hexamethonium has been researched along with Heart Diseases in 4 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hexamethonium pretreatment induced significantly less QRS widening and QTc lengthening than was seen in group 1 but worsened the bupivacaine effects on bradycardia, atria-His and PR intervals, mean aortic pressure, and first derivative of left ventricular pressure." | 1.29 | Mechanisms of the putative cardioprotective effect of hexamethonium in anesthetized dogs given a large dose of bupivacaine. ( Bassoul, B; Bruelle, P; de La Coussaye, JE; Desch, G; Eledjam, JJ; Lefrant, JY; Peray, PA; Sassine, A, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, N | 1 |
| Orr-Urtreger, A | 1 |
| Chapman, J | 1 |
| Rabinowitz, R | 1 |
| Korczyn, AD | 1 |
| HIMBERT, J | 1 |
| GRAS, H | 1 |
| de La Coussaye, JE | 1 |
| Eledjam, JJ | 1 |
| Bruelle, P | 1 |
| Lefrant, JY | 1 |
| Bassoul, B | 1 |
| Peray, PA | 1 |
| Desch, G | 1 |
| Sassine, A | 1 |
| Uechi, M | 1 |
| Asai, K | 1 |
| Osaka, M | 1 |
| Smith, A | 1 |
| Sato, N | 1 |
| Wagner, TE | 1 |
| Ishikawa, Y | 1 |
| Hayakawa, H | 1 |
| Vatner, DE | 1 |
| Shannon, RP | 1 |
| Homcy, CJ | 1 |
| Vatner, SF | 1 |
4 other studies available for hexamethonium and Heart Diseases
| Article | Year |
|---|---|
Deficiency of nicotinic acetylcholine receptor beta 4 subunit causes autonomic cardiac and intestinal dysfunction.
Topics: Acetylcholine; Animals; Aortic Bodies; Disease Models, Animal; Ganglia, Autonomic; Ganglionic Blocke | 2003 |
[Effect of hexamethonium on renal circulation and function in cardiacs and hypertensives].
Topics: Heart Diseases; Hexamethonium; Hexamethonium Compounds; Humans; Hypertension; Kidney; Renal Circulat | 1959 |
Mechanisms of the putative cardioprotective effect of hexamethonium in anesthetized dogs given a large dose of bupivacaine.
Topics: Anesthesia; Animals; Antihypertensive Agents; Atrial Function; Atropine; Bupivacaine; Cardiac Pacing | 1994 |
Depressed heart rate variability and arterial baroreflex in conscious transgenic mice with overexpression of cardiac Gsalpha.
Topics: Adrenergic beta-Agonists; Animals; Baroreflex; Blood Pressure; Circadian Rhythm; Consciousness; Dobu | 1998 |