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hexamethonium and Fasting Hypoglycemia

hexamethonium has been researched along with Fasting Hypoglycemia in 11 studies

Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.

Fasting Hypoglycemia: HYPOGLYCEMIA expressed in the postabsorptive state, after prolonged FASTING, or an overnight fast.

Research Excerpts

ExcerptRelevanceReference
" In addition, it is not known to what extent increased glucagon secretion during hypoglycemia in mice is neurally mediated vs."7.68Autonomic control of pancreatic polypeptide and glucagon secretion during neuroglucopenia and hypoglycemia in mice. ( Ahren, B; Akpan, JO; Curry, DL; Gingerich, RL; Havel, PJ; Stern, JS, 1993)
"To determine the role of the autonomic nervous system (ANS) in mediating the glucagon response to marked insulin-induced hypoglycemia in dogs, we measured arterial and pancreatic venous glucagon responses to insulin-induced hypoglycemia during acute, terminal experiments in halothane-anesthetized dogs in which the ANS was intact (control; n = 9), pharmacologically blocked by the nicotinic ganglionic antagonist hexamethonium (n = 6), or surgically ablated by cervical vagotomy and cervical spinal cord section (n = 6)."7.68Role for autonomic nervous system to increase pancreatic glucagon secretion during marked insulin-induced hypoglycemia in dogs. ( Dunning, BE; Havel, PJ; Taborsky, GJ; Veith, RC, 1991)
" In addition, it is not known to what extent increased glucagon secretion during hypoglycemia in mice is neurally mediated vs."3.68Autonomic control of pancreatic polypeptide and glucagon secretion during neuroglucopenia and hypoglycemia in mice. ( Ahren, B; Akpan, JO; Curry, DL; Gingerich, RL; Havel, PJ; Stern, JS, 1993)
"To investigate the neural regulation of pancreatic polypeptide (PP) secretion during hypoglycemia in the rat, insulin was administered to chronically cannulated rats, and plasma PP responses were compared between saline-treated animals and animals pretreated with a ganglionic blocking agent (hexamethonium), a muscarinic antagonist (atropine), combined alpha- and beta-adrenergic receptor blockade (propranolol + tolazoline), or combined adrenergic blockade + atropine."3.68Autonomic nervous system mediation of the pancreatic polypeptide response to insulin-induced hypoglycemia in conscious rats. ( Akpan, JO; Curry, DL; Gingerich, RL; Havel, PJ; Parry, SJ; Stern, JS, 1992)
"To determine the role of the autonomic nervous system (ANS) in mediating the glucagon response to marked insulin-induced hypoglycemia in dogs, we measured arterial and pancreatic venous glucagon responses to insulin-induced hypoglycemia during acute, terminal experiments in halothane-anesthetized dogs in which the ANS was intact (control; n = 9), pharmacologically blocked by the nicotinic ganglionic antagonist hexamethonium (n = 6), or surgically ablated by cervical vagotomy and cervical spinal cord section (n = 6)."3.68Role for autonomic nervous system to increase pancreatic glucagon secretion during marked insulin-induced hypoglycemia in dogs. ( Dunning, BE; Havel, PJ; Taborsky, GJ; Veith, RC, 1991)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19906 (54.55)18.7374
1990's5 (45.45)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
BILLINGTON, BP1
PATON, A1
REYNOLDS, TB1
SHERLOCK, S1
JUDSON, WE1
HOLLANDER, W1
MARLEY, E1
YAMASHITA, K1
SCHACHTER, M1
LAURENCE, DR1
STACEY, RS1
Havel, PJ4
Akpan, JO2
Curry, DL2
Stern, JS2
Gingerich, RL2
Ahren, B1
Parry, SJ1
Mundinger, TO1
Veith, RC2
Dunning, BE2
Taborsky, GJ2
Zhou, XF1
Jhamandas, KH1
Livett, BG1

Other Studies

11 other studies available for hexamethonium and Fasting Hypoglycemia

ArticleYear
The effect of hexamethonium bromide on the circulatory and metabolic response to insulin hypoglycemia in man.
    The Journal of laboratory and clinical medicine, 1954, Volume: 43, Issue:6

    Topics: Hexamethonium; Humans; Hypoglycemia; Insulin; Male; Muscle Relaxants, Central; Pancreatic Diseases

1954
The effects of insulin-induced hypoglycemia in patients with angina pectoris; before and after intravenous hexamethonium.
    American heart journal, 1956, Volume: 52, Issue:2

    Topics: Angina Pectoris; Cardiovascular Agents; Hexamethonium; Humans; Hyperinsulinism; Hypoglycemia; Insuli

1956
Modification of hypoglycaemia with hexamethonium bromide.
    British medical journal, 1957, Apr-20, Volume: 1, Issue:5024

    Topics: Hexamethonium; Hexamethonium Compounds; Humans; Hypoglycemia; Insulin; Pancreatic Diseases

1957
Effect of hexamethonium on the augmented adrenaline secretion of the adrenal gland causable by insulin hypoglycemia.
    The Tohoku journal of experimental medicine, 1957, Aug-25, Volume: 66, Issue:2

    Topics: Adrenal Glands; Epinephrine; Hexamethonium; Hexamethonium Compounds; Hyperinsulinism; Hypoglycemia;

1957
Hexamethonium and insulin hypoglycaemia.
    The Journal of physiology, 1951, Oct-29, Volume: 115, Issue:2

    Topics: Hexamethonium; Humans; Hyperinsulinism; Hypoglycemia; Insulin Antagonists; Insulins; Muscle Relaxant

1951
Effect of hexamethonium on the response to insulin in animals and man.
    British journal of pharmacology and chemotherapy, 1952, Volume: 7, Issue:2

    Topics: Animals; Cardiovascular Agents; Hexamethonium; Humans; Hypoglycemia; Insulin; Male; Muscle Relaxants

1952
Autonomic control of pancreatic polypeptide and glucagon secretion during neuroglucopenia and hypoglycemia in mice.
    The American journal of physiology, 1993, Volume: 265, Issue:1 Pt 2

    Topics: Animals; Atropine; Autonomic Nervous System; Blood Glucose; Brain Diseases; Eating; Female; Glucagon

1993
Autonomic nervous system mediation of the pancreatic polypeptide response to insulin-induced hypoglycemia in conscious rats.
    Endocrinology, 1992, Volume: 130, Issue:4

    Topics: Animals; Autonomic Nervous System; Blood Glucose; Hexamethonium; Hexamethonium Compounds; Hypoglycem

1992
Corelease of galanin and NE from pancreatic sympathetic nerves during severe hypoglycemia in dogs.
    The American journal of physiology, 1992, Volume: 263, Issue:1 Pt 1

    Topics: Animals; Blood Glucose; Denervation; Dogs; Galanin; Ganglionic Blockers; Glucagon; Hexamethonium; He

1992
Role for autonomic nervous system to increase pancreatic glucagon secretion during marked insulin-induced hypoglycemia in dogs.
    Diabetes, 1991, Volume: 40, Issue:9

    Topics: Animals; Autonomic Nervous System; Blood Glucose; Dogs; Epinephrine; Glucagon; Hematocrit; Hexametho

1991
Capsaicin-sensitive nerves are required for glucostasis but not for catecholamine output during hypoglycemia in rats.
    The American journal of physiology, 1990, Volume: 258, Issue:1 Pt 1

    Topics: Animals; Animals, Newborn; Blood Glucose; Body Weight; Capsaicin; Epinephrine; Hexamethonium; Hexame

1990