hexamethonium has been researched along with Disease Models, Animal in 40 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When hexamethonium was used to assess autonomic control of MAP, no differences in the decrease of MAP in response to ganglionic blockade were detected during the induction." | 5.40 | CNS neuroplasticity and salt-sensitive hypertension induced by prior treatment with subpressor doses of ANG II or aldosterone. ( Beltz, T; Clayton, SC; Johnson, AK; Xue, B; Zhang, Z, 2014) |
| "Early hexamethonium treatment attenuates acute excessive release of catecholamines to prevent cardiac dysfunction and pulmonary edema for increasing survival rate." | 3.79 | Hexamethonium reverses the lethal cardiopulmonary damages in a rat model of brainstem lesions mimicking fatal enterovirus 71 encephalitis. ( Ger, LP; Ho, WY; Hsiao, M; Hsieh, KS; Lai, CC; Lu, PJ; Lu, WH; Tseng, CJ; Wang, JS; Wu, YS, 2013) |
| "In acute experiments in anesthetized rabbits the changes of the pulmonary hemodynamics following myocardial ischemia in the region of the descendent left coronary artery were studied in control animals and after the blockade of alpha-adrenoreceptors by phentolamine or N-cholinoreceptors of autonomic ganglia by hexamethonium." | 3.78 | [The adrenergic mechanisms are involved in the pulmonary hemodynamics changes following experimental myocardial ischemia in rabbits]. ( Evlakhov, VI; Poiasov, IZ, 2012) |
| "Pretreatment with hexamethonium, a ganglion blocker (20 mg/kg, i." | 1.51 | Late Phases of Cardioprotection During Remote Ischemic Preconditioning and Adenosine Preconditioning Involve Activation of Neurogenic Pathway. ( Jaggi, AS; Kumar, M; Singh, H; Singh, N, 2019) |
| "Myocardial infarction is the leading cause of death worldwide." | 1.46 | Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus. ( Chang, YT; Chen, CC; Chen, WH; Chen, YH; Cheng, YF; Shih, HC; Shyu, BC, 2017) |
| "When hexamethonium was used to assess autonomic control of MAP, no differences in the decrease of MAP in response to ganglionic blockade were detected during the induction." | 1.40 | CNS neuroplasticity and salt-sensitive hypertension induced by prior treatment with subpressor doses of ANG II or aldosterone. ( Beltz, T; Clayton, SC; Johnson, AK; Xue, B; Zhang, Z, 2014) |
| "Trigeminal autonomic cephalalgias are highly disabling primary headache disorders, characterized by severe unilateral head pain and associated ipsilateral cranial autonomic features." | 1.38 | A translational in vivo model of trigeminal autonomic cephalalgias: therapeutic characterization. ( Akerman, S; Goadsby, PJ; Holland, PR; Lasalandra, MP; Summ, O, 2012) |
| "Losartan-treated (LOS group, n = 10) and untreated rats served as controls (n = 11)." | 1.35 | Hyperinsulinemic rats are normotensive but sensitized to angiotensin II. ( Alexanderson, C; Andersson, IJ; Bergström, G; Holmäng, A; Johansson, ME; Skøtt, O, 2008) |
| "Pre-treatment with mecamylamine (50 mug; i." | 1.35 | Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations. ( Cansev, M; Hamurtekin, E; Ilcol, YO; Ulus, IH; Yilmaz, MS, 2008) |
| "Tegaserod treatment, which did not affect cholinergic contractions of tissues from low cholesterol fed animals, abrogated the increase caused by the high cholesterol diet." | 1.33 | Increased cholinergic contractions of jejunal smooth muscle caused by a high cholesterol diet are prevented by the 5-HT4 agonist--tegaserod. ( Mathison, R; Shaffer, E, 2006) |
| "Pretreatment with nicotine significantly decreased each of these markers in vagotomized mice with DSS colitis, and all markers except DAI and IL-6 in sham-operated DSS-treated mice." | 1.33 | The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model. ( Blennerhassett, P; Collins, SM; Ghia, JE; Kumar-Ondiveeran, H; Verdu, EF, 2006) |
| "Nicotine was administered orally in the drinking water to achieve serum levels consistent with those of chronic smokers." | 1.32 | Nicotine increases size and severity of experimental choroidal neovascularization. ( Cousins, SW; Espinosa-Heidmann, DG; Hernandez, EP; Marin-Castano, ME; Pereira-Simon, S; Suñer, IJ, 2004) |
| "Production of malignant hypertension was affected by occlusion of one of the adjustable renal clips 3 weeks after BRC." | 1.27 | Characterization of neurohormonal changes following the production of the benign and malignant phases of two-kidney, two-clip Goldblatt hypertension. ( Brosnihan, KB; Ferrario, CM; Saruta, T; Suzuki, H, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.50) | 18.7374 |
| 1990's | 4 (10.00) | 18.2507 |
| 2000's | 23 (57.50) | 29.6817 |
| 2010's | 11 (27.50) | 24.3611 |
| 2020's | 1 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Cheng, YF | 1 |
| Chang, YT | 1 |
| Chen, WH | 1 |
| Shih, HC | 1 |
| Chen, YH | 1 |
| Shyu, BC | 1 |
| Chen, CC | 1 |
| Singh, H | 1 |
| Kumar, M | 1 |
| Singh, N | 1 |
| Jaggi, AS | 1 |
| Clayton, SC | 1 |
| Zhang, Z | 1 |
| Beltz, T | 1 |
| Xue, B | 3 |
| Johnson, AK | 3 |
| Yokoyama, S | 1 |
| Hiramoto, K | 1 |
| Koyama, M | 1 |
| Ooi, K | 1 |
| Leng, Y | 1 |
| Yamamoto, T | 1 |
| Kadowaki, M | 1 |
| Badaue-Passos, D | 1 |
| Guo, F | 2 |
| Gomez-Sanchez, CE | 1 |
| Hay, M | 2 |
| Moreira, TS | 1 |
| Takakura, AC | 1 |
| Colombari, E | 1 |
| Menani, JV | 1 |
| Singh, M | 1 |
| González-Hernández, A | 1 |
| Muñoz-Islas, E | 1 |
| Lozano-Cuenca, J | 1 |
| Ramírez-Rosas, MB | 1 |
| Sánchez-López, A | 1 |
| Centurión, D | 1 |
| Ramírez-San Juan, E | 1 |
| Villalón, CM | 1 |
| Kingma, JG | 1 |
| Simard, D | 1 |
| Voisine, P | 1 |
| Rouleau, JR | 1 |
| Leal, AK | 1 |
| Murphy, MN | 1 |
| Iwamoto, GA | 1 |
| Mitchell, JH | 1 |
| Smith, SA | 1 |
| Evlakhov, VI | 1 |
| Poiasov, IZ | 1 |
| Akerman, S | 1 |
| Holland, PR | 1 |
| Summ, O | 1 |
| Lasalandra, MP | 1 |
| Goadsby, PJ | 1 |
| Lu, WH | 1 |
| Hsieh, KS | 1 |
| Lu, PJ | 1 |
| Wu, YS | 1 |
| Ho, WY | 1 |
| Lai, CC | 1 |
| Wang, JS | 1 |
| Ger, LP | 1 |
| Hsiao, M | 1 |
| Tseng, CJ | 1 |
| Wang, N | 1 |
| Orr-Urtreger, A | 1 |
| Chapman, J | 1 |
| Rabinowitz, R | 1 |
| Korczyn, AD | 1 |
| Rueter, LE | 1 |
| Kohlhaas, KL | 1 |
| Curzon, P | 1 |
| Surowy, CS | 1 |
| Meyer, MD | 1 |
| Suñer, IJ | 1 |
| Espinosa-Heidmann, DG | 1 |
| Marin-Castano, ME | 1 |
| Hernandez, EP | 1 |
| Pereira-Simon, S | 1 |
| Cousins, SW | 1 |
| Gülpinar, MA | 1 |
| Ozbeyli, D | 1 |
| Arbak, S | 1 |
| Yeğen, BC | 1 |
| Yoon, SY | 1 |
| Kim, HW | 1 |
| Roh, DH | 1 |
| Kwon, YB | 1 |
| Jeong, TO | 1 |
| Han, HJ | 1 |
| Lee, HJ | 1 |
| Choi, SM | 1 |
| Ryu, YH | 1 |
| Beitz, AJ | 1 |
| Lee, JH | 1 |
| DeNoble, VJ | 1 |
| Mele, PC | 1 |
| Mathison, R | 1 |
| Shaffer, E | 1 |
| Smith, AD | 1 |
| Dar, MS | 1 |
| Ghia, JE | 1 |
| Blennerhassett, P | 1 |
| Kumar-Ondiveeran, H | 1 |
| Verdu, EF | 1 |
| Collins, SM | 1 |
| Zoccal, DB | 1 |
| Bonagamba, LG | 1 |
| Oliveira, FR | 1 |
| Antunes-Rodrigues, J | 1 |
| Machado, BH | 1 |
| Chen, X | 1 |
| Patel, K | 1 |
| Connors, SG | 1 |
| Mendonca, M | 1 |
| Welch, WJ | 1 |
| Wilcox, CS | 1 |
| Johansson, ME | 1 |
| Andersson, IJ | 1 |
| Alexanderson, C | 1 |
| Skøtt, O | 1 |
| Holmäng, A | 1 |
| Bergström, G | 1 |
| Cansev, M | 1 |
| Ilcol, YO | 1 |
| Yilmaz, MS | 1 |
| Hamurtekin, E | 1 |
| Ulus, IH | 1 |
| Sorrentino, R | 1 |
| Pinto, A | 1 |
| Onuaguluchi, G | 1 |
| Igbo, IN | 1 |
| Kirstetter, P | 1 |
| Moreau, R | 1 |
| Soupison, T | 1 |
| Cailmail, S | 1 |
| Hartleb, M | 1 |
| Lebrec, D | 1 |
| Magder, S | 1 |
| Rastepagarnah, M | 1 |
| Schneider, H | 1 |
| Schaub, CD | 1 |
| Chen, CA | 1 |
| Andreoni, KA | 1 |
| Schwartz, AR | 1 |
| Smith, PL | 1 |
| Robotham, JL | 1 |
| O'Donnell, CP | 1 |
| Greyson, C | 1 |
| Xu, Y | 1 |
| Lu, L | 1 |
| Schwartz, GG | 1 |
| Ugdyzhekova, DS | 1 |
| Davydova, YG | 1 |
| Maimeskulova, LA | 1 |
| Mechoulam, R | 1 |
| Rong, P | 1 |
| Wilkinson-Berka, JL | 1 |
| Skinner, SL | 1 |
| Satoh, K | 1 |
| Hayakawa, T | 1 |
| Kase, Y | 1 |
| Ishige, A | 1 |
| Sasaki, H | 1 |
| Nishikawa, S | 1 |
| Kurosawa, S | 1 |
| Yakabi, K | 1 |
| Nakamura, T | 1 |
| Sayer, B | 1 |
| Lu, J | 1 |
| Green, C | 1 |
| Söderholm, JD | 1 |
| Akhtar, M | 1 |
| McKay, DM | 1 |
| Suzuki, H | 1 |
| Saruta, T | 1 |
| Ferrario, CM | 1 |
| Brosnihan, KB | 1 |
40 other studies available for hexamethonium and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus.
Topics: Animals; Butadienes; Chronic Pain; Disease Models, Animal; Enzyme Inhibitors; Ganglionic Blockers; H | 2017 |
Late Phases of Cardioprotection During Remote Ischemic Preconditioning and Adenosine Preconditioning Involve Activation of Neurogenic Pathway.
Topics: Adenosine; Animals; Autonomic Nervous System; Creatine Kinase; Disease Models, Animal; Ganglionic Bl | 2019 |
CNS neuroplasticity and salt-sensitive hypertension induced by prior treatment with subpressor doses of ANG II or aldosterone.
Topics: Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Brain; Brain-Derived | 2014 |
Impairment of skin barrier function via cholinergic signal transduction in a dextran sulphate sodium-induced colitis mouse model.
Topics: Animals; Antibodies, Monoclonal; Atropine; Cell Count; Colitis; Colon; Dextran Sulfate; Disease Mode | 2015 |
Alteration of cholinergic, purinergic and sensory neurotransmission in the mouse colon of food allergy model.
Topics: Acetylcholine; Animals; Atropine; Capsaicin; Chemokine CCL2; Colon; Disease Models, Animal; Electric | 2008 |
Sex differences and central protective effect of 17beta-estradiol in the development of aldosterone/NaCl-induced hypertension.
Topics: Administration, Oral; Aldosterone; Animals; Blood Pressure; Body Weight; Brain; Disease Models, Anim | 2009 |
Antihypertensive effects of central ablations in spontaneously hypertensive rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Baroreflex; Blood Pressur | 2009 |
Protective actions of estrogen on angiotensin II-induced hypertension: role of central nitric oxide.
Topics: Angiotensin II; Animals; Blood Pressure; Blotting, Western; Disease Models, Animal; Enzyme Inhibitor | 2009 |
Activation of 5-HT1B receptors inhibits the vasodepressor sensory CGRPergic outflow in pithed rats.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dose-Response Rela | 2010 |
Role of the autonomic nervous system in cardioprotection by remote preconditioning in isoflurane-anaesthetized dogs.
Topics: Anesthesia, General; Anesthetics, Inhalation; Animals; Autonomic Denervation; Autonomic Nervous Syst | 2011 |
A role for nitric oxide within the nucleus tractus solitarii in the development of muscle mechanoreflex dysfunction in hypertension.
Topics: Animals; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Ganglionic Blockers; Heart Rate; | 2012 |
[The adrenergic mechanisms are involved in the pulmonary hemodynamics changes following experimental myocardial ischemia in rabbits].
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cardiac Output; Coronary Vessels; Disease Mod | 2012 |
A translational in vivo model of trigeminal autonomic cephalalgias: therapeutic characterization.
Topics: Action Potentials; Analysis of Variance; Animals; Disease Models, Animal; Electric Stimulation; Elec | 2012 |
Hexamethonium reverses the lethal cardiopulmonary damages in a rat model of brainstem lesions mimicking fatal enterovirus 71 encephalitis.
Topics: Animals; Biopsy, Needle; Brain Stem; Catecholamines; Diagnosis, Differential; Disease Models, Animal | 2013 |
Deficiency of nicotinic acetylcholine receptor beta 4 subunit causes autonomic cardiac and intestinal dysfunction.
Topics: Acetylcholine; Animals; Aortic Bodies; Disease Models, Animal; Ganglia, Autonomic; Ganglionic Blocke | 2003 |
Peripheral and central sites of action for A-85380 in the spinal nerve ligation model of neuropathic pain.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Chlorisondamine; Disease Models, Animal; Dose-Respons | 2003 |
Nicotine increases size and severity of experimental choroidal neovascularization.
Topics: Administration, Oral; Animals; Cell Division; Choroid; Choroidal Neovascularization; Disease Models, | 2004 |
Anti-inflammatory effect of acute stress on experimental colitis is mediated by cholecystokinin-B receptors.
Topics: Acute Disease; Animals; Colitis; Colon; Disease Models, Animal; Electric Stimulation; Ganglionic Blo | 2004 |
The anti-inflammatory effect of peripheral bee venom stimulation is mediated by central muscarinic type 2 receptors and activation of sympathetic preganglionic neurons.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Atropine; Autonomic Fibers, Preganglionic; Bee | 2005 |
Intravenous nicotine self-administration in rats: effects of mecamylamine, hexamethonium and naloxone.
Topics: Animals; Association Learning; Brain; Conditioning, Operant; Disease Models, Animal; Dose-Response R | 2006 |
Increased cholinergic contractions of jejunal smooth muscle caused by a high cholesterol diet are prevented by the 5-HT4 agonist--tegaserod.
Topics: Action Potentials; Animals; Carbachol; Cholesterol, Dietary; Cholinergic Agonists; Disease Models, A | 2006 |
Mouse cerebellar nicotinic-cholinergic receptor modulation of Delta9-THC ataxia: role of the alpha4beta2 subtype.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cannabinoid Receptor Agonists; Cerebellar Ataxia; | 2006 |
The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model.
Topics: Animals; Anticoagulants; Appetite Depressants; Dextran Sulfate; Dinitrofluorobenzene; Disease Models | 2006 |
Increased sympathetic activity in rats submitted to chronic intermittent hypoxia.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Chronic Disease; Disease Models, A | 2007 |
Acute antihypertensive action of Tempol in the spontaneously hypertensive rat.
Topics: Amitrole; Animals; Antihypertensive Agents; Blood Pressure; Buthionine Sulfoximine; Catalase; Cromak | 2007 |
Hyperinsulinemic rats are normotensive but sensitized to angiotensin II.
Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Ag | 2008 |
Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations.
Topics: Adrenal Glands; Animals; Atropine Derivatives; Autonomic Nervous System; Central Nervous System; Cho | 2008 |
Effect of methylguanidine on rat blood pressure: role of endothelial nitric oxide synthase.
Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Endothe | 1995 |
Effect of levamisole hydrochloride on the guinea-pig atrium.
Topics: Animals; Arrhythmias, Cardiac; Atropine; Disease Models, Animal; Drug Antagonism; Drug Evaluation, P | 1993 |
Role of sympathetic cardiovascular tone in control of arterial pressure in rats with cirrhosis.
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Hemodynamics; Hexamethonium; Liver Cirrhosi | 1996 |
Role of neurosympathetic pathways in the vascular response to sepsis.
Topics: Adaptation, Physiological; Animals; Cyclooxygenase Inhibitors; Denervation; Disease Models, Animal; | 1998 |
Neural and local effects of hypoxia on cardiovascular responses to obstructive apnea.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Cardiovascular System; Disease Models, Animal; Do | 2000 |
Right ventricular pressure and dilation during pressure overload determine dysfunction after pressure overload.
Topics: Animals; Atropine; Cardiac Catheterization; Cardiotonic Agents; Cardiovascular Agents; Diastole; Dil | 2000 |
Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine.
Topics: Animals; Arrhythmias, Cardiac; Cannabinoids; Disease Models, Animal; Dronabinol; Epinephrine; Gangli | 2000 |
Control of renin secretion from adrenal gland in transgenic Ren-2 and normal rats.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitor | 2001 |
Mechanisms for contractile effect of Dai-kenchu-to in isolated guinea pig ileum.
Topics: Acetylcholine; Animals; Atropine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Eva | 2001 |
Dextran sodium sulphate-induced colitis perturbs muscarinic cholinergic control of colonic epithelial ion transport.
Topics: Animals; Atropine; Carbachol; Cholinergic Agonists; Colitis; Dextran Sulfate; Disease Models, Animal | 2002 |
Characterization of neurohormonal changes following the production of the benign and malignant phases of two-kidney, two-clip Goldblatt hypertension.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Arginine Vasopressin; Captopril; Ca | 1987 |