatner, DE | 1 |
| Neumann, T | 1 |
| Ravens, U | 1 |
| Heusch, G | 1 |
12 other studies available for hexamethonium and Heart Failure
| Article | Year |
|---|---|
The effects of hexamethonium on certain manifestations of congestive heart failure.
Topics: Cardiovascular Agents; Heart Failure; Hexamethonium; Hypertension; Muscle Relaxants, Central | 1953 |
Effect of hexamethonium on normotensive heart failure; a possible correlation between the mechanism of essential hypertension and normotensive heart failure.
Topics: Essential Hypertension; Heart Failure; Hexamethonium; Hypertension; Muscle Relaxants, Central | 1953 |
The haemodynamic effects of hexamethonium bromide in patients with pulmonary hypertension and heart failure.
Topics: Blood Circulation; Heart Failure; Hemodynamics; Hexamethonium; Hypertension; Hypertension, Pulmonary | 1953 |
The effects of intravenous hexamethonium on venous pressure of normotensive and hypertensive patients with and without congestive heart failure.
Topics: Blood Pressure; Blood Pressure Determination; Heart Failure; Hexamethonium; Humans; Hypertension; Ve | 1955 |
The lymphatic system, with particular reference to cardiac edema; an experimental study of the lymphodynamic effects of hexamethonium.
Topics: Cortisone; Edema; Edema, Cardiac; Heart Failure; Hexamethonium; Humans; Lymph; Lymphatic System; Mus | 1955 |
The effect of a ganglionic blocking agent (hexamethonium) on renal function and on excretion of water and electrolytes in hypertension and in congestive heart failure.
Topics: Electrolytes; Ganglionic Blockers; Heart Failure; Hexamethonium; Humans; Hypertension; Kidney Functi | 1956 |
Preload and afterload reduction in treating congestive heart failure.
Topics: Autonomic Nerve Block; Heart Failure; Hemodynamics; Hexamethonium; Hexamethonium Compounds; Humans; | 1984 |
The digital circulation in congestive heart failure.
Topics: Air Conditioning; Blood Circulation; Conditioning, Classical; Dose-Response Relationship, Drug; Envi | 1983 |
Hemodynamic and norepinephrine responses to pacing-induced heart failure in conscious sinoaortic-denervated dogs.
Topics: Animals; Blood Pressure; Cardiac Pacing, Artificial; Cholinergic Antagonists; Dogs; Female; Heart Fa | 1996 |
Effects of cardiac denervation on development of heart failure and catecholamine desensitization.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Atropine Derivatives; Blood Pressure; | 1997 |
Characterization of excitation-contraction coupling in conscious dogs with pacing-induced heart failure.
Topics: Animals; Atropine; Cardiac Pacing, Artificial; Dogs; Echocardiography; Electric Stimulation; Female; | 1998 |
Hexamethonium, a forgotten drug in relation to "new" concepts in the management of heart failure.
Topics: Ganglionic Blockers; Heart Failure; Hexamethonium; Hexamethonium Compounds; Humans | 1989 |